Published in J Exp Med on April 04, 2005
From evolutionary genetics to human immunology: how selection shapes host defence genes. Nat Rev Genet (2009) 2.98
Recognition of peptide-MHC class I complexes by activating killer immunoglobulin-like receptors. Proc Natl Acad Sci U S A (2005) 2.55
HLA alleles determine differences in human natural killer cell responsiveness and potency. Proc Natl Acad Sci U S A (2008) 2.31
A second major histocompatibility complex susceptibility locus for multiple sclerosis. Ann Neurol (2007) 1.99
Distinct KIR/HLA compound genotypes affect the kinetics of human antiviral natural killer cell responses. J Clin Invest (2008) 1.52
Natural killer cells, killer immunoglobulin-like receptors and human leucocyte antigen class I in disease. Clin Exp Immunol (2007) 1.38
Rapid detection of structural variation in a human genome using nanochannel-based genome mapping technology. Gigascience (2014) 1.36
Dramatically reduced surface expression of NK cell receptor KIR2DS3 is attributed to multiple residues throughout the molecule. Genes Immun (2008) 1.28
Identification of a single killer immunoglobulin-like receptor (KIR) gene in the porcine leukocyte receptor complex on chromosome 6q. Immunogenetics (2006) 1.26
Genome-wide association study SNPs in the human genome diversity project populations: does selection affect unlinked SNPs with shared trait associations? PLoS Genet (2011) 1.17
Human-specific evolution and adaptation led to major qualitative differences in the variable receptors of human and chimpanzee natural killer cells. PLoS Genet (2010) 1.16
The leukocyte receptor complex in chicken is characterized by massive expansion and diversification of immunoglobulin-like Loci. PLoS Genet (2006) 1.01
Epigenetic mechanisms of age-dependent KIR2DL4 expression in T cells. J Leukoc Biol (2008) 1.00
A novel method for KIR-ligand typing by pyrosequencing to predict NK cell alloreactivity. Clin Immunol (2007) 0.96
Interactions of NK cell receptor KIR3DL1*004 with chaperones and conformation-specific antibody reveal a functional folded state as well as predominant intracellular retention. J Immunol (2010) 0.95
Natural killer cell responses to HIV-1 peptides are associated with more activating KIR genes and HLA-C genes of the C1 allotype. J Acquir Immune Defic Syndr (2011) 0.93
T-cell co-stimulatory pathways in autoimmunity. Arthritis Res Ther (2008) 0.91
Epistasis and immunity: the role of genetic interactions in autoimmune diseases. Immunology (2012) 0.90
Distribution of killer cell immunoglobulin-like receptors genes in the Italian Caucasian population. J Transl Med (2006) 0.88
Natural killer cells and their receptors in multiple sclerosis. Brain (2012) 0.87
Signatures of historical demography and pathogen richness on MHC class I genes. Immunogenetics (2011) 0.87
Killer cell Ig-like receptor (KIR) 3DL1 down-regulation enhances inhibition of type 1 diabetes by autoantigen-specific regulatory T cells. Proc Natl Acad Sci U S A (2011) 0.87
Human leucocyte antigen class II association in idiopathic bronchiectasis, a disease of chronic lung infection, implicates a role for adaptive immunity. Clin Exp Immunol (2008) 0.86
Complexity in cattle KIR genes: transcription and genome analysis. Immunogenetics (2007) 0.84
Role of host genetic factors in the outcome of hepatitis C virus infection. Viruses (2009) 0.84
Genetic susceptibility to Chagas disease: an overview about the infection and about the association between disease and the immune response genes. Biomed Res Int (2013) 0.84
Killer-cell immunoglobulin-like receptor and human leukocyte antigen-C genes in common variable immunodeficiency. Wien Klin Wochenschr (2015) 0.82
Immunogenetic characteristics of patients with autoimmune gastritis. World J Gastroenterol (2010) 0.82
Activation or tolerance of natural killer cells is modulated by ligand quality in a nonmonotonic manner. Biophys J (2010) 0.81
