Published in Am J Respir Crit Care Med on August 31, 2006
Epithelial cell death is an important contributor to oxidant-mediated acute lung injury. Am J Respir Crit Care Med (2010) 1.84
Mitochondrial complex III-generated oxidants activate ASK1 and JNK to induce alveolar epithelial cell death following exposure to particulate matter air pollution. J Biol Chem (2008) 1.37
Particulate matter Air Pollution induces hypermethylation of the p16 promoter Via a mitochondrial ROS-JNK-DNMT1 pathway. Sci Rep (2012) 1.03
Proapoptotic Noxa is required for particulate matter-induced cell death and lung inflammation. FASEB J (2009) 1.01
Decreased PM10 exposure attenuates age-related lung function decline: genetic variants in p53, p21, and CCND1 modify this effect. Environ Health Perspect (2009) 0.94
Regulation of lung injury and fibrosis by p53-mediated changes in urokinase and plasminogen activator inhibitor-1. Am J Pathol (2013) 0.94
Lung injury after cigarette smoking is particle related. Int J Chron Obstruct Pulmon Dis (2011) 0.91
Ambient particulate matter affects occludin distribution and increases alveolar transepithelial electrical conductance. Respirology (2011) 0.88
AKT/mTOR and c-Jun N-terminal kinase signaling pathways are required for chrysotile asbestos-induced autophagy. Free Radic Biol Med (2014) 0.83
TP53 genetic polymorphisms, interactions with lifestyle factors and lung cancer risk: a case control study in a Chinese population. BMC Cancer (2013) 0.82
Epigenetic Regulation in Particulate Matter-Mediated Cardiopulmonary Toxicities: A Systems Biology Perspective. Curr Pharmacogenomics Person Med (2012) 0.80
Asbestos-induced pulmonary fibrosis is augmented in 8-oxoguanine DNA glycosylase knockout mice. Am J Respir Cell Mol Biol (2015) 0.77
AMPK is required for PM2.5-induced autophagy in human lung epithelial A549 cells. Int J Clin Exp Med (2015) 0.76
The c-Jun N-terminal kinase signaling pathway mediates chrysotile asbestos-induced alveolar epithelial cell apoptosis. Mol Med Rep (2014) 0.75
Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution. JAMA (2002) 28.72
Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell (1995) 14.90
Air pollution and cardiovascular disease: a statement for healthcare professionals from the Expert Panel on Population and Prevention Science of the American Heart Association. Circulation (2004) 13.07
PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell (2001) 11.04
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science (2004) 9.52
Movement of Bax from the cytosol to mitochondria during apoptosis. J Cell Biol (1997) 9.18
A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Science (1999) 6.97
An overview of real-time quantitative PCR: applications to quantify cytokine gene expression. Methods (2001) 6.68
Decision making by p53: life, death and cancer. Cell Death Differ (2003) 5.52
PUMA couples the nuclear and cytoplasmic proapoptotic function of p53. Science (2005) 5.49
Facile detection of mitochondrial DNA mutations in tumors and bodily fluids. Science (2000) 4.87
Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling. J Biol Chem (2000) 4.11
Atmosphere. Air pollution-related illness: effects of particles. Science (2005) 3.88
Use of genetic suppressor elements to dissect distinct biological effects of separate p53 domains. Proc Natl Acad Sci U S A (1996) 2.66
Inflammatory lung injury after bronchial instillation of air pollution particles. Am J Respir Crit Care Med (2001) 2.48
The transcriptional targets of p53 in apoptosis control. Biochem Biophys Res Commun (2005) 2.25
Influence of induced reactive oxygen species in p53-mediated cell fate decisions. Mol Cell Biol (2003) 2.16
Particulate levels are associated with early asthma worsening in children with persistent disease. Am J Respir Crit Care Med (2006) 2.11
