Published in Proc Natl Acad Sci U S A on November 01, 1984
A 42-kD tyrosine kinase substrate linked to chromaffin cell secretion exhibits an associated MAP kinase activity and is highly related to a 42-kD mitogen-stimulated protein in fibroblasts. J Cell Biol (1990) 2.41
Inositol trisphosphate receptor: phosphorylation by protein kinase C and calcium calmodulin-dependent protein kinases in reconstituted lipid vesicles. Proc Natl Acad Sci U S A (1991) 1.91
Inositol 1,4,5-trisphosphate receptors: distinct neuronal and nonneuronal forms derived by alternative splicing differ in phosphorylation. Proc Natl Acad Sci U S A (1991) 1.76
In vitro phosphorylation of maize leaf phosphoenolpyruvate carboxylase. Plant Physiol (1986) 1.69
Structure and nucleotide sequence of a Drosophila melanogaster protein kinase C gene. EMBO J (1987) 1.32
Forskolin increases the rate of acetylcholine receptor desensitization at rat soleus endplates. Proc Natl Acad Sci U S A (1986) 1.29
Calcitonin gene-related peptide enhances the rate of desensitization of the nicotinic acetylcholine receptor in cultured mouse muscle cells. Proc Natl Acad Sci U S A (1988) 1.29
Protein tyrosine phosphorylation in synaptic vesicles. Proc Natl Acad Sci U S A (1988) 1.26
Modulation of the Kv1.3 potassium channel by receptor tyrosine kinases. J Gen Physiol (1997) 1.26
The tyrosine kinase p60c-src regulates the fast gate of the cystic fibrosis transmembrane conductance regulator chloride channel. Biophys J (1996) 1.14
Two distinct kinetic phases of desensitization of acetylcholine receptors of clonal rat PC12 cells. J Physiol (1987) 1.13
Regulation of nicotinic acetylcholine receptor phosphorylation in rat myotubes by forskolin and cAMP. Proc Natl Acad Sci U S A (1987) 1.12
Protein tyrosine kinase activity and its endogenous substrates in rat brain: a subcellular and regional survey. J Neurochem (1988) 1.08
Activators of protein kinase C enhance acetylcholine receptor desensitization in sympathetic ganglion neurons. Proc Natl Acad Sci U S A (1987) 1.04
Change in desensitization of cat muscle acetylcholine receptor caused by coexpression of Torpedo acetylcholine receptor subunits in Xenopus oocytes. Proc Natl Acad Sci U S A (1989) 1.03
Phosphorylation modulates potassium conductance and gating current of perfused giant axons of squid. J Gen Physiol (1990) 0.97
Changes in kinetics of acetylcholine receptor channels after initial expression in Xenopus myocyte culture. J Physiol (1990) 0.96
The 70-Kilodalton Heat Shock Cognate Can Act as a Molecular Chaperone during the Membrane Translocation of a Plant Secretory Protein Precursor. Plant Cell (1992) 0.95
Induction of phosphorylation and cell surface redistribution of acetylcholine receptors by phorbol ester and carbamylcholine in cultured chick muscle cells. J Cell Biol (1988) 0.94
Regulation of phosphorylation of nicotinic acetylcholine receptors in mouse BC3H1 myocytes. Proc Natl Acad Sci U S A (1987) 0.91
Muscarinic agonists and phorbol esters increase tyrosine phosphorylation of a 40-kilodalton protein in hippocampal slices. Proc Natl Acad Sci U S A (1989) 0.90
Acceleration of desensitization by agonist pre-treatment in the snake. J Physiol (1987) 0.90
Tyrosine phosphorylation and acetylcholine receptor cluster formation in cultured Xenopus muscle cells. J Cell Biol (1993) 0.89
Protein phosphorylation in Bradyrhizobium japonicum bacteroids and cultures. J Bacteriol (1989) 0.88
Agonist-independent activation of acetylcholine receptor channels by protein kinase A phosphorylation. Proc Natl Acad Sci U S A (1991) 0.87
Tunicamycin increases desensitization of acetylcholine receptors in cultured mouse muscle cells. Proc Natl Acad Sci U S A (1991) 0.86
