Published in Carcinogenesis on April 14, 2005
Multifaceted roles of alkyltransferase and related proteins in DNA repair, DNA damage, resistance to chemotherapy, and research tools. Chem Res Toxicol (2011) 1.30
A genome-wide association analysis of temozolomide response using lymphoblastoid cell lines shows a clinically relevant association with MGMT. Pharmacogenet Genomics (2012) 1.23
Human variants of O6-alkylguanine-DNA alkyltransferase. DNA Repair (Amst) (2007) 0.97
Risk analysis of severe myelotoxicity with temozolomide: the effects of clinical and genetic factors. Neuro Oncol (2009) 0.94
Candidate gene association study of esophageal squamous cell carcinoma in a high-risk region in Iran. Cancer Res (2009) 0.94
Single nucleotide polymorphisms in DNA repair genes and prostate cancer risk. Methods Mol Biol (2009) 0.90
Differential inactivation of polymorphic variants of human O6-alkylguanine-DNA alkyltransferase. Biochem Pharmacol (2007) 0.83
The L84F polymorphic variant of human O6-methylguanine-DNA methyltransferase alters stability in U87MG glioma cells but not temozolomide sensitivity. Neuro Oncol (2008) 0.78
DNA alkylation and DNA methylation: cooperating mechanisms driving the formation of colorectal adenomas and adenocarcinomas? Gut (2007) 0.76
Gut Microbiota Imbalance and Base Excision Repair Dynamics in Colon Cancer. J Cancer (2016) 0.76
Tumor-associated mutations in O⁶ -methylguanine DNA-methyltransferase (MGMT) reduce DNA repair functionality. Mol Carcinog (2012) 0.75
The role of O(6)-methylguanine-DNA methyltransferase polymorphisms in colorectal cancer susceptibility: a meta analysis. Int J Clin Exp Med (2015) 0.75
Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. Nat Genet (2009) 6.04
IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours. J Pathol (2011) 5.73
Dissecting virulence: systematic and functional analyses of a pathogenicity island. Proc Natl Acad Sci U S A (2004) 5.34
Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus. Nat Genet (2007) 4.76
Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. Curr Biol (2004) 3.45
Aurora kinases as anticancer drug targets. Clin Cancer Res (2008) 2.92
Relative efficacy of drugs: an emerging issue between regulatory agencies and third-party payers. Nat Rev Drug Discov (2010) 2.63
Alcohol intake and blood pressure: a systematic review implementing a Mendelian randomization approach. PLoS Med (2008) 2.61
Identification and characterization of NleA, a non-LEE-encoded type III translocated virulence factor of enterohaemorrhagic Escherichia coli O157:H7. Mol Microbiol (2004) 2.51
Haplotypes and SNPs in 13 lipid-relevant genes explain most of the genetic variance in high-density lipoprotein and low-density lipoprotein cholesterol. Hum Mol Genet (2004) 2.45
Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV. EMBO J (2004) 2.24
Nodal staging in lung cancer: a risk stratification model for lymph nodes classified as negative by EBUS-TBNA. J Thorac Oncol (2015) 1.98
A common variant on chromosome 11q13 is associated with atopic dermatitis. Nat Genet (2009) 1.91
A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis. Nat Genet (2006) 1.90
Flipping of alkylated DNA damage bridges base and nucleotide excision repair. Nature (2009) 1.70
Brachyury expression in extra-axial skeletal and soft tissue chordomas: a marker that distinguishes chordoma from mixed tumor/myoepithelioma/parachordoma in soft tissue. Am J Surg Pathol (2008) 1.67
Vacant niches and the possible operation of natural laws in ecosystems. Riv Biol (2008) 1.66
O6-alkylguanine-DNA alkyltransferase: role in carcinogenesis and chemotherapy. Bioessays (2002) 1.58
Systemic interleukin-2 and adoptive transfer of lymphokine-activated killer cells improves antibody-dependent cellular cytotoxicity in patients with relapsed B-cell lymphoma treated with rituximab. Clin Cancer Res (2007) 1.56
Variability and regulation of O6-alkylguanine-DNA alkyltransferase. Carcinogenesis (2003) 1.54
Cotinine levels and self-reported smoking status in patients attending a bronchoscopy clinic. Biomarkers (2003) 1.49
Cyclin D1 in non-small cell lung cancer: a key driver of malignant transformation. Lung Cancer (2006) 1.44
Frequency of allogeneic hematopoietic cell transplantation among patients with high- or intermediate-risk acute myeloid leukemia in first complete remission. J Clin Oncol (2013) 1.41
Carboxylesterase 3 (EC 3.1.1.1) is a major adipocyte lipase. J Biol Chem (2004) 1.40
Circulating folate, vitamin B12, homocysteine, vitamin B12 transport proteins, and risk of prostate cancer: a case-control study, systematic review, and meta-analysis. Cancer Epidemiol Biomarkers Prev (2010) 1.40
