| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Discovery of 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase.
|
J Med Chem
|
2011
|
1.88
|
|
2
|
Legume transcription factors: global regulators of plant development and response to the environment.
|
Plant Physiol
|
2007
|
1.64
|
|
3
|
Genetics of symbiosis in Lotus japonicus: recombinant inbred lines, comparative genetic maps, and map position of 35 symbiotic loci.
|
Mol Plant Microbe Interact
|
2006
|
1.21
|
|
4
|
Identification of imidazo-pyrrolopyridines as novel and potent JAK1 inhibitors.
|
J Med Chem
|
2012
|
1.10
|
|
5
|
Discovery of a potent, selective, and orally available class I phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) kinase inhibitor (GDC-0980) for the treatment of cancer.
|
J Med Chem
|
2011
|
1.08
|
|
6
|
Discovery of novel PI3-kinase δ specific inhibitors for the treatment of rheumatoid arthritis: taming CYP3A4 time-dependent inhibition.
|
J Med Chem
|
2012
|
1.03
|
|
7
|
Inhibiting alternative pathway complement activation by targeting the factor D exosite.
|
J Biol Chem
|
2012
|
1.01
|
|
8
|
Global reprogramming of transcription and metabolism in Medicago truncatula during progressive drought and after rewatering.
|
Plant Cell Environ
|
2014
|
0.99
|
|
9
|
Invasion of Lotus japonicus root hairless 1 by Mesorhizobium loti involves the nodulation factor-dependent induction of root hairs.
|
Plant Physiol
|
2005
|
0.98
|
|
10
|
The development of peptide-based tools for the analysis of angiogenesis.
|
Chem Biol
|
2011
|
0.97
|
|
11
|
Allosteric peptides bind a caspase zymogen and mediate caspase tetramerization.
|
Nat Chem Biol
|
2012
|
0.91
|
|
12
|
Lead optimization of a 4-aminopyridine benzamide scaffold to identify potent, selective, and orally bioavailable TYK2 inhibitors.
|
J Med Chem
|
2013
|
0.88
|
|
13
|
Lead identification of novel and selective TYK2 inhibitors.
|
Eur J Med Chem
|
2013
|
0.88
|
|
14
|
Discovery of novel pyrazolo[1,5-a]pyrimidines as potent pan-Pim inhibitors by structure- and property-based drug design.
|
Bioorg Med Chem Lett
|
2013
|
0.87
|
|
15
|
Potent and selective inhibitors of PI3Kδ: obtaining isoform selectivity from the affinity pocket and tryptophan shelf.
|
Bioorg Med Chem Lett
|
2012
|
0.83
|
|
16
|
Discovery of thiazolobenzoxepin PI3-kinase inhibitors that spare the PI3-kinase β isoform.
|
Bioorg Med Chem Lett
|
2013
|
0.81
|
|
17
|
Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6.
|
PLoS One
|
2012
|
0.81
|
|
18
|
Discovery of potent and selective pyrazolopyrimidine janus kinase 2 inhibitors.
|
J Med Chem
|
2012
|
0.80
|
|
19
|
Inhibitory mechanism of an allosteric antibody targeting the glucagon receptor.
|
J Biol Chem
|
2013
|
0.80
|
|
20
|
Cis-amide isosteric replacement in thienobenzoxepin inhibitors of PI3-kinase.
|
Bioorg Med Chem Lett
|
2012
|
0.76
|