Quinones and aromatic chemical compounds in particulate matter induce mitochondrial dysfunction: implications for ultrafine particle toxicity. Environ Health Perspect (2004) 2.09
The role of free radicals in asbestos-induced diseases. Free Radic Biol Med (1992) 1.87
The role of a mitochondrial pathway in the induction of apoptosis by chemicals extracted from diesel exhaust particles. J Immunol (2000) 1.71
Effect of ambient air pollution on pulmonary exacerbations and lung function in cystic fibrosis. Am J Respir Crit Care Med (2004) 1.61
Proapoptotic Bid is required for pulmonary fibrosis. Proc Natl Acad Sci U S A (2006) 1.59
Abrogation of the G2 checkpoint results in differential radiosensitization of G1 checkpoint-deficient and G1 checkpoint-competent cells. Cancer Res (1995) 1.59
Air pollution and cancer: biomarker studies in human populations. Carcinogenesis (2005) 1.54
Asbestos causes apoptosis in alveolar epithelial cells: role of iron-induced free radicals. J Lab Clin Med (2001) 1.53
Particulate matter induces alveolar epithelial cell DNA damage and apoptosis: role of free radicals and the mitochondria. Am J Respir Cell Mol Biol (2003) 1.47
Transcription, apoptosis and p53: catch-22. Trends Genet (2005) 1.39
p53 functions in the incorporation step in DNA base excision repair in mouse liver mitochondria. Oncogene (2004) 1.33
Human papillomavirus-induced carcinogenesis and the ubiquitin-proteasome system. Semin Cancer Biol (2003) 1.32
Redox regulation of p53 during hypoxia. Oncogene (2000) 1.28
Release of inflammatory cytokines, cell toxicity and apoptosis in epithelial lung cells after exposure to ambient air particles of different size fractions. Toxicol In Vitro (2004) 1.27
Mitochondrial-derived free radicals mediate asbestos-induced alveolar epithelial cell apoptosis. Am J Physiol Lung Cell Mol Physiol (2004) 1.20
p53 inhibitor pifithrin alpha can suppress heat shock and glucocorticoid signaling pathways. J Biol Chem (2003) 1.10
Role of p53 and reactive oxygen species in apoptotic response to copper and zinc in epithelial breast cancer cells. Apoptosis (2005) 1.07
P53 mediates amosite asbestos-induced alveolar epithelial cell mitochondria-regulated apoptosis. Am J Respir Cell Mol Biol (2005) 1.03
Inhaled asbestos fibers induce p53 expression in the rat lung. Am J Respir Cell Mol Biol (1997) 1.02
The role of hydroxyl radical as a messenger in Cr(VI)-induced p53 activation. Am J Physiol Cell Physiol (2000) 1.01
Molecular epidemiology studies of carcinogenic environmental pollutants. Effects of polycyclic aromatic hydrocarbons (PAHs) in environmental pollution on exogenous and oxidative DNA damage. Mutat Res (2003) 1.01
The mitochondria-regulated death pathway mediates asbestos-induced alveolar epithelial cell apoptosis. Am J Respir Cell Mol Biol (2003) 0.99
Cardiopulmonary health effects of air pollution: is a mechanism emerging? Am J Respir Crit Care Med (2005) 0.96
Catalase protects HepG2 cells from apoptosis induced by DNA-damaging agents by accelerating the degradation of p53. J Biol Chem (2002) 0.95
Essential role of p53 in silica-induced apoptosis. Am J Physiol Lung Cell Mol Physiol (2004) 0.94
Growth suppression induced by downregulation of E6-AP expression in human papillomavirus-positive cancer cell lines depends on p53. J Virol (2005) 0.91
p53 gene expression in relation to indoor exposure to unvented coal smoke in Xuan Wei, China. J Occup Environ Med (2001) 0.87
Detection of p53 and K-ras mutations in sputum of individuals exposed to smoky coal emissions in Xuan Wei County, China. Carcinogenesis (2004) 0.86
Development of lung tumors in mutant p53-expressing mice after inhalation exposure to asbestos. Chest (2004) 0.83
