Published in Science on January 21, 2010
Cells of origin in cancer. Nature (2011) 6.85
The molecular basis of T cell acute lymphoblastic leukemia. J Clin Invest (2012) 3.09
Reprogramming committed murine blood cells to induced hematopoietic stem cells with defined factors. Cell (2014) 2.44
Dynamic transformations of genome-wide epigenetic marking and transcriptional control establish T cell identity. Cell (2012) 2.38
Cell competition is a tumour suppressor mechanism in the thymus. Nature (2014) 1.97
Clonal evolution enhances leukemia-propagating cell frequency in T cell acute lymphoblastic leukemia through Akt/mTORC1 pathway activation. Cancer Cell (2014) 1.79
Signal integration and crosstalk during thymocyte migration and emigration. Nat Rev Immunol (2011) 1.45
Nuclear adaptor Ldb1 regulates a transcriptional program essential for the maintenance of hematopoietic stem cells. Nat Immunol (2010) 1.43
Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes. Genes Dev (2010) 1.42
Prediction of survival in diffuse large B-cell lymphoma based on the expression of 2 genes reflecting tumor and microenvironment. Blood (2011) 1.41
Multilayered specification of the T-cell lineage fate. Immunol Rev (2010) 1.32
LIM-domain-only proteins in cancer. Nat Rev Cancer (2013) 1.19
Developmental gene networks: a triathlon on the course to T cell identity. Nat Rev Immunol (2014) 1.14
Current advances in retroviral gene therapy. Curr Gene Ther (2011) 1.13
Hematopoietic stem cell engineering at a crossroads. Blood (2011) 1.10
Gene therapy on the move. EMBO Mol Med (2013) 1.10
Genetic predisposition to neuroblastoma mediated by a LMO1 super-enhancer polymorphism. Nature (2015) 1.07
Gene set control analysis predicts hematopoietic control mechanisms from genome-wide transcription factor binding data. Exp Hematol (2012) 1.06
Notch1 inhibition targets the leukemia-initiating cells in a Tal1/Lmo2 mouse model of T-ALL. Blood (2011) 1.03
Notch signaling expands a pre-malignant pool of T-cell acute lymphoblastic leukemia clones without affecting leukemia-propagating cell frequency. Leukemia (2012) 1.03
Integrated cistromic and expression analysis of amplified NKX2-1 in lung adenocarcinoma identifies LMO3 as a functional transcriptional target. Genes Dev (2013) 1.00
Functional interactions between Lmo2, the Arf tumor suppressor, and Notch1 in murine T-cell malignancies. Blood (2011) 0.98
BET protein inhibition shows efficacy against JAK2V617F-driven neoplasms. Leukemia (2013) 0.97
Lmo2 induces hematopoietic stem cell-like features in T-cell progenitor cells prior to leukemia. Stem Cells (2013) 0.96
ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling. Nat Commun (2015) 0.91
LIM domain only-2 (LMO2) induces T-cell leukemia by two distinct pathways. PLoS One (2014) 0.91
Regulatory gene network circuits underlying T cell development from multipotent progenitors. Wiley Interdiscip Rev Syst Biol Med (2011) 0.91
A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth. Genes Dev (2015) 0.91
Identification of LMO2 transcriptome and interactome in diffuse large B-cell lymphoma. Blood (2012) 0.90
Identification of c-Myb Target Genes in K562 Cells Reveals a Role for c-Myb as a Master Regulator. Genes Cancer (2011) 0.89
The LIM-only transcription factor LMO2 determines tumorigenic and angiogenic traits in glioma stem cells. Cell Death Differ (2015) 0.87
LMO2 at 25 years: a paradigm of chromosomal translocation proteins. Open Biol (2015) 0.86
Cancer stem cells: potential target for bioactive food components. J Nutr Biochem (2012) 0.86
Role of the transcription factor Bcl11b in development and lymphomagenesis. Proc Jpn Acad Ser B Phys Biol Sci (2012) 0.85
SCL, LMO1 and Notch1 reprogram thymocytes into self-renewing cells. PLoS Genet (2014) 0.84
HOX-mediated LMO2 expression in embryonic mesoderm is recapitulated in acute leukaemias. Oncogene (2013) 0.83
A mouse model for inducible overexpression of Prdm14 results in rapid-onset and highly penetrant T-cell acute lymphoblastic leukemia (T-ALL). Dis Model Mech (2013) 0.82
