Published in Nat Chem Biol on June 10, 2012
A caspase cascade regulating developmental axon degeneration. J Neurosci (2012) 1.57
Expanding the number of 'druggable' targets: non-enzymes and protein-protein interactions. Chem Biol Drug Des (2013) 1.21
Structural basis of the interaction of MbtH-like proteins, putative regulators of nonribosomal peptide biosynthesis, with adenylating enzymes. J Biol Chem (2012) 0.97
Zinc-mediated allosteric inhibition of caspase-6. J Biol Chem (2012) 0.92
Identification of a small peptide that inhibits PCSK9 protein binding to the low density lipoprotein receptor. J Biol Chem (2013) 0.90
A multipronged approach for compiling a global map of allosteric regulation in the apoptotic caspases. Methods Enzymol (2014) 0.79
Small Molecule Active Site Directed Tools for Studying Human Caspases. Chem Rev (2015) 0.77
Palmitoylation of caspase-6 by HIP14 regulates its activation. Cell Death Differ (2016) 0.76
Caspase vinyl sulfone small molecule inhibitors prevent axonal degeneration in human neurons and reverse cognitive impairment in Caspase-6-overexpressing mice. Mol Neurodegener (2017) 0.75
Peptide inhibitors: Four of a kind beats a pair. Nat Chem Biol (2012) 0.75
Rapid and efficient site-specific mutagenesis without phenotypic selection. Methods Enzymol (1987) 66.52
Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain. Science (1997) 11.53
IAP proteins: blocking the road to death's door. Nat Rev Mol Cell Biol (2002) 7.23
Human ICE/CED-3 protease nomenclature. Cell (1996) 7.11
Molecular mechanisms of caspase regulation during apoptosis. Nat Rev Mol Cell Biol (2004) 6.76
APP binds DR6 to trigger axon pruning and neuron death via distinct caspases. Nature (2009) 6.17
A unified model for apical caspase activation. Mol Cell (2003) 6.12
Mechanisms of caspase activation and inhibition during apoptosis. Mol Cell (2002) 5.31
Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin. Cell (2006) 4.53
Substrate specificities of caspase family proteases. J Biol Chem (1997) 4.16
Caspase activation: the induced-proximity model. Proc Natl Acad Sci U S A (1999) 3.86
Executioner caspase-3, -6, and -7 perform distinct, non-redundant roles during the demolition phase of apoptosis. J Biol Chem (2000) 3.85
IAPs, RINGs and ubiquitylation. Nat Rev Mol Cell Biol (2005) 3.68
Human caspases: activation, specificity, and regulation. J Biol Chem (2009) 3.67
Internally quenched fluorescent peptide substrates disclose the subsite preferences of human caspases 1, 3, 6, 7 and 8. Biochem J (2000) 2.58
Discovery of an allosteric site in the caspases. Proc Natl Acad Sci U S A (2004) 2.51
Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding. Cell (2001) 2.39
Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis. Proc Natl Acad Sci U S A (1996) 2.31
Active caspase-6 and caspase-6-cleaved tau in neuropil threads, neuritic plaques, and neurofibrillary tangles of Alzheimer's disease. Am J Pathol (2004) 2.19
Structural basis for the activation of human procaspase-7. Proc Natl Acad Sci U S A (2001) 2.14
A common allosteric site and mechanism in caspases. Proc Natl Acad Sci U S A (2006) 2.12
Cleavage of automodified poly(ADP-ribose) polymerase during apoptosis. Evidence for involvement of caspase-7. J Biol Chem (1999) 2.09
Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease. J Neurosci (2002) 2.05
Caspases: keys in the ignition of cell death. Chem Rev (2002) 1.91
Guidelines for protein design: the energetics of beta sheet side chain interactions. Science (1995) 1.88
The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A. J Biol Chem (1996) 1.84
Caspase-6 gene disruption reveals a requirement for lamin A cleavage in apoptotic chromatin condensation. EMBO J (2002) 1.82
Inhibition of Wnt signaling by Dishevelled PDZ peptides. Nat Chem Biol (2009) 1.65
Activation of caspase-6 in aging and mild cognitive impairment. Am J Pathol (2007) 1.53
Covalent inhibition revealed by the crystal structure of the caspase-8/p35 complex. Nature (2001) 1.51
Caspase activation, inhibition, and reactivation: a mechanistic view. Protein Sci (2004) 1.48
Targets of caspase-6 activity in human neurons and Alzheimer disease. Mol Cell Proteomics (2008) 1.48
Caspase inhibitors: viral, cellular and chemical. Cell Death Differ (2006) 1.45
Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease. Cell Death Differ (2004) 1.44
Caspases - controlling intracellular signals by protease zymogen activation. Biochim Biophys Acta (2000) 1.42
Mechanism of procaspase-8 activation by c-FLIPL. Proc Natl Acad Sci U S A (2009) 1.39
An allosteric circuit in caspase-1. J Mol Biol (2008) 1.38
Self-activation of Caspase-6 in vitro and in vivo: Caspase-6 activation does not induce cell death in HEK293T cells. Biochim Biophys Acta (2008) 1.31
Crystal structures of human caspase 6 reveal a new mechanism for intramolecular cleavage self-activation. EMBO Rep (2010) 1.17
Caspase-8 can be activated by interchain proteolysis without receptor-triggered dimerization during drug-induced apoptosis. J Biol Chem (2004) 1.16
Substrate-induced conformational changes occur in all cleaved forms of caspase-6. J Mol Biol (2010) 1.10
Cleavage at the 586 amino acid caspase-6 site in mutant huntingtin influences caspase-6 activation in vivo. J Neurosci (2010) 1.10
Caspase-6 activation in familial alzheimer disease brains carrying amyloid precursor protein or presenilin i or presenilin II mutations. J Neuropathol Exp Neurol (2009) 1.09
Caspase inhibitors: a pharmaceutical industry perspective. Curr Top Med Chem (2005) 1.06
Identification of the primary caspase 3 cleavage site in alpha II-spectrin during apoptosis. Apoptosis (2003) 0.85
A whole cell assay to measure caspase-6 activity by detecting cleavage of lamin A/C. PLoS One (2012) 0.83
Ecological and socioeconomic effects of China's policies for ecosystem services. Proc Natl Acad Sci U S A (2008) 6.03
Complete genome sequence of citrus huanglongbing bacterium, 'Candidatus Liberibacter asiaticus' obtained through metagenomics. Mol Plant Microbe Interact (2009) 3.33
A specificity map for the PDZ domain family. PLoS Biol (2008) 3.16
CRIg: a macrophage complement receptor required for phagocytosis of circulating pathogens. Cell (2006) 2.89
Structure of C3b in complex with CRIg gives insights into regulation of complement activation. Nature (2006) 2.69
Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target. Sci Transl Med (2011) 2.51
A two-in-one antibody against HER3 and EGFR has superior inhibitory activity compared with monospecific antibodies. Cancer Cell (2011) 2.14
Neogenin regulation of BMP-induced canonical Smad signaling and endochondral bone formation. Dev Cell (2010) 1.97
Engineering and structural characterization of a linear polyubiquitin-specific antibody. J Mol Biol (2011) 1.93
Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer. Cancer Res (2012) 1.89
The complete genome sequence of 'Candidatus Liberibacter solanacearum', the bacterium associated with potato zebra chip disease. PLoS One (2011) 1.79
Cholinergic input is required during embryonic development to mediate proper assembly of spinal locomotor circuits. Neuron (2005) 1.77
A therapeutic antibody targeting BACE1 inhibits amyloid-β production in vivo. Sci Transl Med (2011) 1.75
A prospective investigation of outcomes after hospital discharge for endemic, community-acquired methicillin-resistant and -susceptible Staphylococcus aureus skin infection. Clin Infect Dis (2007) 1.74
Inhibition of Wnt signaling by Dishevelled PDZ peptides. Nat Chem Biol (2009) 1.65
Legume transcription factors: global regulators of plant development and response to the environment. Plant Physiol (2007) 1.64
Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6. J Biol Chem (2010) 1.63
ATP-dependent L-cysteine:1D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase, mycothiol biosynthesis enzyme MshC, is related to class I cysteinyl-tRNA synthetases. Biochemistry (2002) 1.61
Genetic disruptions of O/E2 and O/E3 genes reveal involvement in olfactory receptor neuron projection. Development (2004) 1.59
A caspase cascade regulating developmental axon degeneration. J Neurosci (2012) 1.57
The crystal structure of the catalytic domain of the NF-κB inducing kinase reveals a narrow but flexible active site. Structure (2012) 1.57
DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury. Proc Natl Acad Sci U S A (2013) 1.53
'Ca. Liberibacter asiaticus' carries an excision plasmid prophage and a chromosomally integrated prophage that becomes lytic in plant infections. Mol Plant Microbe Interact (2011) 1.52
