Three-dimensional EM structure of the ectodomain of integrin {alpha}V{beta}3 in a complex with fibronectin.

PubWeight™: 1.97‹?› | Rank: Top 2%

🔗 View Article (PMC 2171847)

Published in J Cell Biol on March 28, 2005

Authors

Brian D Adair1, Jian-Ping Xiong, Catherine Maddock, Simon L Goodman, M Amin Arnaout, Mark Yeager

Author Affiliations

1: Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

Articles citing this

Structural basis of integrin regulation and signaling. Annu Rev Immunol (2007) 8.60

The final steps of integrin activation: the end game. Nat Rev Mol Cell Biol (2010) 4.72

The integrins. Genome Biol (2007) 3.72

Integrin structure, activation, and interactions. Cold Spring Harb Perspect Biol (2011) 2.58

Structure and mechanics of integrin-based cell adhesion. Curr Opin Cell Biol (2007) 2.48

Recreation of the terminal events in physiological integrin activation. J Cell Biol (2010) 2.48

The structure of the integrin alphaIIbbeta3 transmembrane complex explains integrin transmembrane signalling. EMBO J (2009) 2.45

The GPIIb/IIIa (integrin alphaIIbbeta3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend. Blood (2008) 2.22

Linking integrin conformation to function. J Cell Sci (2009) 2.15

Integrin structures and conformational signaling. Curr Opin Cell Biol (2006) 2.03

The antithrombotic potential of selective blockade of talin-dependent integrin alpha IIb beta 3 (platelet GPIIb-IIIa) activation. J Clin Invest (2007) 1.95

Genetic analysis of beta1 integrin "activation motifs" in mice. J Cell Biol (2006) 1.73

Crystal structure of the complete integrin alphaVbeta3 ectodomain plus an alpha/beta transmembrane fragment. J Cell Biol (2009) 1.68

The tail of integrin activation. Trends Biochem Sci (2011) 1.62

How the headpiece hinge angle is opened: New insights into the dynamics of integrin activation. J Cell Biol (2006) 1.60

Crystal structure of α5β1 integrin ectodomain: atomic details of the fibronectin receptor. J Cell Biol (2012) 1.52

The beta-tail domain (betaTD) regulates physiologic ligand binding to integrin CD11b/CD18. Blood (2006) 1.40

Complete integrin headpiece opening in eight steps. J Cell Biol (2013) 1.37

Integrin activation. Biochem Soc Trans (2008) 1.36

Closed headpiece of integrin αIIbβ3 and its complex with an αIIbβ3-specific antagonist that does not induce opening. Blood (2010) 1.29

Integrin alpha IIb beta 3 in a membrane environment remains the same height after Mn2+ activation when observed by cryoelectron tomography. J Mol Biol (2008) 1.29

Tests of the extension and deadbolt models of integrin activation. J Biol Chem (2007) 1.28

Focal adhesions are sites of integrin extension. J Cell Biol (2010) 1.26

Specific integrin alpha and beta chain phosphorylations regulate LFA-1 activation through affinity-dependent and -independent mechanisms. J Cell Biol (2005) 1.25

Integrin conformational regulation: uncoupling extension/tail separation from changes in the head region by a multiresolution approach. Structure (2008) 1.16

Structural specializations of α(4)β(7), an integrin that mediates rolling adhesion. J Cell Biol (2012) 1.13

Neutrophil arrest by LFA-1 activation. Front Immunol (2012) 1.11

Clustering and internalization of integrin alphavbeta3 with a tetrameric RGD-synthetic peptide. Mol Ther (2009) 1.09

Intact alphaIIbbeta3 integrin is extended after activation as measured by solution X-ray scattering and electron microscopy. J Biol Chem (2011) 1.07

Coordinate regulation of estrogen-mediated fibronectin matrix assembly and epidermal growth factor receptor transactivation by the G protein-coupled receptor, GPR30. Mol Endocrinol (2009) 1.05

Reconstruction of integrin activation. Blood (2011) 1.04

α(V)β(3) integrin crystal structures and their functional implications. Biochemistry (2012) 1.02

Multiscale simulations suggest a mechanism for integrin inside-out activation. Proc Natl Acad Sci U S A (2011) 1.00

Three-dimensional reconstruction of intact human integrin αIIbβ3: new implications for activation-dependent ligand binding. Blood (2013) 0.96

