Published in J Cell Mol Med on August 01, 2009
Osteoporosis: now and the future. Lancet (2011) 5.81
Strontium potently inhibits mineralisation in bone-forming primary rat osteoblast cultures and reduces numbers of osteoclasts in mouse marrow cultures. Osteoporos Int (2014) 2.00
How strontium ranelate, via opposite effects on bone resorption and formation, prevents osteoporosis. Osteoporos Int (2010) 1.68
Targeting subchondral bone for treating osteoarthritis: what is the evidence? Best Pract Res Clin Rheumatol (2010) 1.33
Osteoporosis - a current view of pharmacological prevention and treatment. Drug Des Devel Ther (2013) 1.29
Essential role of nuclear factor of activated T cells (NFAT)-mediated Wnt signaling in osteoblast differentiation induced by strontium ranelate. J Biol Chem (2010) 1.00
A review on strontium ranelate long-term antifracture efficacy in the treatment of postmenopausal osteoporosis. Ther Adv Musculoskelet Dis (2013) 0.97
Possible benefits of strontium ranelate in complicated long bone fractures. Rheumatol Int (2010) 0.92
Targeted approaches in the treatment of osteoporosis: differential mechanism of action of denosumab and clinical utility. Ther Clin Risk Manag (2012) 0.90
Impaired osteoblast function in GPRC6A null mice. J Bone Miner Res (2010) 0.87
Deregulation of bone forming cells in bone diseases and anabolic effects of strontium-containing agents and biomaterials. Biomed Res Int (2014) 0.85
The osteocyte as a therapeutic target in the treatment of osteoporosis. Ther Adv Musculoskelet Dis (2014) 0.82
Low-dose TNF augments fracture healing in normal and osteoporotic bone by up-regulating the innate immune response. EMBO Mol Med (2015) 0.82
The calcium-sensing receptor in bone metabolism: from bench to bedside and back. Osteoporos Int (2015) 0.81
Strontium doping of bone graft extender. Acta Orthop (2011) 0.78
Interplay between CaSR and PTH1R signaling in skeletal development and osteoanabolism. Semin Cell Dev Biol (2015) 0.78
Dose-dependent Effects of Strontium Ranelate on Ovariectomy Rat Bone Marrow Mesenchymal Stem Cells and Human Umbilical Vein Endothelial Cells. Int J Biol Sci (2016) 0.75
Strontium Ranelate: Long-Term Efficacy against Vertebral, Nonvertebral and Hip Fractures in Patients with Postmenopausal Osteoporosis. Ther Adv Musculoskelet Dis (2010) 0.75
Calcium Sensing Receptor Function Supports Osteoblast Survival and Acts as a Co-Factor in PTH Anabolic Actions in Bone. J Cell Biochem (2016) 0.75
Sr-substituted bone cements direct mesenchymal stem cells, osteoblasts and osteoclasts fate. PLoS One (2017) 0.75
Effect of Strontium Chloride on Experimental Bladder Inflammation in Rat. Int Sch Res Notices (2014) 0.75
FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease. Genes Dev (2002) 4.16
PTH-independent regulation of blood calcium concentration by the calcium-sensing receptor. J Clin Invest (2012) 2.61
Transfer of differentiation signal by membrane microvesicles harboring hedgehog morphogens. Blood (2006) 1.58
Senescence-associated intrinsic mechanisms of osteoblast dysfunctions. Aging Cell (2011) 1.38
ErbB3 silencing reduces osteosarcoma cell proliferation and tumor growth in vivo. Gene (2013) 1.38
Priming integrin alpha5 promotes human mesenchymal stromal cell osteoblast differentiation and osteogenesis. Proc Natl Acad Sci U S A (2009) 1.35
Evidence in favor of a calcium-sensing receptor in arterial endothelial cells: studies with calindol and Calhex 231. Circ Res (2005) 1.34
Blockade of the RhoA-JNK-c-Jun-MMP2 cascade by atorvastatin reduces osteosarcoma cell invasion. J Biol Chem (2008) 1.29
N-cadherin interacts with axin and LRP5 to negatively regulate Wnt/beta-catenin signaling, osteoblast function, and bone formation. Mol Cell Biol (2008) 1.27
Chemoattractive activity of sonic hedgehog in the adult subventricular zone modulates the number of neural precursors reaching the olfactory bulb. Stem Cells (2008) 1.25
Fibroblast growth factor receptor signaling crosstalk in skeletogenesis. Sci Signal (2010) 1.24
Sonic Hedgehog signaling in the mammalian brain. J Neurochem (2010) 1.23
FHL2 mediates dexamethasone-induced mesenchymal cell differentiation into osteoblasts by activating Wnt/beta-catenin signaling-dependent Runx2 expression. FASEB J (2008) 1.23
Delineating a Ca2+ binding pocket within the venus flytrap module of the human calcium-sensing receptor. J Biol Chem (2005) 1.22
A role for fibroblast growth factor receptor-2 in the altered osteoblast phenotype induced by Twist haploinsufficiency in the Saethre-Chotzen syndrome. Hum Mol Genet (2005) 1.19
