Amyloidogenesis in Alzheimer's disease: some possible therapeutic opportunities.

PubWeight™: 0.86‹?›

🔗 View Article (PMID 1574806)

Published in Trends Pharmacol Sci on March 01, 1992

Authors

S Gandy1, P Greengard

Author Affiliations

1: Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, New York 10021.

Articles by these authors

(truncated to the top 100)

Synapsin I (protein I), a nerve terminal-specific phosphoprotein. III. Its association with synaptic vesicles studied in a highly purified synaptic vesicle preparation. J Cell Biol (1983) 7.55

Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline. JAMA (2000) 6.55

Cyclic nucleotide-dependent protein kinases. IV. Widespread occurrence of adenosine 3',5'-monophosphate-dependent protein kinase in various tissues and phyla of the animal kingdom. Proc Natl Acad Sci U S A (1969) 6.02

Cyclic nucleotide-dependent protein kinases. 3. Purification and properties of adenosine 3',5'-monophosphate-dependent protein kinase from bovine brain. J Biol Chem (1969) 5.37

Cyclic AMP-dependent endogenous phosphorylation of a microtubule-associated protein. Proc Natl Acad Sci U S A (1975) 5.25

Phosphorylated proteins as physiological effectors. Science (1978) 5.03

Synapsin I (protein I), a nerve terminal-specific phosphoprotein. I. Its general distribution in synapses of the central and peripheral nervous system demonstrated by immunofluorescence in frozen and plastic sections. J Cell Biol (1983) 4.73

A 38,000-dalton membrane protein (p38) present in synaptic vesicles. Proc Natl Acad Sci U S A (1985) 4.35

Adenosine 3':5'-monophosphate-regulated phosphoprotein system of neuronal membranes. I. Solubilization, purification, and some properties of an endogenous phosphoprotein. J Biol Chem (1977) 4.33

Dopamine-sensitive adenylate cyclase in caudate nucleus of rat brain, and its similarity to the "dopamine receptor". Proc Natl Acad Sci U S A (1972) 4.03

Intraneuronal Abeta42 accumulation in human brain. Am J Pathol (2000) 3.83

Three-dimensional structure of the catalytic subunit of protein serine/threonine phosphatase-1. Nature (1995) 3.77

Protein p38: an integral membrane protein specific for small vesicles of neurons and neuroendocrine cells. J Cell Biol (1986) 3.68

Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons. Nature (1999) 3.50

Synapsin I (Protein I), a nerve terminal-specific phosphoprotein. II. Its specific association with synaptic vesicles demonstrated by immunocytochemistry in agarose-embedded synaptosomes. J Cell Biol (1983) 3.49

A quantitative dot-immunobinding assay for proteins using nitrocellulose membrane filters. Proc Natl Acad Sci U S A (1984) 3.35

Intraterminal injection of synapsin I or calcium/calmodulin-dependent protein kinase II alters neurotransmitter release at the squid giant synapse. Proc Natl Acad Sci U S A (1985) 3.23

Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5. Nature (2001) 3.09

Cyclic AMP-dependent protein kinase opens chloride channels in normal but not cystic fibrosis airway epithelium. Nature (1988) 3.06

Multiple phosphorylation sites in protein I and their differential regulation by cyclic AMP and calcium. Proc Natl Acad Sci U S A (1979) 2.96

Distinct pools of synaptic vesicles in neurotransmitter release. Nature (1995) 2.96

Possible role for cyclic nucleotides and phosphorylated membrane proteins in postsynaptic actions of neurotransmitters. Nature (1976) 2.95

Depolarization-induced phosphorylation of specific proteins, mediated by calcium ion influx, in rat brain synaptosomes. J Biol Chem (1977) 2.94

Cyclic nucleotide-dependent protein kinases. VI. Isolation and partial purification of a protein kinase activated by guanosine 3',5'-monophosphate. J Biol Chem (1970) 2.89

Synapsin dispersion and reclustering during synaptic activity. Nat Neurosci (2001) 2.87

An adenosine 3',5'-monophosphate-dependent protein kinase from Escherichia coli. J Biol Chem (1969) 2.86

Microinjection of catalytic subunit of cyclic AMP-dependent protein kinase enhances calcium action potentials of bag cell neurons in cell culture. Proc Natl Acad Sci U S A (1980) 2.84

Cyclic AMP mediates the effects of adrenaline on cardiac purkinje fibres. Nat New Biol (1972) 2.84

Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors? J Biol Chem (2001) 2.79

Spinophilin, a novel protein phosphatase 1 binding protein localized to dendritic spines. Proc Natl Acad Sci U S A (1997) 2.77

