Published in Nat Methods on January 01, 2005
New mouse lines for the analysis of neuronal morphology using CreER(T)/loxP-directed sparse labeling. PLoS One (2009) 1.28
Genetically engineered mouse models in cancer research. Adv Cancer Res (2010) 1.18
The Ews-ERG fusion protein can initiate neoplasia from lineage-committed haematopoietic cells. PLoS Biol (2005) 1.01
Animal models of soft-tissue sarcoma. Dis Model Mech (2010) 1.01
Rearranging the centromere of the human Y chromosome with phiC31 integrase. Nucleic Acids Res (2005) 0.99
GFP-tagged proteins visualized by freeze-fracture immuno-electron microscopy: a new tool in cellular and molecular medicine. J Cell Mol Med (2008) 0.91
The construction of transgenic and gene knockout/knockin mouse models of human disease. Transgenic Res (2011) 0.91
Mouse chromosome engineering for modeling human disease. Annu Rev Genomics Hum Genet (2006) 0.90
Genomic hallmarks of genes involved in chromosomal translocations in hematological cancer. PLoS Comput Biol (2012) 0.83
Cancer gene discovery in mouse and man. Biochim Biophys Acta (2009) 0.81
High expression of precursor microRNA-155/BIC RNA in children with Burkitt lymphoma. Genes Chromosomes Cancer (2004) 11.79
Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity. Nature (2010) 10.34
Activation of the T-cell oncogene LMO2 after gene therapy for X-linked severe combined immunodeficiency. N Engl J Med (2004) 4.05
Transcription factor RORα is critical for nuocyte development. Nat Immunol (2012) 3.72
A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q- syndrome. Nat Med (2009) 2.89
Innate IL-13-producing nuocytes arise during allergic lung inflammation and contribute to airways hyperreactivity. J Allergy Clin Immunol (2011) 2.80
The Lmo2 oncogene initiates leukemia in mice by inducing thymocyte self-renewal. Science (2010) 2.64
Progressive 3q amplification consistently targets SOX2 in preinvasive squamous lung cancer. Am J Respir Crit Care Med (2010) 2.04
Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndrome. Genes Dev (2011) 1.89
Extending the repertoire of the mixed-lineage leukemia gene MLL in leukemogenesis. Genes Dev (2004) 1.81
Engineering de novo reciprocal chromosomal translocations associated with Mll to replicate primary events of human cancer. Cancer Cell (2003) 1.79
Lmo2 and Scl/Tal1 convert non-axial mesoderm into haemangioblasts which differentiate into endothelial cells in the absence of Gata1. Development (2003) 1.67
Distinct pathways regulated by menin and by MLL1 in hematopoietic stem cells and developing B cells. Blood (2013) 1.60
The role of LMO2 in development and in T cell leukemia after chromosomal translocation or retroviral insertion. Mol Ther (2005) 1.52
Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia. Nat Immunol (2010) 1.49
Interrogation of genomes by molecular copy-number counting (MCC). Nat Methods (2006) 1.47
The LMO2 T-cell oncogene is activated via chromosomal translocations or retroviral insertion during gene therapy but has no mandatory role in normal T-cell development. Mol Cell Biol (2003) 1.44
Late relapses evolve from slow-responding subclones in t(12;21)-positive acute lymphoblastic leukemia: evidence for the persistence of a preleukemic clone. Blood (2002) 1.32
Prenatal and postnatal myeloid cells demonstrate stepwise progression in the pathogenesis of MLL fusion gene leukemia. Blood (2002) 1.27
Mouse Af9 is a controller of embryo patterning, like Mll, whose human homologue fuses with Af9 after chromosomal translocation in leukemia. Mol Cell Biol (2002) 1.26
ETV6/RUNX1-positive relapses evolve from an ancestral clone and frequently acquire deletions of genes implicated in glucocorticoid signaling. Blood (2011) 1.21