Computer aided identification of small molecules disrupting uPAR/alpha5beta1--integrin interaction: a new paradigm for metastasis prevention. PLoS One (2009) 0.93

Effects of limiting extension at the alphaIIb genu on ligand binding to integrin alphaIIbbeta3. J Biol Chem (2010) 0.93

Integrin alphaIIbbeta3:ligand interactions are linked to binding-site remodeling. Protein Sci (2006) 0.92

Using self-assembled monolayers to model cell adhesion to the 9th and 10th type III domains of fibronectin. Langmuir (2009) 0.92

Structural requirements for activation in alphaIIb beta3 integrin. J Biol Chem (2010) 0.92

Unique disulfide bonds in epidermal growth factor (EGF) domains of β3 affect structure and function of αIIbβ3 and αvβ3 integrins in different manner. J Biol Chem (2012) 0.90

Three-dimensional model of human platelet integrin alphaIIb beta3 in solution obtained by small angle neutron scattering. J Biol Chem (2009) 0.90

Targeted molecular dynamics reveals overall common conformational changes upon hybrid domain swing-out in beta3 integrins. Proteins (2009) 0.88

Structural basis for pure antagonism of integrin αVβ3 by a high-affinity form of fibronectin. Nat Struct Mol Biol (2014) 0.87

Leukocyte arrest: Biomechanics and molecular mechanisms of β2 integrin activation. Biorheology (2015) 0.87

Opposing effects of collagen I and vitronectin on fibronectin fibril structure and function. Matrix Biol (2014) 0.86

The Structure of a Full-length Membrane-embedded Integrin Bound to a Physiological Ligand. J Biol Chem (2015) 0.84

Atomic basis for the species-specific inhibition of αV integrins by monoclonal antibody 17E6 is revealed by the crystal structure of αVβ3 ectodomain-17E6 Fab complex. J Biol Chem (2014) 0.84

Immunolocalization of endocan during the endothelial-mesenchymal transition process. Eur J Histochem (2011) 0.83

Transmembrane helices that form two opposite homodimeric interactions: an asparagine scan study of alphaM and beta2 integrins. Protein Sci (2008) 0.82

Identification and characterization of a unique role for EDB fibronectin in phagocytosis. J Mol Med (Berl) (2015) 0.80

Single-particle EM reveals plasticity of interactions between the adenovirus penton base and integrin αVβ3. Proc Natl Acad Sci U S A (2014) 0.80

Activation mechanisms of αVβ3 integrin by binding to fibronectin: A computational study. Protein Sci (2017) 0.79

Epitope mapping for monoclonal antibody reveals the activation mechanism for αVβ3 integrin. PLoS One (2013) 0.77

The role of integrins in glaucoma. Exp Eye Res (2016) 0.76

EM structure of the ectodomain of integrin CD11b/CD18 and localization of its ligand-binding site relative to the plasma membrane. PLoS One (2013) 0.76

Biology and structure of leukocyte β 2 integrins and their role in inflammation. F1000Res (2016) 0.76

A single disulfide bond disruption in the β3 integrin subunit promotes thiol/disulfide exchange, a molecular dynamics study. PLoS One (2013) 0.76

Measurement of cationic and intracellular modulation of integrin binding affinity by AFM-based nanorobot. Biophys J (2013) 0.76

Can Integrin Agonists Have Cards to Play against Cancer? A Literature Survey of Small Molecules Integrin Activators. Cancers (Basel) (2017) 0.76

Neutrophil recruitment limited by high-affinity bent β2 integrin binding ligand in cis. Nat Commun (2016) 0.75

Cold adaptation, ca2+ dependency and autolytic stability are related features in a highly active cold-adapted trypsin resistant to autoproteolysis engineered for biotechnological applications. PLoS One (2013) 0.75

Inhibition of αIIbβ3 Ligand Binding by an αIIb Peptide that Clasps the Hybrid Domain to the βI Domain of β3. PLoS One (2015) 0.75

Identification, characterization, and epitope mapping of human monoclonal antibody J19 that specifically recognizes activated integrin α4β7. J Biol Chem (2012) 0.75

Structural and mechanical functions of integrins. Biophys Rev (2013) 0.75

The Croonian lecture 2006. Structure of the living cell. Philos Trans R Soc Lond B Biol Sci (2008) 0.75

High Affinity vs. Native Fibronectin in the Modulation of αvβ3 Integrin Conformational Dynamics: Insights from Computational Analyses and Implications for Molecular Design. PLoS Comput Biol (2017) 0.75

