Published in Hum Mol Genet on April 13, 2005
Allele-specific up-regulation of FGFR2 increases susceptibility to breast cancer. PLoS Biol (2008) 3.49
Growth of the normal skull vault and its alteration in craniosynostosis: insights from human genetics and experimental studies. J Anat (2005) 2.58
Normal and disease-related biological functions of Twist1 and underlying molecular mechanisms. Cell Res (2011) 1.99
Twist1 homodimers enhance FGF responsiveness of the cranial sutures and promote suture closure. Dev Biol (2008) 1.47
Redundant or separate entities?--roles of Twist1 and Twist2 as molecular switches during gene transcription. Nucleic Acids Res (2010) 1.35
Runx2 regulates G protein-coupled signaling pathways to control growth of osteoblast progenitors. J Biol Chem (2008) 1.32
EphA4 as an effector of Twist1 in the guidance of osteogenic precursor cells during calvarial bone growth and in craniosynostosis. Development (2009) 1.26
Intricate gene regulatory networks of helix-loop-helix (HLH) proteins support regulation of bone-tissue related genes during osteoblast differentiation. J Cell Biochem (2008) 1.19
Hypoxia inhibits osteogenesis in human mesenchymal stem cells through direct regulation of RUNX2 by TWIST. PLoS One (2011) 1.06
Fibroblast growth factor signaling in skeletal development and disease. Genes Dev (2015) 1.04
A newly described bovine type 2 scurs syndrome segregates with a frame-shift mutation in TWIST1. PLoS One (2011) 1.01
FGFR1 activation is an escape mechanism in human lung cancer cells resistant to afatinib, a pan-EGFR family kinase inhibitor. Oncotarget (2014) 1.00
Down-regulation of ubiquitin ligase Cbl induced by twist haploinsufficiency in Saethre-Chotzen syndrome results in increased PI3K/Akt signaling and osteoblast proliferation. Am J Pathol (2006) 0.90
Molecular studies on the roles of Runx2 and Twist1 in regulating FGF signaling. Dev Dyn (2012) 0.83
Scalp fibroblasts have a shared expression profile in monogenic craniosynostosis. J Med Genet (2009) 0.81
Development of an efficient, non-viral transfection method for studying gene function and bone growth in human primary cranial suture mesenchymal cells reveals that the cells respond to BMP2 and BMP3. BMC Biotechnol (2012) 0.80
Twist1- and Twist2-haploinsufficiency results in reduced bone formation. PLoS One (2014) 0.79
Aberrant gene expression profiles, during in vitro osteoblast differentiation, of telomerase deficient mouse bone marrow stromal stem cells (mBMSCs). J Biomed Sci (2015) 0.79
Twist1 Is Essential for Tooth Morphogenesis and Odontoblast Differentiation. J Biol Chem (2015) 0.75
Association of TWIST1 gene polymorphisms with bone mineral density in postmenopausal women. Osteoporos Int (2009) 0.75
FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease. Genes Dev (2002) 4.16
Senescence-associated intrinsic mechanisms of osteoblast dysfunctions. Aging Cell (2011) 1.38
ErbB3 silencing reduces osteosarcoma cell proliferation and tumor growth in vivo. Gene (2013) 1.38
Priming integrin alpha5 promotes human mesenchymal stromal cell osteoblast differentiation and osteogenesis. Proc Natl Acad Sci U S A (2009) 1.35
Blockade of the RhoA-JNK-c-Jun-MMP2 cascade by atorvastatin reduces osteosarcoma cell invasion. J Biol Chem (2008) 1.29
N-cadherin interacts with axin and LRP5 to negatively regulate Wnt/beta-catenin signaling, osteoblast function, and bone formation. Mol Cell Biol (2008) 1.27
Fibroblast growth factor receptor signaling crosstalk in skeletogenesis. Sci Signal (2010) 1.24