Nasal epithelium as a sentinel for airborne environmental pollution. Toxicol Sci (1998) 0.82
Nasal biopsies of children exposed to air pollutants. Toxicol Pathol (2001) 0.81
Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity. Proc Natl Acad Sci U S A (2010) 8.12
Ambient particulate matter accelerates coagulation via an IL-6-dependent pathway. J Clin Invest (2007) 2.36
Flow cytometric analysis of macrophages and dendritic cell subsets in the mouse lung. Am J Respir Cell Mol Biol (2013) 1.90
Asbestos and the pleura: a review. Chest (2004) 1.87
Epithelial cell death is an important contributor to oxidant-mediated acute lung injury. Am J Respir Crit Care Med (2010) 1.84
Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ATP ratio. Free Radic Biol Med (2009) 1.78
Minimizing oxidation and stable nanoscale dispersion improves the biocompatibility of graphene in the lung. Nano Lett (2011) 1.63
Wnt coreceptor Lrp5 is a driver of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med (2014) 1.61
Proapoptotic Bid is required for pulmonary fibrosis. Proc Natl Acad Sci U S A (2006) 1.59
Leptin resistance protects mice from hyperoxia-induced acute lung injury. Am J Respir Crit Care Med (2006) 1.57
Particulate matter induces alveolar epithelial cell DNA damage and apoptosis: role of free radicals and the mitochondria. Am J Respir Cell Mol Biol (2003) 1.47
Keratinocyte growth factor expression is suppressed in early acute lung injury/acute respiratory distress syndrome by smad and c-Abl pathways. Crit Care Med (2009) 1.46
Regulation of reticuloendothelial iron transporter MTP1 (Slc11a3) by inflammation. J Biol Chem (2002) 1.45
CpG sites associated with cigarette smoking: analysis of epigenome-wide data from the Sister Study. Environ Health Perspect (2014) 1.44
Nuclear β-catenin is increased in systemic sclerosis pulmonary fibrosis and promotes lung fibroblast migration and proliferation. Am J Respir Cell Mol Biol (2011) 1.44
Predictors of acute lung injury and severe hypoxemia in patients undergoing operative talc pleurodesis. Ann Thorac Surg (2006) 1.43
Mitochondrial complex III-generated oxidants activate ASK1 and JNK to induce alveolar epithelial cell death following exposure to particulate matter air pollution. J Biol Chem (2008) 1.37
Beta-catenin/T-cell factor signaling is activated during lung injury and promotes the survival and migration of alveolar epithelial cells. J Biol Chem (2009) 1.35
Leptin promotes fibroproliferative acute respiratory distress syndrome by inhibiting peroxisome proliferator-activated receptor-γ. Am J Respir Crit Care Med (2011) 1.34
Oxidative stress and pulmonary fibrosis. Biochim Biophys Acta (2012) 1.31
TRPV4-mediated calcium influx into human bronchial epithelia upon exposure to diesel exhaust particles. Environ Health Perspect (2011) 1.29
Extrinsic coagulation blockade attenuates lung injury and proinflammatory cytokine release after intratracheal lipopolysaccharide. Am J Respir Cell Mol Biol (2002) 1.25
Particulate matter-induced lung inflammation increases systemic levels of PAI-1 and activates coagulation through distinct mechanisms. PLoS One (2011) 1.21
Mitochondrial-derived free radicals mediate asbestos-induced alveolar epithelial cell apoptosis. Am J Physiol Lung Cell Mol Physiol (2004) 1.20
Hypoxia leads to Na,K-ATPase downregulation via Ca(2+) release-activated Ca(2+) channels and AMPK activation. Mol Cell Biol (2011) 1.18
Toll-like receptor 4 signaling augments transforming growth factor-β responses: a novel mechanism for maintaining and amplifying fibrosis in scleroderma. Am J Pathol (2012) 1.11
Pulmonary complications of tumor necrosis factor-targeted therapy. Respir Med (2009) 1.11
Images in clinical medicine. Splenic and mediastinal calcifications in histoplasmosis. N Engl J Med (2006) 1.10