Conservation of the glycoprotein B homologs of the Kaposi׳s sarcoma-associated herpesvirus (KSHV/HHV8) and old world primate rhadinoviruses of chimpanzees and macaques. Virology (2016) 0.75

Three-Dimensional Structures of Full-Length, Membrane-Embedded Human αIIbβ3 Integrin Complexes. Biophys J (2016) 0.75

Articles cited by this

Integrins: bidirectional, allosteric signaling machines. Cell (2002) 36.25

EMAN: semiautomated software for high-resolution single-particle reconstructions. J Struct Biol (1999) 27.52

SPIDER and WEB: processing and visualization of images in 3D electron microscopy and related fields. J Struct Biol (1996) 22.89

Crystal structure of the extracellular segment of integrin alpha Vbeta3. Science (2001) 8.12

Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand. Science (2002) 7.87

Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling. Cell (2002) 7.03

Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics. Nature (2004) 5.87

Biosynthetic and functional properties of an Arg-Gly-Asp-directed receptor involved in human melanoma cell attachment to vitronectin, fibrinogen, and von Willebrand factor. J Biol Chem (1987) 4.87

2.0 A crystal structure of a four-domain segment of human fibronectin encompassing the RGD loop and synergy region. Cell (1996) 4.05

Integrin structure. Biochem Soc Trans (2000) 3.49

The three-dimensional structure of the tenth type III module of fibronectin: an insight into RGD-mediated interactions. Cell (1992) 3.20

Shapes, domain organizations and flexibility of laminin and fibronectin, two multifunctional proteins of the extracellular matrix. J Mol Biol (1981) 3.15

Structure of integrin alpha5beta1 in complex with fibronectin. EMBO J (2003) 2.99

Regulation of the fibronectin receptor affinity by divalent cations. J Biol Chem (1988) 2.78

Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation. Nat Struct Biol (2002) 2.56

STUDIES OF CHEMICALLY REACTING SYSTEMS ON SEPHADEX. I. CHROMATOGRAPHIC DEMONSTRATION OF THE GILBERT THEORY. Biochemistry (1964) 2.17

Resolution measurement in structures derived from single particles. Acta Crystallogr D Biol Crystallogr (2000) 1.98

Three-dimensional model of the human platelet integrin alpha IIbbeta 3 based on electron cryomicroscopy and x-ray crystallography. Proc Natl Acad Sci U S A (2002) 1.93

Crystal structure of the tenth type III cell adhesion module of human fibronectin. J Mol Biol (1994) 1.91

Structure of an integrin-ligand complex deduced from solution x-ray scattering and site-directed mutagenesis. J Biol Chem (2003) 1.81

Electron microscopy and structural model of human fibronectin receptor. EMBO J (1988) 1.69

A novel adaptation of the integrin PSI domain revealed from its crystal structure. J Biol Chem (2004) 1.68

Fibronectin in extended and compact conformations. Electron microscopy and sedimentation analysis. J Biol Chem (1983) 1.58

Defining fibronectin's cell adhesion synergy site by site-directed mutagenesis. J Cell Biol (2000) 1.58

Solution structure and dynamics of linked cell attachment modules of mouse fibronectin containing the RGD and synergy regions: comparison with the human fibronectin crystal structure. J Mol Biol (1998) 1.53

Real time analysis of the affinity regulation of alpha 4-integrin. The physiologically activated receptor is intermediate in affinity between resting and Mn(2+) or antibody activation. J Biol Chem (2001) 1.51

New insights into the structural basis of integrin activation. Blood (2003) 1.45

Capturing time-resolved changes in molecular structure by negative staining. J Struct Biol (2003) 1.40

AVS software for visualization in molecular microscopy. J Struct Biol (1996) 1.34

Functional and structural correlations of individual alphaIIbbeta3 molecules. Blood (2004) 1.30

Transmembrane-truncated alphavbeta3 integrin retains high affinity for ligand binding: evidence for an 'inside-out' suppressor? Biochem J (1998) 1.27

Interactions between type III domains in the 110 kDa cell-binding fragment of fibronectin. J Mol Biol (1995) 1.20

Integrin structure: new twists and turns in dynamic cell adhesion. Immunol Rev (2002) 1.09

Disruption of the beta3 663-687 disulfide bridge confers constitutive activity to beta3 integrins. Blood (2003) 1.06

