Published in Cancer Res on March 01, 2005
p53 and metabolism. Nat Rev Cancer (2009) 5.05
PUMA, a potent killer with or without p53. Oncogene (2008) 3.09
ROS and p53: a versatile partnership. Free Radic Biol Med (2008) 2.52
Apolipoprotein L1, a novel Bcl-2 homology domain 3-only lipid-binding protein, induces autophagic cell death. J Biol Chem (2008) 2.30
Regulation of reactive oxygen species generation in cell signaling. Mol Cells (2011) 1.85
p53 independent induction of PUMA mediates intestinal apoptosis in response to ischaemia-reperfusion. Gut (2006) 1.56
Glutathione binding to the Bcl-2 homology-3 domain groove: a molecular basis for Bcl-2 antioxidant function at mitochondria. J Biol Chem (2007) 1.26
The Role of p53 in Metabolic Regulation. Genes Cancer (2011) 1.25
p53, oxidative stress, and aging. Antioxid Redox Signal (2011) 1.18
Proteomics identification of ITGB3 as a key regulator in reactive oxygen species-induced migration and invasion of colorectal cancer cells. Mol Cell Proteomics (2011) 1.12
Apolipoprotein L6, induced in atherosclerotic lesions, promotes apoptosis and blocks Beclin 1-dependent autophagy in atherosclerotic cells. J Biol Chem (2011) 1.03
A cohort study of STMN1 expression in colorectal cancer: body mass index and prognosis. Am J Gastroenterol (2009) 1.03
p53-Dependent p21-mediated growth arrest pre-empts and protects HCT116 cells from PUMA-mediated apoptosis induced by EGCG. Cancer Lett (2010) 0.96
Human Delta1-pyrroline-5-carboxylate synthase: function and regulation. Amino Acids (2008) 0.96
Expression and phosphorylation of stathmin correlate with cell migration in esophageal squamous cell carcinoma. Oncol Rep (2012) 0.95
Cytochrome P450 2E1 (CYP2E1) regulates the response to oxidative stress and migration of breast cancer cells. Breast Cancer Res (2013) 0.93
Critical role of p53 upregulated modulator of apoptosis in benzyl isothiocyanate-induced apoptotic cell death. PLoS One (2012) 0.92
Bcl-2 is a novel interacting partner for the 2-oxoglutarate carrier and a key regulator of mitochondrial glutathione. Free Radic Biol Med (2011) 0.92
Autophagy regulates lipolysis and cell survival through lipid droplet degradation in androgen-sensitive prostate cancer cells. Prostate (2012) 0.87
Proteome alterations in primary human alveolar macrophages in response to influenza A virus infection. J Proteome Res (2012) 0.85
Pathogenesis of colorectal carcinoma and therapeutic implications: the roles of the ubiquitin-proteasome system and Cox-2. J Cell Mol Med (2007) 0.84
Immunohistochemical study of PUMA, c-Myb and p53 expression in the benign and malignant lesions of gallbladder and their clinicopathological significances. Int J Clin Oncol (2012) 0.82
Caspase-2 promotes cytoskeleton protein degradation during apoptotic cell death. Cell Death Dis (2013) 0.78
Inhibition of type I interferon production via suppressing IKK-gamma expression: a new strategy for counteracting host antiviral defense by influenza A viruses? J Proteome Res (2011) 0.78
Renal stromal miRNAs are required for normal nephrogenesis and glomerular mesangial survival. Physiol Rep (2015) 0.77
Thiopurines induce oxidative stress in T-lymphocytes: a proteomic approach. Mediators Inflamm (2015) 0.76
Genetic variants of a BH3-only pro-apoptotic gene, PUMA, and risk of HPV16-associated squamous cell carcinoma of the head and neck. Mol Carcinog (2011) 0.75
The role of ROS and subsequent DNA-damage response in PUMA-induced apoptosis of ovarian cancer cells. Oncotarget (2017) 0.75
Down-regulation of Stathmin Is Required for the Phenotypic Changes and Classical Activation of Macrophages. J Biol Chem (2015) 0.75
Idelalisib induces PUMA-dependent apoptosis in colon cancer cells. Oncotarget (2017) 0.75
Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N Engl J Med (2002) 36.55
Landscape of transcription in human cells. Nature (2012) 20.18
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell (2007) 17.98