Suppression of inflammation and acute lung injury by Miz1 via repression of C/EBP-δ. Nat Immunol (2013) 1.08
P53 mediates amosite asbestos-induced alveolar epithelial cell mitochondria-regulated apoptosis. Am J Respir Cell Mol Biol (2005) 1.03
Particulate matter Air Pollution induces hypermethylation of the p16 promoter Via a mitochondrial ROS-JNK-DNMT1 pathway. Sci Rep (2012) 1.03
Asbestos-induced pulmonary toxicity: role of DNA damage and apoptosis. Exp Biol Med (Maywood) (2003) 1.02
Targeted deletion of nrf2 impairs lung development and oxidant injury in neonatal mice. Antioxid Redox Signal (2012) 1.02
Molecular basis of asbestos-induced lung disease. Annu Rev Pathol (2013) 1.01
Fibroblast growth factor-10 attenuates H2O2-induced alveolar epithelial cell DNA damage: role of MAPK activation and DNA repair. Am J Respir Cell Mol Biol (2004) 1.01
Proapoptotic Noxa is required for particulate matter-induced cell death and lung inflammation. FASEB J (2009) 1.01
β₂-Adrenergic agonists augment air pollution-induced IL-6 release and thrombosis. J Clin Invest (2014) 1.00
Eosinophil and T cell markers predict functional decline in COPD patients. Respir Res (2009) 1.00
The mitochondria-regulated death pathway mediates asbestos-induced alveolar epithelial cell apoptosis. Am J Respir Cell Mol Biol (2003) 0.99
Role of mutagenicity in asbestos fiber-induced carcinogenicity and other diseases. J Toxicol Environ Health B Crit Rev (2011) 0.98
The intrinsic apoptotic pathway is required for lipopolysaccharide-induced lung endothelial cell death. J Immunol (2007) 0.97
The transition of closely opposed lesions to double-strand breaks during long-patch base excision repair is prevented by the coordinated action of DNA polymerase delta and Rad27/Fen1. Mol Cell Biol (2008) 0.95
Proteasomal regulation of pulmonary fibrosis. Proc Am Thorac Soc (2010) 0.95
Images in cardiovascular medicine. Pulmonary embolization of acrylic cement during vertebroplasty. Circulation (2006) 0.95
beta(2)-Agonists for treatment of pulmonary edema: ready for clinical studies? Crit Care Med (2004) 0.93
Fibroblast growth factor-10 prevents asbestos-induced alveolar epithelial cell apoptosis by a mitogen-activated protein kinase-dependent mechanism. Am J Respir Cell Mol Biol (2004) 0.93
Particulate matter air pollution causes oxidant-mediated increase in gut permeability in mice. Part Fibre Toxicol (2011) 0.92
FGF-10 prevents mechanical stretch-induced alveolar epithelial cell DNA damage via MAPK activation. Am J Physiol Lung Cell Mol Physiol (2003) 0.92
Stretch-induced activation of AMP kinase in the lung requires dystroglycan. Am J Respir Cell Mol Biol (2008) 0.91
Idiopathic pulmonary fibrosis: the inflammation hypothesis revisited. Chest (2003) 0.91
Mitochondria-targeted Ogg1 and aconitase-2 prevent oxidant-induced mitochondrial DNA damage in alveolar epithelial cells. J Biol Chem (2014) 0.90
Proteasomal inhibition after injury prevents fibrosis by modulating TGF-β(1) signalling. Thorax (2011) 0.90
The effect of rosuvastatin in a murine model of influenza A infection. PLoS One (2012) 0.89
Risk assessment for inpatient survival in the long-term acute care setting after prolonged critical illness. Chest (2003) 0.87
Molecular mechanisms of asbestos-induced lung epithelial cell apoptosis. Chem Biol Interact (2010) 0.86
Effects of body temperature on ventilator-induced lung injury. J Crit Care (2005) 0.86
Soy Formula and Epigenetic Modifications: Analysis of Vaginal Epithelial Cells from Infant Girls in the IFED Study. Environ Health Perspect (2016) 0.86
KGF prevents oxygen-mediated damage in ARPE-19 cells. Invest Ophthalmol Vis Sci (2005) 0.85
Effects of beta2-adrenergic receptor overexpression on alveolar epithelial active transport. J Allergy Clin Immunol (2002) 0.83
