Published in Trends Pharmacol Sci on March 01, 2005
A single lentiviral vector platform for microRNA-based conditional RNA interference and coordinated transgene expression. Proc Natl Acad Sci U S A (2006) 3.06
Deconvolution of complex G protein-coupled receptor signaling in live cells using dynamic mass redistribution measurements. Nat Biotechnol (2010) 2.11
G protein subunit Galpha13 binds to integrin alphaIIbbeta3 and mediates integrin "outside-in" signaling. Science (2010) 2.09
Heterotrimeric G-proteins: a short history. Br J Pharmacol (2006) 1.79
Distinct profiles of functional discrimination among G proteins determine the actions of G protein-coupled receptors. Sci Signal (2015) 1.61
Novel cannabinoid receptors. Br J Pharmacol (2007) 1.55
The G12 family of heterotrimeric G proteins promotes breast cancer invasion and metastasis. Proc Natl Acad Sci U S A (2006) 1.54
The G12 family of G proteins as a reporter of thromboxane A2 receptor activity. Mol Pharmacol (2006) 1.53
Regulation of RhoGEF proteins by G12/13-coupled receptors. Br J Pharmacol (2009) 1.45
Heterotrimeric Gi proteins link Hedgehog signaling to activation of Rho small GTPases to promote fibroblast migration. J Biol Chem (2011) 1.41
LGR6 is a high affinity receptor of R-spondins and potentially functions as a tumor suppressor. PLoS One (2012) 1.22
Galpha12/13 regulate epiboly by inhibiting E-cadherin activity and modulating the actin cytoskeleton. J Cell Biol (2009) 1.15
G-protein-coupled receptor agonists activate endogenous phospholipase Cepsilon and phospholipase Cbeta3 in a temporally distinct manner. J Biol Chem (2005) 1.14
Gα12 gep oncogene deregulation of p53-responsive microRNAs promotes epithelial-mesenchymal transition of hepatocellular carcinoma. Oncogene (2014) 1.13
The systematic annotation of the three main GPCR families in Reactome. Database (Oxford) (2010) 1.09
PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12. Nat Cell Biol (2012) 1.08
Lysophospholipid receptor activation of RhoA and lipid signaling pathways. Biochim Biophys Acta (2012) 1.07
Regulation of heterotrimeric G protein signaling in airway smooth muscle. Proc Am Thorac Soc (2008) 1.06
Role of G12 proteins in oncogenesis and metastasis. Br J Pharmacol (2009) 1.05
Revisited and revised: is RhoA always a villain in cardiac pathophysiology? J Cardiovasc Transl Res (2010) 1.05
Central role of Gq in the hypertrophic signal transduction of angiotensin II in vascular smooth muscle cells. Endocrinology (2008) 1.00
Signalling mechanisms of RhoGTPase regulation by the heterotrimeric G proteins G12 and G13. J Biochem (2011) 0.99
Phospholipase C epsilon links G protein-coupled receptor activation to inflammatory astrocytic responses. Proc Natl Acad Sci U S A (2013) 0.98
G alpha12 is targeted to the mitochondria and affects mitochondrial morphology and motility. FASEB J (2008) 0.97
Kaposi sarcoma-associated herpesvirus promotes tumorigenesis by modulating the Hippo pathway. Oncogene (2014) 0.96
Endothelial nitric oxide synthase inhibits G12/13 and rho-kinase activated by the angiotensin II type-1 receptor: implication in vascular migration. Arterioscler Thromb Vasc Biol (2008) 0.93
G alpha 12 inhibits alpha2 beta1 integrin-mediated Madin-Darby canine kidney cell attachment and migration on collagen-I and blocks tubulogenesis. Mol Biol Cell (2009) 0.93
Regulation and physiological functions of G12/13-mediated signaling pathways. Neurosignals (2009) 0.93
Tubulin, actin and heterotrimeric G proteins: coordination of signaling and structure. Biochim Biophys Acta (2013) 0.92
CCK activates RhoA and Rac1 differentially through Galpha13 and Galphaq in mouse pancreatic acini. Am J Physiol Cell Physiol (2009) 0.90
Protease-activated receptor 1 (PAR1) coupling to G(q/11) but not to G(i/o) or G(12/13) is mediated by discrete amino acids within the receptor second intracellular loop. Cell Signal (2012) 0.89
Probing heterotrimeric G protein activation: applications to biased ligands. Curr Pharm Des (2012) 0.89
G protein-coupled receptors go extracellular: RhoA integrates the integrins. Mol Interv (2008) 0.89
Heterotrimeric G proteins and apoptosis: intersecting signaling pathways leading to context dependent phenotypes. Curr Mol Med (2009) 0.88
P2Y5 is a G(alpha)i, G(alpha)12/13 G protein-coupled receptor activated by lysophosphatidic acid that reduces intestinal cell adhesion. Am J Physiol Gastrointest Liver Physiol (2009) 0.88
Role of protein kinase C and epidermal growth factor receptor signalling in growth stimulation by neurotensin in colon carcinoma cells. BMC Cancer (2011) 0.88