FHL2 mediates dexamethasone-induced mesenchymal cell differentiation into osteoblasts by activating Wnt/beta-catenin signaling-dependent Runx2 expression. FASEB J (2008) 1.23
Fibroblast growth factor receptor 2 promotes osteogenic differentiation in mesenchymal cells via ERK1/2 and protein kinase C signaling. J Biol Chem (2008) 1.18
Cbl-mediated ubiquitination of alpha5 integrin subunit mediates fibronectin-dependent osteoblast detachment and apoptosis induced by FGFR2 activation. J Cell Sci (2005) 1.17
Strontium signaling: molecular mechanisms and therapeutic implications in osteoporosis. Pharmacol Ther (2012) 1.16
Transforming growth factor beta2 inhibits adipocyte differentiation induced by skeletal unloading in rat bone marrow stroma. J Bone Miner Res (2002) 1.15
A soluble form of fibroblast growth factor receptor 2 (FGFR2) with S252W mutation acts as an efficient inhibitor for the enhanced osteoblastic differentiation caused by FGFR2 activation in Apert syndrome. J Biol Chem (2004) 1.07
Cbl-mediated degradation of Lyn and Fyn induced by constitutive fibroblast growth factor receptor-2 activation supports osteoblast differentiation. J Biol Chem (2004) 1.06
Calcium sensing receptor-dependent and receptor-independent activation of osteoblast replication and survival by strontium ranelate. J Cell Mol Med (2009) 1.03
Essential role of nuclear factor of activated T cells (NFAT)-mediated Wnt signaling in osteoblast differentiation induced by strontium ranelate. J Biol Chem (2010) 1.00
Statin-induced inhibition of 3-hydroxy-3-methyl glutaryl coenzyme a reductase sensitizes human osteosarcoma cells to anticancer drugs. J Pharmacol Exp Ther (2008) 0.99
N-cadherin negatively regulates osteoblast proliferation and survival by antagonizing Wnt, ERK and PI3K/Akt signalling. PLoS One (2009) 0.98
Pivotal role of Twist in skeletal biology and pathology. Gene (2010) 0.97
Crosstalks between integrin alpha 5 and IGF2/IGFBP2 signalling trigger human bone marrow-derived mesenchymal stromal osteogenic differentiation. BMC Cell Biol (2010) 0.96
Twist haploinsufficiency in Saethre-Chotzen syndrome induces calvarial osteoblast apoptosis due to increased TNFalpha expression and caspase-2 activation. Hum Mol Genet (2002) 0.95
CYR61 downregulation reduces osteosarcoma cell invasion, migration, and metastasis. J Bone Miner Res (2011) 0.94
FGFR2-Cbl interaction in lipid rafts triggers attenuation of PI3K/Akt signaling and osteoblast survival. Bone (2008) 0.94
Syndecan-2 affects the basal and chemotherapy-induced apoptosis in osteosarcoma. Cancer Res (2007) 0.91
FHL2 silencing reduces Wnt signaling and osteosarcoma tumorigenesis in vitro and in vivo. PLoS One (2013) 0.91
Bone morphogenetic protein receptor IB signaling mediates apoptosis independently of differentiation in osteoblastic cells. J Biol Chem (2003) 0.90
TWIST inactivation reduces CBFA1/RUNX2 expression and DNA binding to the osteocalcin promoter in osteoblasts. Biochem Biophys Res Commun (2002) 0.90
Down-regulation of ubiquitin ligase Cbl induced by twist haploinsufficiency in Saethre-Chotzen syndrome results in increased PI3K/Akt signaling and osteoblast proliferation. Am J Pathol (2006) 0.90
Autocrine fibroblast growth factor 18 mediates dexamethasone-induced osteogenic differentiation of murine mesenchymal stem cells. J Cell Physiol (2010) 0.89
Molecular silencing of Twist1 enhances osteogenic differentiation of murine mesenchymal stem cells: implication of FGFR2 signaling. J Cell Biochem (2010) 0.89