The role of KIR and HLA interactions in pregnancy complications. Immunogenetics (2017) 0.81
Self-association of an activating natural killer cell receptor, KIR2DS1. PLoS One (2011) 0.80
Killer-cell immunoglobulin-like receptors and malaria caused by Plasmodium falciparum in The Gambia. Tissue Antigens (2012) 0.79
Association of Killer Cell Immunoglobulin- Like Receptor Genes in Iranian Patients with Rheumatoid Arthritis. PLoS One (2015) 0.78
KIR2DL3 and KIR2DL1 show similar impact on licensing of human NK cells. Eur J Immunol (2015) 0.78
Influence of KIR genes and their HLA ligands in the pathogenesis of leprosy in a hyperendemic population of Rondonópolis, Southern Brazil. BMC Infect Dis (2014) 0.77
The association of the immune response genes to human papillomavirus-related cervical disease in a Brazilian population. Biomed Res Int (2013) 0.77
Importance of killer immunoglobulin-like receptors in allogeneic hematopoietic stem cell transplantation. Rev Bras Hematol Hemoter (2011) 0.77
Genetic epistasis between killer immunoglobulin-like receptors and human leukocyte antigens in Kawasaki disease susceptibility. Genes Immun (2015) 0.76
Genotypic diversity of the Killer Cell Immunoglobulin-like Receptors (KIR) and their HLA class I Ligands in a Saudi population. Genet Mol Biol (2016) 0.76
NKG2C(+)CD57(+) Natural Killer Cell Expansion Parallels Cytomegalovirus-Specific CD8(+) T Cell Evolution towards Senescence. J Immunol Res (2016) 0.75
Influence of host resistance on viral adaptation: hepatitis C virus as a case study. Infect Drug Resist (2015) 0.75
KIR and HLA Genotypes Implicated in Reduced Killer Lymphocytes Immunity Are Associated with Vogt-Koyanagi-Harada Disease. PLoS One (2016) 0.75
HLA class I and class II frequencies in patients with cutaneous malignant melanoma from southeastern Spain: the role of HLA-C in disease prognosis. Immunogenetics (2005) 0.75
Canonical and Cross-reactive Binding of NK Cell Inhibitory Receptors to HLA-C Allotypes Is Dictated by Peptides Bound to HLA-C. Front Immunol (2017) 0.75
Analysis of killer cell immunoglobulin-like receptors (KIRs) and their HLA ligand genes polymorphisms in Iranian patients with systemic sclerosis. Clin Rheumatol (2017) 0.75
Human Leukocyte Antigen (HLA) and Immune Regulation: How Do Classical and Non-Classical HLA Alleles Modulate Immune Response to Human Immunodeficiency Virus and Hepatitis C Virus Infections? Front Immunol (2017) 0.75
HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection. Science (2004) 8.22
Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors. Science (2002) 7.70
Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS. Nat Genet (2002) 7.58
MHC class I molecules and KIRs in human history, health and survival. Nat Rev Immunol (2005) 6.98
HL-A, immune-response genes, and disease. Lancet (1974) 5.67
Recognition of a virus-encoded ligand by a natural killer cell activation receptor. Proc Natl Acad Sci U S A (2002) 5.17
KIR: diverse, rapidly evolving receptors of innate and adaptive immunity. Annu Rev Immunol (2001) 4.24
Combinations of maternal KIR and fetal HLA-C genes influence the risk of preeclampsia and reproductive success. J Exp Med (2004) 3.87
Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors. Immunity (1997) 3.84
Crystal structure of an NK cell immunoglobulin-like receptor in complex with its class I MHC ligand. Nature (2000) 3.54
Direct binding and functional transfer of NK cell inhibitory receptors reveal novel patterns of HLA-C allotype recognition. J Immunol (1998) 2.79
Major histocompatibility complex class I-recognizing receptors are disease risk genes in rheumatoid arthritis. J Exp Med (2001) 2.41
Killer Ig-like receptor haplotype analysis by gene content: evidence for genomic diversity with a minimum of six basic framework haplotypes, each with multiple subsets. J Immunol (2002) 2.38
Recognition of HLA-A3 and HLA-A11 by KIR3DL2 is peptide-specific. Eur J Immunol (2004) 2.24