Hhex is Required at Multiple Stages of Adult Hematopoietic Stem and Progenitor Cell Differentiation. Stem Cells (2015) 0.81
Targeting leukemia stem cells: which pathways drive self-renewal activity in T-cell acute lymphoblastic leukemia? Curr Oncol (2016) 0.81
Transcription factor-mediated reprogramming toward hematopoietic stem cells. EMBO J (2015) 0.81
Self-renewal of thymocytes in the absence of competitive precursor replenishment. J Exp Med (2012) 0.80
Solution structure of a tethered Lmo2(LIM2) /Ldb1(LID) complex. Protein Sci (2012) 0.80
Beyond transcription factors: how oncogenic signalling reshapes the epigenetic landscape. Nat Rev Cancer (2016) 0.80
Transcriptional establishment of cell-type identity: dynamics and causal mechanisms of T-cell lineage commitment. Cold Spring Harb Symp Quant Biol (2013) 0.79
It takes two to tango, a dance between the cells of origin and cancer stem cells in the Drosophila larval brain. Semin Cell Dev Biol (2014) 0.79
Loss of T cell progenitor checkpoint control underlies leukemia initiation in Rag1-deficient nonobese diabetic mice. J Immunol (2013) 0.79
BCAT1 expression associates with ovarian cancer progression: possible implications in altered disease metabolism. Oncotarget (2015) 0.79
LMO2 induces T-cell leukemia with epigenetic deregulation of CD4. Exp Hematol (2014) 0.79
Cancer chemoprevention by traditional chinese herbal medicine and dietary phytochemicals: targeting nrf2-mediated oxidative stress/anti-inflammatory responses, epigenetics, and cancer stem cells. J Tradit Complement Med (2013) 0.79
Hhex regulates Kit to promote radioresistance of self-renewing thymocytes in Lmo2-transgenic mice. Leukemia (2014) 0.79
Cyclophosphamide alters the gene expression profile in patients treated with high doses prior to stem cell transplantation. PLoS One (2014) 0.78
Acute myeloid leukemia requires Hhex to enable PRC2-mediated epigenetic repression of Cdkn2a. Genes Dev (2016) 0.78
LMO2 promotes tumor cell invasion and metastasis in basal-type breast cancer by altering actin cytoskeleton remodeling. Oncotarget (2016) 0.78
Integration site and clonal expansion in human chronic retroviral infection and gene therapy. Viruses (2014) 0.78
Bivalent promoter marks and a latent enhancer may prime the leukaemia oncogene LMO1 for ectopic expression in T-cell leukaemia. Leukemia (2013) 0.78
Loss-of-function mutations of Dynamin 2 promote T-ALL by enhancing IL-7 signalling. Leukemia (2016) 0.78
Contribution of JAK2 mutations to T-cell lymphoblastic lymphoma development. Leukemia (2015) 0.77
PRDM1/Blimp1 downregulates expression of germinal center genes LMO2 and HGAL. FEBS J (2011) 0.77
Enforced expression of E47 has differential effects on Lmo2-induced T-cell leukemias. Leuk Res (2014) 0.77
Epigenetic regulation of the Ink4a-Arf (Cdkn2a) tumor suppressor locus in the initiation and progression of Notch1-driven T cell acute lymphoblastic leukemia. Exp Hematol (2012) 0.76
FOXP3 can modulate TAL1 transcriptional activity through interaction with LMO2. Oncogene (2015) 0.76
The T-ALL paradox in cancer. Nat Med (2010) 0.76
The thymus under siege: Lmo2 induces precancerous stem cells in a mouse model of T-ALL. Cell Cycle (2010) 0.76
Evaluating the Safety of Retroviral Vectors Based on Insertional Oncogene Activation and Blocked Differentiation in Cultured Thymocytes. Mol Ther (2016) 0.76
The LMO2 oncogene regulates DNA replication in hematopoietic cells. Proc Natl Acad Sci U S A (2016) 0.76
LMO2 and IL2RG synergize in thymocytes to mimic the evolution of SCID-X1 gene therapy-associated T-cell leukaemia. Leukemia (2016) 0.76
Conformational flexibility of the oncogenic protein LMO2 primes the formation of the multi-protein transcription complex. Sci Rep (2014) 0.76
LMO2 Enhances Lamellipodia/Filopodia Formation in Basal-Type Breast Cancer Cells by Mediating ARP3-Profilin1 Interaction. Med Sci Monit (2017) 0.75
