Published in Cancer Res on March 15, 2005
Evolution of the cancer genome. Nat Rev Genet (2012) 3.24
Mitf regulation of Dia1 controls melanoma proliferation and invasiveness. Genes Dev (2006) 2.87
Role for histone deacetylase 1 in human tumor cell proliferation. Mol Cell Biol (2007) 2.07
The other pigment cell: specification and development of the pigmented epithelium of the vertebrate eye. Pigment Cell Res (2006) 1.59
Senescent cells develop a PARP-1 and nuclear factor-{kappa}B-associated secretome (PNAS). Genes Dev (2011) 1.52
Tbx20 regulation of endocardial cushion cell proliferation and extracellular matrix gene expression. Dev Biol (2006) 1.49
Suppressed expression of T-box transcription factors is involved in senescence in chronic obstructive pulmonary disease. PLoS Comput Biol (2012) 1.41
Retracted MicroRNA-340-mediated degradation of microphthalmia-associated transcription factor mRNA is inhibited by the coding region determinant-binding protein. J Biol Chem (2010) 1.32
The microphthalmia-associated transcription factor Mitf interacts with beta-catenin to determine target gene expression. Mol Cell Biol (2006) 1.31
The Highly Homologous T-Box Transcription Factors, TBX2 and TBX3, Have Distinct Roles in the Oncogenic Process. Genes Cancer (2010) 1.23
A pathway for the control of anoikis sensitivity by E-cadherin and epithelial-to-mesenchymal transition. Mol Cell Biol (2011) 1.23
The level of BMP4 signaling is critical for the regulation of distinct T-box gene expression domains and growth along the dorso-ventral axis of the optic cup. BMC Dev Biol (2006) 1.19
P53 in human melanoma fails to regulate target genes associated with apoptosis and the cell cycle and may contribute to proliferation. BMC Cancer (2011) 1.18
Classical and Novel Prognostic Markers for Breast Cancer and their Clinical Significance. Clin Med Insights Oncol (2010) 1.13
Side population cells from human melanoma tumors reveal diverse mechanisms for chemoresistance. J Invest Dermatol (2012) 1.12
MITF and cell proliferation: the role of alternative splice forms. Pigment Cell Res (2005) 1.10
Role of cyclin D1 as a mediator of c-Met- and beta-catenin-induced hepatocarcinogenesis. Cancer Res (2009) 1.07
The roles of microphthalmia-associated transcription factor and pigmentation in melanoma. Arch Biochem Biophys (2014) 1.05
T-box factors determine cardiac design. Cell Mol Life Sci (2007) 1.04
MITF-siRNA formulation is a safe and effective therapy for human melasma. Mol Ther (2010) 1.01
Molecular Network Associated with MITF in Skin Melanoma Development and Progression. J Skin Cancer (2011) 1.01
The T box transcription factor TBX2 promotes epithelial-mesenchymal transition and invasion of normal and malignant breast epithelial cells. PLoS One (2012) 1.00
TBX3 over-expression causes mammary gland hyperplasia and increases mammary stem-like cells in an inducible transgenic mouse model. BMC Dev Biol (2011) 1.00
Resistance to transforming growth factor β-mediated tumor suppression in melanoma: are multiple mechanisms in place? Carcinogenesis (2010) 0.97
Physical and functional interaction between PML and TBX2 in the establishment of cellular senescence. EMBO J (2011) 0.94
14-3-3sigma gene silencing during melanoma progression and its role in cell cycle control and cellular senescence. Mol Cancer (2009) 0.92
The retinoblastoma protein modulates Tbx2 functional specificity. Mol Biol Cell (2010) 0.92
Tbx2 controls lung growth by direct repression of the cell cycle inhibitor genes Cdkn1a and Cdkn1b. PLoS Genet (2013) 0.91