Agonist-specific structural rearrangements of integrin alpha IIbbeta 3. Confirmation of the bent conformation in platelets at rest and after activation. J Biol Chem (2002) 1.04

Reversible conformational changes induced in glycoprotein IIb-IIIa by a potent and selective peptidomimetic inhibitor. Blood (1992) 1.02

Reversible inactivation of purified leukocyte integrin CR3 (CD11b/CD18, alpha m beta 2) by removal of divalent cations from a cryptic site. Cell Adhes Commun (1995) 0.87

Articles by these authors

Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand. Science (2002) 7.87

Abatacept in B7-1-positive proteinuric kidney disease. N Engl J Med (2013) 5.62

Structure of full-length HIV-1 CA: a model for the mature capsid lattice. Cell (2007) 4.25

X-ray structures of the hexameric building block of the HIV capsid. Cell (2009) 4.08

The structural biology of HIV assembly. Curr Opin Struct Biol (2008) 3.71

Type IV pilus structure by cryo-electron microscopy and crystallography: implications for pilus assembly and functions. Mol Cell (2006) 3.36

Type IV pilin structure and assembly: X-ray and EM analyses of Vibrio cholerae toxin-coregulated pilus and Pseudomonas aeruginosa PAK pilin. Mol Cell (2003) 2.78

Structure and mechanics of integrin-based cell adhesion. Curr Opin Cell Biol (2007) 2.48

Atomic-level modelling of the HIV capsid. Nature (2011) 2.41

Hexagonal assembly of a restricting TRIM5alpha protein. Proc Natl Acad Sci U S A (2010) 2.40

Reduction of ischemia and reperfusion-induced myocardial damage by cytochrome P450 inhibitors. Proc Natl Acad Sci U S A (2004) 2.11

Analysis of full and partial agonists binding to beta2-adrenergic receptor suggests a role of transmembrane helix V in agonist-specific conformational changes. J Mol Recognit (2009) 2.05

Solution state characterization of amyloid beta-derived diffusible ligands. Biochemistry (2006) 1.96

Three-dimensional model of the human platelet integrin alpha IIbbeta 3 based on electron cryomicroscopy and x-ray crystallography. Proc Natl Acad Sci U S A (2002) 1.93

Structure-based discovery of novel chemotypes for adenosine A(2A) receptor antagonists. J Med Chem (2010) 1.88

Multimeric cyclic RGD peptides as potential tools for tumor targeting: solid-phase peptide synthesis and chemoselective oxime ligation. Chemistry (2003) 1.69

Does the integrin alphaA domain act as a ligand for its betaA domain? Curr Biol (2002) 1.69

Inhibition of integrin alphavbeta6 on cholangiocytes blocks transforming growth factor-beta activation and retards biliary fibrosis progression. Gastroenterology (2008) 1.69

A novel adaptation of the integrin PSI domain revealed from its crystal structure. J Biol Chem (2004) 1.68

Crystal structure of the complete integrin alphaVbeta3 ectodomain plus an alpha/beta transmembrane fragment. J Cell Biol (2009) 1.68

Ultrastructural and biophysical characterization of hepatitis C virus particles produced in cell culture. J Virol (2010) 1.64

Three-dimensional structure of the M-MuLV CA protein on a lipid monolayer: a general model for retroviral capsid assembly. EMBO J (2003) 1.58

GPCR 3D homology models for ligand screening: lessons learned from blind predictions of adenosine A2a receptor complex. Proteins (2010) 1.57

A Calpha model for the transmembrane alpha helices of gap junction intercellular channels. Mol Cell (2004) 1.54

alphav beta 3 and alphav beta 5 integrin antagonists inhibit angiogenesis in vitro. Angiogenesis (2003) 1.48

New insights into the structural basis of integrin activation. Blood (2003) 1.45

Native hepatitis B virions and capsids visualized by electron cryomicroscopy. Mol Cell (2006) 1.44

Regulation of alpha5beta1 integrin conformation and function by urokinase receptor binding. J Cell Biol (2005) 1.44

Complementarity in the supramolecular design of arenaviruses and retroviruses revealed by electron cryomicroscopy and image analysis. J Virol (2005) 1.40

The beta-tail domain (betaTD) regulates physiologic ligand binding to integrin CD11b/CD18. Blood (2006) 1.40

Pharmacological inhibition of integrin alphavbeta3 aggravates experimental liver fibrosis and suppresses hepatic angiogenesis. Hepatology (2009) 1.39

