Novel specificities emerge by stepwise duplication of functional modules.

PubWeight™: 1.47‹?› | Rank: Top 5%

🔗 View Article (PMC 1074369)

Published in Genome Res on April 01, 2005

Authors

José B Pereira-Leal1, Sarah A Teichmann

Author Affiliations

1: MRC-Laboratory of Molecular Biology, Structural Studies Division, Cambridge CB2 2QH, United Kingdom. jleal@mrc-lmb.cam.ac.uk

Articles citing this

What properties characterize the hub proteins of the protein-protein interaction network of Saccharomyces cerevisiae? Genome Biol (2006) 2.27

3D complex: a structural classification of protein complexes. PLoS Comput Biol (2006) 2.21

Inferring protein domain interactions from databases of interacting proteins. Genome Biol (2005) 1.97

The evolution of modularity in bacterial metabolic networks. Proc Natl Acad Sci U S A (2008) 1.96

Evolution of protein complexes by duplication of homomeric interactions. Genome Biol (2007) 1.88

The origins and evolution of functional modules: lessons from protein complexes. Philos Trans R Soc Lond B Biol Sci (2006) 1.71

Specificity and evolvability in eukaryotic protein interaction networks. PLoS Comput Biol (2006) 1.64

An integrated approach to the prediction of domain-domain interactions. BMC Bioinformatics (2006) 1.52

Practical and theoretical advances in predicting the function of a protein by its phylogenetic distribution. J R Soc Interface (2008) 1.24

Construction of a large extracellular protein interaction network and its resolution by spatiotemporal expression profiling. Mol Cell Proteomics (2010) 1.22

Mechanisms of protein oligomerization, the critical role of insertions and deletions in maintaining different oligomeric states. Proc Natl Acad Sci U S A (2010) 1.21

Caught in self-interaction: evolutionary and functional mechanisms of protein homooligomerization. Phys Biol (2011) 1.09

The evolutionary dynamics of the Saccharomyces cerevisiae protein interaction network after duplication. Proc Natl Acad Sci U S A (2008) 1.05

Evaluating dosage compensation as a cause of duplicate gene retention in Paramecium tetraurelia. Genome Biol (2007) 1.00

Comprehensive analysis reveals dynamic and evolutionary plasticity of Rab GTPases and membrane traffic in Tetrahymena thermophila. PLoS Genet (2010) 1.00

Topological and functional properties of the small GTPases protein interaction network. PLoS One (2012) 0.98

Modularity of stress response evolution. Proc Natl Acad Sci U S A (2008) 0.97

Complex fate of paralogs. BMC Evol Biol (2008) 0.95

Loss of genetic redundancy in reductive genome evolution. PLoS Comput Biol (2011) 0.94

A protein interaction atlas for the nuclear receptors: properties and quality of a hub-based dimerisation network. BMC Syst Biol (2007) 0.94

Multiple domain insertions and losses in the evolution of the Rab prenylation complex. BMC Evol Biol (2007) 0.92

Protein interaction networks in plants. Planta (2006) 0.89

Comparative evolutionary analysis of protein complexes in E. coli and yeast. BMC Genomics (2010) 0.86

A complex-centric view of protein network evolution. Nucleic Acids Res (2009) 0.85

Protein function assignment through mining cross-species protein-protein interactions. PLoS One (2008) 0.85

Comparative interaction networks: bridging genotype to phenotype. Adv Exp Med Biol (2012) 0.83

Genetic interference reduces the evolvability of modular and non-modular visual neural networks. Philos Trans R Soc Lond B Biol Sci (2007) 0.82

Comparison of topological clustering within protein networks using edge metrics that evaluate full sequence, full structure, and active site microenvironment similarity. Protein Sci (2015) 0.82

Evolutionary, physicochemical, and functional mechanisms of protein homooligomerization. Prog Mol Biol Transl Sci (2013) 0.81

Evidence for the additions of clustered interacting nodes during the evolution of protein interaction networks from network motifs. BMC Evol Biol (2011) 0.80

Improvisation in evolution of genes and genomes: whose structure is it anyway? Curr Opin Struct Biol (2008) 0.77

Tetrahymena thermophila: a divergent perspective on membrane traffic. J Exp Zool B Mol Dev Evol (2014) 0.77

Gene duplications contribute to the overrepresentation of interactions between proteins of a similar age. BMC Evol Biol (2012) 0.75

Inferring domain-domain interactions from protein-protein interactions in the complex network conformation. BMC Syst Biol (2012) 0.75