Autophosphorylation of the pea mitochondrial heat-shock protein homolog. Plant Physiol (1992) 0.85
Immunochemical demonstration that amino acids 360-377 of the acetylcholine receptor gamma-subunit are cytoplasmic. J Cell Biol (1985) 0.84
Transmembrane topography of the nicotinic acetylcholine receptor delta subunit. EMBO J (1987) 0.81
Activation of protein kinase C potentiates postsynaptic acetylcholine response at developing neuromuscular synapses. Br J Pharmacol (1993) 0.79
Phosphotyrosine phosphatase activity associated with c-Src in large multimeric complexes isolated from adrenal medullary chromaffin cells. Biochem J (1997) 0.79
PKC and PKA regulate AChR dynamics at the neuromuscular junction of living mice. PLoS One (2013) 0.78
Mapping of the cAMP-dependent phosphorylation sites on the acetylcholine receptor. EMBO J (1986) 0.77
Analysis of acetylcholine receptor phosphorylation sites using antibodies to synthetic peptides and monoclonal antibodies. EMBO J (1986) 0.76
Profile of Richard L. Huganir. Proc Natl Acad Sci U S A (2006) 0.75
Additive effect of ADP and CGRP in modulation of the acetylcholine receptor channel in Xenopus embryonic myocytes. Br J Pharmacol (1995) 0.75
Protein measurement with the Folin phenol reagent. J Biol Chem (1951) 1743.91
Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (1970) 1528.65
Transforming gene product of Rous sarcoma virus phosphorylates tyrosine. Proc Natl Acad Sci U S A (1980) 22.30
Identification of phosphotyrosine as a product of epidermal growth factor-activated protein kinase in A-431 cell membranes. J Biol Chem (1980) 7.71
Epidermal growth factor-receptor-protein kinase interactions. Co-purification of receptor and epidermal growth factor-enhanced phosphorylation activity. J Biol Chem (1980) 5.19
Epidermal growth factor induces rapid tyrosine phosphorylation of proteins in A431 human tumor cells. Cell (1981) 5.08
Insulin stimulates the phosphorylation of the 95,000-dalton subunit of its own receptor. Science (1982) 5.01
Role of multiple basic residues in determining the substrate specificity of cyclic AMP-dependent protein kinase. J Biol Chem (1977) 4.87
Stimulation of tyrosine-specific phosphorylation by platelet-derived growth factor. Nature (1982) 4.74
Amphipathic analysis and possible formation of the ion channel in an acetylcholine receptor. Proc Natl Acad Sci U S A (1984) 4.70
Structural homology of Torpedo californica acetylcholine receptor subunits. Nature (1983) 4.70
Primary structure of alpha-subunit precursor of Torpedo californica acetylcholine receptor deduced from cDNA sequence. Nature (1982) 3.69
Analysis of the sequence of amino acids surrounding sites of tyrosine phosphorylation. Proc Natl Acad Sci U S A (1982) 3.28
Nucleotide and deduced amino acid sequences of Torpedo californica acetylcholine receptor gamma subunit. Proc Natl Acad Sci U S A (1983) 3.01
Complete mRNA coding sequence of the acetylcholine binding alpha-subunit of Torpedo marmorata acetylcholine receptor: a model for the transmembrane organization of the polypeptide chain. Proc Natl Acad Sci U S A (1983) 2.98
Large-scale purification of the acetylcholine-receptor protein in its membrane-bound and detergent-extracted forms from Torpedo marmorata electric organ. Eur J Biochem (1977) 2.59
Insulin stimulation of phosphorylation of the beta subunit of the insulin receptor. Formation of both phosphoserine and phosphotyrosine. J Biol Chem (1982) 2.58
Primary structures of beta- and delta-subunit precursors of Torpedo californica acetylcholine receptor deduced from cDNA sequences. Nature (1983) 2.55
Tyrosine-specific protein kinase activity is associated with the purified insulin receptor. Proc Natl Acad Sci U S A (1983) 2.49
A simple assay for the study of solubilized acetylcholine receptors. Anal Biochem (1973) 2.44
