Published in Nat Med on March 24, 2013
The Orphan Nuclear Receptor TLX Is an Enhancer of STAT1-Mediated Transcription and Immunity to Toxoplasma gondii. PLoS Biol (2015) 1.42
Biallelic mutations in SNX14 cause a syndromic form of cerebellar atrophy and lysosome-autophagosome dysfunction. Nat Genet (2015) 1.05
New insights into the therapeutic potential of Girk channels. Trends Neurosci (2013) 1.01
Endocytosis, signaling, and beyond. Cold Spring Harb Perspect Biol (2014) 1.01
A unique PDZ domain and arrestin-like fold interaction reveals mechanistic details of endocytic recycling by SNX27-retromer. Proc Natl Acad Sci U S A (2014) 1.00
A role for sorting nexin 27 in AMPA receptor trafficking. Nat Commun (2014) 0.99
Retromer mediates a discrete route of local membrane delivery to dendrites. Neuron (2014) 0.97
Dysregulation of protein trafficking in neurodegeneration. Mol Neurodegener (2014) 0.95
Mutations in SNX14 cause a distinctive autosomal-recessive cerebellar ataxia and intellectual disability syndrome. Am J Hum Genet (2014) 0.92
A defect in the retromer accessory protein, SNX27, manifests by infantile myoclonic epilepsy and neurodegeneration. Neurogenetics (2015) 0.91
β1-adrenergic receptor recycles via a membranous organelle, recycling endosome, by binding with sorting nexin27. J Membr Biol (2013) 0.90
Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis. Neuron (2015) 0.89
Sorting nexin 27 regulates Aβ production through modulating γ-secretase activity. Cell Rep (2014) 0.89
Sorting Nexin 27 regulates basal and activity-dependent trafficking of AMPARs. Proc Natl Acad Sci U S A (2014) 0.89
Sorting nexin 27 regulation of G protein-gated inwardly rectifying K⁺ channels attenuates in vivo cocaine response. Neuron (2014) 0.89
Sorting nexin 27 couples PTHR trafficking to retromer for signal regulation in osteoblasts during bone growth. Mol Biol Cell (2016) 0.89
Snx14 regulates neuronal excitability, promotes synaptic transmission, and is imprinted in the brain of mice. PLoS One (2014) 0.88
The Sorting Receptor SorCS1 Regulates Trafficking of Neurexin and AMPA Receptors. Neuron (2015) 0.85
Caspase-2 cleavage of tau reversibly impairs memory. Nat Med (2016) 0.83
GPCR Signaling and Trafficking: The Long and Short of It. Trends Endocrinol Metab (2016) 0.83
Phosphoinositide binding by the SNX27 FERM domain regulates its localization at the immune synapse of activated T-cells. J Cell Sci (2015) 0.82
miR-155 Is Essential for Inflammation-Induced Hippocampal Neurogenic Dysfunction. J Neurosci (2015) 0.81
The role of the retromer complex in aging-related neurodegeneration: a molecular and genomic review. Mol Genet Genomics (2014) 0.81
Parent ratings of ability to consent for clinical trials in fragile X syndrome. J Empir Res Hum Res Ethics (2014) 0.81
Apolipoprotein E lipoprotein particles inhibit amyloid-β uptake through cell surface heparan sulphate proteoglycan. Mol Neurodegener (2016) 0.80
Down Syndrome Developmental Brain Transcriptome Reveals Defective Oligodendrocyte Differentiation and Myelination. Neuron (2016) 0.80
A nexus for receptor recycling. Nat Cell Biol (2013) 0.79
TLR3 ligand Poly IC Attenuates Reactive Astrogliosis and Improves Recovery of Rats after Focal Cerebral Ischemia. CNS Neurosci Ther (2015) 0.79
A molecular code for endosomal recycling of phosphorylated cargos by the SNX27-retromer complex. Nat Struct Mol Biol (2016) 0.79
Dissecting Alzheimer disease in Down syndrome using mouse models. Front Behav Neurosci (2015) 0.79
SNX15 Regulates Cell Surface Recycling of APP and Aβ Generation. Mol Neurobiol (2015) 0.78
Atypical parkinsonism-associated retromer mutant alters endosomal sorting of specific cargo proteins. J Cell Biol (2016) 0.78
Sorting receptors at Down's syndrome synapses. Nat Med (2013) 0.77
Genome-wide miR-155 and miR-802 target gene identification in the hippocampus of Ts65Dn Down syndrome mouse model by miRNA sponges. BMC Genomics (2015) 0.77
ER to synapse trafficking of NMDA receptors. Front Cell Neurosci (2014) 0.77
Systematic reanalysis of partial trisomy 21 cases with or without Down syndrome suggests a small region on 21q22.13 as critical to the phenotype. Hum Mol Genet (2016) 0.77
SNX27 and SORLA Interact to Reduce Amyloidogenic Subcellular Distribution and Processing of Amyloid Precursor Protein. J Neurosci (2016) 0.76