Loss of Tbx2 delays optic vesicle invagination leading to small optic cups. Dev Biol (2009) 0.89
Prognostic significance of TBX2 expression in non-small cell lung cancer. J Mol Histol (2014) 0.86
BMP4-Smad signaling pathway mediates adriamycin-induced premature senescence in lung cancer cells. J Biol Chem (2009) 0.86
p63 is an alternative p53 repressor in melanoma that confers chemoresistance and a poor prognosis. J Exp Med (2013) 0.85
Cellular senescence and protein degradation: breaking down cancer. Cell Cycle (2014) 0.85
TBX2 blocks myogenesis and promotes proliferation in rhabdomyosarcoma cells. Int J Cancer (2014) 0.84
TBX2 represses CST6 resulting in uncontrolled legumain activity to sustain breast cancer proliferation: a novel cancer-selective target pathway with therapeutic opportunities. Oncotarget (2014) 0.84
The anti-proliferative function of the TGF-β1 signaling pathway involves the repression of the oncogenic TBX2 by its homologue TBX3. J Biol Chem (2014) 0.84
Skeletal muscle phenotypically converts and selectively inhibits metastatic cells in mice. PLoS One (2010) 0.84
A novel role for the anti-senescence factor TBX2 in DNA repair and cisplatin resistance. Cell Death Dis (2013) 0.83
Anchorage-independent growth of pocket protein-deficient murine fibroblasts requires bypass of G2 arrest and can be accomplished by expression of TBX2. Mol Cell Biol (2008) 0.83
Novel cis-regulatory modules control expression of the Hairy and Enhancer of Split-1 (HES1) transcription factor in myoblasts. J Biol Chem (2011) 0.82
MicroRNA-340-mediated degradation of microphthalmia-associated transcription factor (MITF) mRNA is inhibited by coding region determinant-binding protein (CRD-BP). J Biol Chem (2014) 0.82
Phosphorylation of histone H3 by protein kinase C signaling plays a critical role in the regulation of the developmentally important TBX2 gene. J Biol Chem (2009) 0.81
Brachyury and related Tbx proteins interact with the Mixl1 homeodomain protein and negatively regulate Mixl1 transcriptional activity. PLoS One (2011) 0.81
TBX2 expression is regulated by PAX3 in the melanocyte lineage. Pigment Cell Melanoma Res (2012) 0.81
Changes in the gene expression profile of A375 human melanoma cells induced by overexpression of multifunctional pigment epithelium-derived factor. Melanoma Res (2011) 0.80
Insm1 promotes endocrine cell differentiation by modulating the expression of a network of genes that includes Neurog3 and Ripply3. Development (2014) 0.80
gdf6a is required for cone photoreceptor subtype differentiation and for the actions of tbx2b in determining rod versus cone photoreceptor fate. PLoS One (2014) 0.79
The transcription factors TBX2 and TBX3 interact with human papillomavirus 16 (HPV16) L2 and repress the long control region of HPVs. J Virol (2013) 0.79
The orthologous Tbx transcription factors Omb and TBX2 induce epithelial cell migration and extrusion in vivo without involvement of matrix metalloproteinases. Oncotarget (2014) 0.78
Association of TBX2 and P21 expression with clinicopathological features and survival of laryngeal squamous cell carcinoma. Int J Clin Exp Med (2014) 0.78
New insights into signalling-pathway alterations in rhabdomyosarcoma. Br J Cancer (2014) 0.78
Dynamic expression of Tbx2 and Tbx3 in developing mouse pancreas. Gene Expr Patterns (2011) 0.78
TBX2 represses PTEN in rhabdomyosarcoma and skeletal muscle. Oncogene (2015) 0.78
Expression of the class 1 histone deacetylases HDAC8 and 3 are associated with improved survival of patients with metastatic melanoma. Mod Pathol (2015) 0.77