Role of Galpha12 and Galpha13 as novel switches for the activity of Nrf2, a key antioxidative transcription factor. Mol Cell Biol (2007) 0.87
Receptor-G protein interaction studied by bioluminescence resonance energy transfer: lessons from protease-activated receptor 1. Front Endocrinol (Lausanne) (2012) 0.87
Interaction of Protease-Activated Receptor 2 with G Proteins and β-Arrestin 1 Studied by Bioluminescence Resonance Energy Transfer. Front Endocrinol (Lausanne) (2013) 0.86
G Protein and β-arrestin signaling bias at the ghrelin receptor. J Biol Chem (2014) 0.85
Polycystin-1 protein level determines activity of the Galpha12/JNK apoptosis pathway. J Biol Chem (2010) 0.84
Heterotrimeric G-protein alpha-12 (Gα12) subunit promotes oral cancer metastasis. Oncotarget (2014) 0.84
Mouse EP3 alpha, beta, and gamma receptor variants reduce tumor cell proliferation and tumorigenesis in vivo. J Biol Chem (2008) 0.84
The alpha subunit of the G protein G13 regulates activity of one or more Gli transcription factors independently of smoothened. J Biol Chem (2011) 0.83
The Gq and G12 families of heterotrimeric G proteins report functional selectivity. Mol Pharmacol (2008) 0.83
G12 signaling through c-Jun NH2-terminal kinase promotes breast cancer cell invasion. PLoS One (2011) 0.82
Unique interaction pattern for a functionally biased ghrelin receptor agonist. J Biol Chem (2011) 0.81
Gα12 activation in podocytes leads to cumulative changes in glomerular collagen expression, proteinuria and glomerulosclerosis. Lab Invest (2012) 0.81
Angiotensin II type-1 receptor regulates RhoA and Rho-kinase/ROCK activation via multiple mechanisms. Focus on "Angiotensin II induces RhoA activation through SHP2-dependent dephosphorylation of the RhoGAP p190A in vascular smooth muscle cells". Am J Physiol Cell Physiol (2009) 0.80
Regulation of thymus-dependent and thymus-independent production of immunoglobulin G subclasses by Galpha12 and Galpha13. J Mol Signal (2008) 0.78
RhoGEF12 controls cardiac remodeling by integrating G protein- and integrin-dependent signaling cascades. J Exp Med (2013) 0.78
Stimulation of Dopamine D3 Receptor Attenuates Renal Ischemia-Reperfusion Injury via Increased Linkage With Gα12. Transplantation (2015) 0.77
Antagonist minigenes identify genes regulated by parathyroid hormone through G protein-selective and G protein co-regulated mechanisms in osteoblastic cells. Cell Signal (2010) 0.77
Pulsatile equibiaxial stretch inhibits thrombin-induced RhoA and NF-kappaB activation. Biochem Biophys Res Commun (2008) 0.75
Potentiation of receptor responses induced by prolonged binding of Gα13 and leukemia-associated RhoGEF. FASEB J (2017) 0.75
Activation of heterotrimeric G proteins by Smoothened. Proc Natl Acad Sci U S A (2006) 1.84
Pathways of signal transduction employed by vertebrate Hedgehogs. Biochem J (2007) 1.58
The G12 family of G proteins as a reporter of thromboxane A2 receptor activity. Mol Pharmacol (2006) 1.53
Heterotrimeric Gi proteins link Hedgehog signaling to activation of Rho small GTPases to promote fibroblast migration. J Biol Chem (2011) 1.41
Signaling through Gi family members in platelets. Redundancy and specificity in the regulation of adenylyl cyclase and other effectors. J Biol Chem (2002) 1.17
Behavioral and neurochemical effects of 5-(4-[4-(5-Cyano-3-indolyl)-butyl)-butyl]-1-piperazinyl)-benzofuran-2-carboxamide (EMD 68843): a combined selective inhibitor of serotonin reuptake and 5-hydroxytryptamine(1A) receptor partial agonist. J Pharmacol Exp Ther (2002) 1.06
Pathways of transduction engaged by sphingosine 1-phosphate through G protein-coupled receptors. Biochim Biophys Acta (2002) 1.03
Sonic Hedgehog activates the GTPases Rac1 and RhoA in a Gli-independent manner through coupling of smoothened to Gi proteins. Sci Signal (2011) 1.02
Smoothened is a fully competent activator of the heterotrimeric G protein G(i). Mol Pharmacol (2013) 0.91
Analysis of G protein activation in Sf9 and mammalian cells by agonist-promoted [35S]GTP gamma S binding. Methods Enzymol (2002) 0.86
The alpha subunit of the G protein G13 regulates activity of one or more Gli transcription factors independently of smoothened. J Biol Chem (2011) 0.83
The Gq and G12 families of heterotrimeric G proteins report functional selectivity. Mol Pharmacol (2008) 0.83
An N-terminal polybasic motif of Gαq is required for signaling and influences membrane nanodomain distribution. Mol Pharmacol (2010) 0.78
Expression of G protein-coupled receptors and G proteins in Sf9 cells: analysis of coupling by radioligand binding. Methods Enzymol (2002) 0.76