Published in Curr Opin Neurobiol on February 01, 2005
Intra-axonal translation and retrograde trafficking of CREB promotes neuronal survival. Nat Cell Biol (2008) 2.37
Unc-51-like kinase 1/2-mediated endocytic processes regulate filopodia extension and branching of sensory axons. Proc Natl Acad Sci U S A (2007) 1.95
Recruitment of actin modifiers to TrkA endosomes governs retrograde NGF signaling and survival. Cell (2011) 1.87
Long-distance control of synapse assembly by target-derived NGF. Neuron (2010) 1.81
Action in the axon: generation and transport of signaling endosomes. Curr Opin Neurobiol (2008) 1.69
Function and regulation of local axonal translation. Curr Opin Neurobiol (2008) 1.69
Endocytosis and signaling: cell logistics shape the eukaryotic cell plan. Physiol Rev (2012) 1.61
A model for neuronal competition during development. Science (2008) 1.52
Endocytosis and cancer. Cold Spring Harb Perspect Biol (2013) 1.40
Cdk5 is involved in BDNF-stimulated dendritic growth in hippocampal neurons. PLoS Biol (2007) 1.28
Genetic control of programmed cell death during animal development. Annu Rev Genet (2009) 1.24
Roles of BLOC-1 and adaptor protein-3 complexes in cargo sorting to synaptic vesicles. Mol Biol Cell (2009) 1.22
Als2-deficient mice exhibit disturbances in endosome trafficking associated with motor behavioral abnormalities. Proc Natl Acad Sci U S A (2006) 1.21
Pathogenic cascades in lysosomal disease-Why so complex? J Inherit Metab Dis (2009) 1.20
Controlled and stochastic retention concentrates dynein at microtubule ends to keep endosomes on track. EMBO J (2011) 1.18
Gαs promotes EEA1 endosome maturation and shuts down proliferative signaling through interaction with GIV (Girdin). Mol Biol Cell (2012) 1.15
Neurotrophin-mediated dendrite-to-nucleus signaling revealed by microfluidic compartmentalization of dendrites. Proc Natl Acad Sci U S A (2011) 1.15
β-Amyloid impairs axonal BDNF retrograde trafficking. Neurobiol Aging (2009) 1.13
Kinesin-3 and dynein cooperate in long-range retrograde endosome motility along a nonuniform microtubule array. Mol Biol Cell (2011) 1.13
Pincher-generated Nogo-A endosomes mediate growth cone collapse and retrograde signaling. J Cell Biol (2010) 1.09
Myopic acts in the endocytic pathway to enhance signaling by the Drosophila EGF receptor. Development (2008) 1.06
Snapin recruits dynein to BDNF-TrkB signaling endosomes for retrograde axonal transport and is essential for dendrite growth of cortical neurons. Cell Rep (2012) 1.06
Trk activation of the ERK1/2 kinase pathway stimulates intermediate chain phosphorylation and recruits cytoplasmic dynein to signaling endosomes for retrograde axonal transport. J Neurosci (2012) 1.06
Kidins220/ARMS is transported by a kinesin-1-based mechanism likely to be involved in neuronal differentiation. Mol Biol Cell (2006) 1.05
Proneurotrophin-3 is a neuronal apoptotic ligand: evidence for retrograde-directed cell killing. J Neurosci (2009) 1.03
Endocytic trafficking of neurotrophins in neural development. Trends Cell Biol (2012) 1.01
Modeling the signaling endosome hypothesis: why a drive to the nucleus is better than a (random) walk. Theor Biol Med Model (2005) 0.98
Subcellular resolution mapping of endogenous cytokine secretion by nano-plasmonic-resonator sensor array. Nano Lett (2011) 0.93
Up-regulation of brain-derived neurotrophic factor is regulated by extracellular signal-regulated protein kinase 5 and by nerve growth factor retrograde signaling in colonic afferent neurons in colitis. Exp Neurol (2012) 0.88
GDNF-based therapies, GDNF-producing interneurons, and trophic support of the dopaminergic nigrostriatal pathway. Implications for Parkinson's disease. Front Neuroanat (2015) 0.87
Activation of extracellular signal-regulated protein kinase 5 is essential for cystitis- and nerve growth factor-induced calcitonin gene-related peptide expression in sensory neurons. Mol Pain (2012) 0.87
Effects of membrane trafficking on signaling by receptor tyrosine kinases. Cold Spring Harb Perspect Biol (2013) 0.87
Endosome-mediated retrograde axonal transport of P2X3 receptor signals in primary sensory neurons. Cell Res (2011) 0.86
ERK-mediated NGF signaling in the rat septo-hippocampal pathway diminishes with age. Psychopharmacology (Berl) (2006) 0.86