Genetically linked C-type lectin-related ligands for the NKRP1 family of natural killer cell receptors. Nat Immunol (2003) 2.09
Hierarchy of resistance to cervical neoplasia mediated by combinations of killer immunoglobulin-like receptor and human leukocyte antigen loci. J Exp Med (2005) 2.06
Role of amino acid position 70 in the binding affinity of p50.1 and p58.1 receptors for HLA-Cw4 molecules. Eur J Immunol (1997) 1.84
Cutting edge: heterozygote advantage in autoimmune disease: hierarchy of protection/susceptibility conferred by HLA and killer Ig-like receptor combinations in psoriatic arthritis. J Immunol (2004) 1.83
Missing self-recognition of Ocil/Clr-b by inhibitory NKR-P1 natural killer cell receptors. Proc Natl Acad Sci U S A (2004) 1.76
A signal peptide derived from hsp60 binds HLA-E and interferes with CD94/NKG2A recognition. J Exp Med (2002) 1.67
Killer cell immunoglobulin receptors and T cell receptors bind peptide-major histocompatibility complex class I with distinct thermodynamic and kinetic properties. J Biol Chem (1999) 1.50
KIR in type 1 diabetes: disparate distribution of activating and inhibitory natural killer cell receptors in patients versus HLA-matched control subjects. Diabetes (2003) 1.42
Kinetics of interaction of HLA-C ligands with natural killer cell inhibitory receptors. Immunity (1998) 1.38
HLA class I recognition by killer cell Ig-like receptors. Semin Immunol (2000) 1.37
Gene for the activating natural killer cell receptor, KIR2DS1, is associated with susceptibility to psoriasis vulgaris. Hum Immunol (2004) 1.37
MHC class I-independent recognition of NK-activating receptor KIR2DS4. J Immunol (2004) 1.22
HPV innate immunity. Front Biosci (2002) 1.21
Selective activation of the c-Jun NH2-terminal protein kinase signaling pathway by stimulatory KIR in the absence of KARAP/DAP12 in CD4+ T cells. J Exp Med (2003) 1.18
Zinc bound to the killer cell-inhibitory receptor modulates the negative signal in human NK cells. J Immunol (1998) 1.10
The role of zinc in the binding of killer cell Ig-like receptors to class I MHC proteins. Proc Natl Acad Sci U S A (2001) 1.02
Genetic polymorphism of NK receptors and their ligands in melanoma patients: prevalence of inhibitory over activating signals. Cancer Immunol Immunother (2004) 1.02
Synergy among receptors on resting NK cells for the activation of natural cytotoxicity and cytokine secretion. Blood (2005) 3.99
Regulation of human NK-cell cytokine and chemokine production by target cell recognition. Blood (2009) 3.46
Cytolytic granule polarization and degranulation controlled by different receptors in resting NK cells. J Exp Med (2005) 3.41
Activation, coactivation, and costimulation of resting human natural killer cells. Immunol Rev (2006) 3.30
Defective cytotoxic lymphocyte degranulation in syntaxin-11 deficient familial hemophagocytic lymphohistiocytosis 4 (FHL4) patients. Blood (2007) 2.32
Line of attack: NK cell specificity and integration of signals. Curr Opin Immunol (2008) 2.15
Vav1 dephosphorylation by the tyrosine phosphatase SHP-1 as a mechanism for inhibition of cellular cytotoxicity. Mol Cell Biol (2003) 2.15
Activation of NK cells by an endocytosed receptor for soluble HLA-G. PLoS Biol (2006) 2.08
Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions. N Engl J Med (2012) 2.08
Inhibitory receptor signaling via tyrosine phosphorylation of the adaptor Crk. Immunity (2008) 2.03
LFA-1 contributes an early signal for NK cell cytotoxicity. J Immunol (2004) 2.00
Integrin-dependent organization and bidirectional vesicular traffic at cytotoxic immune synapses. Immunity (2009) 1.74
Minimal requirement for induction of natural cytotoxicity and intersection of activation signals by inhibitory receptors. Blood (2009) 1.62
Molecular basis for positive and negative signaling by the natural killer cell receptor 2B4 (CD244). Blood (2005) 1.61