The acetylcholine receptor: an "allosteric" membrane protein. Harvey Lect (1982) 2.42
Tyrosine phosphorylation of the insulin receptor beta subunit activates the receptor-associated tyrosine kinase activity. J Biol Chem (1984) 2.21
In vitro phosphorylation of angiotensin analogs by tyrosyl protein kinases. J Biol Chem (1983) 2.10
Molecular weight in detergent solution of acetylcholine receptor from Torpedo californica. Biochemistry (1978) 2.08
Catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase is associated with phosphorylation of the beta-adrenergic receptor. Proc Natl Acad Sci U S A (1983) 1.74
cAMP-dependent protein kinase phosphorylates the nicotinic acetylcholine receptor. Proc Natl Acad Sci U S A (1983) 1.63
Protein phosphorylation in the brain. Nature (1983) 1.60
Studies of the composition of purified Torpedo californica acetylcholine receptor and of its subunits. Biochemistry (1979) 1.59
In vitro phosphorylation of the acetylcholine receptor. Nature (1977) 1.40
Phosphorylation of acetylcholine receptor by endogenous membrane protein kinase in receptor-enriched membranes of Torpedo californica. Nature (1977) 1.37
Characterization of platelet-derived growth factor-stimulated phosphorylation in cell membranes. J Biol Chem (1983) 1.31
Bromoacetylcholine as an affinity label of the acetylcholine receptor from Torpedo californica. Biochem Biophys Res Commun (1978) 1.27
Possibility of shape conformers of the protein inhibitor of the cyclic adenosine monophosphate dependent protein kinase. Biochemistry (1979) 1.24
Regulation of acetylcholine receptor phosphorylation by calcium and calmodulin. Proc Natl Acad Sci U S A (1981) 1.09
Properties of proteoliposomes reconstituted with acetylcholine receptor from Torpedo californica. J Biol Chem (1982) 1.08
Decomposition of phosphoserine and phosphothreonine during acid hydrolysis. Anal Biochem (1976) 1.05
Specificity and localization of the acetylcholine receptor kinase. Proc Natl Acad Sci U S A (1982) 1.01
Protein phosphatase activity in acetylcholine receptor-enriched membranes. Biochem Biophys Res Commun (1979) 1.00
Change in state of phosphorylation of acetylcholine receptor during maturation of the electromotor synapse in Torpedo marmorata electric organ. Proc Natl Acad Sci U S A (1981) 0.97
Patch-recorded single-channel currents of the purified and reconstituted Torpedo acetylcholine receptor. Proc Natl Acad Sci U S A (1983) 0.96
Transformation by Rous sarcoma virus prevents acetylcholine receptor clustering on cultured chicken muscle fibers. Proc Natl Acad Sci U S A (1984) 0.91
cAMP, not Ca2+/calmodulin, regulates the phosphorylation of acetylcholine receptor in Torpedo californica electroplax. Biochim Biophys Acta (1984) 0.85
Synapsin I (protein I), a nerve terminal-specific phosphoprotein. III. Its association with synaptic vesicles studied in a highly purified synaptic vesicle preparation. J Cell Biol (1983) 7.55
Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline. JAMA (2000) 6.55
Cyclic nucleotide-dependent protein kinases. IV. Widespread occurrence of adenosine 3',5'-monophosphate-dependent protein kinase in various tissues and phyla of the animal kingdom. Proc Natl Acad Sci U S A (1969) 6.02
Cyclic nucleotide-dependent protein kinases. 3. Purification and properties of adenosine 3',5'-monophosphate-dependent protein kinase from bovine brain. J Biol Chem (1969) 5.37
Cyclic AMP-dependent endogenous phosphorylation of a microtubule-associated protein. Proc Natl Acad Sci U S A (1975) 5.25
Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity. Nature (2000) 5.14
Phosphorylated proteins as physiological effectors. Science (1978) 5.03
