Published in J Gen Physiol on March 01, 2005
Structure of the human BK channel Ca2+-activation apparatus at 3.0 A resolution. Science (2010) 3.03
Activation of Slo1 BK channels by Mg2+ coordinated between the voltage sensor and RCK1 domains. Nat Struct Mol Biol (2008) 2.28
Structure of the gating ring from the human large-conductance Ca(2+)-gated K(+) channel. Nature (2010) 2.00
Molecular mechanisms of BK channel activation. Cell Mol Life Sci (2009) 1.81
BK channel activation: structural and functional insights. Trends Neurosci (2010) 1.65
Intra- and intersubunit cooperativity in activation of BK channels by Ca2+. J Gen Physiol (2006) 1.39
The RCK2 domain of the human BKCa channel is a calcium sensor. Proc Natl Acad Sci U S A (2007) 1.38
Heme regulates allosteric activation of the Slo1 BK channel. J Gen Physiol (2005) 1.32
Reciprocal regulation of the Ca2+ and H+ sensitivity in the SLO1 BK channel conferred by the RCK1 domain. Nat Struct Mol Biol (2008) 1.26
Measurements of the BKCa channel's high-affinity Ca2+ binding constants: effects of membrane voltage. J Gen Physiol (2008) 1.26
A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity. Elife (2014) 1.23
Three methionine residues located within the regulator of conductance for K+ (RCK) domains confer oxidative sensitivity to large-conductance Ca2+-activated K+ channels. J Physiol (2006) 1.22
Mg2+ mediates interaction between the voltage sensor and cytosolic domain to activate BK channels. Proc Natl Acad Sci U S A (2007) 1.21
A BK (Slo1) channel journey from molecule to physiology. Channels (Austin) (2013) 1.17
A linkage analysis toolkit for studying allosteric networks in ion channels. J Gen Physiol (2012) 1.15
Ethanol modulates BKCa channels by acting as an adjuvant of calcium. Mol Pharmacol (2008) 1.14
TRPC6 channels and their binding partners in podocytes: role in glomerular filtration and pathophysiology. Am J Physiol Renal Physiol (2010) 1.14
Ion sensing in the RCK1 domain of BK channels. Proc Natl Acad Sci U S A (2010) 1.13
Allosteric interactions and the modular nature of the voltage- and Ca2+-activated (BK) channel. J Physiol (2010) 1.13
Charge substitution for a deep-pore residue reveals structural dynamics during BK channel gating. J Gen Physiol (2011) 1.12
Transduction of voltage and Ca2+ signals by Slo1 BK channels. Physiology (Bethesda) (2013) 1.10
Alternatively spliced C-terminal domains regulate the surface expression of large conductance calcium-activated potassium channels. Neuroscience (2007) 1.07
Functional role and affinity of inorganic cations in stabilizing the tetrameric structure of the KcsA K+ channel. J Gen Physiol (2005) 1.04
Impaired Ca2+-dependent activation of large-conductance Ca2+-activated K+ channels in the coronary artery smooth muscle cells of Zucker Diabetic Fatty rats. Biophys J (2008) 1.04
Modes of operation of the BKCa channel beta2 subunit. J Gen Physiol (2007) 1.04
The RCK2 domain uses a coordination site present in Kir channels to confer sodium sensitivity to Slo2.2 channels. J Neurosci (2010) 1.03
Mechanism of increased BK channel activation from a channel mutation that causes epilepsy. J Gen Physiol (2009) 1.02
The BK channel: a vital link between cellular calcium and electrical signaling. Protein Cell (2012) 1.01
Differential regulation of action potentials by inactivating and noninactivating BK channels in rat adrenal chromaffin cells. Biophys J (2009) 1.01
Homology modeling identifies C-terminal residues that contribute to the Ca2+ sensitivity of a BKCa channel. Biophys J (2005) 1.00
Alternatively spliced domains interact to regulate BK potassium channel gating. Proc Natl Acad Sci U S A (2011) 0.98
Effects of multiple metal binding sites on calcium and magnesium-dependent activation of BK channels. J Gen Physiol (2005) 0.95
The Ca2+-activated K+ current of human sperm is mediated by Slo3. Elife (2014) 0.95
SLO, SLO, quick, quick, slow: calcium-activated potassium channels as regulators of Caenorhabditis elegans behaviour and targets for anthelmintics. Invert Neurosci (2007) 0.94
The NH2 terminus of RCK1 domain regulates Ca2+-dependent BK(Ca) channel gating. J Gen Physiol (2005) 0.92
Modulation of the conductance-voltage relationship of the BK Ca channel by mutations at the putative flexible interface between two RCK domains. Biophys J (2007) 0.92
The contribution of RCK domains to human BK channel allosteric activation. J Biol Chem (2012) 0.91