Regulation of cellular metabolism by protein lysine acetylation. Science (2010) 10.55
The DNA methylome of human peripheral blood mononuclear cells. PLoS Biol (2010) 4.25
Survey of tyrosine kinase signaling reveals ROS kinase fusions in human cholangiocarcinoma. PLoS One (2011) 3.10
Retracted Contribution of human alpha-defensin 1, 2, and 3 to the anti-HIV-1 activity of CD8 antiviral factor. Science (2002) 2.81
PUMA regulates intestinal progenitor cell radiosensitivity and gastrointestinal syndrome. Cell Stem Cell (2008) 2.68
Long noncoding RNAs are rarely translated in two human cell lines. Genome Res (2012) 2.64
microRNA-21 negatively regulates Cdc25A and cell cycle progression in colon cancer cells. Cancer Res (2009) 2.32
Enhanced reversibility and unusual microstructure of a phase-transforming material. Nature (2013) 2.21
Influence of induced reactive oxygen species in p53-mediated cell fate decisions. Mol Cell Biol (2003) 2.16
Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells. Proc Natl Acad Sci U S A (2011) 2.12
Oxidative mechanism of arsenic toxicity and carcinogenesis. Mol Cell Biochem (2004) 2.07
Effects and Clinical Characteristics of Intracranial Pressure Monitoring-Targeted Management for Subsets of Traumatic Brain Injury: An Observational Multicenter Study. Crit Care Med (2015) 2.06
Single base-resolution methylome of the silkworm reveals a sparse epigenomic map. Nat Biotechnol (2010) 2.03
PUMA Dissociates Bax and Bcl-X(L) to induce apoptosis in colon cancer cells. J Biol Chem (2006) 2.02
Following cytochrome c release, autophagy is inhibited during chemotherapy-induced apoptosis by caspase 8-mediated cleavage of Beclin 1. Cancer Res (2011) 1.99
Normobaric hyperoxia reduces the neurovascular complications associated with delayed tissue plasminogen activator treatment in a rat model of focal cerebral ischemia. Stroke (2009) 1.90
A margin-negative R0 resection accomplished with minimal postoperative complications is the surgeon's contribution to long-term survival in pancreatic cancer. J Gastrointest Surg (2006) 1.89
Apolipoprotein l6, a novel proapoptotic Bcl-2 homology 3-only protein, induces mitochondria-mediated apoptosis in cancer cells. Mol Cancer Res (2005) 1.87
G1 cell cycle progression and the expression of G1 cyclins are regulated by PI3K/AKT/mTOR/p70S6K1 signaling in human ovarian cancer cells. Am J Physiol Cell Physiol (2004) 1.85
PUMA-mediated apoptosis drives chemical hepatocarcinogenesis in mice. Hepatology (2011) 1.82
Comprehensive proteomic profiling of the membrane constituents of a Mycobacterium tuberculosis strain. Mol Cell Proteomics (2003) 1.77
Bispecific antibodies directed to CD4 domain 2 and HIV envelope exhibit exceptional breadth and picomolar potency against HIV-1. Proc Natl Acad Sci U S A (2013) 1.76
Molecular characterization of human immunodeficiency virus type 1 and hepatitis C virus in paid blood donors and injection drug users in china. J Virol (2004) 1.76
Mycobacterium tuberculosis functional network analysis by global subcellular protein profiling. Mol Biol Cell (2004) 1.73
The nuclear function of p53 is required for PUMA-mediated apoptosis induced by DNA damage. Proc Natl Acad Sci U S A (2007) 1.73
Selection against PUMA gene expression in Myc-driven B-cell lymphomagenesis. Mol Cell Biol (2008) 1.72
Enhanced microtubule-dependent trafficking and p53 nuclear accumulation by suppression of microtubule dynamics. Proc Natl Acad Sci U S A (2002) 1.64
A nomenclature for intestinal in vitro cultures. Am J Physiol Gastrointest Liver Physiol (2012) 1.61
Impact of thymectomy on the peripheral T cell pool in rhesus macaques before and after infection with simian immunodeficiency virus. Eur J Immunol (2005) 1.60
Interstitial pO2 in ischemic penumbra and core are differentially affected following transient focal cerebral ischemia in rats. J Cereb Blood Flow Metab (2004) 1.60
Enhanced radical scavenging activity by antioxidant-functionalized gold nanoparticles: a novel inspiration for development of new artificial antioxidants. Free Radic Biol Med (2007) 1.59
Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis. World J Gastroenterol (2004) 1.58
p53 independent induction of PUMA mediates intestinal apoptosis in response to ischaemia-reperfusion. Gut (2006) 1.56
Electron paramagnetic resonance-guided normobaric hyperoxia treatment protects the brain by maintaining penumbral oxygenation in a rat model of transient focal cerebral ischemia. J Cereb Blood Flow Metab (2006) 1.54
Amino acid residue specific stable isotope labeling for quantitative proteomics. Rapid Commun Mass Spectrom (2002) 1.54
Normobaric hyperoxia attenuates early blood-brain barrier disruption by inhibiting MMP-9-mediated occludin degradation in focal cerebral ischemia. J Neurochem (2009) 1.53
Evidence of positive selection on a class I ADH locus. Am J Hum Genet (2007) 1.48
Novel potent human ether-a-go-go-related gene (hERG) potassium channel enhancers and their in vitro antiarrhythmic activity. Mol Pharmacol (2005) 1.47
Inhibition of histone deacetylases potentiates BMP9-induced osteogenic signaling in mouse mesenchymal stem cells. Cell Physiol Biochem (2013) 1.47
Modifications of superoxide dismutase (SOD1) in human erythrocytes: a possible role in amyotrophic lateral sclerosis. J Biol Chem (2009) 1.46
Sp1 and p73 activate PUMA following serum starvation. Carcinogenesis (2008) 1.46
Downregulation of Dkk3 activates beta-catenin/TCF-4 signaling in lung cancer. Carcinogenesis (2007) 1.46
Arsenite interacts selectively with zinc finger proteins containing C3H1 or C4 motifs. J Biol Chem (2011) 1.45
Inhibition of poly(ADP-ribose) polymerase-1 by arsenite interferes with repair of oxidative DNA damage. J Biol Chem (2008) 1.44
The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy. Immunity (2012) 1.44
Elevation of receptor tyrosine kinase EphA2 mediates resistance to trastuzumab therapy. Cancer Res (2009) 1.44
PUMA-mediated intestinal epithelial apoptosis contributes to ulcerative colitis in humans and mice. J Clin Invest (2011) 1.43
Inhibition of CDK4/6 protects against radiation-induced intestinal injury in mice. J Clin Invest (2016) 1.43
Inactivation of a bacterial virulence pheromone by phagocyte-derived oxidants: new role for the NADPH oxidase in host defense. Proc Natl Acad Sci U S A (2004) 1.42
Water quality in the upper Han River basin, China: the impacts of land use/land cover in riparian buffer zone. J Hazard Mater (2008) 1.42
Vanadate-induced expression of hypoxia-inducible factor 1 alpha and vascular endothelial growth factor through phosphatidylinositol 3-kinase/Akt pathway and reactive oxygen species. J Biol Chem (2002) 1.41
Single-base resolution maps of cultivated and wild rice methylomes and regulatory roles of DNA methylation in plant gene expression. BMC Genomics (2012) 1.40
Benzo(a)pyrene quinones increase cell proliferation, generate reactive oxygen species, and transactivate the epidermal growth factor receptor in breast epithelial cells. Cancer Res (2003) 1.39
Jmjd1a demethylase-regulated histone modification is essential for cAMP-response element modulator-regulated gene expression and spermatogenesis. J Biol Chem (2009) 1.38
Whole human genome proteogenomic mapping for ENCODE cell line data: identifying protein-coding regions. BMC Genomics (2013) 1.38
Deletion of Puma protects hematopoietic stem cells and confers long-term survival in response to high-dose gamma-irradiation. Blood (2010) 1.38
Arsenite causes DNA damage in keratinocytes via generation of hydroxyl radicals. Chem Res Toxicol (2004) 1.37
Large-scale cDNA transfection screening for genes related to cancer development and progression. Proc Natl Acad Sci U S A (2004) 1.35
Uncoupling p53 functions in radiation-induced intestinal damage via PUMA and p21. Mol Cancer Res (2011) 1.34
Up-regulation of DLK1 as an imprinted gene could contribute to human hepatocellular carcinoma. Carcinogenesis (2006) 1.33
BH3 mimetics to improve cancer therapy; mechanisms and examples. Drug Resist Updat (2007) 1.33