Commuting within the cell-mind the GAPs. Workshop on Systems Dynamics of Intracellular Communication: overcoming Distance in Signalling Networks. EMBO Rep (2007) 0.85
The STAT3 beacon: IL-6 recurrently activates STAT 3 from endosomal structures. Exp Cell Res (2011) 0.85
Characterization of trans-neuronal trafficking of Cbln1. Mol Cell Neurosci (2009) 0.85
EphA2 signaling following endocytosis: role of Tiam1. Traffic (2013) 0.84
Functional characterization and axonal transport of quantum dot labeled BDNF. Integr Biol (Camb) (2012) 0.84
The role of rab proteins in neuronal cells and in the trafficking of neurotrophin receptors. Membranes (Basel) (2014) 0.83
BDNF and NT4 play interchangeable roles in gustatory development. Dev Biol (2013) 0.83
Charcot-Marie-Tooth disease and intracellular traffic. Prog Neurobiol (2012) 0.81
In vivo regulation of brain-derived neurotrophic factor in dorsal root ganglia is mediated by nerve growth factor-triggered Akt activation during cystitis. PLoS One (2013) 0.81
Endophilin B1: Guarding the gate to destruction. Commun Integr Biol (2009) 0.80
Epidermal growth factor stimulates extracellular-signal regulated kinase phosphorylation of a novel site on cytoplasmic Dynein intermediate chain 2. Int J Mol Sci (2013) 0.80
Regulation of neurotrophin receptor (Trk) signaling: suppressor of cytokine signaling 2 (SOCS2) is a new player. Front Mol Neurosci (2014) 0.78
Heterogeneous intracellular trafficking dynamics of brain-derived neurotrophic factor complexes in the neuronal soma revealed by single quantum dot tracking. PLoS One (2014) 0.77
Retrograde neurotrophic signaling requires a protein interacting with receptor tyrosine kinases via C2H2 zinc fingers. Mol Biol Cell (2009) 0.76
There and back again: coordinated transcription, translation and transport in axonal survival and regeneration. Curr Opin Neurobiol (2016) 0.76
Outsourcing CREB translation to axons to survive. Nat Cell Biol (2008) 0.76
Regulation of dendritic development by semaphorin 3A through novel intracellular remote signaling. Cell Adh Migr (2016) 0.75
RabGEF1/Rabex-5 Regulates TrkA-Mediated Neurite Outgrowth and NMDA-Induced Signaling Activation in NGF-Differentiated PC12 Cells. PLoS One (2015) 0.75
The Roles of Microtubule-Based Transport at Presynaptic Nerve Terminals. Front Synaptic Neurosci (2016) 0.75
Synaptic generation of an intracellular retrograde signal requires activation of the tyrosine kinase and mitogen-activated protein kinase signaling cascades in Aplysia. Neurobiol Learn Mem (2015) 0.75
NGF-TrkA Signaling by Sensory Nerves Coordinates the Vascularization and Ossification of Developing Endochondral Bone. Cell Rep (2016) 0.75
Regulation of neurokine receptor signaling and trafficking. Neurochem Int (2012) 0.75
Chemoenzymatically prepared konjac ceramide inhibits NGF-induced neurite outgrowth by a semaphorin 3A-like action. Biochem Biophys Rep (2015) 0.75
Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration. Neuron (2006) 3.51
NGF signaling in sensory neurons: evidence that early endosomes carry NGF retrograde signals. Neuron (2003) 3.23
The 50th anniversary of the discovery of trisomy 21: the past, present, and future of research and treatment of Down syndrome. Genet Med (2009) 2.83
One at a time, live tracking of NGF axonal transport using quantum dots. Proc Natl Acad Sci U S A (2007) 2.74
Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome. J Neurosci (2004) 2.73
Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease. Neuron (2010) 2.20
Review of the toxicology of chlorpyrifos with an emphasis on human exposure and neurodevelopment. Crit Rev Toxicol (2008) 1.93
Synaptic structural abnormalities in the Ts65Dn mouse model of Down Syndrome. J Comp Neurol (2004) 1.92
Signaling endosome hypothesis: A cellular mechanism for long distance communication. J Neurobiol (2004) 1.63
Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome. Nat Med (2013) 1.61
Widespread changes in dendritic and axonal morphology in Mecp2-mutant mouse models of Rett syndrome: evidence for disruption of neuronal networks. J Comp Neurol (2009) 1.57
TrkB binds and tyrosine-phosphorylates Tiam1, leading to activation of Rac1 and induction of changes in cellular morphology. Proc Natl Acad Sci U S A (2006) 1.48
The "Down syndrome critical region" is sufficient in the mouse model to confer behavioral, neurophysiological, and synaptic phenotypes characteristic of Down syndrome. J Neurosci (2009) 1.46
