Published in J Pharmacol Exp Ther on May 22, 2008
A G-rich element forms a G-quadruplex and regulates BACE1 mRNA alternative splicing. J Neurochem (2012) 1.70
BACE1 (β-secretase) inhibitors for the treatment of Alzheimer's disease. Chem Soc Rev (2014) 1.14
beta-Secretase inhibitor potency is decreased by aberrant beta-cleavage location of the "Swedish mutant" amyloid precursor protein. J Biol Chem (2009) 0.96
Inhibition of beta-secretase in vivo via antibody binding to unique loops (D and F) of BACE1. J Biol Chem (2011) 0.86
BACE-1 inhibition prevents the γ-secretase inhibitor evoked Aβ rise in human neuroblastoma SH-SY5Y cells. J Biomed Sci (2011) 0.81
Viable mouse gene ablations that robustly alter brain Aβ levels are rare. BMC Neurosci (2010) 0.79
Rafts, Nanoparticles and Neural Disease. Nanomaterials (Basel) (2012) 0.75
Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1. Cell (2011) 5.63
Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins. Cancer Res (2004) 5.57
Cord-blood transplants from unrelated donors in patients with Hurler's syndrome. N Engl J Med (2004) 4.15
Lineage-specific gene duplication and loss in human and great ape evolution. PLoS Biol (2004) 3.45
A method for calling gains and losses in array CGH data. Biostatistics (2005) 2.86
Comparison of BD Phoenix, Vitek 2, and MicroScan automated systems for detection and inference of mechanisms responsible for carbapenem resistance in Enterobacteriaceae. J Clin Microbiol (2010) 2.30
Dust mite, cockroach, cat, and dog allergen concentrations in homes of asthmatic children in the northeastern United States: impact of socioeconomic factors and population density. Environ Health Perspect (2002) 1.99
On the nature of cardiovascular activation at an arousal from sleep. Sleep (2003) 1.96
STAT3 regulates arginase-I in myeloid-derived suppressor cells from cancer patients. J Clin Invest (2013) 1.94
An introductory characterization of a combat-casualty-care relevant swine model of closed head injury resulting from exposure to explosive blast. J Neurotrauma (2009) 1.86
Nano-bio-chip sensor platform for examination of oral exfoliative cytology. Cancer Prev Res (Phila) (2010) 1.76
The Southeast Scotland Foundation Doctor Teaching Programme--is "near-peer" teaching feasible, efficacious and sustainable on a regional scale? Med Teach (2009) 1.73
In vivo imaging of tumor response to therapy using a dual-modality imaging strategy. Int J Cancer (2006) 1.62
Limitations of dual time point PET in the assessment of lung nodules with low FDG avidity. Lung Cancer (2009) 1.59
Interstitial pneumonitis related to rituximab therapy. N Engl J Med (2003) 1.59
Canonical Wnt signaling regulates Slug activity and links epithelial-mesenchymal transition with epigenetic Breast Cancer 1, Early Onset (BRCA1) repression. Proc Natl Acad Sci U S A (2012) 1.59
Response shift in outcome assessment in patients undergoing total knee arthroplasty. J Bone Joint Surg Am (2006) 1.55
Association between rectal optical signatures and colonic neoplasia: potential applications for screening. Cancer Res (2009) 1.53
Discovery and preclinical profile of Saxagliptin (BMS-477118): a highly potent, long-acting, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. J Med Chem (2005) 1.49
Improved outcomes in liver transplantation in children with acute liver failure. J Pediatr Gastroenterol Nutr (2014) 1.45
Metal oxide thin film phototransistor for remote touch interactive displays. Adv Mater (2012) 1.43
Both 5-arylidene-2-thioxodihydropyrimidine-4,6(1H,5H)-diones and 3-thioxo-2,3-dihydro-1H-imidazo[1,5-a]indol-1-ones are light-dependent tumor necrosis factor-alpha antagonists. Bioorg Med Chem Lett (2003) 1.39
Urokinase receptors are required for alpha 5 beta 1 integrin-mediated signaling in tumor cells. J Biol Chem (2006) 1.37
New adoptive immunotherapy strategies for solid tumours with CIK cells. Expert Opin Biol Ther (2012) 1.33
Increased acyclovir oral bioavailability via a bile acid conjugate. Mol Pharm (2004) 1.32
The effects of normal aging on sleep spindle and K-complex production. Clin Neurophysiol (2002) 1.31