Activity-dependent modulation of synaptic AMPA receptor accumulation. Neuron (1998) 4.77
GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors. Nature (1997) 4.49
A 38,000-dalton membrane protein (p38) present in synaptic vesicles. Proc Natl Acad Sci U S A (1985) 4.35
Adenosine 3':5'-monophosphate-regulated phosphoprotein system of neuronal membranes. I. Solubilization, purification, and some properties of an endogenous phosphoprotein. J Biol Chem (1977) 4.33
Homer: a protein that selectively binds metabotropic glutamate receptors. Nature (1997) 4.18
Dopamine-sensitive adenylate cyclase in caudate nucleus of rat brain, and its similarity to the "dopamine receptor". Proc Natl Acad Sci U S A (1972) 4.03
Characterization of multiple phosphorylation sites on the AMPA receptor GluR1 subunit. Neuron (1996) 4.00
Interaction of the N-ethylmaleimide-sensitive factor with AMPA receptors. Neuron (1998) 3.90
NMDA induces long-term synaptic depression and dephosphorylation of the GluR1 subunit of AMPA receptors in hippocampus. Neuron (1998) 3.86
Intraneuronal Abeta42 accumulation in human brain. Am J Pathol (2000) 3.83
Three-dimensional structure of the catalytic subunit of protein serine/threonine phosphatase-1. Nature (1995) 3.77
Protein p38: an integral membrane protein specific for small vesicles of neurons and neuroendocrine cells. J Cell Biol (1986) 3.68
Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons. Nature (1999) 3.50
Synapsin I (Protein I), a nerve terminal-specific phosphoprotein. II. Its specific association with synaptic vesicles demonstrated by immunocytochemistry in agarose-embedded synaptosomes. J Cell Biol (1983) 3.49
Phosphorylation of the AMPA receptor subunit GluR2 differentially regulates its interaction with PDZ domain-containing proteins. J Neurosci (2000) 3.44
A quantitative dot-immunobinding assay for proteins using nitrocellulose membrane filters. Proc Natl Acad Sci U S A (1984) 3.35
Purified inositol 1,4,5-trisphosphate receptor mediates calcium flux in reconstituted lipid vesicles. Nature (1989) 3.35
Clustering of AMPA receptors by the synaptic PDZ domain-containing protein PICK1. Neuron (1999) 3.33
Synaptic clustering of AMPA receptors by the extracellular immediate-early gene product Narp. Neuron (1999) 3.28
Intraterminal injection of synapsin I or calcium/calmodulin-dependent protein kinase II alters neurotransmitter release at the squid giant synapse. Proc Natl Acad Sci U S A (1985) 3.23
Rapid, experience-dependent expression of synaptic NMDA receptors in visual cortex in vivo. Nat Neurosci (1999) 3.21
Control of GluR1 AMPA receptor function by cAMP-dependent protein kinase. J Neurosci (2000) 3.10
PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands. Neuron (1998) 3.09
Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5. Nature (2001) 3.09
Cyclic AMP-dependent protein kinase opens chloride channels in normal but not cystic fibrosis airway epithelium. Nature (1988) 3.06
Targeting of PKA to glutamate receptors through a MAGUK-AKAP complex. Neuron (2000) 3.03
Multiple phosphorylation sites in protein I and their differential regulation by cyclic AMP and calcium. Proc Natl Acad Sci U S A (1979) 2.96
Distinct pools of synaptic vesicles in neurotransmitter release. Nature (1995) 2.96
PDZ domains in synapse assembly and signalling. Trends Cell Biol (2000) 2.96
Possible role for cyclic nucleotides and phosphorylated membrane proteins in postsynaptic actions of neurotransmitters. Nature (1976) 2.95
Depolarization-induced phosphorylation of specific proteins, mediated by calcium ion influx, in rat brain synaptosomes. J Biol Chem (1977) 2.94
Cerebellar long-term depression requires PKC-regulated interactions between GluR2/3 and PDZ domain-containing proteins. Neuron (2000) 2.93