Improved homology-driven computational validation of protein-protein interactions motivated by the evolutionary gene duplication and divergence hypothesis. BMC Bioinformatics (2009) 0.75

The impact of the protein interactome on the syntenic structure of mammalian genomes. PLoS One (2017) 0.75

Articles cited by this

Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet (2000) 336.52

The Pfam protein families database. Nucleic Acids Res (2004) 56.46

Functional organization of the yeast proteome by systematic analysis of protein complexes. Nature (2002) 45.19

Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature (2002) 37.66

Global analysis of protein localization in budding yeast. Nature (2003) 33.22

Lethality and centrality in protein networks. Nature (2001) 29.64

The large-scale organization of metabolic networks. Nature (2000) 27.57

The evolutionary fate and consequences of duplicate genes. Science (2000) 24.22

From molecular to modular cell biology. Nature (1999) 23.51

Hierarchical organization of modularity in metabolic networks. Science (2002) 22.47

Rapid and sensitive sequence comparison with FASTP and FASTA. Methods Enzymol (1990) 17.64

Molecular evidence for an ancient duplication of the entire yeast genome. Nature (1997) 13.86

Proof and evolutionary analysis of ancient genome duplication in the yeast Saccharomyces cerevisiae. Nature (2004) 12.32

MIPS: a database for genomes and protein sequences. Nucleic Acids Res (2002) 11.98

Genome evolution in yeasts. Nature (2004) 10.50

Saccharomyces Genome Database (SGD) provides tools to identify and analyze sequences from Saccharomyces cerevisiae and related sequences from other organisms. Nucleic Acids Res (2004) 10.18

Evolution and tinkering. Science (1977) 9.07

Dosage sensitivity and the evolution of gene families in yeast. Nature (2003) 6.77

Revealing modular organization in the yeast transcriptional network. Nat Genet (2002) 6.73

The SUPERFAMILY database in 2004: additions and improvements. Nucleic Acids Res (2004) 6.72

Modular organization of cellular networks. Proc Natl Acad Sci U S A (2003) 6.24

A Sm-like protein complex that participates in mRNA degradation. EMBO J (2000) 5.08

Splitting pairs: the diverging fates of duplicated genes. Nat Rev Genet (2002) 4.89

Biological networks: the tinkerer as an engineer. Science (2003) 4.15

Evolutionary conservation of motif constituents in the yeast protein interaction network. Nat Genet (2003) 4.04

The yeast protein interaction network evolves rapidly and contains few redundant duplicate genes. Mol Biol Evol (2001) 3.86

Gene regulatory network growth by duplication. Nat Genet (2004) 3.79

Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin. EMBO J (1999) 3.68

Protein prenyltransferases. J Biol Chem (1996) 3.52

Vesicle tethering complexes in membrane traffic. J Cell Sci (2002) 3.17

Recent advances in understanding chromatin remodeling by Swi/Snf complexes. Curr Opin Genet Dev (2003) 3.16

Detection of functional modules from protein interaction networks. Proteins (2004) 3.08

Adaptins: the final recount. Mol Biol Cell (2001) 2.94

The altered evolutionary trajectories of gene duplicates. Trends Genet (2004) 2.81

BioLayout--an automatic graph layout algorithm for similarity visualization. Bioinformatics (2001) 2.52

The Sec34/35 Golgi transport complex is related to the exocyst, defining a family of complexes involved in multiple steps of membrane traffic. Dev Cell (2001) 2.33

Asymmetric sequence divergence of duplicate genes. Genome Res (2003) 2.28

The evolution and structural anatomy of the small molecule metabolic pathways in Escherichia coli. J Mol Biol (2001) 2.15

Structural assignments to the Mycoplasma genitalium proteins show extensive gene duplications and domain rearrangements. Proc Natl Acad Sci U S A (1998) 2.08

The structure and early evolution of recently arisen gene duplicates in the Caenorhabditis elegans genome. Genetics (2003) 1.94

Convergent evolution of gene circuits. Nat Genet (2003) 1.89

Is modularity necessary for evolvability? Remarks on the relationship between pleiotropy and evolvability. Biosystems (2003) 1.79

Quantifying modularity in the evolution of biomolecular systems. Genome Res (2004) 1.67

Bioinformatics analysis of experimentally determined protein complexes in the yeast Saccharomyces cerevisiae. Genome Res (2003) 1.53

Evolution of cis-regulatory elements in duplicated genes of yeast. Trends Genet (2003) 1.49