A prospective study of secondary degeneration following subcortical infarction using diffusion tensor imaging. J Neurol Neurosurg Psychiatry (2007) 1.31
Mitochondrial signaling in cell death via the Bcl-2 family. Cancer Biol Ther (2010) 1.30
Structural characterization of formaldehyde-induced cross-links between amino acids and deoxynucleosides and their oligomers. J Am Chem Soc (2010) 1.28
Overexpression of proline oxidase induces proline-dependent and mitochondria-mediated apoptosis. Mol Cell Biochem (2006) 1.27
Chemoprevention by nonsteroidal anti-inflammatory drugs eliminates oncogenic intestinal stem cells via SMAC-dependent apoptosis. Proc Natl Acad Sci U S A (2010) 1.26
A coordinated action of Bax, PUMA, and p53 promotes MG132-induced mitochondria activation and apoptosis in colon cancer cells. Mol Cancer Ther (2007) 1.26
Fibulin-5 suppresses lung cancer invasion by inhibiting matrix metalloproteinase-7 expression. Cancer Res (2009) 1.25
Oxidative stress and apoptosis in metal ion-induced carcinogenesis. Free Radic Biol Med (2004) 1.25
Normobaric hyperoxia inhibits NADPH oxidase-mediated matrix metalloproteinase-9 induction in cerebral microvessels in experimental stroke. J Neurochem (2008) 1.24
DEC1 is a downstream target of TGF-beta with sequence-specific transcriptional repressor activities. Proc Natl Acad Sci U S A (2002) 1.24
Complementary analysis of microRNA and mRNA expression during phorbol 12-myristate 13-acetate (TPA)-induced differentiation of HL-60 cells. Biotechnol Lett (2008) 1.24
Heat shock protein 70 regulates cellular redox status by modulating glutathione-related enzyme activities. Cell Stress Chaperones (2007) 1.23
Pentamidine reduces hERG expression to prolong the QT interval. Br J Pharmacol (2005) 1.23
A critical role of luteolin-induced reactive oxygen species in blockage of tumor necrosis factor-activated nuclear factor-kappaB pathway and sensitization of apoptosis in lung cancer cells. Mol Pharmacol (2007) 1.23
Intra- and interpopulation genotype reconstruction from tagging SNPs. Genome Res (2006) 1.21
SMAC/Diablo-dependent apoptosis induced by nonsteroidal antiinflammatory drugs (NSAIDs) in colon cancer cells. Proc Natl Acad Sci U S A (2004) 1.20
Frequent inactivation of RAMP2, EFEMP1 and Dutt1 in lung cancer by promoter hypermethylation. Clin Cancer Res (2007) 1.19
Inorganic arsenic compounds cause oxidative damage to DNA and protein by inducing ROS and RNS generation in human keratinocytes. Mol Cell Biochem (2005) 1.19
Use of 3-acetoxymethoxycarbonyl-2,2,5,5-tetramethyl-1-pyrrolidinyloxyl as an EPR oximetry probe: potential for in vivo measurement of tissue oxygenation in mouse brain. Magn Reson Med (2006) 1.18
Steroid receptor coactivator 3 maintains circulating insulin-like growth factor I (IGF-I) by controlling IGF-binding protein 3 expression. Mol Cell Biol (2008) 1.17
PUMA suppresses intestinal tumorigenesis in mice. Cancer Res (2009) 1.16
HDA18 affects cell fate in Arabidopsis root epidermis via histone acetylation at four kinase genes. Plant Cell (2013) 1.16
Cdc42 regulates arsenic-induced NADPH oxidase activation and cell migration through actin filament reorganization. J Biol Chem (2004) 1.15
Prolactin modulates the naive B cell repertoire. J Clin Invest (2003) 1.14
Generation of hydrogen peroxide during brief oxygen-glucose deprivation induces preconditioning neuronal protection in primary cultured neurons. J Neurosci Res (2005) 1.14
p130CAS is required for netrin signaling and commissural axon guidance. J Neurosci (2007) 1.14
BCCIP functions through p53 to regulate the expression of p21Waf1/Cip1. Cell Cycle (2004) 1.14
Lung adenocarcinoma with EGFR amplification has distinct clinicopathologic and molecular features in never-smokers. Cancer Res (2009) 1.13
Comparative proteomic analysis of all-trans-retinoic acid treatment reveals systematic posttranscriptional control mechanisms in acute promyelocytic leukemia. Blood (2004) 1.13