Published in J Biol Chem on March 01, 2005
Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1. J Biol Chem (2006) 5.32
Phosphorylation via PKC Regulates the Function of the Drosophila Odorant Co-Receptor. Front Cell Neurosci (2011) 1.08
The STIM1-ORAI1 microdomain. Cell Calcium (2015) 0.90
Mechanism and functional significance of TRPC channel multimerization. Semin Cell Dev Biol (2006) 0.87
Identification of an L-phenylalanine binding site enhancing the cooperative responses of the calcium-sensing receptor to calcium. J Biol Chem (2014) 0.83
New insights into the activation mechanism of store-operated calcium channels: roles of STIM and Orai. J Zhejiang Univ Sci B (2008) 0.81
STIM1 Protein Activates Store-Operated Calcium Channels in Cellular Model of Huntington's Disease. Acta Naturae (2014) 0.79
Regulation of store-operated calcium entry by FK506-binding immunophilins. Cell Calcium (2013) 0.77
STIM1 and STIM2 proteins differently regulate endogenous store-operated channels in HEK293 cells. J Biol Chem (2014) 0.77
Regulation of store-operated channels by scaffold proteins in a431 cells. Acta Naturae (2010) 0.75
Modeling an Excitable Biosynthetic Tissue with Inherent Variability for Paired Computational-Experimental Studies. PLoS Comput Biol (2017) 0.75
Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations. Cell (2006) 4.10
Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1. Neuron (2003) 3.25
Allele-specific silencing of mutant huntingtin and ataxin-3 genes by targeting expanded CAG repeats in mRNAs. Nat Biotechnol (2009) 2.36
Disturbed Ca2+ signaling and apoptosis of medium spiny neurons in Huntington's disease. Proc Natl Acad Sci U S A (2005) 2.15
Modulation of type 1 inositol (1,4,5)-trisphosphate receptor function by protein kinase a and protein phosphatase 1alpha. J Neurosci (2003) 2.12
Secondary structure of Huntingtin amino-terminal region. Structure (2009) 1.98
G-protein-coupled receptor modulation of striatal CaV1.3 L-type Ca2+ channels is dependent on a Shank-binding domain. J Neurosci (2005) 1.84
Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1. J Clin Invest (2007) 1.68
Reelin modulates NMDA receptor activity in cortical neurons. J Neurosci (2005) 1.65
Role of presenilins in neuronal calcium homeostasis. J Neurosci (2010) 1.59
Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 2. J Neurosci (2009) 1.59
Synaptic targeting of N-type calcium channels in hippocampal neurons. J Neurosci (2002) 1.53
Dopaminergic signaling and striatal neurodegeneration in Huntington's disease. J Neurosci (2007) 1.44
Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 3. J Neurosci (2008) 1.44
Functional characterization of mammalian inositol 1,4,5-trisphosphate receptor isoforms. Biophys J (2004) 1.43
The dysregulation of intracellular calcium in Alzheimer disease. Cell Calcium (2010) 1.40
Small-molecule activation of neuronal cell fate. Nat Chem Biol (2008) 1.33
Association of CaV1.3 L-type calcium channels with Shank. J Neurosci (2005) 1.25
Neuronal store-operated calcium entry pathway as a novel therapeutic target for Huntington's disease treatment. Chem Biol (2011) 1.25
Association of type 1 inositol 1,4,5-trisphosphate receptor with AKAP9 (Yotiao) and protein kinase A. J Biol Chem (2004) 1.23
Modulation of mammalian inositol 1,4,5-trisphosphate receptor isoforms by calcium: a role of calcium sensor region. Biophys J (2004) 1.23
Dopamine receptor-mediated Ca(2+) signaling in striatal medium spiny neurons. J Biol Chem (2004) 1.18
Acute dosing of latrepirdine (Dimebon), a possible Alzheimer therapeutic, elevates extracellular amyloid-beta levels in vitro and in vivo. Mol Neurodegener (2009) 1.18
Ca1.2 and CaV1.3 neuronal L-type calcium channels: differential targeting and signaling to pCREB. Eur J Neurosci (2006) 1.15
Functional and biochemical analysis of the type 1 inositol (1,4,5)-trisphosphate receptor calcium sensor. Biophys J (2003) 1.14
Evaluation of Dimebon in cellular model of Huntington's disease. Mol Neurodegener (2008) 1.14
Familial Alzheimer's disease mutations in presenilins: effects on endoplasmic reticulum calcium homeostasis and correlation with clinical phenotypes. J Alzheimers Dis (2010) 1.14
Neuroprotective effects of inositol 1,4,5-trisphosphate receptor C-terminal fragment in a Huntington's disease mouse model. J Neurosci (2009) 1.14
Functional characterization of the type 1 inositol 1,4,5-trisphosphate receptor coupling domain SII(+/-) splice variants and the Opisthotonos mutant form. Biophys J (2002) 1.12
Full length mutant huntingtin is required for altered Ca2+ signaling and apoptosis of striatal neurons in the YAC mouse model of Huntington's disease. Neurobiol Dis (2008) 1.12
Deranged calcium signaling in Purkinje cells and pathogenesis in spinocerebellar ataxia 2 (SCA2) and other ataxias. Cerebellum (2012) 1.12