Nonlinear effects in macromolecular assembly and dosage sensitivity. J Theor Biol (2003) 1.42

Genes encoding subunits of stable complexes are clustered on the yeast chromosomes: an interpretation from a dosage balance perspective. Genetics (2004) 1.19

Duplication of modules facilitates the evolution of functional specialization. Artif Life (2000) 1.11

Conserved structural motifs in intracellular trafficking pathways: structure of the gammaCOP appendage domain. Mol Cell (2003) 1.06

Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using yeast three-hybrid system. Biochem Biophys Res Commun (2001) 0.97

Articles by these authors

Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94

Genomic analysis of regulatory network dynamics reveals large topological changes. Nature (2004) 9.32

A census of human transcription factors: function, expression and evolution. Nat Rev Genet (2009) 9.19

An atlas of combinatorial transcriptional regulation in mouse and man. Cell (2010) 6.24

Structure and evolution of transcriptional regulatory networks. Curr Opin Struct Biol (2004) 4.48

Evolution of the protein repertoire. Science (2003) 4.24

Accounting for technical noise in single-cell RNA-seq experiments. Nat Methods (2013) 3.61

Tight regulation of unstructured proteins: from transcript synthesis to protein degradation. Science (2008) 3.48

DBD--taxonomically broad transcription factor predictions: new content and functionality. Nucleic Acids Res (2007) 3.18

Evolution of transcription factors and the gene regulatory network in Escherichia coli. Nucleic Acids Res (2003) 2.87

RNA sequencing reveals two major classes of gene expression levels in metazoan cells. Mol Syst Biol (2011) 2.77

The importance of sequence diversity in the aggregation and evolution of proteins. Nature (2005) 2.70

Structure, function and evolution of multidomain proteins. Curr Opin Struct Biol (2004) 2.58

DBD: a transcription factor prediction database. Nucleic Acids Res (2006) 2.46

Evolutionary dynamics of prokaryotic transcriptional regulatory networks. J Mol Biol (2006) 2.44

Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer. Proc Natl Acad Sci U S A (2013) 2.41

Assembly reflects evolution of protein complexes. Nature (2008) 2.27

3D complex: a structural classification of protein complexes. PLoS Comput Biol (2006) 2.21

The folding and evolution of multidomain proteins. Nat Rev Mol Cell Biol (2007) 2.16

FlyTF: a systematic review of site-specific transcription factors in the fruit fly Drosophila melanogaster. Bioinformatics (2006) 2.13

The relationship between domain duplication and recombination. J Mol Biol (2004) 2.08

The transcriptional program controlled by the stem cell leukemia gene Scl/Tal1 during early embryonic hematopoietic development. Blood (2009) 1.97

The immunoglobulin superfamily in Drosophila melanogaster and Caenorhabditis elegans and the evolution of complexity. Development (2003) 1.96

Evolution of protein complexes by duplication of homomeric interactions. Genome Biol (2007) 1.88

Supra-domains: evolutionary units larger than single protein domains. J Mol Biol (2004) 1.82

Polycomb associates genome-wide with a specific RNA polymerase II variant, and regulates metabolic genes in ESCs. Cell Stem Cell (2012) 1.80

Relative rates of gene fusion and fission in multi-domain proteins. Trends Genet (2005) 1.75

The origins and evolution of functional modules: lessons from protein complexes. Philos Trans R Soc Lond B Biol Sci (2006) 1.71

Statistical analysis of domains in interacting protein pairs. Bioinformatics (2004) 1.64

The interface of protein structure, protein biophysics, and molecular evolution. Protein Sci (2012) 1.54

FlyTF: improved annotation and enhanced functionality of the Drosophila transcription factor database. Nucleic Acids Res (2009) 1.48

Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia and anemia. J Exp Med (2013) 1.40

Functional determinants of transcription factors in Escherichia coli: protein families and binding sites. Trends Genet (2003) 1.34

Functional protein divergence in the evolution of Homo sapiens. Genome Biol (2008) 1.32

Integrated mapping, chromosomal sequencing and sequence analysis of Cryptosporidium parvum. Genome Res (2003) 1.29

Assessing computational methods of cis-regulatory module prediction. PLoS Comput Biol (2010) 1.27

BloodExpress: a database of gene expression in mouse haematopoiesis. Nucleic Acids Res (2008) 1.24

EpiChIP: gene-by-gene quantification of epigenetic modification levels. Nucleic Acids Res (2010) 1.23

