Published in Nat Biotechnol on March 01, 2005
Imaging in the era of molecular oncology. Nature (2008) 11.10
Multiscale photoacoustic microscopy and computed tomography. Nat Photonics (2009) 9.20
Going deeper than microscopy: the optical imaging frontier in biology. Nat Methods (2010) 5.65
Diffuse Optics for Tissue Monitoring and Tomography. Rep Prog Phys (2010) 3.33
Deep-tissue focal fluorescence imaging with digitally time-reversed ultrasound-encoded light. Nat Commun (2012) 2.73
Optical contrast agents and imaging systems for detection and diagnosis of cancer. Int J Cancer (2008) 2.72
Clinical Cerenkov luminescence imaging of (18)F-FDG. J Nucl Med (2013) 2.63
Noninvasive cell-tracking methods. Nat Rev Clin Oncol (2011) 2.26
Volumetric tomography of fluorescent proteins through small animals in vivo. Proc Natl Acad Sci U S A (2005) 2.16
A time domain fluorescence tomography system for small animal imaging. IEEE Trans Med Imaging (2008) 2.05
Obtaining adequate surgical margins in breast-conserving therapy for patients with early-stage breast cancer: current modalities and future directions. Ann Surg Oncol (2009) 2.02
Early photon tomography allows fluorescence detection of lung carcinomas and disease progression in mice in vivo. Proc Natl Acad Sci U S A (2008) 2.00
Use of gene expression profiling to direct in vivo molecular imaging of lung cancer. Proc Natl Acad Sci U S A (2005) 1.91
A tetrahedron-based inhomogeneous Monte Carlo optical simulator. Phys Med Biol (2010) 1.89
Multifunctional Nanocarriers for diagnostics, drug delivery and targeted treatment across blood-brain barrier: perspectives on tracking and neuroimaging. Part Fibre Toxicol (2010) 1.89
Multimodal MRI contrast agents. J Biol Inorg Chem (2007) 1.86
A three-dimensional multispectral fluorescence optical tomography imaging system for small animals based on a conical mirror design. Opt Express (2009) 1.84
Optical and multimodality molecular imaging: insights into atherosclerosis. Arterioscler Thromb Vasc Biol (2009) 1.84
A microcomputed tomography guided fluorescence tomography system for small animal molecular imaging. Rev Sci Instrum (2009) 1.83
Heterogeneous in vivo behavior of monocyte subsets in atherosclerosis. Arterioscler Thromb Vasc Biol (2009) 1.79
Compact Image Slicing Spectrometer (ISS) for hyperspectral fluorescence microscopy. Opt Express (2009) 1.78
In vivo imaging in cancer. Cold Spring Harb Perspect Biol (2010) 1.76
Quantitative optical tomography of sub-surface heterogeneities using spatially modulated structured light. Opt Express (2009) 1.73
Time resolved fluorescence tomography of turbid media based on lifetime contrast. Opt Express (2006) 1.70
Multimodality imaging of tumor xenografts and metastases in mice with combined small-animal PET, small-animal CT, and bioluminescence imaging. J Nucl Med (2007) 1.63
Monte Carlo based method for fluorescence tomographic imaging with lifetime multiplexing using time gates. Biomed Opt Express (2011) 1.61
In vivo imaging of molecularly targeted phage. Neoplasia (2006) 1.59
Non-invasive multimodal functional imaging of the intestine with frozen micellar naphthalocyanines. Nat Nanotechnol (2014) 1.56
Accurate measurement of pancreatic islet beta-cell mass using a second-generation fluorescent exendin-4 analog. Proc Natl Acad Sci U S A (2011) 1.50
Structured illumination enhances resolution and contrast in thick tissue fluorescence imaging. J Biomed Opt (2010) 1.49
Single-walled carbon nanotubes as a multimodal-thermoacoustic and photoacoustic-contrast agent. J Biomed Opt (2009) 1.48
Label-free Detection of Lymph Node Metastases with US-guided Functional Photoacoustic Imaging. Radiology (2015) 1.48
Source reconstruction for spectrally-resolved bioluminescence tomography with sparse a priori information. Opt Express (2009) 1.46
