Published in Arch Biochem Biophys on April 15, 2005
Discovery of dapagliflozin: a potent, selective renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes. J Med Chem (2008) 5.15
DNA vaccines: progress and challenges. J Immunol (2005) 2.34
Discovery and preclinical profile of Saxagliptin (BMS-477118): a highly potent, long-acting, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. J Med Chem (2005) 1.49
Gene-based vaccines: recent technical and clinical advances. Trends Mol Med (2006) 1.32
Eosinophilic gastroenteritis: clinical manifestations and morphological characteristics, a retrospective study of 42 patients. Scand J Gastroenterol (2011) 1.25
Development of a safe neutralization assay for SARS-CoV and characterization of S-glycoprotein. Virology (2004) 1.17
Vaccine delivery methods using viral vectors. Mol Pharm (2007) 1.17
Gene vaccines. Ann Intern Med (2003) 1.13
A pre-steady state analysis of ligand binding to human glucokinase: evidence for a preexisting equilibrium. Biochemistry (2007) 1.08
Differentiation of Hdm2-mediated p53 ubiquitination and Hdm2 autoubiquitination activity by small molecular weight inhibitors. Proc Natl Acad Sci U S A (2002) 1.03
Ethical issues for vaccines and immunization. Nat Rev Immunol (2002) 0.94
Mechanism of Gly-Pro-pNA cleavage catalyzed by dipeptidyl peptidase-IV and its inhibition by saxagliptin (BMS-477118). Arch Biochem Biophys (2005) 0.94
Involvement of DPP-IV catalytic residues in enzyme-saxagliptin complex formation. Protein Sci (2008) 0.92
P-glycoprotein efflux and other factors limit brain amyloid beta reduction by beta-site amyloid precursor protein-cleaving enzyme 1 inhibitors in mice. J Pharmacol Exp Ther (2008) 0.88
Serum markers for necroinflammatory activity in patients with chronic viral hepatitis and normal or mildly elevated aminotransferase levels. Liver Int (2011) 0.88
Kinetic studies on beta-site amyloid precursor protein-cleaving enzyme (BACE). Confirmation of an iso mechanism. J Biol Chem (2002) 0.88
Potency, selectivity and prolonged binding of saxagliptin to DPP4: maintenance of DPP4 inhibition by saxagliptin in vitro and ex vivo when compared to a rapidly-dissociating DPP4 inhibitor. BMC Pharmacol (2012) 0.87
DNA vaccines: recent technological and clinical advances. Discov Med (2006) 0.86
Differential activation of recombinant human acetyl-CoA carboxylases 1 and 2 by citrate. Arch Biochem Biophys (2008) 0.84
Aglycone exploration of C-arylglucoside inhibitors of renal sodium-dependent glucose transporter SGLT2. Bioorg Med Chem Lett (2008) 0.84
Full sequence of HIV type 1 Korean subtype B in an AIDS case with atypical seroconversion: TAAAA at TATA box. AIDS Res Hum Retroviruses (2005) 0.83
Natural polymorphisms of protease in protease inhibitor-naive HIV-1 infected patients in Korea: a novel L63M in subtype B. AIDS Res Hum Retroviruses (2003) 0.83
TEE-guided one-stage excision of intravenous leiomyomatosis with cardiac extension through an abdominal approach. J Cardiothorac Vasc Anesth (2005) 0.82
Scalarane sesterterpenoids: semisynthesis and biological activity. J Nat Prod (2009) 0.81
Diprolyl nitriles as potent dipeptidyl peptidase IV inhibitors. Bioorg Med Chem Lett (2005) 0.81
Effects of angiotensin-II receptor blockers on experimental autoimmune myocarditis. Int J Cardiol (2009) 0.80
Parallel synthesis of potent, pyrazole-based inhibitors of Helicobacter pylori dihydroorotate dehydrogenase. J Med Chem (2002) 0.79
Antidepressant efficacy screening of novel targets in the chick anxiety-depression model. Behav Pharmacol (2009) 0.79
DPP8 and DPP9 expression in cynomolgus monkey and Sprague Dawley rat tissues. Regul Pept (2013) 0.78
Substituted piperidinyl glycinyl 2-cyano-4,5-methano pyrrolidines as potent and stable dipeptidyl peptidase IV inhibitors. Bioorg Med Chem Lett (2013) 0.77
Cloning and characterization of a novel dehydrin gene, SiDhn2, from Saussurea involucrata Kar. et Kir. Plant Mol Biol (2013) 0.77
Potent non-nitrile dipeptidic dipeptidyl peptidase IV inhibitors. Bioorg Med Chem Lett (2007) 0.76
DNA vaccines for HIV/AIDS. Curr Opin HIV AIDS (2006) 0.76
Minor nef gene alterations after human HIV-DNA immunisation. AIDS (2004) 0.76
Discovery of 6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2-carboxamides as potent, selective dipeptidyl peptidase-4 (DPP4) inhibitors. J Med Chem (2010) 0.76
7-Oxopyrrolopyridine-derived DPP4 inhibitors-mitigation of CYP and hERG liabilities via introduction of polar functionalities in the active site. Bioorg Med Chem Lett (2011) 0.76
Gene-based passive antibody protection from HIV. Nat Biotechnol (2012) 0.76
Small-interfering RNA-mediated silencing of the MAPK p42 gene induces dual effects in HeLa cells. Oncol Lett (2010) 0.75
Synthesis and in vivo evaluation of cyclic diaminopropane BACE-1 inhibitors. Bioorg Med Chem Lett (2011) 0.75
[Construction of a bivalent plant expression vector carrying VvSUC11 and VvSUC12 genes and its genetic transformation in sugar beet]. Sheng Wu Gong Cheng Xue Bao (2011) 0.75
[3H]BMS-599240--a novel tritiated ligand for the characterization of BACE1 inhibitors. Eur J Pharmacol (2008) 0.75
Seco-prolinenitrile inhibitors of dipeptidyl peptidase IV define minimal pharmacophore requirements at P1. Bioorg Med Chem Lett (2005) 0.75
Comparative studies of active site-ligand interactions among various recombinant constructs of human beta-amyloid precursor protein cleaving enzyme. Arch Biochem Biophys (2003) 0.75
Synthesis and SAR of azolopyrimidines as potent and selective dipeptidyl peptidase-4 (DPP4) inhibitors for type 2 diabetes. Bioorg Med Chem Lett (2010) 0.75
Synthesis, SAR, and atropisomerism of imidazolopyrimidine DPP4 inhibitors. Bioorg Med Chem Lett (2010) 0.75
Monosubstituted γ-lactam and conformationally constrained 1,3-diaminopropan-2-ol transition-state isostere inhibitors of β-secretase (BACE). Bioorg Med Chem Lett (2011) 0.75
Mitotically Active Leiomyoma in a Woman with Mayer-Rokitansky-Küster-Hauser Syndrome: A Case Report. J Reprod Med (2016) 0.75