Published in Nat Genet on May 14, 2006
The pancreatic stellate cell: a star on the rise in pancreatic diseases. J Clin Invest (2007) 3.39
Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis. Nat Genet (2007) 2.48
Alcohol and smoking as risk factors in an epidemiology study of patients with chronic pancreatitis. Clin Gastroenterol Hepatol (2010) 2.46
Variants in CPA1 are strongly associated with early onset chronic pancreatitis. Nat Genet (2013) 2.10
Association of rare chymotrypsinogen C (CTRC) gene variations in patients with idiopathic chronic pancreatitis. Hum Genet (2008) 1.94
The role of alcohol and smoking in pancreatitis. Nat Rev Gastroenterol Hepatol (2010) 1.67
Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis. Nat Genet (2012) 1.63
Hereditary pancreatitis caused by mutation-induced misfolding of human cationic trypsinogen: a novel disease mechanism. Hum Mutat (2009) 1.56
Hereditary chronic pancreatitis. Orphanet J Rare Dis (2007) 1.40
American Pancreatic Association Practice Guidelines in Chronic Pancreatitis: evidence-based report on diagnostic guidelines. Pancreas (2014) 1.30
Intra-acinar trypsinogen activation mediates early stages of pancreatic injury but not inflammation in mice with acute pancreatitis. Gastroenterology (2011) 1.27
Pancreatitis-associated chymotrypsinogen C (CTRC) mutant elicits endoplasmic reticulum stress in pancreatic acinar cells. Gut (2009) 1.20
A recombined allele of the lipase gene CEL and its pseudogene CELP confers susceptibility to chronic pancreatitis. Nat Genet (2015) 1.19
Pathogenic cellular role of the p.L104P human cationic trypsinogen variant in chronic pancreatitis. Am J Physiol Gastrointest Liver Physiol (2016) 1.13
Chymotrypsin C mutations in chronic pancreatitis. J Gastroenterol Hepatol (2011) 1.12
Genetic mechanisms underlying the pathogenesis of tropical calcific pancreatitis. World J Gastroenterol (2009) 1.04
Hereditary pancreatitis caused by a double gain-of-function trypsinogen mutation. Hum Genet (2008) 0.98
Cigarette smoke-induced pancreatic damage: experimental data. Langenbecks Arch Surg (2008) 0.93
Role of Intrapancreatic SPINK1/Spink3 Expression in the Development of Pancreatitis. Front Physiol (2012) 0.93
No Association Between CEL-HYB Hybrid Allele and Chronic Pancreatitis in Asian Populations. Gastroenterology (2016) 0.89
Comprehensive screening for PRSS1, SPINK1, CFTR, CTRC and CLDN2 gene mutations in Chinese paediatric patients with idiopathic chronic pancreatitis: a cohort study. BMJ Open (2013) 0.87
The -409 C/T genotype of PRSS1 protects against pancreatic cancer in the Han Chinese population. Dig Dis Sci (2011) 0.87
Characterisation of a transgenic mouse expressing R122H human cationic trypsinogen. BMC Gastroenterol (2006) 0.86
Human cationic trypsinogen is sulfated on Tyr154. FEBS J (2006) 0.85
The guinea pig pancreas secretes a single trypsinogen isoform, which is defective in autoactivation. Pancreas (2008) 0.85
Role of genetic disorders in acute recurrent pancreatitis. World J Gastroenterol (2008) 0.85
New PRSS1 and common CFTR mutations in a child with acute recurrent pancreatitis, could be considered an "Hereditary" form of pancreatitis ? BMC Gastroenterol (2010) 0.84
A common African polymorphism abolishes tyrosine sulfation of human anionic trypsinogen (PRSS2). Biochem J (2009) 0.84
Alcohol consumption on pancreatic diseases. World J Gastroenterol (2013) 0.84
Trypsinogen activation in acute and chronic pancreatitis: is it a prerequisite? Gut (2011) 0.82
Hereditary Pancreatitis Associated With the N29T Mutation of the PRSS1 Gene in a Brazilian Family: A Case-Control Study. Medicine (Baltimore) (2015) 0.82
Genetic and phenotypic heterogeneity in tropical calcific pancreatitis. World J Gastroenterol (2014) 0.81
Acute pancreatitis: risk of recurrence and late consequences of the disease. Nat Rev Gastroenterol Hepatol (2009) 0.79
Hereditary pancreatitis for the endoscopist. Therap Adv Gastroenterol (2013) 0.79
A common variant of PNPLA3 (p.I148M) is not associated with alcoholic chronic pancreatitis. PLoS One (2012) 0.79