Hyaluronidase expression induces prostate tumor metastasis in an orthotopic mouse model. Am J Pathol (2006) 1.45
FMT-XCT: in vivo animal studies with hybrid fluorescence molecular tomography-X-ray computed tomography. Nat Methods (2012) 1.44
Quantitative fluorescence tomography with functional and structural a priori information. Appl Opt (2009) 1.44
Noninvasive biophotonic imaging for studies of infectious disease. FEMS Microbiol Rev (2010) 1.44
Peptide-based probes for targeted molecular imaging. Biochemistry (2010) 1.43
Self-luminescing BRET-FRET near-infrared dots for in vivo lymph-node mapping and tumour imaging. Nat Commun (2012) 1.42
Hydrazone ligation strategy to assemble multifunctional viral nanoparticles for cell imaging and tumor targeting. Nano Lett (2010) 1.42
Snapshot Image Mapping Spectrometer (IMS) with high sampling density for hyperspectral microscopy. Opt Express (2010) 1.42
Paramagnetic lipid-coated silica nanoparticles with a fluorescent quantum dot core: a new contrast agent platform for multimodality imaging. Bioconjug Chem (2008) 1.37
Molecular and magnetic resonance imaging of human embryonic stem cell-derived neural stem cell grafts in ischemic rat brain. Mol Ther (2009) 1.34
Review of Long-Wavelength Optical and NIR Imaging Materials: Contrast Agents, Fluorophores and Multifunctional Nano Carriers. Chem Mater (2012) 1.32
A comparison between a time domain and continuous wave small animal optical imaging system. IEEE Trans Med Imaging (2008) 1.31
Behavior of endogenous tumor-associated macrophages assessed in vivo using a functionalized nanoparticle. Neoplasia (2009) 1.28
Human ferritin cages for imaging vascular macrophages. Biomaterials (2010) 1.28
A near-infrared cell tracker reagent for multiscopic in vivo imaging and quantification of leukocyte immune responses. PLoS One (2007) 1.26
Fast iterative image reconstruction methods for fully 3D multispectral bioluminescence tomography. Phys Med Biol (2008) 1.25
Breaking the spatial resolution barrier via iterative sound-light interaction in deep tissue microscopy. Sci Rep (2012) 1.25
A study on tetrahedron-based inhomogeneous Monte Carlo optical simulation. Biomed Opt Express (2010) 1.23
Dual-modality molecular imaging using antibodies labeled with activatable fluorescence and a radionuclide for specific and quantitative targeted cancer detection. Bioconjug Chem (2009) 1.23
Imaging and nanomedicine in inflammatory atherosclerosis. Sci Transl Med (2014) 1.23
Photoswitchable nanoparticles for triggered tissue penetration and drug delivery. J Am Chem Soc (2012) 1.22
Multispectral optoacoustic tomography of matrix metalloproteinase activity in vulnerable human carotid plaques. Mol Imaging Biol (2012) 1.22
Noninvasive optical imaging of nanomedicine biodistribution. ACS Nano (2012) 1.19
Early-photon fluorescence tomography: spatial resolution improvements and noise stability considerations. J Opt Soc Am A Opt Image Sci Vis (2009) 1.19
Combined magnetic resonance and fluorescence imaging of the living mouse brain reveals glioma response to chemotherapy. Neuroimage (2008) 1.16
In vivo assembly of nanoparticle components to improve targeted cancer imaging. Proc Natl Acad Sci U S A (2010) 1.15
Reduction of excitation light leakage to improve near-infrared fluorescence imaging for tissue surface and deep tissue imaging. Med Phys (2010) 1.14
Three-dimensional reconstruction in free-space whole-body fluorescence tomography of mice using optically reconstructed surface and atlas anatomy. J Biomed Opt (2010) 1.12
Synthesis of [18F]BODIPY: bifunctional reporter for hybrid optical/positron emission tomography imaging. Angew Chem Int Ed Engl (2012) 1.11
Fluorescence tomography characterization for sub-surface imaging with protoporphyrin IX. Opt Express (2008) 1.11
