Published in Proc Natl Acad Sci U S A on December 27, 2007
Structure of the human BK channel Ca2+-activation apparatus at 3.0 A resolution. Science (2010) 3.03
Structure of the gating ring from the human large-conductance Ca(2+)-gated K(+) channel. Nature (2010) 2.00
Molecular mechanisms of BK channel activation. Cell Mol Life Sci (2009) 1.81
BK channel activation: structural and functional insights. Trends Neurosci (2010) 1.65
Modulation of BKCa channel gating by endogenous signaling molecules. Physiology (Bethesda) (2009) 1.38
Profiling the phospho-status of the BKCa channel alpha subunit in rat brain reveals unexpected patterns and complexity. Mol Cell Proteomics (2008) 1.29
Regulation of bestrophin Cl channels by calcium: role of the C terminus. J Gen Physiol (2008) 1.29
Dual role of protein kinase C on BK channel regulation. Proc Natl Acad Sci U S A (2010) 1.29
Regulation of synaptic transmission by presynaptic CaMKII and BK channels. Mol Neurobiol (2008) 1.15
Allosteric interactions and the modular nature of the voltage- and Ca2+-activated (BK) channel. J Physiol (2010) 1.13
Transduction of voltage and Ca2+ signals by Slo1 BK channels. Physiology (Bethesda) (2013) 1.10
Molecular mechanism of pharmacological activation of BK channels. Proc Natl Acad Sci U S A (2012) 1.04
Impaired Ca2+-dependent activation of large-conductance Ca2+-activated K+ channels in the coronary artery smooth muscle cells of Zucker Diabetic Fatty rats. Biophys J (2008) 1.04
Identification of a thiol/disulfide redox switch in the human BK channel that controls its affinity for heme and CO. J Biol Chem (2010) 1.00
α-Catulin CTN-1 is required for BK channel subcellular localization in C. elegans body-wall muscle cells. EMBO J (2010) 0.97
Targeting BK (big potassium) channels in epilepsy. Expert Opin Ther Targets (2011) 0.95
The contribution of RCK domains to human BK channel allosteric activation. J Biol Chem (2012) 0.91
A novel auxiliary subunit critical to BK channel function in Caenorhabditis elegans. J Neurosci (2010) 0.91
Identification and quantification of full-length BK channel variants in the developing mouse cochlea. J Neurosci Res (2011) 0.91
Modulation of the conductance-voltage relationship of the BK(Ca) channel by shortening the cytosolic loop connecting two RCK domains. Biophys J (2009) 0.90
Barium ions selectively activate BK channels via the Ca2+-bowl site. Proc Natl Acad Sci U S A (2012) 0.90
Operation of the voltage sensor of a human voltage- and Ca2+-activated K+ channel. Proc Natl Acad Sci U S A (2010) 0.89
Relative motion of transmembrane segments S0 and S4 during voltage sensor activation in the human BK(Ca) channel. J Gen Physiol (2010) 0.89
Modeling a Ca(2+) channel/BKCa channel complex at the single-complex level. Biophys J (2014) 0.88
Metal-driven operation of the human large-conductance voltage- and Ca2+-dependent potassium channel (BK) gating ring apparatus. J Biol Chem (2011) 0.88
Relative transmembrane segment rearrangements during BK channel activation resolved by structurally assigned fluorophore-quencher pairing. J Gen Physiol (2012) 0.87
Zn2+ activates large conductance Ca2+-activated K+ channel via an intracellular domain. J Biol Chem (2009) 0.87
Membrane trafficking of large conductance calcium-activated potassium channels is regulated by alternative splicing of a transplantable, acidic trafficking motif in the RCK1-RCK2 linker. J Biol Chem (2010) 0.87
The RCK1 domain of the human BKCa channel transduces Ca2+ binding into structural rearrangements. J Gen Physiol (2010) 0.87
Thiol/Disulfide redox switches in the regulation of heme binding to proteins. Antioxid Redox Signal (2010) 0.86
Distinct sensitivity of slo1 channel proteins to ethanol. Mol Pharmacol (2012) 0.86
Identification of putative potassium channel homologues in pathogenic protozoa. PLoS One (2012) 0.85