Non-muscle myosin II in disease: mechanisms and therapeutic opportunities. Dis Model Mech (2015) 0.76
Sorting nexin 27 regulates basal and stimulated brush border trafficking of NHE3. Mol Biol Cell (2015) 0.76
SNX27 Deletion Causes Hydrocephalus by Impairing Ependymal Cell Differentiation and Ciliogenesis. J Neurosci (2016) 0.76
The GTP- and Phospholipid-Binding Protein TTD14 Regulates Trafficking of the TRPL Ion Channel in Drosophila Photoreceptor Cells. PLoS Genet (2015) 0.76
Epitope Fingerprinting for Recognition of the Polyclonal Serum Autoantibodies of Alzheimer's Disease. Biomed Res Int (2015) 0.75
Inflammation-induced miRNA-155 inhibits self-renewal of neural stem cells via suppression of CCAAT/enhancer binding protein β (C/EBPβ) expression. Sci Rep (2017) 0.75
Role of the Retromer Complex in Neurodegenerative Diseases. Front Aging Neurosci (2016) 0.75
Molecular neurodegeneration: basic biology and disease pathways. Mol Neurodegener (2014) 0.75
Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders. Nat Commun (2016) 0.75
Association of new deletion/duplication region at chromosome 1p21 with intellectual disability, severe speech deficit and autism spectrum disorder-like behavior: an all-in approach to solving the DPYD enigma. Transl Neurosci (2015) 0.75
Retromer/WASH dependent sorting of nutrient transporters requires a multivalent interaction network with ANKRD50. J Cell Sci (2016) 0.75
GRASP1 Regulates Synaptic Plasticity and Learning through Endosomal Recycling of AMPA Receptors. Neuron (2017) 0.75
The use of pharmacological retromer chaperones in Alzheimer's disease and other endosomal-related disorders. Neurotherapeutics (2015) 0.75
GIRK2 splice variants and neuronal G protein-gated K(+) channels: implications for channel function and behavior. Sci Rep (2017) 0.75
A role for novel lipid interactions in the dynamic recruitment of SNX27 to the T-cell immune synapse. Bioarchitecture (2015) 0.75
SNX16 negatively regulates the migration and tumorigenesis of MCF-7 cells. Cell Regen (Lond) (2013) 0.75
VPS35 regulates cell surface recycling and signaling of dopamine receptor D1. Neurobiol Aging (2016) 0.75
Co-expression network analysis of Down's syndrome based on microarray data. Exp Ther Med (2016) 0.75
Inter-Dependent Mechanisms Behind Cognitive Dysfunction, Vascular Biology and Alzheimer's Dementia in Down Syndrome: Multi-Faceted Roles of APP. Front Behav Neurosci (2015) 0.75
Where Environment Meets Cognition: A Focus on Two Developmental Intellectual Disability Disorders. Neural Plast (2016) 0.75
Sorting nexin 27 interacts with Fzd7 and mediates Wnt signalling. Biosci Rep (2016) 0.75
Cysteine 893 is a target of regulatory thiol modifications of GluA1 AMPA receptors. PLoS One (2017) 0.75
Barcoding of GPCR trafficking and signaling through the various trafficking roadmaps by compartmentalized signaling networks. Cell Signal (2017) 0.75
Reinsertion or degradation of AMPA receptors determined by activity-dependent endocytic sorting. Neuron (2000) 7.15
The cell biology of synaptic plasticity: AMPA receptor trafficking. Annu Rev Cell Dev Biol (2007) 6.91
Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat. J Comp Physiol Psychol (1979) 6.07
A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease. Am J Hum Genet (2011) 4.52
VPS35 mutations in Parkinson disease. Am J Hum Genet (2011) 4.16
Enrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1-knockout mice. Nat Neurosci (2000) 4.01
Pharmacotherapy for cognitive impairment in a mouse model of Down syndrome. Nat Neurosci (2007) 3.74
An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes. Science (2005) 3.61
The consolidation of new but not reactivated memory requires hippocampal C/EBPbeta. Nat Neurosci (2001) 3.23
Endosomal sorting and signalling: an emerging role for sorting nexins. Nat Rev Mol Cell Biol (2008) 3.11
Model-guided microarray implicates the retromer complex in Alzheimer's disease. Ann Neurol (2005) 3.01
An essential role for C/EBPbeta in female reproduction. Genes Dev (1997) 2.96
SNX27 mediates retromer tubule entry and endosome-to-plasma membrane trafficking of signalling receptors. Nat Cell Biol (2011) 2.92