Induction of p53 and up-regulation of the p53 pathway in the human 5q- syndrome. Blood (2010) 1.17
Single-molecule analysis of human telomerase monomer. Nat Chem Biol (2008) 1.16
The role of Slit-Robo signaling in the generation, migration and morphological differentiation of cortical interneurons. Dev Biol (2007) 1.15
The promiscuous MLL gene links chromosomal translocations to cellular differentiation and tumour tropism. Trends Mol Med (2002) 1.12
Intrabodies based on intracellular capture frameworks that bind the RAS protein with high affinity and impair oncogenic transformation. EMBO J (2003) 1.12
Tumour prevention by a single antibody domain targeting the interaction of signal transduction proteins with RAS. EMBO J (2007) 1.11
Intracellular antibodies and challenges facing their use as therapeutic agents. Trends Mol Med (2003) 1.09
PCRPi: Presaging Critical Residues in Protein interfaces, a new computational tool to chart hot spots in protein interfaces. Nucleic Acids Res (2009) 1.08
Differences in DNA methylation patterns and expression of the CCRK gene in human and nonhuman primate cortices. Mol Biol Evol (2009) 1.07
Analysis of t(9;11) chromosomal breakpoint sequences in childhood acute leukemia: almost identical MLL breakpoints in therapy-related AML after treatment without etoposides. Genes Chromosomes Cancer (2003) 1.06
Targeted disruption of the 3p12 gene, Dutt1/Robo1, predisposes mice to lung adenocarcinomas and lymphomas with methylation of the gene promoter. Cancer Res (2004) 1.04
Blocking IL-25 signalling protects against gut inflammation in a type-2 model of colitis by suppressing nuocyte and NKT derived IL-13. J Gastroenterol (2012) 1.04
De novo production of diverse intracellular antibody libraries. Nucleic Acids Res (2003) 1.03
The Ews-ERG fusion protein can initiate neoplasia from lineage-committed haematopoietic cells. PLoS Biol (2005) 1.01
Single domain intracellular antibodies: a minimal fragment for direct in vivo selection of antigen-specific intrabodies. J Mol Biol (2003) 1.00
Limiting dilution bisulfite (pyro)sequencing reveals parent-specific methylation patterns in single early mouse embryos and bovine oocytes. Epigenetics (2011) 0.99
The LIM-domain protein Lmo2 is a key regulator of tumour angiogenesis: a new anti-angiogenesis drug target. Oncogene (2002) 0.98
Intracellular antibody capture technology: application to selection of intracellular antibodies recognising the BCR-ABL oncogenic protein. J Mol Biol (2002) 0.98
Mll fusions generated by Cre-loxP-mediated de novo translocations can induce lineage reassignment in tumorigenesis. EMBO J (2005) 0.95
Protracted postnatal natural histories in childhood leukemia. Genes Chromosomes Cancer (2004) 0.93
Homozygous disruption of PDZD7 by reciprocal translocation in a consanguineous family: a new member of the Usher syndrome protein interactome causing congenital hearing impairment. Hum Mol Genet (2008) 0.93
Requirement for Lyl1 in a model of Lmo2-driven early T-cell precursor ALL. Blood (2013) 0.89
New insights into 5q- syndrome as a ribosomopathy. Cell Cycle (2010) 0.89
Genomic EWS-FLI1 fusion sequences in Ewing sarcoma resemble breakpoint characteristics of immature lymphoid malignancies. PLoS One (2013) 0.88
Intracellular antibodies and cancer: new technologies offer therapeutic opportunities. Bioessays (2010) 0.88
Adrenomedullin, calcitonin gene-related peptide and their receptors: evidence for a decreased placental mRNA content in preeclampsia and HELLP syndrome. Eur J Obstet Gynecol Reprod Biol (2002) 0.87
Spontaneous B cell hyperactivity in autoimmune-prone MRL mice. Int Immunol (2006) 0.87
Insights into the infiltrative behavior of adamantinomatous craniopharyngioma in a new xenotransplant mouse model. Brain Pathol (2014) 0.87