High-throughput screening in niche-based assay identifies compounds to target preleukemic stem cells. J Clin Invest (2016) 0.75
LMO2 Oncoprotein Stability in T-Cell Leukemia Requires Direct LDB1 Binding. Mol Cell Biol (2015) 0.75
The LMO2 -25 Region Harbours GATA2-Dependent Myeloid Enhancer and RUNX-Dependent T-Lymphoid Repressor Activity. PLoS One (2015) 0.75
Modelling acute leukemias in mice: clonal evolution and the emergence of leukemic stem cells. BMC Proc (2013) 0.75
Limiting Thymic Precursor Supply Increases the Risk of Lymphoid Malignancy in Murine X-Linked Severe Combined Immunodeficiency. Mol Ther Nucleic Acids (2016) 0.75
Misregulation of the proline rich homeodomain (PRH/HHEX) protein in cancer cells and its consequences for tumour growth and invasion. Cell Biosci (2016) 0.75
Leukemia-Initiating Cells in T-Cell Acute Lymphoblastic Leukemia. Front Oncol (2017) 0.75
LMO2 is required for TAL1 DNA binding activity and initiation of definitive haematopoiesis at the haemangioblast stage. Nucleic Acids Res (2017) 0.75
Activation of the T-cell oncogene LMO2 after gene therapy for X-linked severe combined immunodeficiency. N Engl J Med (2004) 4.05
Regulation of intestinal inflammation by microbiota following allogeneic bone marrow transplantation. J Exp Med (2012) 3.17
The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells. Nat Immunol (2008) 3.07
Interleukin-22 protects intestinal stem cells from immune-mediated tissue damage and regulates sensitivity to graft versus host disease. Immunity (2012) 2.99
Interleukin-22 drives endogenous thymic regeneration in mice. Science (2012) 2.96
A homolog of Drosophila grainy head is essential for epidermal integrity in mice. Science (2005) 2.72
Genetically tagging endothelial cells in vivo: bone marrow-derived cells do not contribute to tumor endothelium. Blood (2004) 2.30
The critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, erythropoiesis, and lineage choice in CFU-S12. Proc Natl Acad Sci U S A (2003) 2.12
Progressive 3q amplification consistently targets SOX2 in preinvasive squamous lung cancer. Am J Respir Crit Care Med (2010) 2.04
Single-chain antigen recognition receptors that costimulate potent rejection of established experimental tumors. Blood (2002) 1.83
Extending the repertoire of the mixed-lineage leukemia gene MLL in leukemogenesis. Genes Dev (2004) 1.81
Engineering de novo reciprocal chromosomal translocations associated with Mll to replicate primary events of human cancer. Cancer Cell (2003) 1.79
Erg is required for self-renewal of hematopoietic stem cells during stress hematopoiesis in mice. Blood (2011) 1.69
Adult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survival. Cell Stem Cell (2009) 1.69
Lmo2 and Scl/Tal1 convert non-axial mesoderm into haemangioblasts which differentiate into endothelial cells in the absence of Gata1. Development (2003) 1.67
A highly conserved novel family of mammalian developmental transcription factors related to Drosophila grainyhead. Mech Dev (2002) 1.64
Targeting of the tumor suppressor GRHL3 by a miR-21-dependent proto-oncogenic network results in PTEN loss and tumorigenesis. Cancer Cell (2011) 1.63
Distinct pathways regulated by menin and by MLL1 in hematopoietic stem cells and developing B cells. Blood (2013) 1.60
Polycomb repressive complex 2 (PRC2) restricts hematopoietic stem cell activity. PLoS Biol (2008) 1.53
The role of LMO2 in development and in T cell leukemia after chromosomal translocation or retroviral insertion. Mol Ther (2005) 1.52
Inositol- and folate-resistant neural tube defects in mice lacking the epithelial-specific factor Grhl-3. Nat Med (2003) 1.51
Underestimation of myelodysplastic syndrome incidence by cancer registries: Results from a population-based data linkage study. Cancer (2014) 1.50
Interrogation of genomes by molecular copy-number counting (MCC). Nat Methods (2006) 1.47
Unbiased analysis, enrichment and purification of thymic stromal cells. J Immunol Methods (2007) 1.45