Experimental bioluminescence tomography with fully parallel radiative-transfer-based reconstruction framework. Opt Express (2009) 1.10
Rapid biocompatibility analysis of materials via in vivo fluorescence imaging of mouse models. PLoS One (2010) 1.10
Quantitative tomographic imaging of intermolecular FRET in small animals. Biomed Opt Express (2012) 1.10
Mesh-based Monte Carlo method in time-domain widefield fluorescence molecular tomography. J Biomed Opt (2012) 1.09
In vivo imaging of integrin alpha v beta 3 expression using fluorescence-mediated tomography. Eur J Nucl Med Mol Imaging (2006) 1.08
Molecular imaging of inflammation in atherosclerosis. Theranostics (2013) 1.08
Optoacoustic imaging and tomography: reconstruction approaches and outstanding challenges in image performance and quantification. Sensors (Basel) (2013) 1.08
Technology Insight: novel imaging of molecular targets is an emerging area crucial to the development of targeted drugs. Nat Clin Pract Oncol (2008) 1.08
Clinical implications of near-infrared fluorescence imaging in cancer. Future Oncol (2009) 1.07
Noninvasive photoacoustic imaging of the thoracic cavity and the kidney in small and large animals. Med Phys (2008) 1.07
Self-illuminating 64Cu-doped CdSe/ZnS nanocrystals for in vivo tumor imaging. J Am Chem Soc (2014) 1.06
Detection of enzyme activity in orthotopic murine breast cancer by fluorescence lifetime imaging using a fluorescence resonance energy transfer-based molecular probe. J Biomed Opt (2011) 1.05
DNA self-assembly of targeted near-infrared-responsive gold nanoparticles for cancer thermo-chemotherapy. Angew Chem Int Ed Engl (2012) 1.05
In-vivo imaging of murine tumors using complete-angle projection fluorescence molecular tomography. J Biomed Opt (2009) 1.05
Phosphorescent nanoscale coordination polymers as contrast agents for optical imaging. Angew Chem Int Ed Engl (2011) 1.04
Fast multispectral optoacoustic tomography (MSOT) for dynamic imaging of pharmacokinetics and biodistribution in multiple organs. PLoS One (2012) 1.03
Effects of sampling strategy on image quality in noncontact panoramic fluorescence diffuse optical tomography for small animal imaging. Opt Express (2009) 1.03
Spectrally resolved bioluminescence tomography with the third-order simplified spherical harmonics approximation. Phys Med Biol (2009) 1.02
Live optical projection tomography. Organogenesis (2009) 1.01
Simultaneous PET and multispectral 3-dimensional fluorescence optical tomography imaging system. J Nucl Med (2011) 1.01
Illumination pattern optimization for fluorescence tomography: theory and simulation studies. Phys Med Biol (2010) 1.01
High throughput transmission optical projection tomography using low cost graphics processing unit. Opt Express (2009) 1.00
Monitoring bacterial burden, inflammation and bone damage longitudinally using optical and μCT imaging in an orthopaedic implant infection in mice. PLoS One (2012) 1.00
X-ray luminescence optical tomography imaging: experimental studies. Opt Lett (2013) 0.99
Excitation spectroscopy in multispectral optical fluorescence tomography: methodology, feasibility and computer simulation studies. Phys Med Biol (2009) 0.99
Algorithms for bioluminescence tomography incorporating anatomical information and reconstruction of tissue optical properties. Biomed Opt Express (2010) 0.98
Quantum dot and Cy5.5 labeled nanoparticles to investigate lipoprotein biointeractions via Förster resonance energy transfer. Nano Lett (2010) 0.98
Quantitative Magnetic Particle Imaging Monitors the Transplantation, Biodistribution, and Clearance of Stem Cells In Vivo. Theranostics (2016) 0.98
Shedding light on nanomedicine. Wiley Interdiscip Rev Nanomed Nanobiotechnol (2012) 0.97