Stabilizing the pro-apoptotic BimBH3 helix (BimSAHB) does not necessarily enhance affinity or biological activity. ACS Chem Biol (2012) 1.50
Identifying specificity profiles for peptide recognition modules from phage-displayed peptide libraries. Nat Protoc (2007) 1.49
DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity. J Cell Biol (2011) 1.45
Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding. EMBO J (2007) 1.43
Comparative structural analysis of the Erbin PDZ domain and the first PDZ domain of ZO-1. Insights into determinants of PDZ domain specificity. J Biol Chem (2006) 1.43
The intrinsic contributions of tyrosine, serine, glycine and arginine to the affinity and specificity of antibodies. J Mol Biol (2008) 1.41
Antibody-drug conjugates for the treatment of non-Hodgkin's lymphoma: target and linker-drug selection. Cancer Res (2009) 1.41
Callose deposition in the phloem plasmodesmata and inhibition of phloem transport in citrus leaves infected with "Candidatus Liberibacter asiaticus". Protoplasma (2011) 1.41
Wnt antagonists bind through a short peptide to the first β-propeller domain of LRP5/6. Structure (2011) 1.34
Wnt isoform-specific interactions with coreceptor specify inhibition or potentiation of signaling by LRP6 antibodies. PLoS One (2010) 1.34
Molecular basis for negative regulation of the glucagon receptor. Proc Natl Acad Sci U S A (2012) 1.33
Antagonists induce a conformational change in cIAP1 that promotes autoubiquitination. Science (2011) 1.32
Structural and functional analysis of the PDZ domains of human HtrA1 and HtrA3. Protein Sci (2007) 1.31
Tissue expression, protease specificity, and Kunitz domain functions of hepatocyte growth factor activator inhibitor-1B (HAI-1B), a new splice variant of HAI-1. J Biol Chem (2003) 1.29
Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152). J Med Chem (2012) 1.27
Histone deacetylase (HDAC) inhibitor kinetic rate constants correlate with cellular histone acetylation but not transcription and cell viability. J Biol Chem (2013) 1.26
FGF as a target-derived chemoattractant for developing motor axons genetically programmed by the LIM code. Neuron (2006) 1.25
Structural basis of ordered binding of donor and acceptor substrates to the retaining glycosyltransferase, alpha-1,3-galactosyltransferase. J Biol Chem (2002) 1.24
JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis. J Cell Biol (2013) 1.22
A novel inhibitor of the alternative pathway of complement reverses inflammation and bone destruction in experimental arthritis. J Exp Med (2007) 1.22
Presenilin-dependent receptor processing is required for axon guidance. Cell (2011) 1.22
Disruption of PH-kinase domain interactions leads to oncogenic activation of AKT in human cancers. Proc Natl Acad Sci U S A (2012) 1.22
Genetics of symbiosis in Lotus japonicus: recombinant inbred lines, comparative genetic maps, and map position of 35 symbiotic loci. Mol Plant Microbe Interact (2006) 1.21
Selective inhibition of fibroblast activation protein protease based on dipeptide substrate specificity. J Biol Chem (2006) 1.21
Conformational stabilization of ubiquitin yields potent and selective inhibitors of USP7. Nat Chem Biol (2012) 1.20
C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice. Proc Natl Acad Sci U S A (2013) 1.17
Chemical genetics identifies Rab geranylgeranyl transferase as an apoptotic target of farnesyl transferase inhibitors. Cancer Cell (2005) 1.15
Identification of imidazo-pyrrolopyridines as novel and potent JAK1 inhibitors. J Med Chem (2012) 1.10
Structural and functional analysis of a C3b-specific antibody that selectively inhibits the alternative pathway of complement. J Biol Chem (2009) 1.09
A key claudin extracellular loop domain is critical for epithelial barrier integrity. Am J Pathol (2008) 1.09
X chromosome-linked inhibitor of apoptosis regulates cell death induction by proapoptotic receptor agonists. J Biol Chem (2009) 1.08
Discovery of a potent, selective, and orally available class I phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) kinase inhibitor (GDC-0980) for the treatment of cancer. J Med Chem (2011) 1.08
