Published in Trends Genet on March 01, 2005
Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy. Proc Natl Acad Sci U S A (2006) 4.68
Activating transcription factor 3, a stress sensor, activates p53 by blocking its ubiquitination. EMBO J (2005) 1.67
Many players in BCL-2 family affairs. Trends Biochem Sci (2014) 1.64
The tumor suppressor protein p53 is required for neurite outgrowth and axon regeneration. EMBO J (2006) 1.54
The Bad guy cooperates with good cop p53: Bad is transcriptionally up-regulated by p53 and forms a Bad/p53 complex at the mitochondria to induce apoptosis. Mol Cell Biol (2006) 1.50
A SNP in the flt-1 promoter integrates the VEGF system into the p53 transcriptional network. Proc Natl Acad Sci U S A (2006) 1.29
Cell shrinkage as a signal to apoptosis in NIH 3T3 fibroblasts. J Physiol (2005) 1.23
Radiation metabolomics and its potential in biodosimetry. Int J Radiat Biol (2011) 1.20
DNA damage, apoptosis and langerhans cells--Activators of UV-induced immune tolerance. Photochem Photobiol (2008) 1.18
Versatile functions of p53 protein in multicellular organisms. Biochemistry (Mosc) (2007) 1.11
p53 modulation as a therapeutic strategy in gastrointestinal stromal tumors. PLoS One (2012) 1.08
Mechanisms involved in injury and repair of the murine lacrimal gland: role of programmed cell death and mesenchymal stem cells. Ocul Surf (2010) 1.08
Apoptosis and autophagy induction in mammalian cells by small interfering RNA knockdown of mRNA capping enzymes. Mol Cell Biol (2008) 1.06
Elk-1 associates with the mitochondrial permeability transition pore complex in neurons. Proc Natl Acad Sci U S A (2006) 1.04
Dysregulation of apoptotic signaling in cancer: molecular mechanisms and therapeutic opportunities. J Cell Biochem (2008) 1.04
P53 mediates amosite asbestos-induced alveolar epithelial cell mitochondria-regulated apoptosis. Am J Respir Cell Mol Biol (2005) 1.03
Decision Making by p53: Life versus Death. Mol Cell Pharmacol (2010) 1.01
p53 mediates particulate matter-induced alveolar epithelial cell mitochondria-regulated apoptosis. Am J Respir Crit Care Med (2006) 0.99
Molecular mechanisms of nutlin-induced apoptosis in multiple myeloma: evidence for p53-transcription-dependent and -independent pathways. Cancer Biol Ther (2010) 0.98
p53 and mitochondrial function in neurons. Biochim Biophys Acta (2014) 0.97
Transcription activity is required for p53-dependent tumor suppression. Oncogene (2009) 0.96
WRN exonuclease activity is blocked by DNA termini harboring 3' obstructive groups. Mech Ageing Dev (2006) 0.94
Expression and function of bcl-2 proteins in melanoma. Curr Genomics (2008) 0.90
Mitochondrial and postmitochondrial survival signaling in cancer. Mitochondrion (2013) 0.90
Modulation of p53, c-fos, RARE, cyclin A, and cyclin D1 expression in human leukemia (HL-60) cells exposed to arsenic trioxide. Mol Cell Biochem (2009) 0.88
Treatment with a BH3 mimetic overcomes the resistance of latency III EBV (+) cells to p53-mediated apoptosis. Cell Death Dis (2011) 0.87
Damaged-DNA Binding Protein-2 Drives Apoptosis Following DNA Damage. Cell Div (2010) 0.84
The beneficial effect of Zinc(II) on low-dose chemotherapeutic sensitivity involves p53 activation in wild-type p53-carrying colorectal cancer cells. J Exp Clin Cancer Res (2015) 0.83
Progressive apoptosis resistance prior to senescence and control by the anti-apoptotic protein BCL-xL. Mech Ageing Dev (2008) 0.83
hHR23B is required for genotoxic-specific activation of p53 and apoptosis. Oncogene (2006) 0.81
Gentian violet induces wtp53 transactivation in cancer cells. Int J Oncol (2014) 0.81
The translational regulators GCN-1 and ABCF-3 act together to promote apoptosis in C. elegans. PLoS Genet (2014) 0.79
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science (2004) 9.52
BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly. Mol Cell (2005) 8.73
Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane. Cell (2002) 8.38
Mitochondria and cell death: outer membrane permeabilization and beyond. Nat Rev Mol Cell Biol (2010) 7.95
The BCL-2 family reunion. Mol Cell (2010) 7.32
Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis. Nature (2007) 7.21
Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1. Mol Cell (2006) 7.18
c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells. Cell (2012) 6.49
Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis. Nature (2011) 6.31
A unified model for apical caspase activation. Mol Cell (2003) 6.12
How do BCL-2 proteins induce mitochondrial outer membrane permeabilization? Trends Cell Biol (2008) 6.02
The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation. Immunity (2011) 6.00
HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells. J Exp Med (2011) 5.99
Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization. Dev Cell (2008) 5.67
PUMA couples the nuclear and cytoplasmic proapoptotic function of p53. Science (2005) 5.49
The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways. Immunity (2002) 5.38
Induction of immunological tolerance by apoptotic cells requires caspase-dependent oxidation of high-mobility group box-1 protein. Immunity (2008) 4.37
GAPDH and autophagy preserve survival after apoptotic cytochrome c release in the absence of caspase activation. Cell (2007) 4.22
CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death. Nature (2005) 3.81
Dynamic programming of CD8+ T lymphocyte responses. Nat Immunol (2003) 3.73
A unified model of mammalian BCL-2 protein family interactions at the mitochondria. Mol Cell (2011) 3.72
Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex I of the electron transport chain. Cell (2004) 3.49
Sphingolipid metabolism cooperates with BAK and BAX to promote the mitochondrial pathway of apoptosis. Cell (2012) 3.23
Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3. Cell (2008) 3.15
Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells. Proc Natl Acad Sci U S A (2011) 3.11
The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function. Nat Immunol (2011) 3.03
Cytochrome c: functions beyond respiration. Nat Rev Mol Cell Biol (2008) 2.95
Necroptosis. N Engl J Med (2014) 2.71
Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins. Proc Natl Acad Sci U S A (2008) 2.67
Metabolic checkpoints in activated T cells. Nat Immunol (2012) 2.47
Caspase-mediated loss of mitochondrial function and generation of reactive oxygen species during apoptosis. J Cell Biol (2003) 2.47
T and B cell hyperactivity and autoimmunity associated with niche-specific defects in apoptotic body clearance in TIM-4-deficient mice. Proc Natl Acad Sci U S A (2010) 2.41
The ubiquitin-protein ligase Itch regulates p73 stability. EMBO J (2005) 2.38
Caspase 8 inhibits programmed necrosis by processing CYLD. Nat Cell Biol (2011) 2.37
Correlated three-dimensional light and electron microscopy reveals transformation of mitochondria during apoptosis. Nat Cell Biol (2007) 2.34
Autosis is a Na+,K+-ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia. Proc Natl Acad Sci U S A (2013) 2.33
The multidomain proapoptotic molecules Bax and Bak are directly activated by heat. Proc Natl Acad Sci U S A (2005) 2.30
Do inducers of apoptosis trigger caspase-independent cell death? Nat Rev Mol Cell Biol (2005) 2.25
Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration. Nat Cell Biol (2012) 2.25
Regional analysis of p53 mutations in rheumatoid arthritis synovium. Proc Natl Acad Sci U S A (2002) 2.19
The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis. Cancer Cell (2011) 2.18
Characterization of cytoplasmic caspase-2 activation by induced proximity. Mol Cell (2009) 2.18
Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice. Nature (2006) 2.17
In situ trapping of activated initiator caspases reveals a role for caspase-2 in heat shock-induced apoptosis. Nat Cell Biol (2005) 2.11
Two independent pathways of regulated necrosis mediate ischemia-reperfusion injury. Proc Natl Acad Sci U S A (2013) 2.10
Survival function of the FADD-CASPASE-8-cFLIP(L) complex. Cell Rep (2012) 2.06
Inducible dimerization and inducible cleavage reveal a requirement for both processes in caspase-8 activation. J Biol Chem (2010) 1.99
RelB/p50 dimers are differentially regulated by tumor necrosis factor-alpha and lymphotoxin-beta receptor activation: critical roles for p100. J Biol Chem (2003) 1.96
Mitochondrial dysfunction in ataxia-telangiectasia. Blood (2011) 1.93
FADD and caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes. J Immunol (2014) 1.89
Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcription. Cancer Cell (2003) 1.88
Phosphorylation of Tip60 by GSK-3 determines the induction of PUMA and apoptosis by p53. Mol Cell (2011) 1.87
Cell death and tissue remodeling in planarian regeneration. Dev Biol (2009) 1.87
Different mitochondrial intermembrane space proteins are released during apoptosis in a manner that is coordinately initiated but can vary in duration. Proc Natl Acad Sci U S A (2006) 1.87
Anthracyclines induce DNA damage response-mediated protection against severe sepsis. Immunity (2013) 1.83
Uptake of apoptotic antigen-coupled cells by lymphoid dendritic cells and cross-priming of CD8(+) T cells produce active immune unresponsiveness. J Immunol (2002) 1.79
It cuts both ways: reconciling the dual roles of caspase 8 in cell death and survival. Nat Rev Mol Cell Biol (2011) 1.76