Comparative effects of H+ and Ca2+ on large-conductance Ca2+- and voltage-gated Slo1 K+ channels. Channels (Austin) (2009) 0.84
Elongation factor 3, EF3, associates with the calcium channel Cch1 and targets Cch1 to the plasma membrane in Cryptococcus neoformans. Eukaryot Cell (2008) 0.84
Enhancement effects of martentoxin on glioma BK channel and BK channel (α+β1) subtypes. PLoS One (2011) 0.83
On the simple random-walk models of ion-channel gate dynamics reflecting long-term memory. Eur Biophys J (2012) 0.79
Modulation of BK Channel Function by Auxiliary Beta and Gamma Subunits. Int Rev Neurobiol (2016) 0.78
The smooth muscle-type β1 subunit potentiates activation by DiBAC4(3) in recombinant BK channels. Channels (Austin) (2013) 0.76
Understanding the conformational motions of RCK gating rings. J Gen Physiol (2017) 0.75
Activation of lysophosphatidic Acid receptor is coupled to enhancement of ca(2+)-activated potassium channel currents. Korean J Physiol Pharmacol (2013) 0.75
CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res (1994) 392.47
Comparative protein modelling by satisfaction of spatial restraints. J Mol Biol (1993) 64.61
Estimation of protein secondary structure from circular dichroism spectra: comparison of CONTIN, SELCON, and CDSSTR methods with an expanded reference set. Anal Biochem (2000) 11.10
Crystal structure and mechanism of a calcium-gated potassium channel. Nature (2002) 10.03
How to study proteins by circular dichroism. Biochim Biophys Acta (2005) 5.79
Single channel recordings of Ca2+-activated K+ currents in rat muscle cell culture. Nature (1981) 5.65
High-conductance potassium channels of the SLO family. Nat Rev Neurosci (2006) 4.26
A novel calcium-sensing domain in the BK channel. Biophys J (1997) 3.86
Reconstitution in planar lipid bilayers of a Ca2+-dependent K+ channel from transverse tubule membranes isolated from rabbit skeletal muscle. Proc Natl Acad Sci U S A (1982) 3.85
Multiple regulatory sites in large-conductance calcium-activated potassium channels. Nature (2002) 3.82
Structure of the RCK domain from the E. coli K+ channel and demonstration of its presence in the human BK channel. Neuron (2001) 3.62
Some precautions in using chelators to buffer metals in biological solutions. Cell Calcium (2004) 3.32
Tetraethylammonium block of Slowpoke calcium-activated potassium channels expressed in Xenopus oocytes: evidence for tetrameric channel formation. Pflugers Arch (1994) 2.75
Mechanism of magnesium activation of calcium-activated potassium channels. Nature (2002) 2.50
MaxiK channel partners: physiological impact. J Physiol (2005) 2.46
Computation and analysis of protein circular dichroism spectra. Methods Enzymol (2004) 2.37
Gating mechanism of BK (Slo1) channels: so near, yet so far. J Gen Physiol (2003) 2.31
Allosteric regulation of BK channel gating by Ca(2+) and Mg(2+) through a nonselective, low affinity divalent cation site. J Gen Physiol (2001) 2.24
Characterization of and modulation by a beta-subunit of a human maxi KCa channel cloned from myometrium. Receptors Channels (1995) 2.24
Voltage-controlled gating in a large conductance Ca2+-sensitive K+channel (hslo). Proc Natl Acad Sci U S A (1997) 2.11
Transplantable sites confer calcium sensitivity to BK channels. Nat Neurosci (1999) 2.04
Role of the S4 segment in a voltage-dependent calcium-sensitive potassium (hSlo) channel. J Biol Chem (1998) 2.03
Elimination of the BK(Ca) channel's high-affinity Ca(2+) sensitivity. J Gen Physiol (2002) 1.98
Crystal structures of a ligand-free MthK gating ring: insights into the ligand gating mechanism of K+ channels. Cell (2006) 1.98
Divalent cation sensitivity of BK channel activation supports the existence of three distinct binding sites. J Gen Physiol (2005) 1.91
Mapping the BKCa channel's "Ca2+ bowl": side-chains essential for Ca2+ sensing. J Gen Physiol (2004) 1.82