Chlorination by-products in tap water and semen quality in England and Wales. Occup Environ Med (2013) 1.40
Soluble epoxide hydrolase is a susceptibility factor for heart failure in a rat model of human disease. Nat Genet (2008) 1.38
Distinct methylation profiles of glioma subtypes. Int J Cancer (2003) 1.38
Temozolomide pharmacodynamics in patients with metastatic melanoma: dna damage and activity of repair enzymes O6-alkylguanine alkyltransferase and poly(ADP-ribose) polymerase-1. Clin Cancer Res (2005) 1.37
Mechanisms of carcinogenicity/chemotherapy by O6-methylguanine. Mutagenesis (2002) 1.34
A non-synonymous variant in ADH1B is strongly associated with prenatal alcohol use in a European sample of pregnant women. Hum Mol Genet (2009) 1.32
Randomized trial of the combination of lomeguatrib and temozolomide compared with temozolomide alone in chemotherapy naive patients with metastatic cutaneous melanoma. J Clin Oncol (2007) 1.29
ERCC1 mRNA expression is not associated with response and survival after platinum-based chemotherapy regimens in advanced non-small cell lung cancer. J Thorac Oncol (2007) 1.29
Alkylpurine-DNA-N-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patients. J Clin Invest (2011) 1.27
Genetic association study of BDNF in depression: finding from two cohort studies and a meta-analysis. Am J Med Genet B Neuropsychiatr Genet (2008) 1.24
Variants in a novel epidermal collagen gene (COL29A1) are associated with atopic dermatitis. PLoS Biol (2007) 1.21
An interaction between filaggrin mutations and early food sensitization improves the prediction of childhood asthma. J Allergy Clin Immunol (2009) 1.19
Nonbacterial osteitis: a clinical, histopathological, and imaging study with a proposal for protocol-based management of patients with this diagnosis. J Orthop Sci (2009) 1.19
Association of folate-pathway gene polymorphisms with the risk of prostate cancer: a population-based nested case-control study, systematic review, and meta-analysis. Cancer Epidemiol Biomarkers Prev (2009) 1.18
Maspin - the most commonly-expressed gene of the 18q21.3 serpin cluster in lung cancer - is strongly expressed in preneoplastic bronchial lesions. Oncogene (2003) 1.17
Association of the 867Asp variant of the human anion exchanger 3 gene with common subtypes of idiopathic generalized epilepsy. Epilepsy Res (2002) 1.17
Sensitivity of MDM2 amplification and unexpected multiple faint alphoid 12 (alpha 12 satellite sequences) signals in atypical lipomatous tumor. Mod Pathol (2012) 1.15
Total N-nitroso compounds and their precursors in hot dogs and in the gastrointestinal tract and feces of rats and mice: possible etiologic agents for colon cancer. J Nutr (2002) 1.13
Investigation of the effect of subcutaneous fat on image quality performance of 2D conventional imaging and tissue harmonic imaging. Ultrasound Med Biol (2005) 1.12
Food insufficiency among HIV-infected crack-cocaine users in Atlanta and Miami. Public Health Nutr (2010) 1.12
Detection of beta-catenin mutations in paraffin-embedded sporadic desmoid-type fibromatosis by mutation-specific restriction enzyme digestion (MSRED): an ancillary diagnostic tool. Am J Surg Pathol (2007) 1.12
Histology and time to progression predict survival for lymphoma recurring after reduced-intensity conditioning and allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant (2011) 1.11
Tumor cell pseudopodial protrusions. Localized signaling domains coordinating cytoskeleton remodeling, cell adhesion, glycolysis, RNA translocation, and protein translation. J Biol Chem (2005) 1.11
Exploring public attitudes towards approaches to discussing costs in the clinical encounter. J Gen Intern Med (2013) 1.10
Association of fascin-1 with mortality, disease progression and metastasis in carcinomas: a systematic review and meta-analysis. BMC Med (2013) 1.09
Global tests of haemostasis in critically ill patients with severe sepsis syndrome compared to controls. Br J Haematol (2006) 1.09
MRI characteristics of lipoma and atypical lipomatous tumor/well-differentiated liposarcoma: retrospective comparison with histology and MDM2 gene amplification. Skeletal Radiol (2012) 1.06
Targeting human 8-oxoguanine DNA glycosylase (hOGG1) to mitochondria enhances cisplatin cytotoxicity in hepatoma cells. Carcinogenesis (2007) 1.04
Meta- and pooled analysis of GSTP1 polymorphism and lung cancer: a HuGE-GSEC review. Am J Epidemiol (2009) 1.04
Prenatal alcohol exposure and offspring cognition and school performance. A 'Mendelian randomization' natural experiment. Int J Epidemiol (2013) 1.04
