Published in Nucleic Acids Res on April 14, 2005
The many functions of APE1/Ref-1: not only a DNA repair enzyme. Antioxid Redox Signal (2009) 2.43
NEIL1 excises 3' end proximal oxidative DNA lesions resistant to cleavage by NTH1 and OGG1. Nucleic Acids Res (2005) 1.20
Human monocytes are severely impaired in base and DNA double-strand break repair that renders them vulnerable to oxidative stress. Proc Natl Acad Sci U S A (2011) 1.14
Human Ape2 protein has a 3'-5' exonuclease activity that acts preferentially on mismatched base pairs. Nucleic Acids Res (2006) 1.11
Interplay between DNA N-glycosylases/AP lyases at multiply damaged sites and biological consequences. Nucleic Acids Res (2007) 1.03
Epigenetic reprogramming: is deamination key to active DNA demethylation? Reproduction (2011) 1.03
Sources of extracellular, oxidatively-modified DNA lesions: implications for their measurement in urine. J Clin Biochem Nutr (2009) 0.98
Apex1 can cleave complex clustered DNA lesions in cells. DNA Repair (Amst) (2009) 0.94
The current state of eukaryotic DNA base damage and repair. Nucleic Acids Res (2015) 0.89
Posttranslational modification of mammalian AP endonuclease (APE1). Cell Mol Life Sci (2010) 0.87
In vitro ligation of oligodeoxynucleotides containing C8-oxidized purine lesions using bacteriophage T4 DNA ligase. Biochemistry (2007) 0.86
DNA polymerase delta-dependent repair of DNA single strand breaks containing 3'-end proximal lesions. Nucleic Acids Res (2007) 0.83
Insight into mechanisms of 3'-5' exonuclease activity and removal of bulky 8,5'-cyclopurine adducts by apurinic/apyrimidinic endonucleases. Proc Natl Acad Sci U S A (2013) 0.82
Ubiquitination of human AP-endonuclease 1 (APE1) enhanced by T233E substitution and by CDK5. Nucleic Acids Res (2011) 0.82
Inter-individual variation in DNA repair capacity: a need for multi-pathway functional assays to promote translational DNA repair research. DNA Repair (Amst) (2014) 0.81
Oxidant and environmental toxicant-induced effects compromise DNA ligation during base excision DNA repair. DNA Repair (Amst) (2015) 0.80
Identification of a residue critical for the excision of 3'-blocking ends in apurinic/apyrimidinic endonucleases of the Xth family. Nucleic Acids Res (2009) 0.80
Endonuclease IV Is the major apurinic/apyrimidinic endonuclease in Mycobacterium tuberculosis and is important for protection against oxidative damage. PLoS One (2013) 0.80
African swine fever virus AP endonuclease is a redox-sensitive enzyme that repairs alkylating and oxidative damage to DNA. Virology (2009) 0.79
Role of Ape1 and base excision repair in the radioresponse and heat-radiosensitization of HeLa Cells. Anticancer Res (2009) 0.78
Crystallization and preliminary X-ray analysis of human endonuclease 1 (APE1) in complex with an oligonucleotide containing a 5,6-dihydrouracil (DHU) or an alpha-anomeric 2'-deoxyadenosine (alphadA) modified base. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.77
Reprint of "Oxidant and environmental toxicant-induced effects compromise DNA ligation during base excision DNA repair". DNA Repair (Amst) (2015) 0.76
AP endonuclease 1 prevents trinucleotide repeat expansion via a novel mechanism during base excision repair. Nucleic Acids Res (2015) 0.76
Oxidized nucleotide insertion by pol β confounds ligation during base excision repair. Nat Commun (2017) 0.75
Development of APE1 enzymatic DNA repair assays: low APE1 activity is associated with increase lung cancer risk. Carcinogenesis (2015) 0.75
Artemis is required to improve the accuracy of repair of double-strand breaks with 5'-blocked termini generated from non-DSB-clustered lesions. Mutagenesis (2013) 0.75
Bypass of a 5',8-cyclopurine-2'-deoxynucleoside by DNA polymerase β during DNA replication and base excision repair leads to nucleotide misinsertions and DNA strand breaks. DNA Repair (Amst) (2015) 0.75
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Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA. Proc Natl Acad Sci U S A (2002) 3.33
Cloning and characterization of hOGG1, a human homolog of the OGG1 gene of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1997) 3.09
Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase. Proc Natl Acad Sci U S A (1997) 2.74