An AUPN/ANA survey of department leader opinions on the health of US academic neurology. Neurology (2004) 1.40
Synaptic and cognitive abnormalities in mouse models of Down syndrome: exploring genotype-phenotype relationships. J Comp Neurol (2007) 1.38
The coming of age of axonal neurotrophin signaling endosomes. J Proteomics (2008) 1.35
Late onset neurodegeneration in the Cln3-/- mouse model of juvenile neuronal ceroid lipofuscinosis is preceded by low level glial activation. Brain Res (2004) 1.32
Excitatory-inhibitory relationship in the fascia dentata in the Ts65Dn mouse model of Down syndrome. J Comp Neurol (2009) 1.31
Comparative study of brain morphology in Mecp2 mutant mouse models of Rett syndrome. J Comp Neurol (2008) 1.26
Endophilin B1 as a novel regulator of nerve growth factor/ TrkA trafficking and neurite outgrowth. J Neurosci (2008) 1.20
Membrane targeting by APPL1 and APPL2: dynamic scaffolds that oligomerize and bind phosphoinositides. Traffic (2007) 1.20
Evidence for both neuronal cell autonomous and nonautonomous effects of methyl-CpG-binding protein 2 in the cerebral cortex of female mice with Mecp2 mutation. Neurobiol Dis (2009) 1.18
Deficits in cognition and synaptic plasticity in a mouse model of Down syndrome ameliorated by GABAB receptor antagonists. J Neurosci (2012) 1.17
A functional dynein-microtubule network is required for NGF signaling through the Rap1/MAPK pathway. Traffic (2007) 1.15
Traffic at the intersection of neurotrophic factor signaling and neurodegeneration. Trends Neurosci (2003) 1.12
Comprehensive behavioral phenotyping of Ts65Dn mouse model of Down syndrome: activation of β1-adrenergic receptor by xamoterol as a potential cognitive enhancer. Neurobiol Dis (2011) 1.09
Increased efficiency of the GABAA and GABAB receptor-mediated neurotransmission in the Ts65Dn mouse model of Down syndrome. Neurobiol Dis (2011) 1.05
Effects of individual segmental trisomies of human chromosome 21 syntenic regions on hippocampal long-term potentiation and cognitive behaviors in mice. Brain Res (2010) 1.05
Illicium sesquiterpenes: divergent synthetic strategy and neurotrophic activity studies. Chemistry (2013) 1.04
The challenge of connecting the dots in the B.R.A.I.N. Neuron (2013) 0.99
Implications for treatment: GABAA receptors in aging, Down syndrome and Alzheimer's disease. J Neurochem (2011) 0.99
Retrolinkin, a membrane protein, plays an important role in retrograde axonal transport. Proc Natl Acad Sci U S A (2007) 0.99
Soluble γ-secretase modulators selectively inhibit the production of the 42-amino acid amyloid β peptide variant and augment the production of multiple carboxy-truncated amyloid β species. Biochemistry (2014) 0.98
Identification and characterization of a new Down syndrome model, Ts[Rb(12.1716)]2Cje, resulting from a spontaneous Robertsonian fusion between T(171)65Dn and mouse chromosome 12. Mamm Genome (2005) 0.96
Going the distance, or not, with neurotrophin signals. Cell (2004) 0.95
Mouse models for Down syndrome-associated developmental cognitive disabilities. Dev Neurosci (2011) 0.95
Using mouse models to explore genotype-phenotype relationship in Down syndrome. Ment Retard Dev Disabil Res Rev (2007) 0.93
Enantioselective synthesis of (-)-jiadifenin, a potent neurotrophic modulator. Org Lett (2011) 0.92
Trafficking the NGF signal: implications for normal and degenerating neurons. Prog Brain Res (2004) 0.92
Deficiencies in the region syntenic to human 21q22.3 cause cognitive deficits in mice. Mamm Genome (2010) 0.91
Sleep and EEG features in genetic models of Down syndrome. Neurobiol Dis (2007) 0.90
Amyloid precursor protein-mediated endocytic pathway disruption induces axonal dysfunction and neurodegeneration. J Clin Invest (2016) 0.87
Cognitive and pharmacological insights from the Ts65Dn mouse model of Down syndrome. Curr Opin Neurobiol (2012) 0.83
Human chromosome 21 orthologous region on mouse chromosome 17 is a major determinant of Down syndrome-related developmental cognitive deficits. Hum Mol Genet (2013) 0.83
Potential use of γ-secretase modulators in the treatment of Alzheimer disease. Arch Neurol (2012) 0.83
Genetic analysis of Down syndrome facilitated by mouse chromosome engineering. Bioeng Bugs (2012) 0.80
Aging and intellectual disability: insights from mouse models of Down syndrome. Dev Disabil Res Rev (2013) 0.79