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Structural basis of integrin regulation and signaling. Annu Rev Immunol (2007) 8.60

Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics. Nature (2004) 5.87

Demonstration of catch bonds between an integrin and its ligand. J Cell Biol (2009) 3.26

Integrin structure, activation, and interactions. Cold Spring Harb Perspect Biol (2011) 2.58

Linking integrin conformation to function. J Cell Sci (2009) 2.15

Integrin structures and conformational signaling. Curr Opin Cell Biol (2006) 2.03

Three-dimensional EM structure of the ectodomain of integrin {alpha}V{beta}3 in a complex with fibronectin. J Cell Biol (2005) 1.97

Integrin inside-out signaling and the immunological synapse. Curr Opin Cell Biol (2011) 1.89

How the headpiece hinge angle is opened: New insights into the dynamics of integrin activation. J Cell Biol (2006) 1.60

Crystal structure of α5β1 integrin ectodomain: atomic details of the fibronectin receptor. J Cell Biol (2012) 1.52

Complete integrin headpiece opening in eight steps. J Cell Biol (2013) 1.37

Requirement of open headpiece conformation for activation of leukocyte integrin alphaXbeta2. Proc Natl Acad Sci U S A (2010) 1.32

Closed headpiece of integrin αIIbβ3 and its complex with an αIIbβ3-specific antagonist that does not induce opening. Blood (2010) 1.29

Tests of the extension and deadbolt models of integrin activation. J Biol Chem (2007) 1.28

Focal adhesions are sites of integrin extension. J Cell Biol (2010) 1.26

Integrin conformational regulation: uncoupling extension/tail separation from changes in the head region by a multiresolution approach. Structure (2008) 1.16

The relative influence of metal ion binding sites in the I-like domain and the interface with the hybrid domain on rolling and firm adhesion by integrin alpha4beta7. J Biol Chem (2004) 1.13

Structural specializations of α(4)β(7), an integrin that mediates rolling adhesion. J Cell Biol (2012) 1.13

The integrin alpha-subunit leg extends at a Ca2+-dependent epitope in the thigh/genu interface upon activation. Proc Natl Acad Sci U S A (2004) 1.11

Interdomain tilt angle determines integrin-dependent function of the ninth and tenth FIII domains of human fibronectin. J Biol Chem (2004) 1.10

Integrin switching modulates adhesion dynamics and cell migration. Cell Adh Migr (2009) 1.10

N-glycosylation of the I-like domain of beta1 integrin is essential for beta1 integrin expression and biological function: identification of the minimal N-glycosylation requirement for alpha5beta1. J Biol Chem (2009) 1.10

Molecular basis of the recognition of nephronectin by integrin alpha8beta1. J Biol Chem (2009) 1.09

Intact alphaIIbbeta3 integrin is extended after activation as measured by solution X-ray scattering and electron microscopy. J Biol Chem (2011) 1.07

The C-terminal region of laminin beta chains modulates the integrin binding affinities of laminins. J Biol Chem (2009) 1.05

Cyclic mechanical reinforcement of integrin-ligand interactions. Mol Cell (2013) 1.05

Potential roles of N-glycosylation in cell adhesion. Glycoconj J (2012) 1.04

The regulation of integrin function by divalent cations. Cell Adh Migr (2012) 1.03

An N-glycosylation site on the beta-propeller domain of the integrin alpha5 subunit plays key roles in both its function and site-specific modification by beta1,4-N-acetylglucosaminyltransferase III. J Biol Chem (2009) 1.03

Nanostructure of fibrillin-1 reveals compact conformation of EGF arrays and mechanism for extensibility. Proc Natl Acad Sci U S A (2006) 0.99

Interleukin 32 (IL-32) contains a typical α-helix bundle structure that resembles focal adhesion targeting region of focal adhesion kinase-1. J Biol Chem (2011) 0.94

Using self-assembled monolayers to model cell adhesion to the 9th and 10th type III domains of fibronectin. Langmuir (2009) 0.92

Integrin alphaIIbbeta3:ligand interactions are linked to binding-site remodeling. Protein Sci (2006) 0.92

Interpretation of solution x-ray scattering by explicit-solvent molecular dynamics. Biophys J (2015) 0.92

Mapping the ligand-binding pocket of integrin alpha5beta1 using a gain-of-function approach. Biochem J (2009) 0.91

Relating conformation to function in integrin α5β1. Proc Natl Acad Sci U S A (2016) 0.88

Cross-Scale Integrin Regulation Organizes ECM and Tissue Topology. Dev Cell (2015) 0.86

Overview: assays for studying integrin-dependent cell adhesion. Methods Mol Biol (2012) 0.82

Epitopes in α8β1 and other RGD-binding integrins delineate classes of integrin-blocking antibodies and major binding loops in α subunits. Sci Rep (2015) 0.78