Ca2+-binding activity of a COOH-terminal fragment of the Drosophila BK channel involved in Ca2+-dependent activation. Proc Natl Acad Sci U S A (2001) 1.77
The alpha-to-beta conformational transition of Alzheimer's Abeta-(1-42) peptide in aqueous media is reversible: a step by step conformational analysis suggests the location of beta conformation seeding. Chembiochem (2006) 1.70
Reactive oxygen species impair Slo1 BK channel function by altering cysteine-mediated calcium sensing. Nat Struct Mol Biol (2004) 1.57
The RCK domain of the KtrAB K+ transporter: multiple conformations of an octameric ring. Cell (2006) 1.56
Stepwise contribution of each subunit to the cooperative activation of BK channels by Ca2+. Proc Natl Acad Sci U S A (2002) 1.41
Ca2+ regulation of interactions between endoplasmic reticulum chaperones. J Biol Chem (1999) 1.39
Intra- and intersubunit cooperativity in activation of BK channels by Ca2+. J Gen Physiol (2006) 1.39
Contribution of potential EF hand motifs to the calcium-dependent gating of a mouse brain large conductance, calcium-sensitive K(+) channel. J Physiol (2001) 1.38
Structures of the MthK RCK domain and the effect of Ca2+ on gating ring stability. J Biol Chem (2005) 1.36
A novel dimer interface and conformational changes revealed by an X-ray structure of B. subtilis SecA. J Mol Biol (2006) 1.27
Maxi-K potassium channels: form, function, and modulation of a class of endogenous regulators of intracellular calcium. Neuroscientist (2001) 1.21
Zinc binding to the HCCH motif of HIV-1 virion infectivity factor induces a conformational change that mediates protein-protein interactions. Proc Natl Acad Sci U S A (2006) 1.20
Hydrophobic interface between two regulators of K+ conductance domains critical for calcium-dependent activation of large conductance Ca2+-activated K+ channels. J Biol Chem (2006) 1.18
Cytoplasmic gatekeepers of K+-channel flux: a structural perspective. Trends Biochem Sci (2004) 1.12
Voltage-dependent conformational changes in human Ca(2+)- and voltage-activated K(+) channel, revealed by voltage-clamp fluorometry. Proc Natl Acad Sci U S A (2006) 1.11
Dynamic oligomeric conversions of the cytoplasmic RCK domains mediate MthK potassium channel activity. Proc Natl Acad Sci U S A (2007) 1.07
Towards a structural understanding of the fibrillization pathway in Machado-Joseph's disease: trapping early oligomers of non-expanded ataxin-3. J Mol Biol (2005) 1.05
Statistical limits to the identification of ion channel domains by sequence similarity. J Gen Physiol (2006) 1.02
Homology modeling identifies C-terminal residues that contribute to the Ca2+ sensitivity of a BKCa channel. Biophys J (2005) 1.00
Gating rings formed by RCK domains: keys to gate opening. J Gen Physiol (2007) 1.00
A reinvestigation of the secondary structure of functionally active vSGLT, the vibrio sodium/galactose cotransporter. Biochemistry (2006) 0.99
How to gate an ion channel: lessons from MthK. Nat Struct Mol Biol (2007) 0.95
Changes in structure and stability of calbindin-D(28K) upon calcium binding. Anal Biochem (2004) 0.91
A rabbit ventricular action potential model replicating cardiac dynamics at rapid heart rates. Biophys J (2008) 4.22
Structure of a tetrameric MscL in an expanded intermediate state. Nature (2009) 1.61
The second Ca2+-binding domain of the Na+ Ca2+ exchanger is essential for regulation: crystal structures and mutational analysis. Proc Natl Acad Sci U S A (2007) 1.41
Modifying L-type calcium current kinetics: consequences for cardiac excitation and arrhythmia dynamics. Biophys J (2008) 1.30
The Na+/Ca2+ exchange molecule: an overview. Ann N Y Acad Sci (2002) 1.28
Early afterdepolarizations in cardiac myocytes: beyond reduced repolarization reserve. Cardiovasc Res (2013) 1.23