KIR2DL4 (CD158d), an NK cell-activating receptor with inhibitory potential. J Immunol (2002) 1.54
Cytotoxic immunological synapses. Immunol Rev (2010) 1.45
Vav1 phosphorylation is induced by beta2 integrin engagement on natural killer cells upstream of actin cytoskeleton and lipid raft reorganization. J Exp Med (2003) 1.44
Natural killer cell inhibitory receptors block actin cytoskeleton-dependent recruitment of 2B4 (CD244) to lipid rafts. J Exp Med (2003) 1.41
DNA-PKcs controls an endosomal signaling pathway for a proinflammatory response by natural killer cells. Sci Signal (2010) 1.39
Coexpression of CD58 or CD48 with intercellular adhesion molecule 1 on target cells enhances adhesion of resting NK cells. J Immunol (2003) 1.33
Cellular senescence induced by CD158d reprograms natural killer cells to promote vascular remodeling. Proc Natl Acad Sci U S A (2012) 1.29
Synergistic signals for natural cytotoxicity are required to overcome inhibition by c-Cbl ubiquitin ligase. Immunity (2010) 1.25
Functional analysis of human NK cells by flow cytometry. Methods Mol Biol (2010) 1.16
Spontaneous clustering and tyrosine phosphorylation of NK cell inhibitory receptor induced by ligand binding. J Immunol (2003) 1.15
KIR2DL4 (CD158d): An activation receptor for HLA-G. Front Immunol (2012) 1.10
Comment on "Killer Ig-like receptor 2DL4 does not mediate NK Cell IFN-γ responses to soluble HLA-G preparations". J Immunol (2014) 1.09
The adaptor protein Crk controls activation and inhibition of natural killer cells. Immunity (2012) 1.07
Pillars article: Recruitment of tyrosine phosphatase HCP by the killer cell inhibitory receptor. Immunity. 1996. 4: 77-85. J Immunol (2013) 1.07
Tethering of intercellular adhesion molecule on target cells is required for LFA-1-dependent NK cell adhesion and granule polarization. J Immunol (2010) 1.04
KIR enrichment at the effector-target cell interface is more sensitive than signaling to the strength of ligand binding. Eur J Immunol (2003) 1.03
β2 integrin induces TCRζ-Syk-phospholipase C-γ phosphorylation and paxillin-dependent granule polarization in human NK cells. J Immunol (2011) 1.02
Signal transduction during activation and inhibition of natural killer cells. Curr Protoc Immunol (2010) 1.00
Distinct role of rab27a in granule movement at the plasma membrane and in the cytosol of NK cells. PLoS One (2010) 0.99
Recruitment of activation receptors at inhibitory NK cell immune synapses. PLoS One (2008) 0.99
Two modes of lytic granule fusion during degranulation by natural killer cells. Immunol Cell Biol (2011) 0.97
Cutting edge: NK cell licensing modulates adhesion to target cells. J Immunol (2013) 0.93
Palmitoylation of MICA, a ligand for NKG2D, mediates its recruitment to membrane microdomains and promotes its shedding. Eur J Immunol (2011) 0.91
Inhibitory receptor gp49B regulates eosinophil infiltration during allergic inflammation. J Leukoc Biol (2007) 0.89
Complementary phosphorylation sites in the adaptor protein SLP-76 promote synergistic activation of natural killer cells. Sci Signal (2012) 0.89
Versatile signaling through NKG2D. Nat Immunol (2002) 0.85
Viral evasion of NK-cell activation. Trends Immunol (2005) 0.82
Cutting edge: NKG2D-dependent cytotoxicity is controlled by ligand distribution in the target cell membrane. J Immunol (2011) 0.82
Lytic granule polarization, rather than degranulation, is the preferred target of inhibitory receptors in NK cells. J Immunol (2010) 0.81
Antagonizing inhibition gets NK cells going. Proc Natl Acad Sci U S A (2010) 0.79
A positive role for senescence in reproduction? Aging (Albany NY) (2013) 0.78
Found: a cellular activating ligand for NKp44. Blood (2013) 0.78
Use of transfected Drosophila S2 cells to study NK cell activation. Methods Mol Biol (2010) 0.78
TNFR-associated factor 6 and TGF-β-activated kinase 1 control signals for a senescence response by an endosomal NK cell receptor. J Immunol (2013) 0.77