C/EBPbeta at the core of the TGFbeta cytostatic response and its evasion in metastatic breast cancer cells. Cancer Cell (2006) 2.87
C/EBP is an immediate-early gene required for the consolidation of long-term facilitation in Aplysia. Cell (1994) 2.42
Segmental trisomy as a mouse model for Down syndrome. Prog Clin Biol Res (1993) 2.29
Impairment of spatial but not contextual memory in CaMKII mutant mice with a selective loss of hippocampal LTP in the range of the theta frequency. Cell (1995) 2.19
SNX27 mediates PDZ-directed sorting from endosomes to the plasma membrane. J Cell Biol (2010) 2.10
Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation. Proc Natl Acad Sci U S A (2008) 2.09
Retracted Human chromosome 21-derived miRNAs are overexpressed in down syndrome brains and hearts. Biochem Biophys Res Commun (2008) 1.91
MicroRNA-155 regulates inflammatory cytokine production in tumor-associated macrophages via targeting C/EBPbeta. Cell Mol Immunol (2009) 1.66
Altered long-term potentiation in the young and old Ts65Dn mouse, a model for Down Syndrome. Neuropharmacology (1998) 1.63
A unique sorting nexin regulates trafficking of potassium channels via a PDZ domain interaction. Nat Neurosci (2007) 1.63
Phox homology band 4.1/ezrin/radixin/moesin-like proteins function as molecular scaffolds that interact with cargo receptors and Ras GTPases. Proc Natl Acad Sci U S A (2011) 1.57
VPS35 haploinsufficiency increases Alzheimer's disease neuropathology. J Cell Biol (2011) 1.50
New sorting nexin (SNX27) and NHERF specifically interact with the 5-HT4a receptor splice variant: roles in receptor targeting. J Cell Sci (2004) 1.40
Deficiency of sorting nexin 27 (SNX27) leads to growth retardation and elevated levels of N-methyl-D-aspartate receptor 2C (NR2C). Mol Cell Biol (2011) 1.32
Mechanism underlying selective regulation of G protein-gated inwardly rectifying potassium channels by the psychostimulant-sensitive sorting nexin 27. Proc Natl Acad Sci U S A (2011) 1.28
Temporal requirement of C/EBPbeta in the amygdala following reactivation but not acquisition of inhibitory avoidance. Learn Mem (2007) 1.24
Ts65Dn, a mouse model of Down syndrome, exhibits increased GABAB-induced potassium current. J Neurophysiol (2006) 1.23
A calcium-dependent switch in a CREST-BRG1 complex regulates activity-dependent gene expression. Neuron (2008) 1.21
Retromer sorting: a pathogenic pathway in late-onset Alzheimer disease. Arch Neurol (2008) 1.19
Dendritic atrophy in children with Down's syndrome. Ann Neurol (1986) 1.16
Brain growth in Down syndrome subjects 15 to 22 weeks of gestational age and birth to 60 months. Clin Neuropathol (1990) 1.11
Fetal life in Down syndrome starts with normal neuronal density but impaired dendritic spines and synaptosomal structure. J Neural Transm Suppl (2001) 1.09
A developmentally regulated and psychostimulant-inducible novel rat gene mrt1 encoding PDZ-PX proteins isolated in the neocortex. Mol Psychiatry (2003) 1.05
GABAB-GIRK2-mediated signaling in Down syndrome. Adv Pharmacol (2010) 0.95
On the cause of mental retardation in Down syndrome: extrapolation from full and segmental trisomy 16 mouse models. Brain Res Brain Res Rev (2001) 0.94
Intracellular trafficking of presenilin 1 is regulated by beta-amyloid precursor protein and phospholipase D1. J Biol Chem (2009) 0.94
Abnormal microRNA expression in Ts65Dn hippocampus and whole blood: contributions to Down syndrome phenotypes. Dev Neurosci (2011) 0.92
Synaptic development in the human fetus: a morphometric analysis of normal and Down's syndrome neocortex. Exp Neurol (1984) 0.91
Behavioral interference and C/EBPbeta expression in the insular-cortex reveal a prolonged time period for taste memory consolidation. Learn Mem (2006) 0.87
Excitatory amino acids and monoamines in parahippocampal gyrus and frontal cortical pole of adults with Down syndrome. Life Sci (1997) 0.86
Amino acid neurotransmitter deficits in adult Down's syndrome brain tissue. Neurosci Lett (1988) 0.84
Mechanisms and functional implications of adult neurogenesis. Cell (2008) 14.50
Functional neurogenesis in the adult hippocampus. Nature (2002) 11.17
New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? Nat Rev Neurosci (2010) 8.09
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet (2013) 8.02