Calpha-H...O = C hydrogen bonds contribute to the specificity of RGD cell-adhesion interactions. BMC Struct Biol (2005) 0.76

Variation in one residue associated with the metal ion-dependent adhesion site regulates αIIbβ3 integrin ligand binding affinity. PLoS One (2013) 0.76

Ligand-induced Epitope Masking: DISSOCIATION OF INTEGRIN α5β1-FIBRONECTIN COMPLEXES ONLY BY MONOCLONAL ANTIBODIES WITH AN ALLOSTERIC MODE OF ACTION. J Biol Chem (2016) 0.75

Mutations in and near the second calcium-binding domain of integrin alphaIIb affect the structure and function of integrin alphaIIbbeta3. Biochem J (2004) 0.75

Integrin ligands at a glance. J Cell Sci (2006) 4.76

Vinculin controls focal adhesion formation by direct interactions with talin and actin. J Cell Biol (2007) 4.28

Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments. Dev Cell (2007) 3.84

The complete folding pathway of a protein from nanoseconds to microseconds. Nature (2003) 3.61

Demonstration of catch bonds between an integrin and its ligand. J Cell Biol (2009) 3.26

Synergistic control of cell adhesion by integrins and syndecans. Nat Rev Mol Cell Biol (2007) 3.21

Integrin structure, activation, and interactions. Cold Spring Harb Perspect Biol (2011) 2.58

Syndecan-4-dependent Rac1 regulation determines directional migration in response to the extracellular matrix. J Cell Biol (2007) 2.33

Collagens at a glance. J Cell Sci (2007) 2.26

Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6. Sci Signal (2009) 2.26

The Structure of the talin head reveals a novel extended conformation of the FERM domain. Structure (2010) 2.22

Neuropilin-1/GIPC1 signaling regulates alpha5beta1 integrin traffic and function in endothelial cells. PLoS Biol (2009) 2.16

Linking integrin conformation to function. J Cell Sci (2009) 2.15

Heparin-II domain of fibronectin is a vascular endothelial growth factor-binding domain: enhancement of VEGF biological activity by a singular growth factor/matrix protein synergism. Circ Res (2006) 2.08

Insights into the structure and domain flexibility of full-length pro-matrix metalloproteinase-9/gelatinase B. Structure (2007) 2.05

SHARPIN is an endogenous inhibitor of β1-integrin activation. Nat Cell Biol (2011) 2.01

Structural basis for protein-protein interactions in the 14-3-3 protein family. Proc Natl Acad Sci U S A (2006) 1.95

Integrin-specific signaling pathways controlling focal adhesion formation and cell migration. J Cell Biol (2003) 1.90

Domain motion in cytochrome P450 reductase: conformational equilibria revealed by NMR and small-angle x-ray scattering. J Biol Chem (2009) 1.87

An oligomeric signaling platform formed by the Toll-like receptor signal transducers MyD88 and IRAK-4. J Biol Chem (2009) 1.85

Fibronectin regulates latent transforming growth factor-beta (TGF beta) by controlling matrix assembly of latent TGF beta-binding protein-1. J Biol Chem (2005) 1.82

Crystal structure of the dimeric protein core of decorin, the archetypal small leucine-rich repeat proteoglycan. Proc Natl Acad Sci U S A (2004) 1.81

Conformational changes in the integrin beta A domain provide a mechanism for signal transduction via hybrid domain movement. J Biol Chem (2003) 1.80

The structure of the C-terminal actin-binding domain of talin. EMBO J (2007) 1.77

Dimer destabilization in superoxide dismutase may result in disease-causing properties: structures of motor neuron disease mutants. Proc Natl Acad Sci U S A (2004) 1.76

The co-chaperone p23 arrests the Hsp90 ATPase cycle to trap client proteins. J Mol Biol (2005) 1.74

Anti-integrin monoclonal antibodies. J Cell Sci (2009) 1.72

Structural correlations in the family of small leucine-rich repeat proteins and proteoglycans. J Struct Biol (2006) 1.66

Integrin activation involves a conformational change in the alpha 1 helix of the beta subunit A-domain. J Biol Chem (2002) 1.65

Quantification of integrin receptor agonism by fluorescence lifetime imaging. J Cell Sci (2008) 1.64

The denatured state of Engrailed Homeodomain under denaturing and native conditions. J Mol Biol (2003) 1.51

Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation. EMBO J (2010) 1.45

Regulation of alpha5beta1 integrin conformation and function by urokinase receptor binding. J Cell Biol (2005) 1.44

A specific alpha5beta1-integrin conformation promotes directional integrin translocation and fibronectin matrix formation. J Cell Sci (2004) 1.42

p190RhoGAP is the convergence point of adhesion signals from alpha 5 beta 1 integrin and syndecan-4. J Cell Biol (2008) 1.41