Proteome profiling of lipopolysaccharide induced L6 rat skeletal muscle cells response to flavonoids from Scutellaria baicalensis Georgi. BMC Complement Altern Med (2014) 0.77
Putative Breast Cancer Driver Mutations in TBX3 Cause Impaired Transcriptional Repression. Front Oncol (2015) 0.77
Tbx2a is required for specification of endodermal pouches during development of the pharyngeal arches. PLoS One (2013) 0.76
SWItching on the transcriptional circuitry in melanoma. Epigenetics (2010) 0.76
Heart chamber size in zebrafish is regulated redundantly by duplicated tbx2 genes. Dev Dyn (2011) 0.76
The T-box transcription factor TBX3 drives proliferation by direct repression of the p21(WAF1) cyclin-dependent kinase inhibitor. Cell Div (2016) 0.76
The role of T-box genes in the tumorigenesis and progression of cancer. Oncol Lett (2016) 0.75
T-box 2 expression predicts poor prognosis in gastric cancer. Oncol Lett (2015) 0.75
Characterizing the Coding Region Determinant-Binding Protein (CRD-BP)-Microphthalmia-associated Transcription Factor (MITF) mRNA interaction. PLoS One (2017) 0.75
TBX2 over-expression promotes nasopharyngeal cancer cell proliferation and invasion. Oncotarget (2017) 0.75
DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer. N Engl J Med (2015) 5.39
Mitf regulation of Dia1 controls melanoma proliferation and invasiveness. Genes Dev (2006) 2.87
Interactions of abiraterone, eplerenone, and prednisolone with wild-type and mutant androgen receptor: a rationale for increasing abiraterone exposure or combining with MDV3100. Cancer Res (2012) 2.81
Mitf cooperates with Rb1 and activates p21Cip1 expression to regulate cell cycle progression. Nature (2005) 2.44
Cancer stem cells versus phenotype-switching in melanoma. Pigment Cell Melanoma Res (2010) 2.43
Prognostic value of blood mRNA expression signatures in castration-resistant prostate cancer: a prospective, two-stage study. Lancet Oncol (2012) 2.31
Beta-catenin induces immortalization of melanocytes by suppressing p16INK4a expression and cooperates with N-Ras in melanoma development. Genes Dev (2007) 1.98
Oncogenic B-RAF(V600E) signaling induces the T-Box3 transcriptional repressor to repress E-cadherin and enhance melanoma cell invasion. J Invest Dermatol (2012) 1.63
Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamides. J Med Chem (2005) 1.51
Tbx3 represses E-cadherin expression and enhances melanoma invasiveness. Cancer Res (2008) 1.48
Tbx2 directly represses the expression of the p21(WAF1) cyclin-dependent kinase inhibitor. Cancer Res (2004) 1.44
The transcription network regulating melanocyte development and melanoma. Pigment Cell Res (2004) 1.42
Precise nucleosome positioning and the TATA box dictate requirements for the histone H4 tail and the bromodomain factor Bdf1. Mol Cell (2004) 1.39
Brn-2 represses microphthalmia-associated transcription factor expression and marks a distinct subpopulation of microphthalmia-associated transcription factor-negative melanoma cells. Cancer Res (2008) 1.37
The microphthalmia-associated transcription factor Mitf interacts with beta-catenin to determine target gene expression. Mol Cell Biol (2006) 1.31
Restoring p53 function in human melanoma cells by inhibiting MDM2 and cyclin B1/CDK1-phosphorylated nuclear iASPP. Cancer Cell (2013) 1.28
The Brn-2 transcription factor links activated BRAF to melanoma proliferation. Mol Cell Biol (2004) 1.24
Target-based approach to inhibitors of histone arginine methyltransferases. J Med Chem (2007) 1.16
Directed phenotype switching as an effective antimelanoma strategy. Cancer Cell (2013) 1.15