Barium ions selectively activate BK channels via the Ca2+-bowl site. Proc Natl Acad Sci U S A (2012) 0.90
Relative motion of transmembrane segments S0 and S4 during voltage sensor activation in the human BK(Ca) channel. J Gen Physiol (2010) 0.89
BK channels: multiple sensors, one activation gate. Front Physiol (2015) 0.88
Metal-driven operation of the human large-conductance voltage- and Ca2+-dependent potassium channel (BK) gating ring apparatus. J Biol Chem (2011) 0.88
Coupling and cooperativity in voltage activation of a limited-state BK channel gating in saturating Ca2+. J Gen Physiol (2010) 0.87
The RCK1 domain of the human BKCa channel transduces Ca2+ binding into structural rearrangements. J Gen Physiol (2010) 0.87
Relative transmembrane segment rearrangements during BK channel activation resolved by structurally assigned fluorophore-quencher pairing. J Gen Physiol (2012) 0.87
Zn2+ activates large conductance Ca2+-activated K+ channel via an intracellular domain. J Biol Chem (2009) 0.87
Distinct gating mechanisms revealed by the structures of a multi-ligand gated K(+) channel. Elife (2012) 0.84
Comparative effects of H+ and Ca2+ on large-conductance Ca2+- and voltage-gated Slo1 K+ channels. Channels (Austin) (2009) 0.84
Molecular mechanisms of large-conductance ca (2+) -activated potassium channel activation by ginseng gintonin. Evid Based Complement Alternat Med (2013) 0.84
The BKCa channel's Ca2+-binding sites, multiple sites, multiple ions. J Gen Physiol (2005) 0.83
Molecular architecture and divalent cation activation of TvoK, a prokaryotic potassium channel. J Biol Chem (2007) 0.82
Structural determinants of phosphatidylinositol 4,5-bisphosphate (PIP2) regulation of BK channel activity through the RCK1 Ca2+ coordination site. J Biol Chem (2014) 0.82
Single-channel kinetics of BK (Slo1) channels. Front Physiol (2015) 0.82
Mg(2+) binding to open and closed states can activate BK channels provided that the voltage sensors are elevated. J Gen Physiol (2011) 0.81
Intracellular Mg2+ influences both open and closed times of a native Ca2+-activated BK channel in cultured human renal proximal tubule cells. J Membr Biol (2005) 0.79
Initial steps of inactivation at the K+ channel selectivity filter. Proc Natl Acad Sci U S A (2014) 0.78
Multiple facets of maxi-k+ channels: the heme connection. J Gen Physiol (2005) 0.78
Negatively charged amino acids near and in transient receptor potential (TRP) domain of TRPM4 channel are one determinant of its Ca2+ sensitivity. J Biol Chem (2014) 0.78
SLO-2 isoforms with unique Ca(2+) - and voltage-dependence characteristics confer sensitivity to hypoxia in C. elegans. Channels (Austin) (2013) 0.78
Mechanisms of two modulatory actions of the channel-binding protein Slob on the Drosophila Slowpoke calcium-dependent potassium channel. J Gen Physiol (2006) 0.77
The large-conductance Ca(2+)-activated K(+) channel interacts with the apolipoprotein ApoA1. Biochem Biophys Res Commun (2009) 0.77
Crystal structure of a Ba(2+)-bound gating ring reveals elementary steps in RCK domain activation. Structure (2012) 0.77
Mg2+-dependent regulation of BK channels: importance of electrostatics. J Gen Physiol (2008) 0.77
Molecular mechanisms underlying the effect of the novel BK channel opener GoSlo: involvement of the S4/S5 linker and the S6 segment. Proc Natl Acad Sci U S A (2015) 0.77
Putative calcium-binding domains of the Caenorhabditis elegans BK channel are dispensable for intoxication and ethanol activation. Genes Brain Behav (2015) 0.77
Combining fragment homology modeling with molecular dynamics aims at prediction of Ca²⁺ binding sites in CaBPs. J Comput Aided Mol Des (2013) 0.77
Return of the electric binding site. J Gen Physiol (2008) 0.76
Cadmium-cysteine coordination in the BK inner pore region and its structural and functional implications. Proc Natl Acad Sci U S A (2015) 0.76
Interactions of divalent cations with calcium binding sites of BK channels reveal independent motions within the gating ring. Proc Natl Acad Sci U S A (2016) 0.76
Understanding the conformational motions of RCK gating rings. J Gen Physiol (2017) 0.75
Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch (1981) 134.60
The structure of the potassium channel: molecular basis of K+ conduction and selectivity. Science (1998) 39.86
Crystal structure and mechanism of a calcium-gated potassium channel. Nature (2002) 10.03