Modeling and mutagenesis of the binding site of Calhex 231, a novel negative allosteric modulator of the extracellular Ca(2+)-sensing receptor. J Biol Chem (2003) 1.19
Positive and negative allosteric modulators of the Ca2+-sensing receptor interact within overlapping but not identical binding sites in the transmembrane domain. J Biol Chem (2004) 1.19
Fibroblast growth factor receptor 2 promotes osteogenic differentiation in mesenchymal cells via ERK1/2 and protein kinase C signaling. J Biol Chem (2008) 1.18
Cbl-mediated ubiquitination of alpha5 integrin subunit mediates fibronectin-dependent osteoblast detachment and apoptosis induced by FGFR2 activation. J Cell Sci (2005) 1.17
Functional characterization of sonic hedgehog mutations associated with holoprosencephaly. J Biol Chem (2004) 1.16
Strontium signaling: molecular mechanisms and therapeutic implications in osteoporosis. Pharmacol Ther (2012) 1.16
Transforming growth factor beta2 inhibits adipocyte differentiation induced by skeletal unloading in rat bone marrow stroma. J Bone Miner Res (2002) 1.15
[New insights into the pharmacology of the extracellular calcium sensing receptor]. Med Sci (Paris) (2004) 1.07
A soluble form of fibroblast growth factor receptor 2 (FGFR2) with S252W mutation acts as an efficient inhibitor for the enhanced osteoblastic differentiation caused by FGFR2 activation in Apert syndrome. J Biol Chem (2004) 1.07
Cbl-mediated degradation of Lyn and Fyn induced by constitutive fibroblast growth factor receptor-2 activation supports osteoblast differentiation. J Biol Chem (2004) 1.06
Molecular determinants of non-competitive antagonist binding to the mouse GPRC6A receptor. Cell Calcium (2009) 1.03
In vitro effects of strontium ranelate on the extracellular calcium-sensing receptor. Biochem Biophys Res Commun (2004) 1.01
Sonic Hedgehog signaling is a positive oligodendrocyte regulator during demyelination. J Neurosci (2013) 1.01
Evidence for the presence of GPRC6A receptors in rat mesenteric arteries. Cell Calcium (2008) 1.01
Essential role of nuclear factor of activated T cells (NFAT)-mediated Wnt signaling in osteoblast differentiation induced by strontium ranelate. J Biol Chem (2010) 1.00
The hedgehog receptor patched is involved in cholesterol transport. PLoS One (2011) 1.00
Sonic Hedgehog signalling in the developing and adult brain. J Physiol Paris (2001) 1.00
The choline transporter-like family SLC44: properties and roles in human diseases. Mol Aspects Med (2013) 1.00
Developmental expression of the cellular prion protein in elongating axons. Eur J Neurosci (2002) 0.99
Statin-induced inhibition of 3-hydroxy-3-methyl glutaryl coenzyme a reductase sensitizes human osteosarcoma cells to anticancer drugs. J Pharmacol Exp Ther (2008) 0.99
N-cadherin negatively regulates osteoblast proliferation and survival by antagonizing Wnt, ERK and PI3K/Akt signalling. PLoS One (2009) 0.98
Pivotal role of Twist in skeletal biology and pathology. Gene (2010) 0.97
Hedgehog signaling controls fibroblast activation and tissue fibrosis in systemic sclerosis. Arthritis Rheum (2012) 0.96
Crosstalks between integrin alpha 5 and IGF2/IGFBP2 signalling trigger human bone marrow-derived mesenchymal stromal osteogenic differentiation. BMC Cell Biol (2010) 0.96
Twist haploinsufficiency in Saethre-Chotzen syndrome induces calvarial osteoblast apoptosis due to increased TNFalpha expression and caspase-2 activation. Hum Mol Genet (2002) 0.95
CYR61 downregulation reduces osteosarcoma cell invasion, migration, and metastasis. J Bone Miner Res (2011) 0.94
FGFR2-Cbl interaction in lipid rafts triggers attenuation of PI3K/Akt signaling and osteoblast survival. Bone (2008) 0.94
N1-Benzoyl-N2-[1-(1-naphthyl)ethyl]-trans-1,2-diaminocyclohexanes: Development of 4-chlorophenylcarboxamide (calhex 231) as a new calcium sensing receptor ligand demonstrating potent calcilytic activity. J Med Chem (2006) 0.94
Calindol, a positive allosteric modulator of the human Ca(2+) receptor, activates an extracellular ligand-binding domain-deleted rhodopsin-like seven-transmembrane structure in the absence of Ca(2+). J Biol Chem (2005) 0.93
Murine Frizzled-1 behaves as an antagonist of the canonical Wnt/beta-catenin signaling. J Biol Chem (2003) 0.92
Syndecan-2 affects the basal and chemotherapy-induced apoptosis in osteosarcoma. Cancer Res (2007) 0.91
FHL2 silencing reduces Wnt signaling and osteosarcoma tumorigenesis in vitro and in vivo. PLoS One (2013) 0.91
Hedgehog trafficking, cilia and brain functions. Differentiation (2011) 0.91