Cyclic nucleotide-dependent protein kinases. VI. Isolation and partial purification of a protein kinase activated by guanosine 3',5'-monophosphate. J Biol Chem (1970) 2.89
Synapsin dispersion and reclustering during synaptic activity. Nat Neurosci (2001) 2.87
An adenosine 3',5'-monophosphate-dependent protein kinase from Escherichia coli. J Biol Chem (1969) 2.86
Microinjection of catalytic subunit of cyclic AMP-dependent protein kinase enhances calcium action potentials of bag cell neurons in cell culture. Proc Natl Acad Sci U S A (1980) 2.84
Cyclic AMP mediates the effects of adrenaline on cardiac purkinje fibres. Nat New Biol (1972) 2.84
Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors? J Biol Chem (2001) 2.79
Spinophilin, a novel protein phosphatase 1 binding protein localized to dendritic spines. Proc Natl Acad Sci U S A (1997) 2.77
Interaction of the AMPA receptor subunit GluR2/3 with PDZ domains regulates hippocampal long-term depression. Proc Natl Acad Sci U S A (2001) 2.75
DARPP-32, a dopamine-regulated neuronal phosphoprotein, is a potent inhibitor of protein phosphatase-1. Nature (1984) 2.74
Phosphorylation of the alpha-amino-3-hydroxy-5-methylisoxazole4-propionic acid receptor GluR1 subunit by calcium/calmodulin-dependent kinase II. J Biol Chem (1997) 2.71
Regulation of endogenous phosphorylation of specific proteins in synaptic membrane fractions from rat brain by adenosine 3':5'-monophosphate. J Biol Chem (1973) 2.66
SynGAP: a synaptic RasGAP that associates with the PSD-95/SAP90 protein family. Neuron (1998) 2.63
Synapsins as mediators of BDNF-enhanced neurotransmitter release. Nat Neurosci (2000) 2.62
Synapsin I bundles F-actin in a phosphorylation-dependent manner. Nature (1987) 2.59
Postsynaptic organization and regulation of excitatory synapses. Nat Rev Neurosci (2000) 2.56
DARPP-32: regulator of the efficacy of dopaminergic neurotransmission. Science (1998) 2.53
The neuronal Rho-GEF Kalirin-7 interacts with PDZ domain-containing proteins and regulates dendritic morphogenesis. Neuron (2001) 2.52
Regulation of chloride channels by protein kinase C in normal and cystic fibrosis airway epithelia. Science (1989) 2.46
Evidence that the major postsynaptic density protein is a component of a Ca2+/calmodulin-dependent protein kinase. Proc Natl Acad Sci U S A (1984) 2.45
Nobel laureates' letter to President Bush. Washington Post (2001) 2.43
Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation. Proc Natl Acad Sci U S A (1990) 2.41
Regulation of morphological postsynaptic silent synapses in developing hippocampal neurons. Nat Neurosci (1999) 2.40
Subcellular distribution in cerebral cortex of two proteins phosphorylated by a cAMP-dependent protein kinase. J Cell Biol (1979) 2.40
Two calcium/calmodulin-dependent protein kinases, which are highly concentrated in brain, phosphorylate protein I at distinct sites. Proc Natl Acad Sci U S A (1981) 2.40
Protein kinases in the brain. Annu Rev Biochem (1985) 2.40
DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated phosphoprotein enriched in dopamine-innervated brain regions. III. Immunocytochemical localization. J Neurosci (1984) 2.39
Ca2+-dependent protein phosphorylation system in membranes from various tissues, and its activation by "calcium-dependent regulator". Proc Natl Acad Sci U S A (1978) 2.38
Cyclic nucleotide-dependent protein kinases. X. An assay method for the measurement of quanosine 3',5'-monophosphate in various biological materials and a study of agents regulating its levels in heart and brain. J Biol Chem (1972) 2.35
Phosphorylation of the nicotinic acetylcholine receptor regulates its rate of desensitization. Nature (1986) 2.35