Transforming growth factor-beta prevents osteoblast apoptosis induced by skeletal unloading via PI3K/Akt, Bcl-2, and phospho-Bad signaling. Am J Physiol Endocrinol Metab (2008) 0.88
Strontium ranelate rebalances bone marrow adipogenesis and osteoblastogenesis in senescent osteopenic mice through NFATc/Maf and Wnt signaling. Aging Cell (2012) 0.87
Lentiviral-mediated integrin α5 expression in human adult mesenchymal stromal cells promotes bone repair in mouse cranial and long-bone defects. Hum Gene Ther (2011) 0.87
Roles of FGFR2 and twist in human craniosynostosis: insights from genetic mutations in cranial osteoblasts. Front Oral Biol (2008) 0.86
The LIM-only protein FHL2 controls mesenchymal cell osteogenic differentiation and bone formation through Wnt5a and Wnt10b. Bone (2012) 0.85
Syndecan-2 overexpression induces osteosarcoma cell apoptosis: Implication of syndecan-2 cytoplasmic domain and JNK signaling. Bone (2005) 0.85
Topographically induced self-deformation of the nuclei of cells: dependence on cell type and proposed mechanisms. J Mater Sci Mater Med (2009) 0.85
Increased EFG- and PDGFalpha-receptor signaling by mutant FGF-receptor 2 contributes to osteoblast dysfunction in Apert craniosynostosis. Hum Mol Genet (2010) 0.85
Functional relevance of the BMD-associated polymorphism rs312009: novel involvement of RUNX2 in LRP5 transcriptional regulation. J Bone Miner Res (2011) 0.84
Calpain-6 is an endothelin-1 signaling dependent protective factor in chemoresistant osteosarcoma. Int J Cancer (2011) 0.83
Distinct osteoblastic differentiation potential of murine fetal liver and bone marrow stroma-derived mesenchymal stem cells. J Cell Biochem (2008) 0.83
Peptide-based mediated disruption of N-cadherin-LRP5/6 interaction promotes Wnt signaling and bone formation. J Bone Miner Res (2012) 0.83
Dual involvement of protein kinase C delta in apoptosis induced by syndecan-2 in osteoblasts. J Cell Biochem (2006) 0.82
Targeted inhibition of T-cell factor activity promotes syndecan-2 expression and sensitization to doxorubicin in osteosarcoma cells and bone tumors in mice. J Bone Miner Res (2012) 0.82
Growth factors and bone formation in osteoporosis: roles for fibroblast growth factor and transforming growth factor beta. Curr Pharm Des (2004) 0.82
Different sympathetic pathways control the metabolism of distinct bone envelopes. Bone (2012) 0.81
Downregulation of ErbB3 by Wnt3a contributes to wnt-induced osteoblast differentiation in mesenchymal cells. J Cell Biochem (2012) 0.80
The green tea compound, (-)-epigallocatechin-3-gallate downregulates N-cadherin and suppresses migration of bladder carcinoma cells. J Cell Biochem (2007) 0.80
Peptide-based activation of alpha5 integrin for promoting osteogenesis. J Cell Biochem (2012) 0.80
Promotion of osteoblast differentiation in mesenchymal cells through Cbl-mediated control of STAT5 activity. Stem Cells (2013) 0.79
Apoptosis in membranous bone formation: role of fibroblast growth factor and bone morphogenetic protein signaling. Crit Rev Eukaryot Gene Expr (2005) 0.79
About the comparison of two anabolic agents, teriparatide and strontium ranelate, in treated osteoporotic women. J Bone Miner Res (2009) 0.78
Spaceflight affects bone formation in rhesus monkeys: a histological and cell culture study. J Appl Physiol (1985) (2002) 0.77
N-cadherin/wnt interaction controls bone marrow mesenchymal cell fate and bone mass during aging. J Cell Physiol (2014) 0.76
Targeting the E3 ubiquitin casitas B-lineage lymphoma decreases osteosarcoma cell growth and survival and reduces tumorigenesis. J Bone Miner Res (2012) 0.76