Properties of single calcium-activated potassium channels in cultured rat muscle. J Physiol (1982) 8.59
mSlo, a complex mouse gene encoding "maxi" calcium-activated potassium channels. Science (1993) 5.88
Gating kinetics of Ca2+-activated K+ channels from rat muscle incorporated into planar lipid bilayers. Evidence for two voltage-dependent Ca2+ binding reactions. J Gen Physiol (1983) 5.30
Coupling between voltage sensor activation, Ca2+ binding and channel opening in large conductance (BK) potassium channels. J Gen Physiol (2002) 5.18
A novel calcium-sensing domain in the BK channel. Biophys J (1997) 3.86
Multiple regulatory sites in large-conductance calcium-activated potassium channels. Nature (2002) 3.82
Structure of the RCK domain from the E. coli K+ channel and demonstration of its presence in the human BK channel. Neuron (2001) 3.62
Allosteric gating of a large conductance Ca-activated K+ channel. J Gen Physiol (1997) 3.57
Allosteric voltage gating of potassium channels I. Mslo ionic currents in the absence of Ca(2+). J Gen Physiol (1999) 3.55
Linker-gating ring complex as passive spring and Ca(2+)-dependent machine for a voltage- and Ca(2+)-activated potassium channel. Neuron (2004) 2.95
Calcium sensitivity of BK-type KCa channels determined by a separable domain. Neuron (1994) 2.94
Mechanism of magnesium activation of calcium-activated potassium channels. Nature (2002) 2.50
Voltage and Ca2+ activation of single large-conductance Ca2+-activated K+ channels described by a two-tiered allosteric gating mechanism. J Gen Physiol (2000) 2.41
Gating kinetics of single large-conductance Ca2+-activated K+ channels in high Ca2+ suggest a two-tiered allosteric gating mechanism. J Gen Physiol (1999) 2.35
Gating mechanism of BK (Slo1) channels: so near, yet so far. J Gen Physiol (2003) 2.31
Allosteric regulation of BK channel gating by Ca(2+) and Mg(2+) through a nonselective, low affinity divalent cation site. J Gen Physiol (2001) 2.24
Transplantable sites confer calcium sensitivity to BK channels. Nat Neurosci (1999) 2.04
Elimination of the BK(Ca) channel's high-affinity Ca(2+) sensitivity. J Gen Physiol (2002) 1.98
Intracellular Mg(2+) enhances the function of BK-type Ca(2+)-activated K(+) channels. J Gen Physiol (2001) 1.82
Mapping the BKCa channel's "Ca2+ bowl": side-chains essential for Ca2+ sensing. J Gen Physiol (2004) 1.82
Na+ block and permeation in a K+ channel of known structure. J Gen Physiol (2002) 1.80
Ca2+-binding activity of a COOH-terminal fragment of the Drosophila BK channel involved in Ca2+-dependent activation. Proc Natl Acad Sci U S A (2001) 1.77
Redox-sensitive extracellular gates formed by auxiliary beta subunits of calcium-activated potassium channels. Nat Struct Biol (2003) 1.73
Activation by divalent cations of a Ca2+-activated K+ channel from skeletal muscle membrane. J Gen Physiol (1988) 1.67
Ligand-dependent activation of Slo family channels is defined by interchangeable cytosolic domains. J Neurosci (2004) 1.46
Contribution of potential EF hand motifs to the calcium-dependent gating of a mouse brain large conductance, calcium-sensitive K(+) channel. J Physiol (2001) 1.38
Gating properties conferred on BK channels by the beta3b auxiliary subunit in the absence of its NH(2)- and COOH termini. J Gen Physiol (2001) 1.25
The cytosolic inactivation domains of BKi channels in rat chromaffin cells do not behave like simple, open-channel blockers. Biophys J (1997) 1.20
Cytoplasmic gatekeepers of K+-channel flux: a structural perspective. Trends Biochem Sci (2004) 1.12
Inactivation of BK channels mediated by the NH(2) terminus of the beta3b auxiliary subunit involves a two-step mechanism: possible separation of binding and blockade. J Gen Physiol (2001) 1.12
The suppression of Ca(2+)- and voltage-dependent outward K+ current during mAChR activation in rat adrenal chromaffin cells. J Physiol (1995) 1.10
Revisiting voltage-dependent relief of block in ion channels: a mechanism independent of punchthrough. Biophys J (2004) 0.97
Setting the stage for molecular dissection of the regulatory components of BK channels. J Gen Physiol (2002) 0.95
Activation and two modes of blockade by strontium of Ca2+-activated K+ channels in goldfish saccular hair cells. J Gen Physiol (1998) 0.91
Multiple regulatory sites in large-conductance calcium-activated potassium channels. Nature (2002) 3.82