The LMO2 T-cell oncogene is activated via chromosomal translocations or retroviral insertion during gene therapy but has no mandatory role in normal T-cell development. Mol Cell Biol (2003) 1.44
Perturbed desmosomal cadherin expression in grainy head-like 1-null mice. EMBO J (2008) 1.42
A mouse model of harlequin ichthyosis delineates a key role for Abca12 in lipid homeostasis. PLoS Genet (2008) 1.40
Nrf2 regulates haematopoietic stem cell function. Nat Cell Biol (2013) 1.38
Spatial and temporal expression of the Grainyhead-like transcription factor family during murine development. Gene Expr Patterns (2006) 1.35
The alpha-toxin of Clostridium septicum is essential for virulence. Mol Microbiol (2005) 1.32
Prospective analysis of incidence and risk factors of dysphagia in spine surgery patients: comparison of anterior cervical, posterior cervical, and lumbar procedures. Spine (Phila Pa 1976) (2004) 1.31
Rejection of syngeneic colon carcinoma by CTLs expressing single-chain antibody receptors codelivering CD28 costimulation. J Immunol (2002) 1.31
Identification of a PRMT5-dependent repressor complex linked to silencing of human fetal globin gene expression. Blood (2010) 1.28
Prenatal and postnatal myeloid cells demonstrate stepwise progression in the pathogenesis of MLL fusion gene leukemia. Blood (2002) 1.27
Mouse Af9 is a controller of embryo patterning, like Mll, whose human homologue fuses with Af9 after chromosomal translocation in leukemia. Mol Cell Biol (2002) 1.26
Epidermal wound repair is regulated by the planar cell polarity signaling pathway. Dev Cell (2010) 1.25
Regional neural tube closure defined by the Grainy head-like transcription factors. Dev Biol (2010) 1.23
Hmgb3: an HMG-box family member expressed in primitive hematopoietic cells that inhibits myeloid and B-cell differentiation. Blood (2003) 1.20
SCL is required for normal function of short-term repopulating hematopoietic stem cells. Blood (2004) 1.20
LIM-domain-only proteins in cancer. Nat Rev Cancer (2013) 1.19
Distinct domains of erythroid Krüppel-like factor modulate chromatin remodeling and transactivation at the endogenous beta-globin gene promoter. Mol Cell Biol (2002) 1.17
The unique and cooperative roles of the Grainy head-like transcription factors in epidermal development reflect unexpected target gene specificity. Dev Biol (2010) 1.17
Single-molecule analysis of human telomerase monomer. Nat Chem Biol (2008) 1.16
The role of Slit-Robo signaling in the generation, migration and morphological differentiation of cortical interneurons. Dev Biol (2007) 1.15
Estimating the proportion of microarray probes expressed in an RNA sample. Nucleic Acids Res (2010) 1.14
The promiscuous MLL gene links chromosomal translocations to cellular differentiation and tumour tropism. Trends Mol Med (2002) 1.12
Intrabodies based on intracellular capture frameworks that bind the RAS protein with high affinity and impair oncogenic transformation. EMBO J (2003) 1.12
Tumour prevention by a single antibody domain targeting the interaction of signal transduction proteins with RAS. EMBO J (2007) 1.11
The identification and characterization of human Sister-of-Mammalian Grainyhead (SOM) expands the grainyhead-like family of developmental transcription factors. Biochem J (2003) 1.10
Adoptive transfer of gene-engineered CD4+ helper T cells induces potent primary and secondary tumor rejection. Blood (2005) 1.10
Critical roles for c-Myb in lymphoid priming and early B-cell development. Blood (2010) 1.09
Intracellular antibodies and challenges facing their use as therapeutic agents. Trends Mol Med (2003) 1.09
PCRPi: Presaging Critical Residues in Protein interfaces, a new computational tool to chart hot spots in protein interfaces. Nucleic Acids Res (2009) 1.08
Molecular and cellular basis of microvascular perfusion deficits induced by Clostridium perfringens and Clostridium septicum. PLoS Pathog (2008) 1.07