DARPP-32, a dopamine-regulated neuronal phosphoprotein, is a potent inhibitor of protein phosphatase-1. Nature (1984) 2.74

Regulation of endogenous phosphorylation of specific proteins in synaptic membrane fractions from rat brain by adenosine 3':5'-monophosphate. J Biol Chem (1973) 2.66

Synapsins as mediators of BDNF-enhanced neurotransmitter release. Nat Neurosci (2000) 2.62

Synapsin I bundles F-actin in a phosphorylation-dependent manner. Nature (1987) 2.59

DARPP-32: regulator of the efficacy of dopaminergic neurotransmission. Science (1998) 2.53

Regulation of chloride channels by protein kinase C in normal and cystic fibrosis airway epithelia. Science (1989) 2.46

Evidence that the major postsynaptic density protein is a component of a Ca2+/calmodulin-dependent protein kinase. Proc Natl Acad Sci U S A (1984) 2.45

Nobel laureates' letter to President Bush. Washington Post (2001) 2.43

Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation. Proc Natl Acad Sci U S A (1990) 2.41

Subcellular distribution in cerebral cortex of two proteins phosphorylated by a cAMP-dependent protein kinase. J Cell Biol (1979) 2.40

Two calcium/calmodulin-dependent protein kinases, which are highly concentrated in brain, phosphorylate protein I at distinct sites. Proc Natl Acad Sci U S A (1981) 2.40

Protein kinases in the brain. Annu Rev Biochem (1985) 2.40

DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated phosphoprotein enriched in dopamine-innervated brain regions. III. Immunocytochemical localization. J Neurosci (1984) 2.39

Ca2+-dependent protein phosphorylation system in membranes from various tissues, and its activation by "calcium-dependent regulator". Proc Natl Acad Sci U S A (1978) 2.38

Cyclic nucleotide-dependent protein kinases. X. An assay method for the measurement of quanosine 3',5'-monophosphate in various biological materials and a study of agents regulating its levels in heart and brain. J Biol Chem (1972) 2.35

Phosphorylation of the nicotinic acetylcholine receptor regulates its rate of desensitization. Nature (1986) 2.35

Synapsins as regulators of neurotransmitter release. Philos Trans R Soc Lond B Biol Sci (1999) 2.32

Spinophilin regulates the formation and function of dendritic spines. Proc Natl Acad Sci U S A (2000) 2.32

Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer beta/A4 amyloid protein precursor. Proc Natl Acad Sci U S A (1992) 2.31

Phosphorylation of the cystic fibrosis transmembrane conductance regulator. J Biol Chem (1992) 2.28

Ca2+/calmodulin-dependent protein kinase II. Isozymic forms from rat forebrain and cerebellum. J Biol Chem (1985) 2.26

Differential phosphorylation of multiple sites in purified protein I by cyclic AMP-dependent and calcium-dependent protein kinases. J Biol Chem (1981) 2.26

Intracellular injection of t he catalytic subunit of cyclic AMP-dependent protein kinase simulates facilitation of transmitter release underlying behavioral sensitization in Aplysia. Proc Natl Acad Sci U S A (1980) 2.24

A synaptic vesicle protein with a novel cytoplasmic domain and four transmembrane regions. Science (1987) 2.21

Stimulus-dependent myristoylation of a major substrate for protein kinase C. Nature (1988) 2.21

Depolarizing agents and cyclic nucleotides regulate the phosphorylation of specific neuronal proteins in rat cerebral cortex slices. Proc Natl Acad Sci U S A (1978) 2.20

Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides. Nat Med (1998) 2.20

cAMP increases junctional conductance and stimulates phosphorylation of the 27-kDa principal gap junction polypeptide. Proc Natl Acad Sci U S A (1986) 2.20

Cocaine-induced proliferation of dendritic spines in nucleus accumbens is dependent on the activity of cyclin-dependent kinase-5. Neuroscience (2003) 2.19

Regulation by synapsin I and Ca(2+)-calmodulin-dependent protein kinase II of the transmitter release in squid giant synapse. J Physiol (1991) 2.18

Bidirectional regulation of DARPP-32 phosphorylation by dopamine. J Neurosci (1997) 2.17

Molecular cloning, characterization, and expression of a cDNA encoding the "80- to 87-kDa" myristoylated alanine-rich C kinase substrate: a major cellular substrate for protein kinase C. Proc Natl Acad Sci U S A (1989) 2.16

Characterization of synapsin I binding to small synaptic vesicles. J Biol Chem (1986) 2.12

Modulation of calcium currents by a D1 dopaminergic protein kinase/phosphatase cascade in rat neostriatal neurons. Neuron (1995) 2.12

Chloride conductance regulated by cyclic AMP-dependent protein kinase in cardiac myocytes. Nature (1989) 2.09