Hyperdynamic microtubules, cognitive deficits, and pathology are improved in tau transgenic mice with low doses of the microtubule-stabilizing agent BMS-241027. J Neurosci (2012) 1.31
Amplification of whole tumor genomes and gene-by-gene mapping of genomic aberrations from limited sources of fresh-frozen and paraffin-embedded DNA. J Mol Diagn (2005) 1.29
Relationship of health behavior theories with self-efficacy among insufficiently active hypertensive African-American women. Patient Educ Couns (2008) 1.28
Do patient expectations of spinal surgery relate to functional outcome? Clin Orthop Relat Res (2008) 1.26
Gamma-secretase inhibitors for Alzheimer's disease: balancing efficacy and toxicity. Drugs R D (2006) 1.25
Quality of life in surgical treatment of metastatic spine disease. Spine (Phila Pa 1976) (2003) 1.25
17-Beta-estradiol increases neuronal excitability through MAP kinase-induced calpain activation. Proc Natl Acad Sci U S A (2009) 1.24
The impact of surgical wait time on patient-based outcomes in posterior lumbar spinal surgery. Eur Spine J (2007) 1.23
Down-regulation of SNAIL suppresses MIN mouse tumorigenesis: modulation of apoptosis, proliferation, and fractal dimension. Mol Cancer Ther (2004) 1.21
Genome-wide characterization of gene expression variations and DNA copy number changes in prostate cancer cell lines. Prostate (2005) 1.20
Bridging the acculturation gap: parent-child relationship quality as a moderator in Mexican American families. Dev Psychol (2008) 1.20
The amyloid-beta rise and gamma-secretase inhibitor potency depend on the level of substrate expression. J Biol Chem (2008) 1.20
New Zealand Pacific peoples' drinking style: too much or nothing at all? N Z Med J (2005) 1.19
Tau transgenic mice as models for cerebrospinal fluid tau biomarkers. J Alzheimers Dis (2011) 1.19
A 2011 updated systematic review and clinical practice guideline for the management of malignant extradural spinal cord compression. Int J Radiat Oncol Biol Phys (2012) 1.14
Neoplastic mast cells in systemic mastocytosis associated with t(8;21) acute myeloid leukemia are derived from the leukemic clone. Leuk Res (2006) 1.11
Rectal mucosal microvascular blood supply increase is associated with colonic neoplasia. Clin Cancer Res (2009) 1.09
A pre-steady state analysis of ligand binding to human glucokinase: evidence for a preexisting equilibrium. Biochemistry (2007) 1.08
Hair cycle-dependent basal cell carcinoma tumorigenesis in Ptc1neo67/+ mice exposed to radiation. Cancer Res (2006) 1.07
Therapeutic strategies for Alzheimer's disease. Mol Neurobiol (2008) 1.06
Investigation of depth selectivity of polarization gating for tissue characterization. Opt Express (2005) 1.03
Inducible nitric oxide synthase (iNOS) mediates the early increase of blood supply (EIBS) in colon carcinogenesis. FEBS Lett (2007) 1.01
Identification and characterization of presenilin-independent Notch signaling. J Biol Chem (2001) 1.00
Discovery of (S)-2-((S)-2-(3,5-difluorophenyl)-2-hydroxyacetamido)-N-((S,Z)-3-methyl-4-oxo-4,5-dihydro-3H-benzo[d][1,2]diazepin-5-yl)propanamide (BMS-433796): a gamma-secretase inhibitor with Abeta lowering activity in a transgenic mouse model of Alzheimer's disease. Bioorg Med Chem Lett (2007) 0.99
Characterization of adherent-invasive Escherichia coli isolated from pediatric patients with inflammatory bowel disease. Inflamm Bowel Dis (2011) 0.99
Expression of PD-L1, a marker of disease status, is not reduced by HAART in aviraemic patients. AIDS (2007) 0.99
Osteoporosis in the home health care setting: A window of opportunity? Arthritis Rheum (2006) 0.98
Aqueous and cosolvent solubility data for drug-like organic compounds. AAPS J (2005) 0.98
Immunophenotyping and protein profiling of Fontan-associated plastic bronchitis airway casts. Ann Am Thorac Soc (2013) 0.98
Fecal HMGB1 is a novel marker of intestinal mucosal inflammation in pediatric inflammatory bowel disease. Am J Gastroenterol (2011) 0.97