Presynaptic external calcium signaling involves the calcium-sensing receptor in neocortical nerve terminals. PLoS One (2010) 0.90
Down-regulation of ubiquitin ligase Cbl induced by twist haploinsufficiency in Saethre-Chotzen syndrome results in increased PI3K/Akt signaling and osteoblast proliferation. Am J Pathol (2006) 0.90
Bone morphogenetic protein receptor IB signaling mediates apoptosis independently of differentiation in osteoblastic cells. J Biol Chem (2003) 0.90
TWIST inactivation reduces CBFA1/RUNX2 expression and DNA binding to the osteocalcin promoter in osteoblasts. Biochem Biophys Res Commun (2002) 0.90
Roles of the calcium sensing receptor in the central nervous system. Best Pract Res Clin Endocrinol Metab (2013) 0.90
Increase of proliferating oligodendroglial progenitors in the adult mouse brain upon Sonic hedgehog delivery in the lateral ventricle. J Neurochem (2006) 0.90
Autocrine fibroblast growth factor 18 mediates dexamethasone-induced osteogenic differentiation of murine mesenchymal stem cells. J Cell Physiol (2010) 0.89
Molecular silencing of Twist1 enhances osteogenic differentiation of murine mesenchymal stem cells: implication of FGFR2 signaling. J Cell Biochem (2010) 0.89
Transforming growth factor-beta prevents osteoblast apoptosis induced by skeletal unloading via PI3K/Akt, Bcl-2, and phospho-Bad signaling. Am J Physiol Endocrinol Metab (2008) 0.88
Strontium ranelate rebalances bone marrow adipogenesis and osteoblastogenesis in senescent osteopenic mice through NFATc/Maf and Wnt signaling. Aging Cell (2012) 0.87
N2-benzyl-N1-(1-(1-naphthyl)ethyl)-3-phenylpropane-1,2-diamines and conformationally restrained indole analogues: development of calindol as a new calcimimetic acting at the calcium sensing receptor. Bioorg Med Chem Lett (2004) 0.87
Lentiviral-mediated integrin α5 expression in human adult mesenchymal stromal cells promotes bone repair in mouse cranial and long-bone defects. Hum Gene Ther (2011) 0.87
Desert hedgehog promotes ischemia-induced angiogenesis by ensuring peripheral nerve survival. Circ Res (2013) 0.86
High Wnt signaling represses the proapoptotic proteoglycan syndecan-2 in osteosarcoma cells. Cancer Res (2010) 0.86
Inhibition of hedgehog signalling prevents experimental fibrosis and induces regression of established fibrosis. Ann Rheum Dis (2012) 0.85
The F508del mutation in cystic fibrosis transmembrane conductance regulator gene impacts bone formation. Am J Pathol (2012) 0.85
The LIM-only protein FHL2 controls mesenchymal cell osteogenic differentiation and bone formation through Wnt5a and Wnt10b. Bone (2012) 0.85
Syndecan-2 overexpression induces osteosarcoma cell apoptosis: Implication of syndecan-2 cytoplasmic domain and JNK signaling. Bone (2005) 0.85
Topographically induced self-deformation of the nuclei of cells: dependence on cell type and proposed mechanisms. J Mater Sci Mater Med (2009) 0.85
Increased EFG- and PDGFalpha-receptor signaling by mutant FGF-receptor 2 contributes to osteoblast dysfunction in Apert craniosynostosis. Hum Mol Genet (2010) 0.85
Virtual screening-based discovery and mechanistic characterization of the acylthiourea MRT-10 family as smoothened antagonists. Mol Pharmacol (2010) 0.84
Identification and mechanism of action of the acylguanidine MRT-83, a novel potent Smoothened antagonist. Mol Pharmacol (2010) 0.84
Functional relevance of the BMD-associated polymorphism rs312009: novel involvement of RUNX2 in LRP5 transcriptional regulation. J Bone Miner Res (2011) 0.84
Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of Smoothened. Mol Pharmacol (2013) 0.84
Distribution of Smoothened at hippocampal mossy fiber synapses. Neuroreport (2007) 0.83
Peptide-based mediated disruption of N-cadherin-LRP5/6 interaction promotes Wnt signaling and bone formation. J Bone Miner Res (2012) 0.83
Calpain-6 is an endothelin-1 signaling dependent protective factor in chemoresistant osteosarcoma. Int J Cancer (2011) 0.83
Distinct osteoblastic differentiation potential of murine fetal liver and bone marrow stroma-derived mesenchymal stem cells. J Cell Biochem (2008) 0.83
Analysis of hedgehog interacting protein in the brain and its expression in nitric oxide synthase-positive cells. Neuroreport (2005) 0.82
Cadherin-mediated cell-cell adhesion and signaling in the skeleton. Calcif Tissue Int (2013) 0.82
Targeted inhibition of T-cell factor activity promotes syndecan-2 expression and sensitization to doxorubicin in osteosarcoma cells and bone tumors in mice. J Bone Miner Res (2012) 0.82