Regulation of AMPA receptor GluR1 subunit surface expression by a 4. 1N-linked actin cytoskeletal association. J Neurosci (2000) 2.34
Synapsins as regulators of neurotransmitter release. Philos Trans R Soc Lond B Biol Sci (1999) 2.32
Spinophilin regulates the formation and function of dendritic spines. Proc Natl Acad Sci U S A (2000) 2.32
Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer beta/A4 amyloid protein precursor. Proc Natl Acad Sci U S A (1992) 2.31
Phosphorylation of the cystic fibrosis transmembrane conductance regulator. J Biol Chem (1992) 2.28
Ca2+/calmodulin-dependent protein kinase II. Isozymic forms from rat forebrain and cerebellum. J Biol Chem (1985) 2.26
Differential phosphorylation of multiple sites in purified protein I by cyclic AMP-dependent and calcium-dependent protein kinases. J Biol Chem (1981) 2.26
Characterization of protein kinase A and protein kinase C phosphorylation of the N-methyl-D-aspartate receptor NR1 subunit using phosphorylation site-specific antibodies. J Biol Chem (1997) 2.25
Intracellular injection of t he catalytic subunit of cyclic AMP-dependent protein kinase simulates facilitation of transmitter release underlying behavioral sensitization in Aplysia. Proc Natl Acad Sci U S A (1980) 2.24
A synaptic vesicle protein with a novel cytoplasmic domain and four transmembrane regions. Science (1987) 2.21
Stimulus-dependent myristoylation of a major substrate for protein kinase C. Nature (1988) 2.21
Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides. Nat Med (1998) 2.20
Depolarizing agents and cyclic nucleotides regulate the phosphorylation of specific neuronal proteins in rat cerebral cortex slices. Proc Natl Acad Sci U S A (1978) 2.20
cAMP increases junctional conductance and stimulates phosphorylation of the 27-kDa principal gap junction polypeptide. Proc Natl Acad Sci U S A (1986) 2.20
Cocaine-induced proliferation of dendritic spines in nucleus accumbens is dependent on the activity of cyclin-dependent kinase-5. Neuroscience (2003) 2.19
Regulation by synapsin I and Ca(2+)-calmodulin-dependent protein kinase II of the transmitter release in squid giant synapse. J Physiol (1991) 2.18
Inactivation of NMDA receptors by direct interaction of calmodulin with the NR1 subunit. Cell (1996) 2.17
Bidirectional regulation of DARPP-32 phosphorylation by dopamine. J Neurosci (1997) 2.17
Molecular cloning, characterization, and expression of a cDNA encoding the "80- to 87-kDa" myristoylated alanine-rich C kinase substrate: a major cellular substrate for protein kinase C. Proc Natl Acad Sci U S A (1989) 2.16
Involvement of a postsynaptic protein kinase A substrate in the expression of homosynaptic long-term depression. Neuron (1998) 2.15
Characterization of synapsin I binding to small synaptic vesicles. J Biol Chem (1986) 2.12
Modulation of calcium currents by a D1 dopaminergic protein kinase/phosphatase cascade in rat neostriatal neurons. Neuron (1995) 2.12
SAP102, a novel postsynaptic protein that interacts with NMDA receptor complexes in vivo. Neuron (1996) 2.10
Chloride conductance regulated by cyclic AMP-dependent protein kinase in cardiac myocytes. Nature (1989) 2.09
Stimulation of brain membrane protein phosphorylation by calcium and an endogenous heat-stable protein. Nature (1978) 2.06
Induction of formation of presynaptic terminals in neuroblastoma cells by synapsin IIb. Nature (1991) 2.06
A dopamine- and cyclic AMP-regulated phosphoprotein enriched in dopamine-innervated brain regions. Nature (1983) 2.04
Generation of Alzheimer beta-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation. Proc Natl Acad Sci U S A (1997) 2.03
Neurotrophins stimulate phosphorylation of synapsin I by MAP kinase and regulate synapsin I-actin interactions. Proc Natl Acad Sci U S A (1996) 2.01