Improved bioluminescence and fluorescence reconstruction algorithms using diffuse optical tomography, normalized data, and optimized selection of the permissible source region. Biomed Opt Express (2010) 0.97
Transillumination fluorescence imaging in mice using biocompatible upconverting nanoparticles. Opt Lett (2009) 0.97
Multimodal imaging and treatment of bone metastasis. Clin Exp Metastasis (2008) 0.97
Absorption reconstruction improves biodistribution assessment of fluorescent nanoprobes using hybrid fluorescence-mediated tomography. Theranostics (2014) 0.97
RGD-conjugated human ferritin nanoparticles for imaging vascular inflammation and angiogenesis in experimental carotid and aortic disease. Mol Imaging Biol (2012) 0.96
Non-invasive in vivo imaging of near infrared-labeled transferrin in breast cancer cells and tumors using fluorescence lifetime FRET. PLoS One (2013) 0.96
Thin polymer etalon arrays for high-resolution photoacoustic imaging. J Biomed Opt (2009) 0.95
DNA nanoparticles: detection of long-term transgene activity in brain using bioluminescence imaging. Mol Imaging (2011) 0.95
Functional photoacoustic microscopy for high-resolution and noninvasive in vivo imaging. Nat Biotechnol (2006) 14.96
Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers. Nat Med (2008) 14.47
Restoration of p53 function leads to tumour regression in vivo. Nature (2007) 12.62
The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions. J Exp Med (2007) 11.51
Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain. Nat Biotechnol (2003) 11.28
Identification of splenic reservoir monocytes and their deployment to inflammatory sites. Science (2009) 10.47
Noninvasive detection of clinically occult lymph-node metastases in prostate cancer. N Engl J Med (2003) 9.09
Optical-resolution photoacoustic microscopy for in vivo imaging of single capillaries. Opt Lett (2008) 8.82
Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata. J Clin Invest (2007) 8.65
Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. Cell (2012) 7.36
Fluorescence imaging with near-infrared light: new technological advances that enable in vivo molecular imaging. Eur Radiol (2002) 6.06
Codon-optimized Gaussia luciferase cDNA for mammalian gene expression in culture and in vivo. Mol Ther (2005) 6.04
Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse. Proc Natl Acad Sci U S A (2006) 5.90
Fluorescence molecular tomography resolves protease activity in vivo. Nat Med (2002) 5.53
The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies. Cancer Cell (2006) 5.34
Arthritis critically dependent on innate immune system players. Immunity (2002) 5.31
Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. Cancer Cell (2002) 5.11
The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha. Cell (2010) 5.11
Myocardial infarction accelerates atherosclerosis. Nature (2012) 4.48
Universal back-projection algorithm for photoacoustic computed tomography. Phys Rev E Stat Nonlin Soft Matter Phys (2005) 4.33
Chip-NMR biosensor for detection and molecular analysis of cells. Nat Med (2008) 4.29
Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivo. Circulation (2007) 4.20
Local proliferation dominates lesional macrophage accumulation in atherosclerosis. Nat Med (2013) 4.14
Magnetic relaxation switches capable of sensing molecular interactions. Nat Biotechnol (2002) 4.13
Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-beta signals in vivo. Proc Natl Acad Sci U S A (2004) 4.12
Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy. Nat Med (2012) 4.11
In vivo dark-field reflection-mode photoacoustic microscopy. Opt Lett (2005) 4.03
A spatially and temporally restricted mouse model of soft tissue sarcoma. Nat Med (2007) 3.96
Therapeutic siRNA silencing in inflammatory monocytes in mice. Nat Biotechnol (2011) 3.95
Tetrazine-based cycloadditions: application to pretargeted live cell imaging. Bioconjug Chem (2008) 3.93
Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation. Immunity (2006) 3.92
Nanoparticle PET-CT imaging of macrophages in inflammatory atherosclerosis. Circulation (2007) 3.85
Fast and sensitive pretargeted labeling of cancer cells through a tetrazine/trans-cyclooctene cycloaddition. Angew Chem Int Ed Engl (2009) 3.63
Noninvasive vascular cell adhesion molecule-1 imaging identifies inflammatory activation of cells in atherosclerosis. Circulation (2006) 3.57
In vivo photoacoustic tomography of chemicals: high-resolution functional and molecular optical imaging at new depths. Chem Rev (2010) 3.55
Noninvasive imaging of hemoglobin concentration and oxygenation in the rat brain using high-resolution photoacoustic tomography. J Biomed Opt (2006) 3.52
Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease. Circulation (2007) 3.51
Molecular imaging in drug discovery and development. Nat Rev Drug Discov (2003) 3.44
Photoacoustic tomography of a rat cerebral cortex in vivo with au nanocages as an optical contrast agent. Nano Lett (2007) 3.42
Porphysome nanovesicles generated by porphyrin bilayers for use as multimodal biophotonic contrast agents. Nat Mater (2011) 3.40
Monocyte accumulation in mouse atherogenesis is progressive and proportional to extent of disease. Proc Natl Acad Sci U S A (2006) 3.38
Time-reversed ultrasonically encoded optical focusing into scattering media. Nat Photonics (2011) 3.36
Multifunctional magnetic nanoparticles for targeted imaging and therapy. Adv Drug Deliv Rev (2008) 3.34
Deep reflection-mode photoacoustic imaging of biological tissue. J Biomed Opt (2007) 3.32
A secreted luciferase for ex vivo monitoring of in vivo processes. Nat Methods (2008) 3.31
Subwavelength-resolution label-free photoacoustic microscopy of optical absorption in vivo. Opt Lett (2010) 3.25
Intravital imaging. Cell (2011) 3.18
Label-free oxygen-metabolic photoacoustic microscopy in vivo. J Biomed Opt (2011) 3.16
Three-dimensional imaging of skin melanoma in vivo by dual-wavelength photoacoustic microscopy. J Biomed Opt (2006) 3.08
Photoacoustic imaging and characterization of the microvasculature. J Biomed Opt (2010) 3.07
Photoacoustic tomography and sensing in biomedicine. Phys Med Biol (2009) 3.04
In vivo imaging of subcutaneous structures using functional photoacoustic microscopy. Nat Protoc (2007) 3.03
Second-generation optical-resolution photoacoustic microscopy with improved sensitivity and speed. Opt Lett (2011) 2.98
A real-time photoacoustic tomography system for small animals. Opt Express (2009) 2.97
Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis. J Exp Med (2012) 2.92
Multivalent effects of RGD peptides obtained by nanoparticle display. J Med Chem (2006) 2.91
MicroRNA-21 knockdown disrupts glioma growth in vivo and displays synergistic cytotoxicity with neural precursor cell delivered S-TRAIL in human gliomas. Cancer Res (2007) 2.90
Impaired infarct healing in atherosclerotic mice with Ly-6C(hi) monocytosis. J Am Coll Cardiol (2010) 2.90
Near-infrared fluorescence: application to in vivo molecular imaging. Curr Opin Chem Biol (2009) 2.89
Gold nanocages covered by smart polymers for controlled release with near-infrared light. Nat Mater (2009) 2.85
An X-ray computed tomography imaging agent based on long-circulating bismuth sulphide nanoparticles. Nat Mater (2006) 2.84
Ultrasensitive clinical enumeration of rare cells ex vivo using a micro-hall detector. Sci Transl Med (2012) 2.82
Near-infrared gold nanocages as a new class of tracers for photoacoustic sentinel lymph node mapping on a rat model. Nano Lett (2009) 2.82
The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism. Cell (2012) 2.78
Dual channel optical tomographic imaging of leukocyte recruitment and protease activity in the healing myocardial infarct. Circ Res (2007) 2.77