Cytoplasmic interactions of syndecan-4 orchestrate adhesion receptor and growth factor receptor signalling. Biochem J (2002) 1.39

Regulation of integrin function through conformational complexity: not simply a knee-jerk reaction? Curr Opin Cell Biol (2004) 1.38

Structure and function of factor XI. Blood (2010) 1.37

Crystal structure of the factor XI zymogen reveals a pathway for transactivation. Nat Struct Mol Biol (2006) 1.36

Role of ADMIDAS cation-binding site in ligand recognition by integrin alpha 5 beta 1. J Biol Chem (2003) 1.36

Site-directed perturbation of protein kinase C- integrin interaction blocks carcinoma cell chemotaxis. Mol Cell Biol (2002) 1.35

Structural determinants of integrin binding to the talin rod. J Biol Chem (2009) 1.35

Cell adhesion to fibrillin-1 molecules and microfibrils is mediated by alpha 5 beta 1 and alpha v beta 3 integrins. J Biol Chem (2003) 1.32

A syndecan-4 hair trigger initiates wound healing through caveolin- and RhoG-regulated integrin endocytosis. Dev Cell (2011) 1.31

Integrin structure: heady advances in ligand binding, but activation still makes the knees wobble. Trends Biochem Sci (2003) 1.30

Evidence that monoclonal antibodies directed against the integrin beta subunit plexin/semaphorin/integrin domain stimulate function by inducing receptor extension. J Biol Chem (2004) 1.29

Focal adhesions are sites of integrin extension. J Cell Biol (2010) 1.26

Biochemical and structural studies of the interaction of Cdc37 with Hsp90. J Mol Biol (2004) 1.25

Molecular interplay between endostatin, integrins, and heparan sulfate. J Biol Chem (2009) 1.25

Alpha v beta3 integrin spatially regulates VASP and RIAM to control adhesion dynamics and migration. J Cell Biol (2010) 1.24

The integrins of the urochordate Ciona intestinalis provide novel insights into the molecular evolution of the vertebrate integrin family. BMC Evol Biol (2005) 1.23

Fibronectin-tissue transglutaminase matrix rescues RGD-impaired cell adhesion through syndecan-4 and beta1 integrin co-signaling. J Biol Chem (2008) 1.21

Novel and recurrent mutations in the C-terminal domain of COMP cluster in two distinct regions and result in a spectrum of phenotypes within the pseudoachondroplasia -- multiple epiphyseal dysplasia disease group. Hum Mutat (2005) 1.20

Assembly of oligomeric death domain complexes during Toll receptor signaling. J Biol Chem (2008) 1.19

Decorin core protein (decoron) shape complements collagen fibril surface structure and mediates its binding. PLoS One (2009) 1.18

Biological role and structural mechanism of twinfilin-capping protein interaction. EMBO J (2004) 1.16

Knotted fusion proteins reveal unexpected possibilities in protein folding. Mol Cell (2008) 1.15

Giving off mixed signals--distinct functions of alpha5beta1 and alphavbeta3 integrins in regulating cell behaviour. IUBMB Life (2009) 1.14

Molecular basis for the dynamic strength of the integrin alpha4beta1/VCAM-1 interaction. Biophys J (2004) 1.14

RCP-driven α5β1 recycling suppresses Rac and promotes RhoA activity via the RacGAP1-IQGAP1 complex. J Cell Biol (2013) 1.13

Syndecan-4 phosphorylation is a control point for integrin recycling. Dev Cell (2013) 1.12

Mapping functional residues onto integrin crystal structures. Curr Opin Struct Biol (2003) 1.11

Quaternary structure and catalytic activity of the Escherichia coli ribonuclease E amino-terminal catalytic domain. Biochemistry (2003) 1.09

Role of dimerization and substrate exclusion in the regulation of bone morphogenetic protein-1 and mammalian tolloid. Proc Natl Acad Sci U S A (2009) 1.09

Cell adhesion to fibrillin-1: identification of an Arg-Gly-Asp-dependent synergy region and a heparin-binding site that regulates focal adhesion formation. J Cell Sci (2007) 1.08

Small-angle X-ray scattering reveals the solution structure of a bacteriophytochrome in the catalytically active Pr state. J Mol Biol (2006) 1.07

Proteomic analysis of integrin adhesion complexes. Sci Signal (2011) 1.06

Interaction of filamin A with the integrin beta 7 cytoplasmic domain: role of alternative splicing and phosphorylation. FEBS Lett (2004) 1.05

Small-angle X-ray scattering reveals the solution structure of the full-length DNA gyrase a subunit. Structure (2005) 1.05

The crystal structure of the N-terminal region of BUB1 provides insight into the mechanism of BUB1 recruitment to kinetochores. Structure (2009) 1.05

Cyclic mechanical reinforcement of integrin-ligand interactions. Mol Cell (2013) 1.05