Radiation sensitization of glioblastoma by cilengitide has unanticipated schedule-dependency. Int J Cancer (2009) 1.39

Coming to grips with integrin binding to ligands. Curr Opin Cell Biol (2002) 1.38

Nodavirus coat protein imposes dodecahedral RNA structure independent of nucleotide sequence and length. J Virol (2004) 1.35

Disulfide bond stabilization of the hexameric capsomer of human immunodeficiency virus. J Mol Biol (2010) 1.35

Supramolecular architecture of severe acute respiratory syndrome coronavirus revealed by electron cryomicroscopy. J Virol (2006) 1.34

Assembly and architecture of HIV. Adv Exp Med Biol (2012) 1.26

An archaeal antioxidant: characterization of a Dps-like protein from Sulfolobus solfataricus. Proc Natl Acad Sci U S A (2005) 1.24

CYR61 and alphaVbeta5 integrin cooperate to promote invasion and metastasis of tumors growing in preirradiated stroma. Cancer Res (2008) 1.15

Polycystin-1 activates and stabilizes the polycystin-2 channel. J Biol Chem (2002) 1.12

Effects of blocking individual maturation cleavages in murine leukemia virus gag. J Virol (2004) 1.12

Virus-like particles of a fish nodavirus display a capsid subunit domain organization different from that of insect nodaviruses. J Virol (2002) 1.09

Cilengitide inhibits progression of experimental breast cancer bone metastases as imaged noninvasively using VCT, MRI and DCE-MRI in a longitudinal in vivo study. Int J Cancer (2011) 1.07

Dynamics and stability in maturation of a T=4 virus. J Mol Biol (2009) 1.07

Single-particle image reconstruction of a tetramer of HIV integrase bound to DNA. J Mol Biol (2006) 1.07

Integrin control of the transforming growth factor-β pathway in glioblastoma. Brain (2013) 1.05

Imaging flow cytometry elucidates limitations of microparticle analysis by conventional flow cytometry. Cytometry A (2014) 1.04

Invasion patterns in brain metastases of solid cancers. Neuro Oncol (2013) 1.04

Pharmacological inhibition of the vitronectin receptor abrogates PDGF-BB-induced hepatic stellate cell migration and activation in vitro. J Hepatol (2006) 1.03

Identification and characterization of Vnx1p, a novel type of vacuolar monovalent cation/H+ antiporter of Saccharomyces cerevisiae. J Biol Chem (2007) 1.03

Voltage dependence and pH regulation of human polycystin-2-mediated cation channel activity. J Biol Chem (2002) 1.03

A viral nanoparticle with dual function as an anthrax antitoxin and vaccine. PLoS Pathog (2007) 1.02

αv-Integrin isoform expression in primary human tumors and brain metastases. Int J Cancer (2013) 1.01

Profiling of membrane protein variants in a baculovirus system by coupling cell-surface detection with small-scale parallel expression. Protein Expr Purif (2007) 1.01

CD11c gene expression in hairy cell leukemia is dependent upon activation of the proto-oncogenes ras and junD. Blood (2003) 1.01

Dissecting the role of matrix metalloproteinases (MMP) and integrin alpha(v)beta3 in angiogenesis in vitro: absence of hemopexin C domain bioactivity, but membrane-Type 1-MMP and alpha(v)beta3 are critical. Cancer Res (2005) 1.00

A synthetic eicosanoid LX-mimetic unravels host-donor interactions in allogeneic BMT-induced GvHD to reveal an early protective role for host neutrophils. FASEB J (2005) 1.00

The transcription factor ZBP-89 controls generation of the hematopoietic lineage in zebrafish and mouse embryonic stem cells. Development (2006) 0.98

Circulating and imaging markers for angiogenesis. Angiogenesis (2008) 0.98

Immature and mature human astrovirus: structure, conformational changes, and similarities to hepatitis E virus. J Mol Biol (2012) 0.95

Two-dimensional crystals of carboxysome shell proteins recapitulate the hexagonal packing of three-dimensional crystals. Protein Sci (2009) 0.94

Characterization of a conformationally sensitive murine monoclonal antibody directed to the metal ion-dependent adhesion site face of integrin CD11b. J Immunol (2002) 0.94

Titanium implant materials with improved biocompatibility through coating with phosphonate-anchored cyclic RGD peptides. Chembiochem (2005) 0.94