The effect of chronic psychological stress on corticosterone, plasma metabolites, and immune responsiveness in European starlings. Gen Comp Endocrinol (2007) 1.08
Spatially coordinated kinase signaling regulates local axon degeneration. J Neurosci (2012) 1.07
Chemical compounds effective against the citrus Huanglongbing bacterium 'Candidatus Liberibacter asiaticus' in planta. Phytopathology (2011) 1.07
Synthesis of a 10,000-membered library of molecules resembling carpanone and discovery of vesicular traffic inhibitors. J Am Chem Soc (2006) 1.06
Targeted mutagenesis of the Mycobacterium smegmatis mca gene, encoding a mycothiol-dependent detoxification protein. J Bacteriol (2004) 1.06
Discovery of novel PI3-kinase δ specific inhibitors for the treatment of rheumatoid arthritis: taming CYP3A4 time-dependent inhibition. J Med Chem (2012) 1.03
High CD21 expression inhibits internalization of anti-CD19 antibodies and cytotoxicity of an anti-CD19-drug conjugate. Br J Haematol (2007) 1.03
On the edge of validation--cancer protease fibroblast activation protein. Mini Rev Med Chem (2008) 1.02
Inhibiting alternative pathway complement activation by targeting the factor D exosite. J Biol Chem (2012) 1.01
Peptide substrate profiling defines fibroblast activation protein as an endopeptidase of strict Gly(2)-Pro(1)-cleaving specificity. FEBS Lett (2006) 1.00
Molecular requirements for duplex recognition and cleavage by eukaryotic RNase III: discovery of an RNA-dependent DNA cleavage activity of yeast Rnt1p. J Mol Biol (2004) 1.00
Membrane targeting of palmitoylated Wnt and Hedgehog revealed by chemical probes. FEBS Lett (2011) 1.00
Global reprogramming of transcription and metabolism in Medicago truncatula during progressive drought and after rewatering. Plant Cell Environ (2014) 0.99
Conformational dynamics control ubiquitin-deubiquitinase interactions and influence in vivo signaling. Proc Natl Acad Sci U S A (2013) 0.99
Invasion of Lotus japonicus root hairless 1 by Mesorhizobium loti involves the nodulation factor-dependent induction of root hairs. Plant Physiol (2005) 0.98
Clinicopathologic characteristics of ALK rearrangements in primary lung adenocarcinoma with identified EGFR and KRAS status. J Cancer Res Clin Oncol (2014) 0.98
Improved real-time PCR detection of 'Candidatus Liberibacter asiaticus' from citrus and psyllid hosts by targeting the intragenic tandem-repeats of its prophage genes. Mol Cell Probes (2012) 0.97
Complement receptor of the Ig superfamily enhances complement-mediated phagocytosis in a subpopulation of tissue resident macrophages. J Immunol (2008) 0.97
The development of peptide-based tools for the analysis of angiogenesis. Chem Biol (2011) 0.97
Structural and functional analysis of HtrA1 and its subdomains. Structure (2012) 0.96
Phosphorylation of Dishevelled by protein kinase RIPK4 regulates Wnt signaling. Science (2013) 0.95
Screening molecules for control of citrus huanglongbing using an optimized regeneration system for 'Candidatus Liberibacter asiaticus'-infected periwinkle (Catharanthus roseus) cuttings. Phytopathology (2010) 0.95
SH3 interactome conserves general function over specific form. Mol Syst Biol (2013) 0.94
TMEFF2 is a PDGF-AA binding protein with methylation-associated gene silencing in multiple cancer types including glioma. PLoS One (2011) 0.93
Wnts influence the timing and efficiency of oligodendrocyte precursor cell generation in the telencephalon. J Neurosci (2010) 0.93
Scalable total synthesis and biological evaluation of haouamine A and its atropisomer. J Am Chem Soc (2009) 0.92
Chemical genetics reveals an RGS/G-protein role in the action of a compound. PLoS Genet (2006) 0.91
In vitro-expanded CD4(+)CD25(high)Foxp3(+) regulatory T cells controls corneal allograft rejection. Hum Immunol (2012) 0.90
Identification of a small peptide that inhibits PCSK9 protein binding to the low density lipoprotein receptor. J Biol Chem (2013) 0.90
Back pocket flexibility provides group II p21-activated kinase (PAK) selectivity for type I 1/2 kinase inhibitors. J Med Chem (2014) 0.90
Development and systematic validation of qPCR assays for rapid and reliable differentiation of Xylella fastidiosa strains causing citrus variegated chlorosis. J Microbiol Methods (2012) 0.90