Consequences of the stoichiometry of Slo1 alpha and auxiliary beta subunits on functional properties of large-conductance Ca2+-activated K+ channels. J Neurosci (2002) 1.75
Redox-sensitive extracellular gates formed by auxiliary beta subunits of calcium-activated potassium channels. Nat Struct Biol (2003) 1.73
Ligand-dependent activation of Slo family channels is defined by interchangeable cytosolic domains. J Neurosci (2004) 1.46
Deletion of the Slo3 gene abolishes alkalization-activated K+ current in mouse spermatozoa. Proc Natl Acad Sci U S A (2011) 1.43
Cysteine scanning and modification reveal major differences between BK channels and Kv channels in the inner pore region. Proc Natl Acad Sci U S A (2011) 1.36
Inactivation of BK channels by the NH2 terminus of the beta2 auxiliary subunit: an essential role of a terminal peptide segment of three hydrophobic residues. J Gen Physiol (2003) 1.28
LRRC52 (leucine-rich-repeat-containing protein 52), a testis-specific auxiliary subunit of the alkalization-activated Slo3 channel. Proc Natl Acad Sci U S A (2011) 1.22
Closed-channel block of BK potassium channels by bbTBA requires partial activation. J Gen Physiol (2009) 1.21
Slo3 K+ channels: voltage and pH dependence of macroscopic currents. J Gen Physiol (2006) 1.20
Block of mouse Slo1 and Slo3 K+ channels by CTX, IbTX, TEA, 4-AP and quinidine. Channels (Austin) (2010) 1.09
pH-regulated Slo3 K+ channels: properties of unitary currents. J Gen Physiol (2006) 1.09
Differential regulation of action potentials by inactivating and noninactivating BK channels in rat adrenal chromaffin cells. Biophys J (2009) 1.01
A limited access compartment between the pore domain and cytosolic domain of the BK channel. J Neurosci (2006) 1.00
Interactions between beta subunits of the KCNMB family and Slo3: beta4 selectively modulates Slo3 expression and function. PLoS One (2009) 1.00
Direct observation of a preinactivated, open state in BK channels with beta2 subunits. J Gen Physiol (2006) 0.97
Steady-state and closed-state inactivation properties of inactivating BK channels. Biophys J (2002) 0.96
Glycine311, a determinant of paxilline block in BK channels: a novel bend in the BK S6 helix. J Gen Physiol (2010) 0.96
The Ca2+-activated K+ current of human sperm is mediated by Slo3. Elife (2014) 0.95
Functional regulation of BK potassium channels by γ1 auxiliary subunits. Proc Natl Acad Sci U S A (2014) 0.94
Simultaneous knockout of Slo3 and CatSper1 abolishes all alkalization- and voltage-activated current in mouse spermatozoa. J Gen Physiol (2013) 0.92
A novel auxiliary subunit critical to BK channel function in Caenorhabditis elegans. J Neurosci (2010) 0.91
Barium ions selectively activate BK channels via the Ca2+-bowl site. Proc Natl Acad Sci U S A (2012) 0.90
Species-specific Differences among KCNMB3 BK beta3 auxiliary subunits: some beta3 N-terminal variants may be primate-specific subunits. J Gen Physiol (2008) 0.88
Stereospecific binding of a disordered peptide segment mediates BK channel inactivation. Nature (2012) 0.87
BK channels with beta3a subunits generate use-dependent slow afterhyperpolarizing currents by an inactivation-coupled mechanism. J Neurosci (2007) 0.85
N-terminal inactivation domains of beta subunits are protected from trypsin digestion by binding within the antechamber of BK channels. J Gen Physiol (2009) 0.82
Inhibition of large-conductance Ca2+-activated K+ channels by nanomolar concentrations of Ag+. Mol Pharmacol (2010) 0.81
Effects of esterified lactoferrin and lactoferrin on control of postharvest blue mold of apple fruit and their possible mechanisms of action. J Agric Food Chem (2012) 0.78
Cardiac Slo2.1 Is Required for Volatile Anesthetic Stimulation of K+ Transport and Anesthetic Preconditioning. Anesthesiology (2016) 0.78
Inhibitory effect of lactoferrin against gray mould on tomato plants caused by Botrytis cinerea and possible mechanisms of action. Int J Food Microbiol (2012) 0.76
Inhibitory effect of sulfated lentinan and lentinan against tobacco mosaic virus (TMV) in tobacco seedlings. Int J Biol Macromol (2013) 0.76
[Reconstruction of forefoot skin defect with island flap pedicled with lateral tarsal artery]. Zhonghua Zheng Xing Wai Ke Za Zhi (2012) 0.75
Inhibitory effect of esterified lactoferin and lactoferrin against tobacco mosaic virus (TMV) in tobacco seedlings. Pestic Biochem Physiol (2012) 0.75