Projection structure of full length connexin 43 by electron cryo-crystallography. Cell Commun Adhes (2003) 0.93

A simple, no-wash cell adhesion-based high-throughput assay for the discovery of small-molecule regulators of the integrin CD11b/CD18. J Biomol Screen (2007) 0.92

Unusual arginine formations in protein function and assembly: rings, strings, and stacks. J Phys Chem B (2012) 0.91

WAC, a novel WW domain-containing adapter with a coiled-coil region, is colocalized with splicing factor SC35. Genomics (2002) 0.91

Molecular modeling and mutagenesis of gap junction channels. Prog Biophys Mol Biol (2007) 0.90

During differentiation of the monocytic cell line U937, Pur alpha mediates induction of the CD11c beta 2 integrin gene promoter. J Immunol (2002) 0.90

Damped-dynamics flexible fitting. Biophys J (2008) 0.89

Electron microscopy of integrins. Methods Enzymol (2007) 0.88

The zinc finger transcription factor ZBP-89 is a repressor of the human beta 2-integrin CD11b gene. Blood (2002) 0.88

Longitudinal expression analysis of αv integrins in human gliomas reveals upregulation of integrin αvβ3 as a negative prognostic factor. J Neuropathol Exp Neurol (2013) 0.88

Left ventricular cardiac tamponade in the setting of cor pulmonale and circumferential pericardial effusion. Case report and review of the literature. Cardiol Rev (2005) 0.87

Intrapleural chemo- and hyperthermotherapies for malignant pleural effusion: a randomized prospective study. Cancer Invest (2011) 0.87

Monitoring multiple angiogenesis-related molecules in the blood of cancer patients shows a correlation between VEGF-A and MMP-9 levels before treatment and divergent changes after surgical vs. conservative therapy. Int J Cancer (2006) 0.86

Single particle image reconstruction of the human recombinant Kv2.1 channel. Biophys J (2008) 0.86

Computational prediction of atomic structures of helical membrane proteins aided by EM maps. Biophys J (2007) 0.86

Phosphorylation of aquaporin PvTIP3;1 defined by mass spectrometry and molecular modeling. Biochemistry (2005) 0.86

Conformational changes accompany activation of reovirus RNA-dependent RNA transcription. J Struct Biol (2008) 0.86

αvβ3, αvβ5 and αvβ6 integrins in brain metastases of lung cancer. Clin Exp Metastasis (2014) 0.85

Comparing the expression of integrins αvβ3, αvβ5, αvβ6, αvβ8, fibronectin and fibrinogen in human brain metastases and their corresponding primary tumors. Int J Clin Exp Pathol (2013) 0.85

Conversion of a mechanosensitive channel protein from a membrane-embedded to a water-soluble form by covalent modification with amphiphiles. J Mol Biol (2004) 0.85

Binding Affinity of Metal Ions to the CD11b A-domain Is Regulated by Integrin Activation and Ligands. J Biol Chem (2004) 0.85

Intensity-modulated radiotherapy as the boost or salvage treatment of nasopharyngeal carcinoma: the appropriate parameters in the inverse planning and the effect of patient's anatomic factors on the planning results. Radiother Oncol (2005) 0.84

Design, synthesis, and properties of branch-chained maltoside detergents for stabilization and crystallization of integral membrane proteins: human connexin 26. Langmuir (2010) 0.84

In vivo functional assay of a recombinant aquaporin in Pichia pastoris. Appl Environ Microbiol (2006) 0.84

Mean platelet volume and integrin alleles correlate with levels of integrins α(IIb)β(3) and α(2)β(1) in acute coronary syndrome patients and normal subjects. Arterioscler Thromb Vasc Biol (2011) 0.83

Effects of monoclonal antibodies against human stathmin combined with paclitaxel on proliferation of the QG-56 human lung carcinoma cell line. Asian Pac J Cancer Prev (2012) 0.83

Use of a bovine model to study the role of adhesion molecule CD11/CD18 in hemodialysis-induced neutropenia. Am J Kidney Dis (2002) 0.83

Expression and purification of functional human anthrax toxin receptor (ATR/TEM8) binding domain from Escherichia coli. Protein Expr Purif (2006) 0.83

Stable coordination of the inhibitory Ca2+ ion at the metal ion-dependent adhesion site in integrin CD11b/CD18 by an antibody-derived ligand aspartate: implications for integrin regulation and structure-based drug design. J Immunol (2011) 0.83