Distinct roles for two histamine receptors (hclA and hclB) at the Drosophila photoreceptor synapse. J Neurosci (2008) 1.10
Detection of anti-MICA antibodies in patients awaiting kidney transplantation, during the post-transplant course, and in eluates from rejected kidney allografts by Luminex flow cytometry. Hum Immunol (2006) 1.08
Evaluation of clinically relevant glutamate pathway inhibitors in in vitro model of Huntington's disease. Neurosci Lett (2006) 1.07
The C terminus of Bax inhibitor-1 forms a Ca2+-permeable channel pore. J Biol Chem (2011) 1.07
Mutagenesis mapping of the presenilin 1 calcium leak conductance pore. J Biol Chem (2011) 1.05
Encoding of luminance and contrast by linear and nonlinear synapses in the retina. Neuron (2012) 1.04
Selective positive modulator of calcium-activated potassium channels exerts beneficial effects in a mouse model of spinocerebellar ataxia type 2. Chem Biol (2012) 1.04
Neuronal calcium signaling, mitochondrial dysfunction, and Alzheimer's disease. J Alzheimers Dis (2010) 1.04
Spikes in retinal bipolar cells phase-lock to visual stimuli with millisecond precision. Curr Biol (2011) 1.03
MICA allele-level typing by sequence-based typing with computerized assignment of polymorphic sites and short tandem repeats within the transmembrane region. Hum Immunol (2006) 1.02
Functional properties of the Drosophila melanogaster inositol 1,4,5-trisphosphate receptor mutants. Biophys J (2004) 1.01
Chronic suppression of inositol 1,4,5-triphosphate receptor-mediated calcium signaling in cerebellar purkinje cells alleviates pathological phenotype in spinocerebellar ataxia 2 mice. J Neurosci (2012) 0.99
Network adaptation improves temporal representation of naturalistic stimuli in Drosophila eye: I dynamics. PLoS One (2009) 0.99
Presenilins function in ER calcium leak and Alzheimer's disease pathogenesis. Cell Calcium (2011) 0.99
Association of the type 1 inositol (1,4,5)-trisphosphate receptor with 4.1N protein in neurons. Mol Cell Neurosci (2003) 0.98
Dantrolene is neuroprotective in Huntington's disease transgenic mouse model. Mol Neurodegener (2011) 0.96
HAP1 facilitates effects of mutant huntingtin on inositol 1,4,5-trisphosphate-induced Ca release in primary culture of striatal medium spiny neurons. Eur J Neurosci (2004) 0.95
Ginsenosides protect striatal neurons in a cellular model of Huntington's disease. J Neurosci Res (2009) 0.94
Expanded polyglutamine-binding peptoid as a novel therapeutic agent for treatment of Huntington's disease. Chem Biol (2011) 0.94
Tetrabenazine is neuroprotective in Huntington's disease mice. Mol Neurodegener (2010) 0.93
Suppression of TRPC3 leads to disappearance of store-operated channels and formation of a new type of store-independent channels in A431 cells. J Biol Chem (2007) 0.93
Role of endoplasmic reticulum Ca2+ signaling in the pathogenesis of Alzheimer disease. Front Mol Neurosci (2013) 0.92
The store-operated calcium entry pathways in human carcinoma A431 cells: functional properties and activation mechanisms. J Gen Physiol (2003) 0.92
Elucidating a normal function of huntingtin by functional and microarray analysis of huntingtin-null mouse embryonic fibroblasts. BMC Neurosci (2008) 0.92
The high-affinity calcium[bond]calmodulin-binding site does not play a role in the modulation of type 1 inositol 1,4,5-trisphosphate receptor function by calcium and calmodulin. Biochem J (2002) 0.91
Corticostriatal circuit dysfunction in Huntington's disease: intersection of glutamate, dopamine and calcium. Future Neurol (2010) 0.89
Localization of L-type calcium channel Ca(V)1.3 in cat lumbar spinal cord--with emphasis on motoneurons. Neurosci Lett (2006) 0.88
The role of ryanodine receptor type 3 in a mouse model of Alzheimer disease. Channels (Austin) (2014) 0.87
Response to Shilling et al. (10.1074/jbc.M111.300491). J Biol Chem (2012) 0.84
Aβ42-binding peptoids as amyloid aggregation inhibitors and detection ligands. ACS Chem Neurosci (2013) 0.81
Homer regulation of native plasma membrane calcium channels in A431 cells. Cell Calcium (2010) 0.80
Can the calcium hypothesis explain synaptic loss in Alzheimer's disease? Neurodegener Dis (2013) 0.80
Presenilins as endoplasmic reticulum calcium leak channels and Alzheimer's disease pathogenesis. Sci China Life Sci (2011) 0.79
TRPC1 protein forms only one type of native store-operated channels in HEK293 cells. Biochimie (2012) 0.79
Functional properties of a pore mutant in the Drosophila melanogaster inositol 1,4,5-trisphosphate receptor. FEBS Lett (2004) 0.76
Inositol 1,4,5-tripshosphate receptor, calcium signaling, and polyglutamine expansion disorders. Curr Top Membr (2010) 0.75
AF710B, a Novel M1/σ1 Agonist with Therapeutic Efficacy in Animal Models of Alzheimer’s Disease. Neurodegener Dis (2016) 0.75
Misery loves company - shared features of neurodegenerative disorders. Biochem Biophys Res Commun (2017) 0.75