The functional basis for hemophagocytic lymphohistiocytosis in a patient with co-inherited missense mutations in the perforin (PFN1) gene. J Exp Med (2004) 1.05
Novel roles for erythroid Ankyrin-1 revealed through an ENU-induced null mouse mutant. Blood (2009) 1.04
A functional role for CD28 costimulation in tumor recognition by single-chain receptor-modified T cells. Cancer Gene Ther (2004) 1.03
De novo production of diverse intracellular antibody libraries. Nucleic Acids Res (2003) 1.03
BMP4-dependent expression of Xenopus Grainyhead-like 1 is essential for epidermal differentiation. Development (2005) 1.02
Functional but abnormal adult erythropoiesis in the absence of the stem cell leukemia gene. Mol Cell Biol (2005) 1.02
The generation and properties of human macrophage populations from hemopoietic stem cells. J Leukoc Biol (2009) 1.01
The Ews-ERG fusion protein can initiate neoplasia from lineage-committed haematopoietic cells. PLoS Biol (2005) 1.01
Aberrant mast-cell differentiation in mice lacking the stem-cell leukemia gene. Blood (2007) 1.01
Single domain intracellular antibodies: a minimal fragment for direct in vivo selection of antigen-specific intrabodies. J Mol Biol (2003) 1.00
The role of p22 NF-E4 in human globin gene switching. J Biol Chem (2004) 0.99
Site-specific acetylation of the fetal globin activator NF-E4 prevents its ubiquitination and regulates its interaction with the histone deacetylase, HDAC1. J Biol Chem (2004) 0.99
Binding of the RING polycomb proteins to specific target genes in complex with the grainyhead-like family of developmental transcription factors. Mol Cell Biol (2002) 0.98
Intracellular antibody capture technology: application to selection of intracellular antibodies recognising the BCR-ABL oncogenic protein. J Mol Biol (2002) 0.98
The LIM-domain protein Lmo2 is a key regulator of tumour angiogenesis: a new anti-angiogenesis drug target. Oncogene (2002) 0.98
Functional interaction of CP2 with GATA-1 in the regulation of erythroid promoters. Mol Cell Biol (2006) 0.97
Adoptively transferred TRAIL+ T cells suppress GVHD and augment antitumor activity. J Clin Invest (2013) 0.96
Point mutation in the gene encoding p300 suppresses thrombocytopenia in Mpl-/- mice. Blood (2008) 0.95
Mll fusions generated by Cre-loxP-mediated de novo translocations can induce lineage reassignment in tumorigenesis. EMBO J (2005) 0.95
The Hedgehog receptor Patched1 regulates myeloid and lymphoid progenitors by distinct cell-extrinsic mechanisms. Blood (2009) 0.95
A critical role for the transcription factor Scl in platelet production during stress thrombopoiesis. Blood (2006) 0.94
Granulocyte colony-stimulating factor and stem cell factor improve endogenous repair after myocardial infarction. Cardiovasc Res (2006) 0.94
Defective extraembryonic angiogenesis in mice lacking LBP-1a, a member of the grainyhead family of transcription factors. Mol Cell Biol (2004) 0.92
Sex steroid ablation enhances immune reconstitution following cytotoxic antineoplastic therapy in young mice. J Immunol (2010) 0.90
Inhibition of apoptosis by BCL2 prevents leukemic transformation of a murine myelodysplastic syndrome. Blood (2012) 0.90
Requirement for Lyl1 in a model of Lmo2-driven early T-cell precursor ALL. Blood (2013) 0.89
Grhl3 and Lmo4 play coordinate roles in epidermal migration. Dev Biol (2008) 0.89
The invertor knock-in conditional chromosomal translocation mimic. Nat Methods (2005) 0.88
ENU mutagenesis identifies the first mouse mutants reproducing human β-thalassemia at the genomic level. Blood Cells Mol Dis (2012) 0.88
Cochlear implants for DFNA17 deafness. Laryngoscope (2006) 0.88
Intracellular antibodies and cancer: new technologies offer therapeutic opportunities. Bioessays (2010) 0.88
The planar cell polarity pathway in vertebrate epidermal development, homeostasis and repair. Organogenesis (2011) 0.87
Age-associated changes in the differentiation potentials of human circulating hematopoietic progenitors to T- or NK-lineage cells. J Immunol (2013) 0.86