Stimulation of brain membrane protein phosphorylation by calcium and an endogenous heat-stable protein. Nature (1978) 2.06

Induction of formation of presynaptic terminals in neuroblastoma cells by synapsin IIb. Nature (1991) 2.06

A dopamine- and cyclic AMP-regulated phosphoprotein enriched in dopamine-innervated brain regions. Nature (1983) 2.04

Generation of Alzheimer beta-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation. Proc Natl Acad Sci U S A (1997) 2.03

Neurotrophins stimulate phosphorylation of synapsin I by MAP kinase and regulate synapsin I-actin interactions. Proc Natl Acad Sci U S A (1996) 2.01

A calcium/calmodulin-dependent protein kinase from mammalian brain that phosphorylates Synapsin I: partial purification and characterization. J Neurosci (1983) 2.00

Impairment of synaptic vesicle clustering and of synaptic transmission, and increased seizure propensity, in synapsin I-deficient mice. Proc Natl Acad Sci U S A (1995) 2.00

On the mode of action of local anesthetics. Annu Rev Pharmacol (1966) 1.99

Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides. Proc Natl Acad Sci U S A (1999) 1.99

Widespread distribution of protein I in the central and peripheral nervous systems. Proc Natl Acad Sci U S A (1979) 1.98

Dopamine and cAMP-regulated phosphoprotein 32 kDa controls both striatal long-term depression and long-term potentiation, opposing forms of synaptic plasticity. J Neurosci (2000) 1.98

The route of absorption of intraperitoneally administered compounds. J Pharmacol Exp Ther (1971) 1.97

The synapsins. Annu Rev Cell Biol (1990) 1.97

Immunocytochemical localization, in synapses, of protein I, an endogenous substrate for protein kinases in mammalian brain. Proc Natl Acad Sci U S A (1979) 1.96

Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling. J Neurosci (2001) 1.95

Paullones are potent inhibitors of glycogen synthase kinase-3beta and cyclin-dependent kinase 5/p25. Eur J Biochem (2000) 1.93

Regulation of neurotransmitter receptor desensitization by protein phosphorylation. Neuron (1990) 1.93

Histamine-sensitive adenylate cyclase in mammalian brain. Nature (1976) 1.91

Relative abundance of Alzheimer A beta amyloid peptide variants in Alzheimer disease and normal aging. Proc Natl Acad Sci U S A (1994) 1.91

Anatomical and physiological evidence for D1 and D2 dopamine receptor colocalization in neostriatal neurons. Nat Neurosci (2000) 1.88

Purification and characterization of Ca2+/calmodulin-dependent protein kinase I from bovine brain. J Biol Chem (1987) 1.88

Regulation of phosphorylation of the GluR1 AMPA receptor in the neostriatum by dopamine and psychostimulants in vivo. J Neurosci (2000) 1.84

Adenosine 3',5'-monophosphate in nervous tissue: increase associated with synaptic transmission. Science (1971) 1.84

Autophosphorylation reversibly regulates the Ca2+/calmodulin-dependence of Ca2+/calmodulin-dependent protein kinase II. Proc Natl Acad Sci U S A (1986) 1.83

Phosphorylation of the nicotinic acetylcholine receptor by an endogenous tyrosine-specific protein kinase. Proc Natl Acad Sci U S A (1984) 1.82

Phosphorylation and inactivation of protein phosphatase 1 by cyclin-dependent kinases. Proc Natl Acad Sci U S A (1994) 1.81

Protein phosphatase 1 modulation of neostriatal AMPA channels: regulation by DARPP-32 and spinophilin. Nat Neurosci (1999) 1.81

Identification of the Alzheimer beta/A4 amyloid precursor protein in clathrin-coated vesicles purified from PC12 cells. J Biol Chem (1993) 1.81

Climate change and the integrity of science. Science (2010) 1.80

Calcium/phospholipid regulates phosphorylation of a Mr "87k" substrate protein in brain synaptosomes. Proc Natl Acad Sci U S A (1982) 1.78

Impairment of axonal development and of synaptogenesis in hippocampal neurons of synapsin I-deficient mice. Proc Natl Acad Sci U S A (1995) 1.75

Enhancement of calcium current in Aplysia neurones by phorbol ester and protein kinase C. Nature (1985) 1.73

Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide. Proc Natl Acad Sci U S A (1993) 1.73

Immunocytochemical localization of calcium/calmodulin-dependent protein kinase II in rat brain. Proc Natl Acad Sci U S A (1984) 1.72

Activation of NMDA receptors induces dephosphorylation of DARPP-32 in rat striatal slices. Nature (1990) 1.71