Published in Drug Metab Dispos on April 08, 2005
Computational prediction of metabolism: sites, products, SAR, P450 enzyme dynamics, and mechanisms. J Chem Inf Model (2012) 1.29
Theoretical characterization of substrate access/exit channels in the human cytochrome P450 3A4 enzyme: involvement of phenylalanine residues in the gating mechanism. J Phys Chem B (2009) 1.23
Mechanics of channel gating of the nicotinic acetylcholine receptor. PLoS Comput Biol (2008) 1.05
Effect of conformational dynamics on substrate recognition and specificity as probed by the introduction of a de novo disulfide bond into cytochrome P450 2B1. J Biol Chem (2009) 0.98
Probing possible egress channels for multiple ligands in human CYP3A4: a molecular modeling study. J Mol Model (2009) 0.82
The role of cytochrome P450 2B6 and 2B4 substrate access channel residues predicted based on crystal structures of the amlodipine complexes. Arch Biochem Biophys (2014) 0.82
Investigation of indazole unbinding pathways in CYP2E1 by molecular dynamics simulations. PLoS One (2012) 0.82
Ligand tunnels in T. brucei and human CYP51: Insights for parasite-specific drug design. Biochim Biophys Acta (2015) 0.78
Analysis of Cytochrome P450 Conserved Sequence Motifs between Helices E and H: Prediction of Critical Motifs and Residues in Enzyme Functions. J Drug Metab Toxicol (2011) 0.75
Studies on 16α-Hydroxylation of Steroid Molecules and Regioselective Binding Mode in Homology-Modeled Cytochrome P450-2C11. Int J Med Chem (2010) 0.75
Molecular basis of P450 OleTJE: an investigation of substrate binding mechanism and major pathways. J Comput Aided Mol Des (2017) 0.75
Molecular anatomy of a trafficking organelle. Cell (2006) 11.47
Prevalence of chronic kidney disease in China: a cross-sectional survey. Lancet (2012) 10.53
The marine viromes of four oceanic regions. PLoS Biol (2006) 10.19
Genomewide association study of leprosy. N Engl J Med (2009) 8.17
Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature (2005) 7.24
Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157. Nucleic Acids Res (2002) 4.92
Metagenomic analysis of the microbial community associated with the coral Porites astreoides. Environ Microbiol (2007) 4.21
Pluripotent stem cells from the adult mouse inner ear. Nat Med (2003) 3.92
Perioperative dexmedetomidine improves outcomes of cardiac surgery. Circulation (2013) 3.91
Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2. Nature (2010) 3.59
Interleukin-29 uses a type 1 interferon-like program to promote antiviral responses in human hepatocytes. Hepatology (2006) 3.46
Structure of the CCR5 chemokine receptor-HIV entry inhibitor maraviroc complex. Science (2013) 3.17
Diffusion-weighted and fluid-attenuated inversion recovery imaging in Creutzfeldt-Jakob disease: high sensitivity and specificity for diagnosis. AJNR Am J Neuroradiol (2005) 3.11
Predicting protein-protein interactions based only on sequences information. Proc Natl Acad Sci U S A (2007) 3.06
Preoperative aspirin use and outcomes in cardiac surgery patients. Ann Surg (2012) 3.03
Uncoupled cardiac nitric oxide synthase mediates diastolic dysfunction. Circulation (2010) 2.95
Viral and microbial community dynamics in four aquatic environments. ISME J (2010) 2.95
A survey on gas sensing technology. Sensors (Basel) (2012) 2.79
An open conformation of mammalian cytochrome P450 2B4 at 1.6-A resolution. Proc Natl Acad Sci U S A (2003) 2.74
Biodiversity and biogeography of phages in modern stromatolites and thrombolites. Nature (2008) 2.70
Structure of mammalian cytochrome P450 2B4 complexed with 4-(4-chlorophenyl)imidazole at 1.9-A resolution: insight into the range of P450 conformations and the coordination of redox partner binding. J Biol Chem (2004) 2.66
SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism. J Biol Chem (2005) 2.64
Sodium-calcium exchange initiated by the Ca2+ transient: an arrhythmia trigger within pulmonary veins. J Am Coll Cardiol (2006) 2.57
Molecular mimicry regulates ABA signaling by SnRK2 kinases and PP2C phosphatases. Science (2011) 2.52
Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA. Nat Chem Biol (2012) 2.45
Fluorine in pharmaceutical industry: fluorine-containing drugs introduced to the market in the last decade (2001-2011). Chem Rev (2013) 2.38