Saccharomyces cerevisiae C1D is implicated in both non-homologous DNA end joining and homologous recombination. Mol Microbiol (2002) 1.13
epigenetic multiple ligands: mixed histone/protein methyltransferase, acetyltransferase, and class III deacetylase (sirtuin) inhibitors. J Med Chem (2008) 1.13
TBX3 and its splice variant TBX3 + exon 2a are functionally similar. Pigment Cell Melanoma Res (2008) 1.11
A novel arginine methyltransferase inhibitor with cellular activity. Bioorg Med Chem Lett (2007) 1.09
Brn-2 expression controls melanoma proliferation and is directly regulated by beta-catenin. Mol Cell Biol (2004) 1.09
Analysis of Dll4 regulation reveals a combinatorial role for Sox and Notch in arterial development. Proc Natl Acad Sci U S A (2013) 1.08
TIS7 interacts with the mammalian SIN3 histone deacetylase complex in epithelial cells. EMBO J (2002) 1.07
MC1R is a potent regulator of PTEN after UV exposure in melanocytes. Mol Cell (2013) 1.05
Discovery of uracil-based histone deacetylase inhibitors able to reduce acquired antifungal resistance and trailing growth in Candida albicans. Bioorg Med Chem Lett (2006) 1.02
Biological and mathematical modeling of melanocyte development. Development (2011) 1.02
UV-induced expression of key component of the tanning process, the POMC and MC1R genes, is dependent on the p-38-activated upstream stimulating factor-1 (USF-1). J Biol Chem (2004) 1.02
Regulated displacement of TBP from the PHO8 promoter in vivo requires Cbf1 and the Isw1 chromatin remodeling complex. Mol Cell (2003) 1.01
Divergent roles of HDAC1 and HDAC2 in the regulation of epidermal development and tumorigenesis. EMBO J (2013) 0.98
Histone deacetylases in fungi: novel members, new facts. Nucleic Acids Res (2003) 0.98
PMA-induced up-regulation of TBX3 is mediated by AP-1 and contributes to breast cancer cell migration. Biochem J (2011) 0.98
DNA damage-dependent interaction of the nuclear matrix protein C1D with Translin-associated factor X (TRAX). J Cell Sci (2002) 0.98
Synthesis and biological validation of novel synthetic histone/protein methyltransferase inhibitors. ChemMedChem (2007) 0.97
Beta-catenin in the melanocyte lineage. Pigment Cell Res (2003) 0.97
Identification of two new synthetic histone deacetylase inhibitors that modulate globin gene expression in erythroid cells from healthy donors and patients with thalassemia. Mol Pharmacol (2007) 0.97
HdaA, a major class 2 histone deacetylase of Aspergillus nidulans, affects growth under conditions of oxidative stress. Eukaryot Cell (2005) 0.96
A phosphatidylinositol 3-kinase-Pax3 axis regulates Brn-2 expression in melanoma. Mol Cell Biol (2012) 0.95
Small molecule inhibitors of histone arginine methyltransferases: homology modeling, molecular docking, binding mode analysis, and biological evaluations. J Med Chem (2007) 0.95
The RING domain of RAG1 ubiquitylates histone H3: a novel activity in chromatin-mediated regulation of V(D)J joining. Mol Cell (2010) 0.95
UV-mediated regulation of the anti-senescence factor Tbx2. J Biol Chem (2007) 0.95
Discovery of (aryloxopropenyl)pyrrolyl hydroxyamides as selective inhibitors of class IIa histone deacetylase homologue HD1-A. J Med Chem (2003) 0.92
Histone deacetylase 1 inactivation by an adenovirus early gene product. Curr Biol (2002) 0.92
A novel motif in fungal class 1 histone deacetylases is essential for growth and development of Aspergillus. Mol Biol Cell (2009) 0.92
The retinoblastoma protein modulates Tbx2 functional specificity. Mol Biol Cell (2010) 0.92