XRCC1 coordinates the initial and late stages of DNA abasic site repair through protein-protein interactions. EMBO J (2001) 2.67
An exonucleolytic activity of human apurinic/apyrimidinic endonuclease on 3' mispaired DNA. Nature (2002) 2.58
Identification and characterization of a novel human DNA glycosylase for repair of cytosine-derived lesions. J Biol Chem (2002) 2.54
Interaction of human apurinic endonuclease and DNA polymerase beta in the base excision repair pathway. Proc Natl Acad Sci U S A (1997) 2.12
A back-up glycosylase in Nth1 knock-out mice is a functional Nei (endonuclease VIII) homologue. J Biol Chem (2002) 1.89
Substrate binding by human apurinic/apyrimidinic endonuclease indicates a Briggs-Haldane mechanism. J Biol Chem (1997) 1.59
Interaction of human AP endonuclease 1 with flap endonuclease 1 and proliferating cell nuclear antigen involved in long-patch base excision repair. Biochemistry (2001) 1.56
The mammalian mismatch repair pathway removes DNA 8-oxodGMP incorporated from the oxidized dNTP pool. Curr Biol (2002) 1.53
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APE1 is the major 3'-phosphoglycolate activity in human cell extracts. Nucleic Acids Res (2004) 1.42
8-oxodGTP incorporation by DNA polymerase beta is modified by active-site residue Asn279. Biochemistry (2000) 1.35
Steady-state and pre-steady-state kinetic analysis of 8-oxo-7,8-dihydroguanosine triphosphate incorporation and extension by replicative and repair DNA polymerases. Biochemistry (1998) 1.26
Properties of and substrate determinants for the exonuclease activity of human apurinic endonuclease Ape1. J Mol Biol (2003) 1.19
Incorporation of the guanosine triphosphate analogs 8-oxo-dGTP and 8-NH2-dGTP by reverse transcriptases and mammalian DNA polymerases. J Biol Chem (1997) 1.13
A novel method for site specific introduction of single model oxidative DNA lesions into oligodeoxyribonucleotides. Nucleic Acids Res (1993) 1.01
Enzymatic processing of DNA containing tandem dihydrouracil by endonucleases III and VIII. Nucleic Acids Res (2001) 0.94
Replication protein A stimulates proliferating cell nuclear antigen-dependent repair of abasic sites in DNA by human cell extracts. Biochemistry (1999) 0.90
Radiation damage to DNA: techniques, quantitation and mechanisms. Bowness-on-Windermere, Lake District, United Kingdom, April 19-24, 1997. Radiat Res (1997) 0.81
CHIP-mediated degradation and DNA damage-dependent stabilization regulate base excision repair proteins. Mol Cell (2008) 2.49
Isolation of a small molecule inhibitor of DNA base excision repair. Nucleic Acids Res (2005) 1.98
Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. Chem Biol (2011) 1.78
Repair of abasic sites in DNA. Mutat Res (2003) 1.71
Poly ADP-ribose polymerase-1: an international molecule of mystery. DNA Repair (Amst) (2008) 1.64
WRN helicase and FEN-1 form a complex upon replication arrest and together process branchmigrating DNA structures associated with the replication fork. Mol Biol Cell (2003) 1.61
Reconstitution of human DNA polymerase delta using recombinant baculoviruses: the p12 subunit potentiates DNA polymerizing activity of the four-subunit enzyme. J Biol Chem (2001) 1.57
APE1 is the major 3'-phosphoglycolate activity in human cell extracts. Nucleic Acids Res (2004) 1.42
Ubiquitin ligase ARF-BP1/Mule modulates base excision repair. EMBO J (2009) 1.41
ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage. Mol Cell (2012) 1.40
Aprataxin, poly-ADP ribose polymerase 1 (PARP-1) and apurinic endonuclease 1 (APE1) function together to protect the genome against oxidative damage. Hum Mol Genet (2009) 1.32
Poly(ADP-ribose) polymerase-1 modulates DNA repair capacity and prevents formation of DNA double strand breaks. DNA Repair (Amst) (2008) 1.23
Poly(ADP-ribose) polymerase in base excision repair: always engaged, but not essential for DNA damage processing. Acta Biochim Pol (2003) 1.21
NEIL1 excises 3' end proximal oxidative DNA lesions resistant to cleavage by NTH1 and OGG1. Nucleic Acids Res (2005) 1.20
Biochemical characterization of the WRN-FEN-1 functional interaction. Biochemistry (2002) 1.19
XRCC1-DNA polymerase beta interaction is required for efficient base excision repair. Nucleic Acids Res (2004) 1.13