STAT6 as an asthma candidate gene: polymorphism-screening, association and haplotype analysis in a Caucasian sib-pair study. Hum Mol Genet (2002) 1.03
Xeroderma pigmentosum group D haplotype predicts for response, survival, and toxicity after platinum-based chemotherapy in advanced nonsmall cell lung cancer. Cancer (2006) 1.02
Alkyltransferase-like proteins. DNA Repair (Amst) (2007) 1.02
Genetic variants in the vitamin d receptor are associated with advanced prostate cancer at diagnosis: findings from the prostate testing for cancer and treatment study and a systematic review. Cancer Epidemiol Biomarkers Prev (2009) 1.02
Common haplotypes in five genes influence genetic variance of LDL and HDL cholesterol in the general population. Hum Mol Genet (2002) 1.02
Two British women studies replicated the association between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) and BMI. Eur J Hum Genet (2009) 1.02
Turning the pump handle: evolving methods for integrating the evidence on gene-disease association. Am J Epidemiol (2007) 1.01
Glutathione-S-transferase P1 isoenzyme polymorphisms, platinum-based chemotherapy, and non-small cell lung cancer. J Thorac Oncol (2006) 1.00
A novel DNA damage recognition protein in Schizosaccharomyces pombe. Nucleic Acids Res (2006) 0.98
Familial tumoral calcinosis and hyperostosis-hyperphosphataemia syndrome are different manifestations of the same disease: novel missense mutations in GALNT3. Skeletal Radiol (2009) 0.97
Maintenance and consolidation therapy in patients with unresectable stage III/IV non-small cell lung cancer. Oncologist (2010) 0.96
Analysis of hepatic glycogen-associated proteins. Proteomics (2010) 0.95
Metabolic gene polymorphisms and lung cancer risk in non-smokers. An update of the GSEC study. Mutat Res (2005) 0.94
Alcohol consumption and PSA-detected prostate cancer risk--a case-control nested in the ProtecT study. Int J Cancer (2012) 0.94
An investigation of self-assessment bias in mental health providers. Psychol Rep (2012) 0.93
What's mom got to do with it? Contributions of maternal executive function and caregiving to the development of executive function across early childhood. Dev Sci (2014) 0.93
Pseudomyogenic (epithelioid sarcoma-like) hemangioendothelioma: characterization of five cases. Skeletal Radiol (2013) 0.93
Toxoflavins and deazaflavins as the first reported selective small molecule inhibitors of tyrosyl-DNA phosphodiesterase II. J Med Chem (2013) 0.92
The effect of single-nucleotide polymorphism marker selection on patterns of haplotype blocks and haplotype frequency estimates. Am J Hum Genet (2005) 0.92
Genome-wide linkage reveals a locus for human essential (primary) hypertension on chromosome 12p. Hum Mol Genet (2003) 0.91
DNA alkylation and repair in the large bowel: animal and human studies. J Nutr (2002) 0.90
Atl1 regulates choice between global genome and transcription-coupled repair of O(6)-alkylguanines. Mol Cell (2012) 0.90
Alkyltransferase-like protein (Atl1) distinguishes alkylated guanines for DNA repair using cation-π interactions. Proc Natl Acad Sci U S A (2012) 0.89
IDH1 mutations are not found in cartilaginous tumours other than central and periosteal chondrosarcomas and enchondromas. Histopathology (2011) 0.89
Late widespread skeletal metastases from myxoid liposarcoma detected by MRI only. World J Surg Oncol (2008) 0.89
Myopericytoma in Kager's fat pad. Skeletal Radiol (2006) 0.89
Obesity and hepatosteatosis in mice with enhanced oxidative DNA damage processing in mitochondria. Am J Pathol (2011) 0.89
Over-expression of Microspan, a novel component of the sarcoplasmic reticulum, causes severe muscle pathology with triad abnormalities. J Muscle Res Cell Motil (2006) 0.88
Induced expression of human CCND1 alternative transcripts in mouse Cyl-1 knockout fibroblasts highlights functional differences. Int J Cancer (2005) 0.88
GSTM1, GSTT1 and GSTP1 polymorphisms and lung cancer risk. Cancer Lett (2002) 0.88
Prenatal exposure to binge pattern of alcohol consumption: mental health and learning outcomes at age 11. Eur Child Adolesc Psychiatry (2014) 0.88
Maternal and offspring fasting glucose and type 2 diabetes-associated genetic variants and cognitive function at age 8: a Mendelian randomization study in the Avon Longitudinal Study of Parents and Children. BMC Med Genet (2012) 0.88
EBUS-TBNA in elderly patients with lung cancer: safety and performance outcomes. J Thorac Oncol (2014) 0.87
Convenient and efficient syntheses of oligodeoxyribonucleotides containing O(6)-(carboxymethyl)guanine and O(6)-(4-oxo-4-(3-pyridyl)butyl)guanine. Nucleosides Nucleotides Nucleic Acids (2012) 0.87
Objective measurements of image quality. Ultrasound Med Biol (2004) 0.87