PB1-F2 proteins from H5N1 and 20 century pandemic influenza viruses cause immunopathology. PLoS Pathog (2010) 1.75
Noncanonical autophagy promotes the visual cycle. Cell (2013) 1.74
Connected to death: the (unexpurgated) mitochondrial pathway of apoptosis. Science (2005) 1.73
Apoptosis and oncogenesis: give and take in the BCL-2 family. Curr Opin Genet Dev (2011) 1.71
Cutting edge: FAS (CD95) mediates noncanonical IL-1β and IL-18 maturation via caspase-8 in an RIP3-independent manner. J Immunol (2012) 1.71
The role of ARK in stress-induced apoptosis in Drosophila cells. J Cell Biol (2002) 1.68
A role for transferrin receptor in triggering apoptosis when targeted with gambogic acid. Proc Natl Acad Sci U S A (2005) 1.65
Role of proteolysis in caspase-8 activation and stabilization. Biochemistry (2007) 1.64
Regulation of joint destruction and inflammation by p53 in collagen-induced arthritis. Am J Pathol (2002) 1.58
The inflammasome adaptor ASC regulates the function of adaptive immune cells by controlling Dock2-mediated Rac activation and actin polymerization. Nat Immunol (2011) 1.58
Caspase-2-induced apoptosis requires bid cleavage: a physiological role for bid in heat shock-induced death. Mol Biol Cell (2006) 1.57
Concerted multi-pronged attack by calpastatin to occlude the catalytic cleft of heterodimeric calpains. Nature (2008) 1.55
Resistance to caspase-independent cell death requires persistence of intact mitochondria. Dev Cell (2010) 1.54
Mitochondria and cell signalling. J Cell Sci (2012) 1.52
Non-apoptotic role of BID in inflammation and innate immunity. Nature (2011) 1.49
Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection. Nat Immunol (2013) 1.47
BID-induced structural changes in BAK promote apoptosis. Nat Struct Mol Biol (2013) 1.45
And all of a sudden it's over: mitochondrial outer-membrane permeabilization in apoptosis. Biochimie (2002) 1.39
Atg8 transfer from Atg7 to Atg3: a distinctive E1-E2 architecture and mechanism in the autophagy pathway. Mol Cell (2011) 1.38
Death receptors bind SHP-1 and block cytokine-induced anti-apoptotic signaling in neutrophils. Nat Med (2002) 1.38
Metabolic reprogramming is required for antibody production that is suppressed in anergic but exaggerated in chronically BAFF-exposed B cells. J Immunol (2014) 1.35
Toll-like receptor signaling in the lysosomal pathways. Immunol Rev (2009) 1.35
Apoptotic cells induce tolerance by generating helpless CD8+ T cells that produce TRAIL. J Immunol (2007) 1.33
Dichotomy between RIP1- and RIP3-mediated necroptosis in tumor necrosis factor-α-induced shock. Mol Med (2012) 1.31
HIV-1 Vpr induces apoptosis through caspase 9 in T cells and peripheral blood mononuclear cells. J Biol Chem (2002) 1.31
PUMA cooperates with direct activator proteins to promote mitochondrial outer membrane permeabilization and apoptosis. Cell Cycle (2009) 1.29
PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis. Nat Chem Biol (2013) 1.28
Regulation of arthritis by p53: critical role of adaptive immunity. Arthritis Rheum (2005) 1.26
Galectin-7 (PIG1) exhibits pro-apoptotic function through JNK activation and mitochondrial cytochrome c release. J Biol Chem (2001) 1.25
Caspase-7 deficiency protects from endotoxin-induced lymphocyte apoptosis and improves survival. Blood (2009) 1.24
Protective roles for caspase-8 and cFLIP in adult homeostasis. Cell Rep (2013) 1.23
TLR2 and RIP2 pathways mediate autophagy of Listeria monocytogenes via extracellular signal-regulated kinase (ERK) activation. J Biol Chem (2011) 1.21
Mitochondrial pathway of apoptosis is ancestral in metazoans. Proc Natl Acad Sci U S A (2012) 1.21
Cytoplasmic p53: bax and forward. Cell Cycle (2004) 1.21
Caspase-12 modulates NOD signaling and regulates antimicrobial peptide production and mucosal immunity. Cell Host Microbe (2008) 1.20
Mitochondrial regulation of cell death. Cold Spring Harb Perspect Biol (2013) 1.19
Metabolic reprogramming and metabolic dependency in T cells. Immunol Rev (2012) 1.18
Apaf-1 and caspase-9 do not act as tumor suppressors in myc-induced lymphomagenesis or mouse embryo fibroblast transformation. J Cell Biol (2004) 1.18
Minimal BH3 peptides promote cell death by antagonizing anti-apoptotic proteins. J Biol Chem (2003) 1.14
Dynamic regulation of FoxP3 expression controls the balance between CD4+ T cell activation and cell death. Eur J Immunol (2005) 1.14
Ripped to death. Trends Cell Biol (2011) 1.14
Measuring apoptosis at the single cell level. Methods (2008) 1.13
Endoplasmic reticulum protein BI-1 regulates Ca²⁺-mediated bioenergetics to promote autophagy. Genes Dev (2012) 1.13