Weight-shift training improves trunk control, proprioception, and balance in patients with chronic hemiparetic stroke. Tohoku J Exp Med (2014) 0.96
Identification of peptide substrates for human MMP-11 (stromelysin-3) using phage display. J Biol Chem (2003) 0.96
Activation of NOD2-mediated intestinal pathway in a pediatric population with Crohn's disease. Inflamm Bowel Dis (2009) 0.94
Quinolines as extremely potent and selective PDE5 inhibitors as potential agents for treatment of erectile dysfunction. Bioorg Med Chem Lett (2004) 0.94
Mechanism of Gly-Pro-pNA cleavage catalyzed by dipeptidyl peptidase-IV and its inhibition by saxagliptin (BMS-477118). Arch Biochem Biophys (2005) 0.94
DNA microarray and proteomic strategies for understanding alcohol action. Alcohol Clin Exp Res (2006) 0.94
Nocathiacins, new thiazolyl peptide antibiotics from Nocardia sp. II. Isolation, characterization, and structure determination. J Antibiot (Tokyo) (2003) 0.94
Development and validation of a preclinical food effect model. J Pharm Sci (2007) 0.94
Optical measurement of rectal microvasculature as an adjunct to flexible sigmoidosocopy: gender-specific implications. Cancer Prev Res (Phila) (2010) 0.93
Lipid production in Porphyridium cruentum grown under different culture conditions. J Biosci Bioeng (2009) 0.92
Involvement of DPP-IV catalytic residues in enzyme-saxagliptin complex formation. Protein Sci (2008) 0.92
Characterization of novel CSF Tau and ptau biomarkers for Alzheimer's disease. PLoS One (2013) 0.92
Inhibition of stimulated dopamine release and hemodynamic response in the brain through electrical stimulation of rat forepaw. Neurosci Lett (2007) 0.91
Measurement of Aβ1-42 in cerebrospinal fluid is influenced by matrix effects. J Neurochem (2011) 0.91
Correlation of computed tomography imaging features with pain response in patients with spine metastases after radiation therapy. Int J Radiat Oncol Biol Phys (2010) 0.91
Scales of spatial heterogeneity of plastic marine debris in the northeast pacific ocean. PLoS One (2013) 0.90
Specialization of function among aldehyde dehydrogenases: the ALD2 and ALD3 genes are required for beta-alanine biosynthesis in Saccharomyces cerevisiae. Genetics (2003) 0.90
Characterization of efflux transporters involved in distribution and disposition of apixaban. Drug Metab Dispos (2013) 0.90
Functional electrical stimulation applied to gluteus medius and tibialis anterior corresponding gait cycle for stroke. Gait Posture (2012) 0.90
A quantitative structure-property relationship for predicting drug solubility in PEG 400/water cosolvent systems. Pharm Res (2004) 0.90
A selective small molecule agonist of the melanocortin-1 receptor inhibits lipopolysaccharide-induced cytokine accumulation and leukocyte infiltration in mice. J Leukoc Biol (2006) 0.90
Laparoscopic treatment of adult sigmoidorectal intussusception caused by a mucinous adenocarcinoma of the sigmoid colon: a case report. J Korean Soc Coloproctol (2011) 0.90
Evaluation of right ventricular volume and mass using retrospective ECG-gated cardiac multidetector computed tomography: comparison with first-pass radionuclide angiography. Eur Radiol (2005) 0.90
Tryptamine and homotryptamine-based sulfonamides as potent and selective inhibitors of 15-lipoxygenase. Bioorg Med Chem Lett (2005) 0.89
Amelioration of experimental autoimmune encephalomyelitis by probiotic mixture is mediated by a shift in T helper cell immune response. Clin Immunol (2013) 0.89
Expression, purification, and kinetic characterization of full-length human fibroblast activation protein. Protein Expr Purif (2002) 0.89
Recent progress in the medicinal chemistry of gamma-secretase inhibitors. Curr Top Med Chem (2008) 0.89
Effects of treadmill training with optic flow on balance and gait in individuals following stroke: randomized controlled trials. Clin Rehabil (2011) 0.89
Preclinical pharmacokinetics and pharmacodynamics of apixaban, a potent and selective factor Xa inhibitor. Eur J Drug Metab Pharmacokinet (2011) 0.89
Plasma IL-6 as a marker of mycobacterial immune restoration disease in HIV-1 infection. AIDS (2003) 0.89