Homology, pathway distance and chromosomal localization of the small molecule metabolism enzymes in Escherichia coli. J Mol Biol (2002) 1.22

Genomic repertoires of DNA-binding transcription factors across the tree of life. Nucleic Acids Res (2010) 1.18

The (in)dependence of alternative splicing and gene duplication. PLoS Comput Biol (2007) 1.17

Divergence of interdomain geometry in two-domain proteins. Structure (2006) 1.14

Probing the diverse landscape of protein flexibility and binding. Curr Opin Struct Biol (2012) 1.14

Cellular crowding imposes global constraints on the chemistry and evolution of proteomes. Proc Natl Acad Sci U S A (2012) 1.13

Protein complexes are under evolutionary selection to assemble via ordered pathways. Cell (2013) 1.12

Multi-domain protein families and domain pairs: comparison with known structures and a random model of domain recombination. J Struct Funct Genomics (2003) 1.10

Relative solvent accessible surface area predicts protein conformational changes upon binding. Structure (2011) 1.07

The impact of genomic neighborhood on the evolution of human and chimpanzee transcriptome. Genome Res (2009) 1.06

Patterns of evolutionary constraints on genes in humans. BMC Evol Biol (2008) 0.99

Structure, dynamics, assembly, and evolution of protein complexes. Annu Rev Biochem (2014) 0.97

DNA sequence preferences of transcriptional activators correlate more strongly than repressors with nucleosomes. Mol Cell (2012) 0.97

The developmental expression dynamics of Drosophila melanogaster transcription factors. Genome Biol (2010) 0.96

Analysis and simulation of gene expression profiles in pure and mixed cell populations. Phys Biol (2011) 0.93

Parallel dynamics and evolution: Protein conformational fluctuations and assembly reflect evolutionary changes in sequence and structure. Bioessays (2013) 0.93

The role of salt bridges, charge density, and subunit flexibility in determining disassembly routes of protein complexes. Structure (2013) 0.92

The emergence of protein complexes: quaternary structure, dynamics and allostery. Colworth Medal Lecture. Biochem Soc Trans (2012) 0.92

Evolution of oligomeric state through geometric coupling of protein interfaces. Proc Natl Acad Sci U S A (2012) 0.92

The properties of protein family space depend on experimental design. Bioinformatics (2005) 0.91

Protein domain organisation: adding order. BMC Bioinformatics (2009) 0.91

Regulation of protein-protein binding by coupling between phosphorylation and intrinsic disorder: analysis of human protein complexes. Mol Biosyst (2013) 0.90

Lineage-specific expansion of DNA-binding transcription factor families. Trends Genet (2010) 0.90

How do proteins gain new domains? Genome Biol (2010) 0.88

Duel of the fates: the role of transcriptional circuits and noise in CD4+ cells. Curr Opin Cell Biol (2012) 0.87

Evolution of protein structures and interactions from the perspective of residue contact networks. Curr Opin Struct Biol (2013) 0.87

Nuclear receptors: the evolution of diversity. Sci STKE (2004) 0.86

Comparison of the small molecule metabolic enzymes of Escherichia coli and Saccharomyces cerevisiae. Genome Res (2002) 0.85

Homomeric protein complexes: evolution and assembly. Biochem Soc Trans (2010) 0.84

The impact of gene expression regulation on evolution of extracellular signaling pathways. Mol Cell Proteomics (2010) 0.82

How do you find transcription factors? Computational approaches to compile and annotate repertoires of regulators for any genome. Methods Mol Biol (2012) 0.79

Computational identification of site-specific transcription factors in Drosophila. Fly (Austin) (2007) 0.77

Sequences and topology: evolution of proteins and evolution of computational approaches. Curr Opin Struct Biol (2010) 0.77

Sequences and topology: from genome structure to protein structure. Curr Opin Struct Biol (2008) 0.76

Corrigendum: Characterizing noise structure in single-cell RNA-seq distinguishes genuine from technical stochastic allelic expression. Nat Commun (2016) 0.76

Uncovering the interplay between DNA sequence preferences of transcription factors and nucleosomes. Cell Cycle (2012) 0.75

High-Resolution mRNA and Secretome Atlas of Human Enteroendocrine Cells. Cell (2020) 0.75

Networks for all. Genome Biol (2008) 0.75

The Human Cell Atlas: from vision to reality. Nature (2017) 0.75

Systemizing the structures and structuring the system. Expert Rev Proteomics (2010) 0.75

Immunology meets genomics. Brief Funct Genomics (2013) 0.75