Regulation of K+ flow by a ring of negative charges in the outer pore of BKCa channels. Part I: Aspartate 292 modulates K+ conduction by external surface charge effect. J Gen Physiol (2004) 1.19
A fluorescent probe designed for studying protein conformational change. Proc Natl Acad Sci U S A (2005) 1.17
Voltage-dependent conformational changes in human Ca(2+)- and voltage-activated K(+) channel, revealed by voltage-clamp fluorometry. Proc Natl Acad Sci U S A (2006) 1.11
Ca2+-dependent structural rearrangements within Na+-Ca2+ exchanger dimers. Proc Natl Acad Sci U S A (2011) 1.07
A single M1 residue in the beta2 subunit alters channel gating of GABAA receptor in anesthetic modulation and direct activation. J Biol Chem (2003) 1.07
Na+/Ca2+ exchange and Na+/K+-ATPase in the heart. J Physiol (2015) 1.06
Shaping a new Ca²⁺ conductance to suppress early afterdepolarizations in cardiac myocytes. J Physiol (2011) 1.06
Modes of operation of the BKCa channel beta2 subunit. J Gen Physiol (2007) 1.04
Molecular coupling between voltage sensor and pore opening in the Arabidopsis inward rectifier K+ channel KAT1. J Gen Physiol (2003) 0.98
Dynamic modulation of intracellular glucose imaged in single cells using a FRET-based glucose nanosensor. Pflugers Arch (2007) 0.98
Single-cell census of mechanosensitive channels in living bacteria. PLoS One (2012) 0.98
GABAA receptor-associated protein regulates GABAA receptor cell-surface number in Xenopus laevis oocytes. Mol Pharmacol (2005) 0.98
Tissue-specific regulation of Ca(2+) channel protein expression by sex hormones. Biochim Biophys Acta (2002) 0.94
Structure and functional analysis of a Ca2+ sensor mutant of the Na+/Ca2+ exchanger. J Biol Chem (2009) 0.93
The contribution of RCK domains to human BK channel allosteric activation. J Biol Chem (2012) 0.91
Toward a topological model of the NCX1 exchanger. Ann N Y Acad Sci (2002) 0.90
What we know about the structure of NCX1 and how it relates to its function. Ann N Y Acad Sci (2007) 0.90
Operation of the voltage sensor of a human voltage- and Ca2+-activated K+ channel. Proc Natl Acad Sci U S A (2010) 0.89
Relative motion of transmembrane segments S0 and S4 during voltage sensor activation in the human BK(Ca) channel. J Gen Physiol (2010) 0.89
Metal-driven operation of the human large-conductance voltage- and Ca2+-dependent potassium channel (BK) gating ring apparatus. J Biol Chem (2011) 0.88
Relative transmembrane segment rearrangements during BK channel activation resolved by structurally assigned fluorophore-quencher pairing. J Gen Physiol (2012) 0.87
The RCK1 domain of the human BKCa channel transduces Ca2+ binding into structural rearrangements. J Gen Physiol (2010) 0.87
The voltage-clamp fluorometry technique. Methods Mol Biol (2008) 0.86
Functional role of CLIC1 ion channel in glioblastoma-derived stem/progenitor cells. J Natl Cancer Inst (2013) 0.85
Conformational changes of a Ca2+-binding domain of the Na+/Ca2+ exchanger monitored by FRET in transgenic zebrafish heart. Am J Physiol Cell Physiol (2008) 0.84
The cardiac Na+-Ca2+ exchanger has two cytoplasmic ion permeation pathways. Proc Natl Acad Sci U S A (2013) 0.84
Regulation of K+ flow by a ring of negative charges in the outer pore of BKCa channels. Part II: Neutralization of aspartate 292 reduces long channel openings and gating current slow component. J Gen Physiol (2004) 0.81
Influence of channel subunit composition on L-type Ca2+ current kinetics and cardiac wave stability. Am J Physiol Heart Circ Physiol (2007) 0.81
Point mutations in the transmembrane region of the clic1 ion channel selectively modify its biophysical properties. PLoS One (2013) 0.80
Bcl-2 down modulation in WEHI-3B/CTRES cells resistant to Cholera Toxin (CT)-induced apoptosis. Cell Res (2006) 0.80
How does regulatory Ca2+ regulate the Na+-Ca2+ exchanger? Channels (Austin) (2008) 0.80
20 years from NCX purification and cloning: milestones. Adv Exp Med Biol (2013) 0.79