PDTD: a web-accessible protein database for drug target identification. BMC Bioinformatics (2008) 2.35
TarFisDock: a web server for identifying drug targets with docking approach. Nucleic Acids Res (2006) 2.26
Structure and mechanism of the reversible photoswitch of a fluorescent protein. Proc Natl Acad Sci U S A (2005) 2.21
Origins and functional specialization of macrophages and of conventional and monocyte-derived dendritic cells in mouse skin. Immunity (2013) 2.20
Overexpression of cytochrome P450 4F2 in mice increases 20-hydroxyeicosatetraenoic acid production and arterial blood pressure. Kidney Int (2009) 2.19
Paradoxical action of fulvestrant in estradiol-induced regression of tamoxifen-stimulated breast cancer. J Natl Cancer Inst (2003) 2.18
Probing the chemistry of thioredoxin catalysis with force. Nature (2007) 2.17
Mechanoenzymatics of titin kinase. Proc Natl Acad Sci U S A (2008) 2.17
Delayed ischemic preconditioning contributes to renal protection by upregulation of miR-21. Kidney Int (2012) 2.12
Characterization of the bell-shaped vibratory angular rate gyro. Sensors (Basel) (2013) 2.04
Mutation analysis of the MVK gene in Chinese patients with disseminated superficial actinic porokeratosis. J Dermatol Sci (2013) 2.04
Targeting the intracellular WT1 oncogene product with a therapeutic human antibody. Sci Transl Med (2013) 2.03
The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active site. Nat Struct Mol Biol (2010) 1.98
Transcriptional adaptation of Shigella flexneri during infection of macrophages and epithelial cells: insights into the strategies of a cytosolic bacterial pathogen. Infect Immun (2005) 1.96
Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy. Nat Genet (2011) 1.95
Structure of microsomal cytochrome P450 2B4 complexed with the antifungal drug bifonazole: insight into P450 conformational plasticity and membrane interaction. J Biol Chem (2005) 1.91
Distinction between recurrent glioma and radiation injury using magnetic resonance spectroscopy in combination with diffusion-weighted imaging. Int J Radiat Oncol Biol Phys (2007) 1.89
Structural basis for molecular recognition at serotonin receptors. Science (2013) 1.86
Metagenomic analysis indicates that stressors induce production of herpes-like viruses in the coral Porites compressa. Proc Natl Acad Sci U S A (2008) 1.86
Generation of hair cells by stepwise differentiation of embryonic stem cells. Proc Natl Acad Sci U S A (2003) 1.81
Inhibition of c-Src tyrosine kinase prevents angiotensin II-mediated connexin-43 remodeling and sudden cardiac death. J Am Coll Cardiol (2011) 1.80
Enhancement of DNA vaccine potency in rhesus macaques by electroporation. Vaccine (2004) 1.74
Ceramide kinase, a novel lipid kinase. Molecular cloning and functional characterization. J Biol Chem (2002) 1.73
Sustainable power generation in microbial fuel cells using bicarbonate buffer and proton transfer mechanisms. Environ Sci Technol (2007) 1.72
Mechanically induced titin kinase activation studied by force-probe molecular dynamics simulations. Biophys J (2004) 1.70
Effectiveness of rapid initial dose escalation of up to forty milligrams per day of oral olanzapine in acute agitation. J Clin Psychopharmacol (2003) 1.70
X-ray phase-attenuation duality and phase retrieval. Opt Lett (2005) 1.68
Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001. Nature (2012) 1.68
Halogen bonding--a novel interaction for rational drug design? J Med Chem (2009) 1.68
1,25-dihydroxyvitamin D(3) ameliorates Th17 autoimmunity via transcriptional modulation of interleukin-17A. Mol Cell Biol (2011) 1.67
Research on bell-shaped vibratory angular rate gyro's character of resonator. Sensors (Basel) (2013) 1.66
A new theory of phase-contrast x-ray imaging based on Wigner distributions. Med Phys (2004) 1.66
Therapeutic potential of a synthetic lethal interaction between the MYC proto-oncogene and inhibition of aurora-B kinase. Proc Natl Acad Sci U S A (2010) 1.65
A Bi2 WO6 -based hybrid photocatalyst with broad spectrum photocatalytic properties under UV, visible, and near-infrared irradiation. Adv Mater (2013) 1.65
Blocking IL-17A promotes the resolution of pulmonary inflammation and fibrosis via TGF-beta1-dependent and -independent mechanisms. J Immunol (2011) 1.65