Mechanisms underlying inflammation in neurodegeneration. Cell (2010) 7.66
A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells. Cell (2010) 7.51
Modelling schizophrenia using human induced pluripotent stem cells. Nature (2011) 7.41
Exercise enhances learning and hippocampal neurogenesis in aged mice. J Neurosci (2005) 7.14
HDAC2 negatively regulates memory formation and synaptic plasticity. Nature (2009) 6.96
Somatic mosaicism in neuronal precursor cells mediated by L1 retrotransposition. Nature (2005) 6.95
Wnt signalling regulates adult hippocampal neurogenesis. Nature (2005) 6.66
Distinct morphological stages of dentate granule neuron maturation in the adult mouse hippocampus. J Neurosci (2006) 6.48
Astroglia induce neurogenesis from adult neural stem cells. Nature (2002) 6.41
An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells. Nat Struct Mol Biol (2009) 6.37
The amsterdam declaration on fungal nomenclature. IMA Fungus (2011) 5.86
Tobacco use and risk of myocardial infarction in 52 countries in the INTERHEART study: a case-control study. Lancet (2006) 5.85
Mammalian heart renewal by pre-existing cardiomyocytes. Nature (2012) 5.56
Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells. Nature (2012) 5.47
In vivo fate analysis reveals the multipotent and self-renewal capacities of Sox2+ neural stem cells in the adult hippocampus. Cell Stem Cell (2007) 5.32
An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus. Proc Natl Acad Sci U S A (2007) 5.30
L1 retrotransposition in human neural progenitor cells. Nature (2009) 4.78
A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death. Cell (2009) 4.60
S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration. Nature (2006) 4.54
Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model. Science (2003) 4.52
Therapeutic interventions after spinal cord injury. Nat Rev Neurosci (2006) 4.51
Early determination and long-term persistence of adult-generated new neurons in the hippocampus of mice. Development (2003) 4.49
Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons. EMBO J (2006) 4.43
In vivo demonstration that alpha-synuclein oligomers are toxic. Proc Natl Acad Sci U S A (2011) 4.38
A role for TAZ in migration, invasion, and tumorigenesis of breast cancer cells. Cancer Res (2008) 4.33
S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury. Science (2009) 4.25
Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy. Nat Rev Neurol (2013) 4.16
A role for adult TLX-positive neural stem cells in learning and behaviour. Nature (2008) 4.14
S-nitrosylation of matrix metalloproteinases: signaling pathway to neuronal cell death. Science (2002) 4.13
The emerging role of the hippo pathway in cell contact inhibition, organ size control, and cancer development in mammals. Cancer Cell (2008) 4.08
Experience-specific functional modification of the dentate gyrus through adult neurogenesis: a critical period during an immature stage. J Neurosci (2007) 4.04
Neurons born in the adult dentate gyrus form functional synapses with target cells. Nat Neurosci (2008) 4.01
NMDA-receptor-mediated, cell-specific integration of new neurons in adult dentate gyrus. Nature (2006) 4.01
Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo. Neuron (2008) 3.98
Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo. Nat Neurosci (2003) 3.98
Direct reprogramming of mouse fibroblasts to neural progenitors. Proc Natl Acad Sci U S A (2011) 3.93
Potential role for adult neurogenesis in the encoding of time in new memories. Nat Neurosci (2006) 3.78
Neuroplasticity in old age: sustained fivefold induction of hippocampal neurogenesis by long-term environmental enrichment. Ann Neurol (2002) 3.76
Cidea-deficient mice have lean phenotype and are resistant to obesity. Nat Genet (2003) 3.71
Direct reprogramming of adult human fibroblasts to functional neurons under defined conditions. Cell Stem Cell (2011) 3.62
Histone deacetylase inhibition-mediated neuronal differentiation of multipotent adult neural progenitor cells. Proc Natl Acad Sci U S A (2004) 3.60
Mosaic copy number variation in human neurons. Science (2013) 3.57
Human neural stem cells differentiate and promote locomotor recovery in spinal cord-injured mice. Proc Natl Acad Sci U S A (2005) 3.56
Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration. Neuron (2006) 3.51
Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry. Proc Natl Acad Sci U S A (2009) 3.49
Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis. Nat Neurosci (2009) 3.47
Noncoding RNAs in the mammalian central nervous system. Annu Rev Neurosci (2006) 3.41
Adult-born hippocampal dentate granule cells undergoing maturation modulate learning and memory in the brain. J Neurosci (2009) 3.37
Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform. J Cell Biol (2002) 3.36
Non-cell-autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells. Cell Stem Cell (2008) 3.34
Synapse formation on neurons born in the adult hippocampus. Nat Neurosci (2007) 3.33
BRCA1 tumour suppression occurs via heterochromatin-mediated silencing. Nature (2011) 3.30
Gain of miR-151 on chromosome 8q24.3 facilitates tumour cell migration and spreading through downregulating RhoGDIA. Nat Cell Biol (2010) 3.27
Expression and function of orphan nuclear receptor TLX in adult neural stem cells. Nature (2004) 3.25
L1 retrotransposition in neurons is modulated by MeCP2. Nature (2010) 3.25
Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats. Learn Mem (2009) 3.23
Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology. Am J Pathol (2002) 3.23
NGF signaling in sensory neurons: evidence that early endosomes carry NGF retrograde signals. Neuron (2003) 3.23
A functional study of miR-124 in the developing neural tube. Genes Dev (2007) 3.21
Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits. Nature (2002) 3.20
Functional convergence of neurons generated in the developing and adult hippocampus. PLoS Biol (2006) 3.16
YAP regulates neural progenitor cell number via the TEA domain transcription factor. Genes Dev (2008) 3.16
Neural stem cells from adult hippocampus develop essential properties of functional CNS neurons. Nat Neurosci (2002) 3.10
Neocortical neurogenesis in humans is restricted to development. Proc Natl Acad Sci U S A (2006) 3.08
Development of a novel mouse glioma model using lentiviral vectors. Nat Med (2009) 3.08
Transcriptional signature and memory retention of human-induced pluripotent stem cells. PLoS One (2009) 3.07
A small modulatory dsRNA specifies the fate of adult neural stem cells. Cell (2004) 2.95
Molecular pathways to neurodegeneration. Nat Med (2004) 2.94
Neurogenesis in the adult brain: new strategies for central nervous system diseases. Annu Rev Pharmacol Toxicol (2004) 2.94
Enriched environment and physical activity stimulate hippocampal but not olfactory bulb neurogenesis. Eur J Neurosci (2003) 2.93
Local generation of glia is a major astrocyte source in postnatal cortex. Nature (2012) 2.87
Draft genome of the wheat A-genome progenitor Triticum urartu. Nature (2013) 2.86
MAPK3/1 (ERK1/2) in ovarian granulosa cells are essential for female fertility. Science (2009) 2.86
Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes. J Biol Chem (2004) 2.85
Resolving new memories: a critical look at the dentate gyrus, adult neurogenesis, and pattern separation. Neuron (2011) 2.84
The 50th anniversary of the discovery of trisomy 21: the past, present, and future of research and treatment of Down syndrome. Genet Med (2009) 2.83
Defining a molecular atlas of the hippocampus using DNA microarrays and high-throughput in situ hybridization. J Neurosci (2004) 2.80
Identification of PRRT2 as the causative gene of paroxysmal kinesigenic dyskinesias. Brain (2011) 2.80
Drug screening for ALS using patient-specific induced pluripotent stem cells. Sci Transl Med (2012) 2.80
Preperitoneal single-port transvesical enucleation of the prostate (STEP) for large-volume BPH: one-year follow-up of Qmax, IPSS, and QoL. Urology (2012) 2.78
Signaling through BMPR-IA regulates quiescence and long-term activity of neural stem cells in the adult hippocampus. Cell Stem Cell (2010) 2.75
Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model. Nat Neurosci (2005) 2.75
Cell-surface marker signatures for the isolation of neural stem cells, glia and neurons derived from human pluripotent stem cells. PLoS One (2011) 2.74
One at a time, live tracking of NGF axonal transport using quantum dots. Proc Natl Acad Sci U S A (2007) 2.74
Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome. J Neurosci (2004) 2.73