Complete analysis of the human mesotrypsinogen gene (PRSS3) in patients with chronic pancreatitis. Pancreatology (2010) 0.78
Hereditary pancreatitis. Pediatr Surg Int (2010) 0.77
Sequence analysis of the human tyrosylprotein sulfotransferase-2 gene in subjects with chronic pancreatitis. Pancreatology (2010) 0.76
Common Variants in CLDN2 and MORC4 Genes Confer Disease Susceptibility in Patients with Chronic Pancreatitis. PLoS One (2016) 0.76
Genetic Risk in Chronic Pancreatitis: The Trypsin-Dependent Pathway. Dig Dis Sci (2017) 0.76
No significant enrichment of rare functionally defective CPA1 variants in a large Chinese idiopathic chronic pancreatitis cohort. Hum Mutat (2017) 0.76
Risk Factors for Steatorrhea in Chronic Pancreatitis: A Cohort of 2,153 Patients. Sci Rep (2016) 0.75
Epidemiology of Recurrent Acute and Chronic Pancreatitis: Similarities and Differences. Dig Dis Sci (2017) 0.75
Risk Factors for Diabetes Mellitus in Chronic Pancreatitis: A Cohort of 2011 Patients. Medicine (Baltimore) (2016) 0.75
Framework for interpretation of trypsin-antitrypsin imbalance and genetic heterogeneity in pancreatitis. Saudi J Gastroenterol (2015) 0.75
Tighter Control by Chymotrypsin C (CTRC) Explains Lack of Association between Human Anionic Trypsinogen and Hereditary Pancreatitis. J Biol Chem (2016) 0.75
Is genetic analysis helpful for diagnosing chronic pancreatitis in its early stage? J Gastroenterol (2007) 0.75
Length of Variable Numbers of Tandem Repeats in the Carboxyl Ester Lipase (CEL) Gene May Confer Susceptibility to Alcoholic Liver Cirrhosis but Not Alcoholic Chronic Pancreatitis. PLoS One (2016) 0.75
Do Animal Models of Acute Pancreatitis Reproduce Human Disease? Cell Mol Gastroenterol Hepatol (2017) 0.75
Strong purifying selection against gene conversions in the trypsin genes of primates. Hum Genet (2012) 0.75
Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics (2004) 125.23
SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling. Electrophoresis (1997) 57.27
Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene. Nat Genet (1996) 7.94
Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis. Nat Genet (2000) 4.83
A signal peptide cleavage site mutation in the cationic trypsinogen gene is strongly associated with chronic pancreatitis. Gastroenterology (1999) 4.10
The complete 685-kilobase DNA sequence of the human beta T cell receptor locus. Science (1996) 2.62
Characterization of human exocrine pancreatic proteins by two-dimensional isoelectric focusing/sodium dodecyl sulfate gel electrophoresis. Gastroenterology (1981) 2.18
Human cationic trypsinogen. Role of Asn-21 in zymogen activation and implications in hereditary pancreatitis. J Biol Chem (2000) 2.12
Gain-of-function mutations associated with hereditary pancreatitis enhance autoactivation of human cationic trypsinogen. Biochem Biophys Res Commun (2000) 1.99
Human anionic trypsinogen: properties of autocatalytic activation and degradation and implications in pancreatic diseases. Eur J Biochem (2003) 1.68
Crystal structure of human trypsin 1: unexpected phosphorylation of Tyr151. J Mol Biol (1996) 1.25
Comparative studies on the mechanism of activation of the two human trypsinogens. Biochim Biophys Acta (1979) 1.11
The two human trypsinogens: catalytic properties of the corresponding trypsins. Biochim Biophys Acta (1978) 0.96
Structural and evolutionary consequences of unpaired cysteines in trypsinogen. Biochem Biophys Res Commun (2003) 0.91
A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer. N Engl J Med (2004) 13.34
IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy. Nat Genet (2009) 13.03
Sunitinib malate for the treatment of pancreatic neuroendocrine tumors. N Engl J Med (2011) 11.93
Guideline to reference gene selection for quantitative real-time PCR. Biochem Biophys Res Commun (2004) 10.03
Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: a genome-wide association study. Gastroenterology (2010) 7.86
Peginterferon Alfa-2a, lamivudine, and the combination for HBeAg-positive chronic hepatitis B. N Engl J Med (2005) 7.18
Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Nat Genet (2009) 6.83
Adjuvant chemotherapy with fluorouracil plus folinic acid vs gemcitabine following pancreatic cancer resection: a randomized controlled trial. JAMA (2010) 6.65
ABT-450/r-ombitasvir and dasabuvir with ribavirin for hepatitis C with cirrhosis. N Engl J Med (2014) 6.31
Celecoxib for the prevention of colorectal adenomatous polyps. N Engl J Med (2006) 6.15
A colorectal cancer classification system that associates cellular phenotype and responses to therapy. Nat Med (2013) 6.09
Risk of community-acquired pneumonia and use of gastric acid-suppressive drugs. JAMA (2004) 6.06
Cystic fibrosis: a worldwide analysis of CFTR mutations--correlation with incidence data and application to screening. Hum Mutat (2002) 5.43
Guidelines for diagnosis of cystic fibrosis in newborns through older adults: Cystic Fibrosis Foundation consensus report. J Pediatr (2008) 5.19
The prevalence of food allergy: a meta-analysis. J Allergy Clin Immunol (2007) 5.16
Eltrombopag for thrombocytopenia in patients with cirrhosis associated with hepatitis C. N Engl J Med (2007) 5.13
Correlation between genetic and geographic structure in Europe. Curr Biol (2008) 5.02
Decoding cilia function: defining specialized genes required for compartmentalized cilia biogenesis. Cell (2004) 5.02
NAT2 slow acetylation, GSTM1 null genotype, and risk of bladder cancer: results from the Spanish Bladder Cancer Study and meta-analyses. Lancet (2005) 5.01
Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus. Nat Genet (2007) 4.76
Gene conversion: mechanisms, evolution and human disease. Nat Rev Genet (2007) 4.62
International consensus diagnostic criteria for autoimmune pancreatitis: guidelines of the International Association of Pancreatology. Pancreas (2011) 4.56
Cohort profile: the study of health in Pomerania. Int J Epidemiol (2010) 4.38
The effective mutation rate at Y chromosome short tandem repeats, with application to human population-divergence time. Am J Hum Genet (2003) 4.34
Preoperative/neoadjuvant therapy in pancreatic cancer: a systematic review and meta-analysis of response and resection percentages. PLoS Med (2010) 4.13
Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer. Cancer Cell (2011) 4.12
A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. Nat Genet (2010) 3.93
Prednisolone and valaciclovir in Bell's palsy: a randomised, double-blind, placebo-controlled, multicentre trial. Lancet Neurol (2008) 3.81
European echinococcosis registry: human alveolar echinococcosis, Europe, 1982-2000. Emerg Infect Dis (2003) 3.80
Stromal biology and therapy in pancreatic cancer. Gut (2010) 3.80
Generalized Venn diagrams: a new method of visualizing complex genetic set relations. Bioinformatics (2004) 3.77
Chronic pancreatitis: challenges and advances in pathogenesis, genetics, diagnosis, and therapy. Gastroenterology (2007) 3.73
A back migration from Asia to sub-Saharan Africa is supported by high-resolution analysis of human Y-chromosome haplotypes. Am J Hum Genet (2002) 3.71
Comparison of adefovir and tenofovir in the treatment of lamivudine-resistant hepatitis B virus infection. Hepatology (2004) 3.70
Detectable clonal mosaicism and its relationship to aging and cancer. Nat Genet (2012) 3.69
Genomic DNA hypomethylation as a biomarker for bladder cancer susceptibility in the Spanish Bladder Cancer Study: a case-control study. Lancet Oncol (2008) 3.60
Fibrosis progression after liver transplantation in patients with recurrent hepatitis C. J Hepatol (2004) 3.56
The molecular dissection of mtDNA haplogroup H confirms that the Franco-Cantabrian glacial refuge was a major source for the European gene pool. Am J Hum Genet (2004) 3.51
Genetic structure of Europeans: a view from the North-East. PLoS One (2009) 3.46
Imprint of human cytomegalovirus infection on the NK cell receptor repertoire. Blood (2004) 3.36
Microsatellite variation and evolution of human lactase persistence. Hum Genet (2005) 3.20