Recurrent Somatic PDGFRB Mutations in Sporadic Infantile/Solitary Adult Myofibromas But Not in Angioleiomyomas and Myopericytomas. Am J Surg Pathol (2016) 0.85
Changing the subcellular location of the oncoprotein Bcr-Abl using rationally designed capture motifs. Pharm Res (2011) 0.85
Use of MLL/GRAF fusion mRNA for measurement of minimal residual disease during chemotherapy in an infant with acute monoblastic leukemia (AML-M5). Genes Chromosomes Cancer (2005) 0.85
NQO1 C609T polymorphism in distinct entities of pediatric hematologic neoplasms. Haematologica (2004) 0.84
Identification of the genomic BCR-ABL1 fusion sequence from blood specimen stored on filter paper. Leuk Res (2012) 0.84
Functional intracellular antibody fragments do not require invariant intra-domain disulfide bonds. J Mol Biol (2007) 0.83
Protocol for the selection of single-domain antibody fragments by third generation intracellular antibody capture. Nat Protoc (2009) 0.83
The first European interdisciplinary ewing sarcoma research summit. Front Oncol (2012) 0.82
Interfering with protein-protein interactions: potential for cancer therapy. Cell Cycle (2008) 0.82
Nonreciprocal chromosomal translocations in renal cancer involve multiple DSBs and NHEJ associated with breakpoint inversion but not necessarily with transcription. Genes Chromosomes Cancer (2013) 0.81
De novo t(12;17)(p13.3;q21.3) translocation with a breakpoint near the 5' end of the HOXB gene cluster in a patient with developmental delay and skeletal malformations. Eur J Hum Genet (2007) 0.81
Sub-proteome differential display: single gel comparison by 2D electrophoresis and mass spectrometry. J Mol Biol (2002) 0.81
Single domain intracellular antibodies from diverse libraries: emphasizing dual functions of LMO2 protein interactions using a single VH domain. J Biol Chem (2010) 0.81
Modeling chromosomal translocations using conditional alleles to recapitulate initiating events in human leukemias. J Natl Cancer Inst Monogr (2008) 0.80
Functional inhibition of β-catenin-mediated Wnt signaling by intracellular VHH antibodies. MAbs (2015) 0.80
Response monitoring of infant acute myeloid leukemia treatment by quantification of the tumor specific MLL-FNBP1 fusion gene. Leuk Lymphoma (2014) 0.80
Screening for leukemia- and clone-specific markers at birth in children with T-cell precursor ALL suggests a predominantly postnatal origin. Blood (2007) 0.80
An unusual manifestation of Wegener's granulomatosis in a 4-year-old girl. Pediatr Neurol (2002) 0.80
Hematologic features and clinical course of an infant with Pearson syndrome caused by a novel deletion of mitochondrial DNA. J Pediatr Hematol Oncol (2003) 0.79
Genomic BCR-ABL1 breakpoints in pediatric chronic myeloid leukemia. Genes Chromosomes Cancer (2012) 0.79
Mouse models for the genetic dissection of atopy. Int Arch Allergy Immunol (2002) 0.78
Preclinical modeling of cytosine arabinoside response in Mll-Enl translocator mouse leukemias. Mol Cancer Ther (2008) 0.77
Intracellular antibody capture (IAC) methods for single domain antibodies. Methods Mol Biol (2012) 0.77
Occurrence of an MLL/LAF4 fusion gene caused by the insertion ins(11;2)(q23;q11.2q11.2) in an infant with acute lymphoblastic leukemia. Genes Chromosomes Cancer (2003) 0.77
The turnover of synovial T cells is higher than in T cells in the peripheral blood in persistent oligoarticular juvenile idiopathic arthritis. Rheumatol Int (2010) 0.77
Indirect determination of pediatric blood count reference intervals. Clin Chem Lab Med (2013) 0.77
Selection of complementary single-variable domains for building monoclonal antibodies to native proteins. Nucleic Acids Res (2009) 0.76
Frequent and sex-biased deletion of SLX4IP by illegitimate V(D)J-mediated recombination in childhood acute lymphoblastic leukemia. Hum Mol Genet (2013) 0.76