The chromatin-remodeling BAF complex mediates cellular antiviral activities by promoter priming. Mol Cell Biol (2004) 1.64
Structures of human cytochrome P-450 2E1. Insights into the binding of inhibitors and both small molecular weight and fatty acid substrates. J Biol Chem (2008) 1.63
Inactivation of a two-component signal transduction system, SaeRS, eliminates adherence and attenuates virulence of Staphylococcus aureus. Infect Immun (2006) 1.63
Anesthetic preconditioning combined with postconditioning offers no additional benefit over preconditioning or postconditioning alone. Anesth Analg (2007) 1.58
An alphavirus replicon particle chimera derived from venezuelan equine encephalitis and sindbis viruses is a potent gene-based vaccine delivery vector. J Virol (2003) 1.56
Construction of genetic linkage maps and comparative genome analysis of catfish using gene-associated markers. Genetics (2009) 1.55
Quality assessment parameters for EST-derived SNPs from catfish. BMC Genomics (2008) 1.54
A tissue engineering approach to progenitor cell delivery results in significant cell engraftment and improved myocardial remodeling. Stem Cells (2007) 1.53
Clinical implementation of x-ray phase-contrast imaging: theoretical foundations and design considerations. Med Phys (2003) 1.53
A nonproton ligand sensor in the acid-sensing ion channel. Neuron (2010) 1.52
Nonclassic functions of human topoisomerase I: genome-wide and pharmacologic analyses. Cancer Res (2007) 1.51
PharmMapper server: a web server for potential drug target identification using pharmacophore mapping approach. Nucleic Acids Res (2010) 1.50
Loss of melanopsin-containing retinal ganglion cells in a rat glaucoma model. Chin Med J (Engl) (2008) 1.48
Emergence of genotype I of Japanese encephalitis virus as the dominant genotype in Asia. J Virol (2011) 1.46
Glutathione S-transferase P1 Ile105Val polymorphism and breast cancer risk: a meta-analysis involving 34,658 subjects. Breast Cancer Res Treat (2010) 1.46
Outbreak of infection caused by Enterobacter cloacae producing the novel VEB-3 beta-lactamase in China. J Clin Microbiol (2005) 1.46
Structural basis for the regulation of cysteine-protease activity by a new class of protease inhibitors in Plasmodium. Structure (2011) 1.46
Multipotential differentiation of human urine-derived stem cells: potential for therapeutic applications in urology. Stem Cells (2013) 1.46
Intracellular distribution of TiO2-DNA oligonucleotide nanoconjugates directed to nucleolus and mitochondria indicates sequence specificity. Nano Lett (2007) 1.43
Generation of genome-scale gene-associated SNPs in catfish for the construction of a high-density SNP array. BMC Genomics (2011) 1.43
Indoleamine 2, 3-Dioxgenase Transfected Mesenchymal Stem Cells Induce Kidney Allograft Tolerance by Increasing the Production and Function of Regulatory T Cells. Transplantation (2015) 1.41
Complete sequence determination of a novel reptile iridovirus isolated from soft-shelled turtle and evolutionary analysis of Iridoviridae. BMC Genomics (2009) 1.40
Six novel mutations of ATP2C1 identified in eight Chinese patients with Hailey-Hailey disease. Indian J Dermatol Venereol Leprol (2013) 1.40
A novel acylglycerol kinase that produces lysophosphatidic acid modulates cross talk with EGFR in prostate cancer cells. J Cell Biol (2005) 1.40
Reactive oxygen species originating from mitochondria regulate the cardiac sodium channel. Circ Res (2010) 1.40
Ranolazine improves cardiac diastolic dysfunction through modulation of myofilament calcium sensitivity. Circ Res (2012) 1.39
[Retrospective study of application of interspinous implants for degenerative lumbar diseases]. Zhonghua Yi Xue Za Zhi (2009) 1.39
Loss of cell wall alpha(1-3) glucan affects Cryptococcus neoformans from ultrastructure to virulence. Mol Microbiol (2007) 1.38
Crystal structure of HAb18G/CD147: implications for immunoglobulin superfamily homophilic adhesion. J Biol Chem (2008) 1.38
Power densities using different cathode catalysts (Pt and CoTMPP) and polymer binders (nafion and PTFE) in single chamber microbial fuel cells. Environ Sci Technol (2006) 1.38
Identification and characterization of catabolic para-nitrophenol 4-monooxygenase and para-benzoquinone reductase from Pseudomonas sp. strain WBC-3. J Bacteriol (2009) 1.37