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat Genet (2011) 3.18
Early monotherapy with pegylated interferon alpha-2b for acute hepatitis C infection: the HEP-NET acute-HCV-II study. Hepatology (2006) 3.18
Daily oral everolimus activity in patients with metastatic pancreatic neuroendocrine tumors after failure of cytotoxic chemotherapy: a phase II trial. J Clin Oncol (2009) 3.18
Primary malignant hepatic epithelioid hemangioendothelioma: a comprehensive review of the literature with emphasis on the surgical therapy. Cancer (2006) 3.16
Identification of genetic loci associated with Helicobacter pylori serologic status. JAMA (2013) 3.15
Sofosbuvir and Velpatasvir for HCV Genotype 2 and 3 Infection. N Engl J Med (2015) 3.13
Changes in morbidity after pancreatic resection: toward the end of completion pancreatectomy. Arch Surg (2003) 3.12
Beringian standstill and spread of Native American founders. PLoS One (2007) 3.10
Long-term efficacy of tenofovir monotherapy for hepatitis B virus-monoinfected patients after failure of nucleoside/nucleotide analogues. Hepatology (2010) 3.02
ENETS Consensus Guidelines for the management of patients with liver and other distant metastases from neuroendocrine neoplasms of foregut, midgut, hindgut, and unknown primary. Neuroendocrinology (2012) 3.00
Significance of histopathological tumor regression after neoadjuvant chemotherapy in gastric adenocarcinomas: a summary of 480 cases. Ann Surg (2011) 2.92
Defining the disease liability of variants in the cystic fibrosis transmembrane conductance regulator gene. Nat Genet (2013) 2.91
Antagonism of the chemokine Ccl5 ameliorates experimental liver fibrosis in mice. J Clin Invest (2010) 2.87
Type of PKD1 mutation influences renal outcome in ADPKD. J Am Soc Nephrol (2013) 2.85
EphB receptor activity suppresses colorectal cancer progression. Nature (2005) 2.84
Clinical and genetic characteristics of hereditary pancreatitis in Europe. Clin Gastroenterol Hepatol (2004) 2.82
Most pancreatic cancer resections are R1 resections. Ann Surg Oncol (2008) 2.79
Nodal/Activin signaling drives self-renewal and tumorigenicity of pancreatic cancer stem cells and provides a target for combined drug therapy. Cell Stem Cell (2011) 2.78
The natural course of atopic dermatitis from birth to age 7 years and the association with asthma. J Allergy Clin Immunol (2004) 2.69
Tenofovir for patients with lamivudine-resistant hepatitis B virus (HBV) infection and high HBV DNA level during adefovir therapy. Hepatology (2006) 2.68
Genes, mutations, and human inherited disease at the dawn of the age of personalized genomics. Hum Mutat (2010) 2.67
The role of stroma in pancreatic cancer: diagnostic and therapeutic implications. Nat Rev Gastroenterol Hepatol (2012) 2.59
Establishment of patient-derived non-small cell lung cancer xenografts as models for the identification of predictive biomarkers. Clin Cancer Res (2008) 2.56
Functional effects of 13 rare PRSS1 variants presumed to cause chronic pancreatitis. Gut (2013) 2.56
Comprehensive mutational screening in a cohort of Danish families with hereditary congenital cataract. Invest Ophthalmol Vis Sci (2009) 2.54
A comprehensive characterization of pancreatic ductal carcinoma cell lines: towards the establishment of an in vitro research platform. Virchows Arch (2003) 2.53
Long-term outcomes of autoimmune pancreatitis: a multicentre, international analysis. Gut (2012) 2.52
Distal pancreatectomy: risk factors for surgical failure in 302 consecutive cases. Ann Surg (2007) 2.51
Contrasting patterns of Y chromosome and mtDNA variation in Africa: evidence for sex-biased demographic processes. Eur J Hum Genet (2005) 2.51
Structure of AMA1 from Plasmodium falciparum reveals a clustering of polymorphisms that surround a conserved hydrophobic pocket. Proc Natl Acad Sci U S A (2005) 2.50
Non-synonymous polymorphisms in melanocortin-4 receptor protect against obesity: the two facets of a Janus obesity gene. Hum Mol Genet (2007) 2.50
Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis. Nat Genet (2007) 2.48