Visualization of antitumor treatment by means of fluorescence molecular tomography with an annexin V-Cy5.5 conjugate. Proc Natl Acad Sci U S A (2004) 2.77
Photoacoustic imaging of lacZ gene expression in vivo. J Biomed Opt (2007) 2.76
Rapid detection and profiling of cancer cells in fine-needle aspirates. Proc Natl Acad Sci U S A (2009) 2.75
Cyclophosphamide enhances glioma virotherapy by inhibiting innate immune responses. Proc Natl Acad Sci U S A (2006) 2.72
In vivo photoacoustic imaging of transverse blood flow by using Doppler broadening of bandwidth. Opt Lett (2010) 2.72
Detection of vascular adhesion molecule-1 expression using a novel multimodal nanoparticle. Circ Res (2005) 2.67
Noninvasive photoacoustic identification of sentinel lymph nodes containing methylene blue in vivo in a rat model. J Biomed Opt (2008) 2.65
Detection of dysplastic intestinal adenomas using enzyme-sensing molecular beacons in mice. Gastroenterology (2002) 2.64
In vivo imaging of proteolytic activity in atherosclerosis. Circulation (2002) 2.62
Molecular imaging in the clinical arena. JAMA (2005) 2.59
A submillimeter resolution fluorescence molecular imaging system for small animal imaging. Med Phys (2003) 2.58
Focal disruption of the blood-brain barrier due to 260-kHz ultrasound bursts: a method for molecular imaging and targeted drug delivery. J Neurosurg (2006) 2.58
miR-296 regulates growth factor receptor overexpression in angiogenic endothelial cells. Cancer Cell (2008) 2.57
Bioorthogonal turn-on probes for imaging small molecules inside living cells. Angew Chem Int Ed Engl (2010) 2.57
Inflammation in atherosclerosis: visualizing matrix metalloproteinase action in macrophages in vivo. Circulation (2006) 2.56
A multimodal nanoparticle for preoperative magnetic resonance imaging and intraoperative optical brain tumor delineation. Cancer Res (2003) 2.55
Real-time catheter molecular sensing of inflammation in proteolytically active atherosclerosis. Circulation (2008) 2.52
Bioorthogonal chemistry amplifies nanoparticle binding and enhances the sensitivity of cell detection. Nat Nanotechnol (2010) 2.49
One-Pot Synthesis of New Symmetric and Asymmetric Xanthene Dyes. Tetrahedron Lett (2007) 2.49
Deeply penetrating photoacoustic tomography in biological tissues enhanced with an optical contrast agent. Opt Lett (2005) 2.47
Assessment of therapeutic efficacy and fate of engineered human mesenchymal stem cells for cancer therapy. Proc Natl Acad Sci U S A (2009) 2.47
Effect of tumor microenvironment modulation on the efficacy of oncolytic virus therapy. J Natl Cancer Inst (2007) 2.46
Near-infrared fluorescent imaging of matrix metalloproteinase activity after myocardial infarction. Circulation (2005) 2.45
Near-infrared fluorescent nanoparticles as combined MR/optical imaging probes. Bioconjug Chem (2002) 2.45
Extramedullary hematopoiesis generates Ly-6C(high) monocytes that infiltrate atherosclerotic lesions. Circulation (2011) 2.45
Functional transcranial brain imaging by optical-resolution photoacoustic microscopy. J Biomed Opt (2009) 2.43
Origins of tumor-associated macrophages and neutrophils. Proc Natl Acad Sci U S A (2012) 2.42
PET/MRI of inflammation in myocardial infarction. J Am Coll Cardiol (2012) 2.39
Photoacoustic Doppler effect from flowing small light-absorbing particles. Phys Rev Lett (2007) 2.38
Identification of the target self-antigens in reperfusion injury. J Exp Med (2006) 2.38
Sentinel lymph nodes in the rat: noninvasive photoacoustic and US imaging with a clinical US system. Radiology (2010) 2.35
Noninvasive label-free imaging of microhemodynamics by optical-resolution photoacoustic microscopy. Opt Express (2009) 2.34
Molecular imaging of cardiovascular disease. Circulation (2007) 2.33