Cloning and functional analysis of ascidian Mitf in vivo: insights into the origin of vertebrate pigment cells. Mech Dev (2003) 0.91
ERK-regulated differential expression of the Mitf 6a/b splicing isoforms in melanoma. Pigment Cell Melanoma Res (2009) 0.91
Regulation of melanoblast and retinal pigment epithelium development by Xenopus laevis Mitf. Dev Dyn (2005) 0.90
Design, synthesis and biological evaluation of carboxy analogues of arginine methyltransferase inhibitor 1 (AMI-1). ChemMedChem (2010) 0.90
Histone methyltransferases in Aspergillus nidulans: evidence for a novel enzyme with a unique substrate specificity. Biochemistry (2004) 0.89
Cell cycle regulation of the T-box transcription factor tbx2. Exp Cell Res (2006) 0.88
New pyrrole-based histone deacetylase inhibitors: binding mode, enzyme- and cell-based investigations. Int J Biochem Cell Biol (2008) 0.87
An orchestrated program regulating secretory pathway genes and cargos by the transmembrane transcription factor CREB-H. Traffic (2013) 0.86
Phosphorylation of BRN2 modulates its interaction with the Pax3 promoter to control melanocyte migration and proliferation. Mol Cell Biol (2012) 0.85
TIS7 regulation of the beta-catenin/Tcf-4 target gene osteopontin (OPN) is histone deacetylase-dependent. J Biol Chem (2005) 0.85
Characterization of inhibitor-resistant histone deacetylase activity in plant-pathogenic fungi. Eukaryot Cell (2002) 0.83
Synthesis and biological properties of novel, uracil-containing histone deacetylase inhibitors. J Med Chem (2006) 0.83
Expression of Tbx2 and Tbx3 in the developing hypothalamic-pituitary axis. Gene Expr Patterns (2008) 0.83
Melanosome-autonomous regulation of size and number: the OA1 receptor sustains PMEL expression. Pigment Cell Melanoma Res (2014) 0.82
1,3,4-Oxadiazole-containing histone deacetylase inhibitors: anticancer activities in cancer cells. J Med Chem (2014) 0.82
Novel insights into the functional role of three protein arginine methyltransferases in Aspergillus nidulans. Fungal Genet Biol (2010) 0.81
T-box factors: targeting to chromatin and interaction with the histone H3 N-terminal tail. Pigment Cell Res (2007) 0.80
Novel pyrrole-containing histone deacetylase inhibitors endowed with cytodifferentiation activity. Int J Biochem Cell Biol (2007) 0.80
Class II-selective histone deacetylase inhibitors. Part 2: alignment-independent GRIND 3-D QSAR, homology and docking studies. Eur J Med Chem (2007) 0.79
Exploring the connection unit in the HDAC inhibitor pharmacophore model: novel uracil-based hydroxamates. Bioorg Med Chem Lett (2005) 0.79
Characterisation of the Phosphatidylinositol 3-Kinase Pathway in Non-Small Cell Lung Cancer Cells Isolated from Pleural Effusions. Oncology (2016) 0.77
Chromatin barcodes as biomarkers for melanoma. Pigment Cell Melanoma Res (2014) 0.76
3-(4-Aroyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 2. Effect of pyrrole-C2 and/or -C4 substitutions on biological activity. J Med Chem (2004) 0.76
Sensitivity to anti-BRAF therapy: lost in translation. Pigment Cell Melanoma Res (2014) 0.75
Aroyl-pyrrolyl hydroxyamides: influence of pyrrole C4-phenylacetyl substitution on histone deacetylase inhibition. ChemMedChem (2006) 0.75
Novel cinnamyl hydroxyamides and 2-aminoanilides as histone deacetylase inhibitors: apoptotic induction and cytodifferentiation activity. ChemMedChem (2011) 0.75
Restoring p53 Function in Human Melanoma Cells by Inhibiting MDM2 and Cyclin B1/CDK1-Phosphorylated Nuclear iASPP. Cancer Cell (2016) 0.75
Melanoma senescence: HDAC1 in focus. Pigment Cell Res (2007) 0.75