Published in Biochemistry on February 22, 2005
Structure modeling of all identified G protein-coupled receptors in the human genome. PLoS Comput Biol (2006) 2.40
Discovery of dermorphin-based affinity labels with subnanomolar affinity for mu opioid receptors. J Med Chem (2009) 0.78
Dual labeled peptides as tools to study receptors: nanomolar affinity derivatives of TIPP (Tyr-Tic-Phe-Phe) containing an affinity label and biotin as probes of delta opioid receptors. Bioconjug Chem (2009) 0.75
Antidepressant-like effects of kappa-opioid receptor antagonists in the forced swim test in rats. J Pharmacol Exp Ther (2003) 3.48
Effects of kappa-opioid receptor ligands on intracranial self-stimulation in rats. Psychopharmacology (Berl) (2004) 2.35
A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers. Proc Natl Acad Sci U S A (2005) 2.31
Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand series. Proc Natl Acad Sci U S A (2005) 2.29
A bivalent ligand (KDN-21) reveals spinal delta and kappa opioid receptors are organized as heterodimers that give rise to delta(1) and kappa(2) phenotypes. Selective targeting of delta-kappa heterodimers. J Med Chem (2004) 1.61
A bivalent ligand (KDAN-18) containing delta-antagonist and kappa-agonist pharmacophores bridges delta2 and kappa1 opioid receptor phenotypes. J Med Chem (2005) 1.41
Sigma receptor agonists: receptor binding and effects on mesolimbic dopamine neurotransmission assessed by microdialysis. Biol Psychiatry (2010) 1.39
Self-treatment of opioid withdrawal using kratom (Mitragynia speciosa korth). Addiction (2008) 1.32
Interaction of bivalent ligand KDN21 with heterodimeric delta-kappa opioid receptors in human embryonic kidney 293 cells. Mol Pharmacol (2005) 1.29
Opioid receptors and legal highs: Salvia divinorum and Kratom. Clin Toxicol (Phila) (2008) 1.28
Targeting the methyl erythritol phosphate (MEP) pathway for novel antimalarial, antibacterial and herbicidal drug discovery: inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) enzyme. Curr Pharm Des (2007) 1.26
Absence of conditioned place preference or reinstatement with bivalent ligands containing mu-opioid receptor agonist and delta-opioid receptor antagonist pharmacophores. Eur J Pharmacol (2007) 1.22
Ligands that interact with putative MOR-mGluR5 heteromer in mice with inflammatory pain produce potent antinociception. Proc Natl Acad Sci U S A (2013) 1.22
Standard opioid agonists activate heteromeric opioid receptors: evidence for morphine and [d-Ala(2)-MePhe(4)-Glyol(5)]enkephalin as selective μ-δ agonists. ACS Chem Neurosci (2009) 1.13
Kappa opioid antagonist effects of the novel kappa antagonist 5'-guanidinonaltrindole (GNTI) in an assay of schedule-controlled behavior in rhesus monkeys. Psychopharmacology (Berl) (2002) 1.09
Induced association of mu opioid (MOP) and type 2 cholecystokinin (CCK2) receptors by novel bivalent ligands. J Med Chem (2009) 1.06
N-naphthoyl-beta-naltrexamine (NNTA), a highly selective and potent activator of μ/kappa-opioid heteromers. Proc Natl Acad Sci U S A (2011) 1.05
Sigma receptors and cocaine abuse. Curr Top Med Chem (2011) 1.02
Allosteric interactions between δ and κ opioid receptors in peripheral sensory neurons. Mol Pharmacol (2011) 1.00
Mitragyna speciosa, a psychoactive tree from Southeast Asia with opioid activity. Curr Top Med Chem (2011) 0.99
A novel substituted piperazine, CM156, attenuates the stimulant and toxic effects of cocaine in mice. J Pharmacol Exp Ther (2010) 0.98
Conversion of a highly selective sigma-1 receptor-ligand to sigma-2 receptor preferring ligands with anticocaine activity. J Med Chem (2008) 0.97
Toward a structure-based model of salvinorin A recognition of the kappa-opioid receptor. J Med Chem (2008) 0.97
Determination of mitragynine in rat plasma by LC-MS/MS: application to pharmacokinetics. J Chromatogr B Analyt Technol Biomed Life Sci (2009) 0.94
A bivalent ligand (KMN-21) antagonist for mu/kappa heterodimeric opioid receptors. Bioorg Med Chem Lett (2009) 0.94
Synthesis and pharmacological evaluation of 6-acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one (SN79), a cocaine antagonist, in rodents. AAPS J (2011) 0.94
A combined ligand-based and target-based drug design approach for G-protein coupled receptors: application to salvinorin A, a selective kappa opioid receptor agonist. J Comput Aided Mol Des (2006) 0.93