Impact of arsenite and its methylated metabolites on PARP-1 activity, PARP-1 gene expression and poly(ADP-ribosyl)ation in cultured human cells. DNA Repair (Amst) (2006) 1.08
USP7/HAUSP stimulates repair of oxidative DNA lesions. Nucleic Acids Res (2010) 1.06
Regulation of oxidative DNA damage repair by DNA polymerase λ and MutYH by cross-talk of phosphorylation and ubiquitination. Proc Natl Acad Sci U S A (2011) 1.04
USP47 is a deubiquitylating enzyme that regulates base excision repair by controlling steady-state levels of DNA polymerase β. Mol Cell (2011) 1.03
DNA polymerase beta promotes recruitment of DNA ligase III alpha-XRCC1 to sites of base excision repair. Biochemistry (2005) 1.03
Poly(ADP-ribose) polymerase-1 protects excessive DNA strand breaks from deterioration during repair in human cell extracts. FEBS J (2005) 1.02
Exchangeability of mammalian DNA ligases between base excision repair pathways. Biochemistry (2004) 1.01
Overexpression of DNA polymerase beta results in an increased rate of frameshift mutations during base excision repair. Mutagenesis (2007) 1.01
Global genome repair of 8-oxoG in hamster cells requires a functional CSB gene product. Oncogene (2002) 1.00
Ubiquitin ligase UBR3 regulates cellular levels of the essential DNA repair protein APE1 and is required for genome stability. Nucleic Acids Res (2011) 0.99
Co-ordination of base excision repair and genome stability. DNA Repair (Amst) (2013) 0.99
Repair of clustered DNA lesions. Sequence-specific inhibition of long-patch base excision repair be 8-oxoguanine. J Biol Chem (2002) 0.96
XRCC1 phosphorylation by CK2 is required for its stability and efficient DNA repair. DNA Repair (Amst) (2010) 0.95
Repair of tandem base lesions in DNA by human cell extracts generates persisting single-strand breaks. J Mol Biol (2005) 0.94
Mode of inhibition of short-patch base excision repair by thymine glycol within clustered DNA lesions. J Biol Chem (2003) 0.93
Base excision repair fidelity in normal and cancer cells. Mutagenesis (2006) 0.91
End-damage-specific proteins facilitate recruitment or stability of X-ray cross-complementing protein 1 at the sites of DNA single-strand break repair. FEBS J (2005) 0.89
The emerging role of Mule and ARF in the regulation of base excision repair. FEBS Lett (2011) 0.89
Phosphorylation of PNKP by ATM prevents its proteasomal degradation and enhances resistance to oxidative stress. Nucleic Acids Res (2012) 0.88
NEIL1 is the major DNA glycosylase that processes 5-hydroxyuracil in the proximity of a DNA single-strand break. Biochemistry (2007) 0.88
Targeting base excision repair to improve cancer therapies. Mol Aspects Med (2007) 0.87
Orchestration of base excision repair by controlling the rates of enzymatic activities. DNA Repair (Amst) (2004) 0.87
USP7S-dependent inactivation of Mule regulates DNA damage signalling and repair. Nucleic Acids Res (2012) 0.85
ARF induction in response to DNA strand breaks is regulated by PARP1. Nucleic Acids Res (2013) 0.83
Mechanism of action of an imidopiperidine inhibitor of human polynucleotide kinase/phosphatase. J Biol Chem (2009) 0.83
DNA polymerase delta-dependent repair of DNA single strand breaks containing 3'-end proximal lesions. Nucleic Acids Res (2007) 0.83
Nijmegen breakage syndrome protein (NBN) causes resistance to methylating anticancer drugs such as temozolomide. Mol Pharmacol (2010) 0.83
CK2 phosphorylation of XRCC1 facilitates dissociation from DNA and single-strand break formation during base excision repair. DNA Repair (Amst) (2011) 0.83
Repair of dihydrouracil supported by base excision repair in mNTH1 knock-out cell extracts. J Biol Chem (2002) 0.83
The role of mammalian NEIL1 protein in the repair of 8-oxo-7,8-dihydroadenine in DNA. FEBS Lett (2010) 0.81
Regulation of USP7/HAUSP in response to DNA damage: yet another role for ATM. Cell Cycle (2012) 0.81
Impact of copper on the induction and repair of oxidative DNA damage, poly(ADP-ribosyl)ation and PARP-1 activity. Mol Nutr Food Res (2007) 0.79
DNA repair fidelity of base excision repair pathways in human cell extracts. DNA Repair (Amst) (2005) 0.78
In vitro base excision repair using mammalian cell extracts. Methods Mol Biol (2012) 0.75