β2-agonists and acute respiratory distress syndrome. Am J Respir Crit Care Med (2014) 0.83
Roles of MAPK pathway activation during cytokine induction in BEAS-2B cells exposed to fine World Trade Center (WTC) dust. J Immunotoxicol (2010) 0.83
Coma with absent brainstem reflexes resulting from zolpidem overdose. Am J Ther (2010) 0.82
Head CT is of limited diagnostic value in critically ill patients who remain unresponsive after discontinuation of sedation. BMC Anesthesiol (2009) 0.82
Balancing the risks and benefits of oxygen therapy in critically III adults. Chest (2013) 0.82
Comparison of surfactant and perfluorochemical liquid enhanced adenovirus-mediated gene transfer in normal rat lung. Mol Ther (2002) 0.82
Cerebrospinal fluid leak and meningitis associated with nasal continuous positive airway pressure therapy. Chest (2005) 0.81
Hyperalbuminemia and elevated transaminases associated with high-protein diet. Scand J Gastroenterol (2006) 0.80
Macrophage-epithelial paracrine crosstalk inhibits lung edema clearance during influenza infection. J Clin Invest (2016) 0.80
Warranting investigation of primary lung adenocarcinoma in patients with an extrapulmonary malignancy and lung nodules due to high frequency. Am J Clin Pathol (2014) 0.80
Sequestration of mitochondrial iron by silica particle initiates a biological effect. Am J Physiol Lung Cell Mol Physiol (2013) 0.80
Calcium stone lithoptysis in primary ciliary dyskinesia. Respir Med (2006) 0.80
Inhibition of allergic inflammation by supplementation with 5-hydroxytryptophan. Am J Physiol Lung Cell Mol Physiol (2012) 0.80
Not much turbulence: addition of heliox to noninvasive ventilation fails to improve outcomes in patients with exacerbations of chronic obstructive pulmonary disease. Crit Care Med (2010) 0.79
Alcohol worsens acute lung injury by inhibiting alveolar sodium transport through the adenosine A1 receptor. PLoS One (2012) 0.79
Circulating microRNA Signatures Associated with Childhood Asthma. Clin Lab (2015) 0.79
Questionnaire assessment of airway disease symptoms in equine barn personnel. Occup Med (Lond) (2009) 0.79
The role of cardiovascular disease-associated iron overload in Libby amphibole-induced acute pulmonary injury and inflammation. Inhal Toxicol (2011) 0.78
Joubert syndrome associated with severe central sleep apnea. J Clin Sleep Med (2010) 0.78
The saga of obstructive sleep apnea syndrome and daytime hypercapnia: work in progress. Chest (2005) 0.78
Loss of TLR4 does not prevent influenza A-induced mortality. Am J Respir Crit Care Med (2014) 0.77
Air pollution impairs lung's ability to clear edema fluid. Am J Cardiol (2006) 0.77
Asbestos-induced pulmonary fibrosis is augmented in 8-oxoguanine DNA glycosylase knockout mice. Am J Respir Cell Mol Biol (2015) 0.77
Markers of prognosis specific to influenza infection: are we there yet? Am J Respir Crit Care Med (2014) 0.77
Acute lung injury does not impair adenoviral-mediated gene transfer to the alveolar epithelium. Chest (2002) 0.77
Update in environmental and occupational medicine 2009. Am J Respir Crit Care Med (2010) 0.76
Impact of acute exposure to WTC dust on ciliated and goblet cells in lungs of rats. Inhal Toxicol (2015) 0.76
Update in environmental and occupational medicine 2010. Am J Respir Crit Care Med (2011) 0.76
Strategies for dissecting genetic-environmental interactions in neurodegenerative disorders. Neurotoxicology (2006) 0.76
Linking air pollution exposure with thrombosis. Blood (2011) 0.75
Reply: β2-agonists and acute respiratory distress syndrome. Am J Respir Crit Care Med (2014) 0.75
Mesothelioma - Update on Diagnostic Strategies. Clin Pulm Med (2012) 0.75
Enhancement of alveolar epithelial beta(2)-adrenergic receptor function via gene transfer. Chest (2002) 0.75
Babesiosis. Am J Respir Crit Care Med (2014) 0.75