Synthesis and in vitro characterization of radioiodinatable benzodiazepines selective for type 1 and type 2 cholecystokinin receptors. J Med Chem (2009) 0.93
Clinically employed opioid analgesics produce antinociception via μ-δ opioid receptor heteromers in Rhesus monkeys. ACS Chem Neurosci (2012) 0.92
Naloxone acts as a potent analgesic in transgenic mouse models of sickle cell anemia. Proc Natl Acad Sci U S A (2007) 0.92
Molecular basis for binding and subtype selectivity of 1,4-benzodiazepine antagonist ligands of the cholecystokinin receptor. J Biol Chem (2012) 0.92
A unique binding epitope for salvinorin A, a non-nitrogenous kappa opioid receptor agonist. FEBS J (2006) 0.90
Early development of sigma-receptor ligands. Future Med Chem (2011) 0.90
The FEMA GRAS assessment of cinnamyl derivatives used as flavor ingredients. Food Chem Toxicol (2004) 0.90
The hallucinogen derived from Salvia divinorum, salvinorin A, has kappa-opioid agonist discriminative stimulus effects in rats. Neuropharmacology (2007) 0.90
CM156, a high affinity sigma ligand, attenuates the stimulant and neurotoxic effects of methamphetamine in mice. Neuropharmacology (2011) 0.89
Homology modeling and molecular dynamics simulations of the mu opioid receptor in a membrane-aqueous system. Chembiochem (2005) 0.89
The δ opioid receptor agonist SNC80 selectively activates heteromeric μ-δ opioid receptors. ACS Chem Neurosci (2012) 0.89
Pharmacological evaluation of SN79, a sigma (σ) receptor ligand, against methamphetamine-induced neurotoxicity in vivo. Eur Neuropsychopharmacol (2012) 0.89
Selectivity of delta- and kappa-opioid ligands depends on the route of central administration in mice. J Pharmacol Exp Ther (2007) 0.89
SN79, a sigma receptor ligand, blocks methamphetamine-induced microglial activation and cytokine upregulation. Exp Neurol (2013) 0.88
Phytochemical characterization of the leaves of Mitragyna speciosa grown in U.S.A. Nat Prod Commun (2009) 0.87
Reduced antinociception of opioids in rats and mice by vaccination with immunogens containing oxycodone and hydrocodone haptens. J Med Chem (2013) 0.86
The evaluation of AZ66, an optimized sigma receptor antagonist, against methamphetamine-induced dopaminergic neurotoxicity and memory impairment in mice. Int J Neuropsychopharmacol (2012) 0.86
Comparison of peptidic and nonpeptidic delta-opioid agonists on guanosine 5'-O-(3-[35S]thio)triphosphate ([35S]GTPgammaS) binding in brain slices from Sprague-Dawley rats. J Pharmacol Exp Ther (2004) 0.85
Opioid receptor function in social attachment in young domestic fowl. Behav Brain Res (2005) 0.85
Modulation of cell surface expression of nonactivated cholecystokinin receptors using bivalent ligand-induced internalization. J Med Chem (2010) 0.84
Bivalent ligands that target μ opioid (MOP) and cannabinoid1 (CB1) receptors are potent analgesics devoid of tolerance. J Med Chem (2013) 0.84
An immunocytochemical-derived correlate for evaluating the bridging of heteromeric mu-delta opioid protomers by bivalent ligands. ACS Chem Biol (2013) 0.83
CM156, a sigma receptor ligand, reverses cocaine-induced place conditioning and transcriptional responses in the brain. Pharmacol Biochem Behav (2011) 0.83
Ultra-performance liquid chromatography tandem mass spectrometry method for the determination of AZ66, a sigma receptor ligand, in rat plasma and its application to in vivo pharmacokinetics. Biomed Chromatogr (2013) 0.82
Dopamine uptake and cocaine binding mechanisms: the involvement of charged amino acids from the transmembrane domains of the human dopamine transporter. Eur J Pharmacol (2006) 0.82
Chemical function-based pharmacophore development for novel, selective kappa opioid receptor agonists. J Mol Graph Model (2008) 0.81
Determination of a highly selective mixed-affinity sigma receptor ligand, in rat plasma by ultra performance liquid chromatography mass spectrometry and its application to a pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci (2011) 0.81
Herbal medicines for the management of opioid addiction: safe and effective alternatives to conventional pharmacotherapy? CNS Drugs (2011) 0.81
Structure-activity relationships of neuropeptide FF and related peptidic and non-peptidic derivatives. Peptides (2006) 0.81
Methadone and heroin antinociception: predominant delta-opioid-receptor responses in methadone-tolerant mice. Jpn J Pharmacol (2002) 0.81
Synthesis and pharmacological characterization of a novel sigma receptor ligand with improved metabolic stability and antagonistic effects against methamphetamine. AAPS J (2011) 0.81
Antidepressive effects of the κ-opioid receptor agonist salvinorin A in a rat model of anhedonia. Behav Pharmacol (2012) 0.81
Consequences of opioid receptor mutation on actions of univalent and bivalent kappa and delta ligands. Psychopharmacology (Berl) (2010) 0.81
Evaluation of σ-1 receptor radioligand 18F-FTC-146 in rats and squirrel monkeys using PET. J Nucl Med (2013) 0.81
A 96-well filtration method for radioligand binding analysis of σ receptor ligands. J Pharm Biomed Anal (2012) 0.80
Toward Mycobacterium tuberculosis DXR inhibitor design: homology modeling and molecular dynamics simulations. J Comput Aided Mol Des (2007) 0.79
Characterization of specific opioid binding sites in neural membranes from the myenteric plexus of porcine small intestine. J Pharmacol Exp Ther (2003) 0.79
Putative kappa opioid heteromers as targets for developing analgesics free of adverse effects. J Med Chem (2014) 0.78
Heteroatom analogues of hydrocodone: synthesis and biological activity. J Org Chem (2013) 0.78
Criteria for the safety evaluation of flavoring substances. The Expert Panel of the Flavor and Extract Manufacturers Association. Food Chem Toxicol (2005) 0.78
Comparative protein modeling of 1-deoxy-D-xylulose-5-phosphate reductoisomerase enzyme from Plasmodium falciparum: a potential target for antimalarial drug discovery. J Chem Inf Model (2006) 0.78
Synthesis and characterization of [³H]-SN56, a novel radioligand for the σ₁ receptor. Eur J Pharmacol (2010) 0.78
Nonpeptide small molecule agonist and antagonist original leads for neuropeptide FF1 and FF2 receptors. J Med Chem (2014) 0.77
Sigma receptor antagonists attenuate acute methamphetamine-induced hyperthermia by a mechanism independent of IL-1β mRNA expression in the hypothalamus. Eur J Pharmacol (2012) 0.77
Solution-phase parallel synthesis of spirohydantoins. J Comb Chem (2005) 0.77
Nonpeptide ligands of neuropeptide FF: current status and structural insights. Future Med Chem (2012) 0.77
Beta-triketone inhibitors of plant p-hydroxyphenylpyruvate dioxygenase: modeling and comparative molecular field analysis of their interactions. J Agric Food Chem (2009) 0.77
σ Receptor antagonist attenuation of methamphetamine-induced neurotoxicity is correlated to body temperature modulation. Pharmacol Rep (2013) 0.76
Opioid activity of spinally selective analogues of N-naphthoyl-β-naltrexamine in HEK-293 cells and mice. J Med Chem (2012) 0.76
My farewell to the Journal of Medicinal Chemistry. J Med Chem (2011) 0.76
Synthesis and pharmacological evaluation of indole-based sigma receptor ligands. Eur J Med Chem (2011) 0.75
Computational Study on the Conformations of Mitragynine and Mitragynaline. Theochem (2010) 0.75
Development and validation of a UPLC-MS/MS method for the determination of 7-hydroxymitragynine, a μ-opioid agonist, in rat plasma and its application to a pharmacokinetic study. Biomed Chromatogr (2013) 0.75
Structure activity relationship study of benzo[d]thiazol-2(3H)one based σ receptor ligands. Bioorg Med Chem Lett (2013) 0.75
Modulation of musculoskeletal hyperalgesia by brown adipose tissue activity in mice. Pain (2016) 0.75
Revision of purity criteria for tested compounds. J Med Chem (2009) 0.75
Inhibition of choline uptake by N-cyclohexylcholine, a high affinity ligand for the choline transporter at the blood-brain barrier. J Drug Target (2005) 0.75
A bivalent ligand that activates mu opioid receptor and antagonizes mGluR5 receptor reduces neuropathic pain in mice. Pain (2017) 0.75
SAR analysis of new dual targeting fluoroquinolones. Implications of the benzenesulfonyl group. Med Chem (2012) 0.75
Opioid receptor-like 1 (ORL1) molecular "road map" to understanding ligand interaction and selectivity. Curr Top Med Chem (2005) 0.75
Naphthalene dicarboxaldehyde as an electrophilic fluorogenic moiety for affinity labeling: application to opioid receptor affinity labels with greatly improved fluorogenic properties. J Med Chem (2002) 0.75
Strategies to treat substance abuse and addiction. Curr Top Med Chem (2011) 0.75
Ligand macromolecule interactions: theoretical principles of molecular recognition. Methods Mol Biol (2009) 0.75
o-Naphthalenedicarboxaldehyde derivative of 7'-aminonaltrindole as a selective delta-opioid receptor affinity label. J Med Chem (2007) 0.75