Published in Structure on April 01, 2005
Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. N Engl J Med (2009) 7.53
Inquiring into the differential action of interferons (IFNs): an IFN-alpha2 mutant with enhanced affinity to IFNAR1 is functionally similar to IFN-beta. Mol Cell Biol (2006) 1.82
Structure and mechanism of receptor sharing by the IL-10R2 common chain. Structure (2010) 1.63
Virus-encoded homologs of cellular interleukin-10 and their control of host immune function. J Virol (2009) 1.49
Structure of IL-22 bound to its high-affinity IL-22R1 chain. Structure (2008) 1.23
Crystal structure of human interferon-λ1 in complex with its high-affinity receptor interferon-λR1. J Mol Biol (2010) 1.09
Viable Borrelia burgdorferi enhances interleukin-10 production and suppresses activation of murine macrophages. Infect Immun (2007) 1.01
Structural analysis of cytokines comprising the IL-10 family. Cytokine Growth Factor Rev (2010) 0.99
Proteins: form and function. Bioeng Bugs (2012) 0.92
Receptor dimerization dynamics as a regulatory valve for plasticity of type I interferon signaling. J Cell Biol (2015) 0.88
Allosteric competitive inactivation of hematopoietic CSF-1 signaling by the viral decoy receptor BARF1. Nat Struct Mol Biol (2012) 0.86
Viral and murine interleukin-10 are correctly processed and retain their biological activity when produced in tobacco. BMC Biotechnol (2009) 0.86
Domain-domain interactions underlying herpesvirus-human protein-protein interaction networks. PLoS One (2011) 0.83
Design and analysis of rhesus cytomegalovirus IL-10 mutants as a model for novel vaccines against human cytomegalovirus. PLoS One (2011) 0.83
Cytokine homologs of human gammaherpesviruses. J Interferon Cytokine Res (2011) 0.83
Epstein-Barr virus IL-10 engages IL-10R1 by a two-step mechanism leading to altered signaling properties. J Biol Chem (2012) 0.83
Effect of host genetics on the development of cytomegalovirus retinitis in patients with AIDS. J Infect Dis (2010) 0.81
Targeting of viral interleukin-10 with an antibody fragment specific to damaged arthritic cartilage improves its therapeutic potency. Arthritis Res Ther (2014) 0.81
Instructive roles for cytokine-receptor binding parameters in determining signaling and functional potency. Sci Signal (2015) 0.80
Identification and characterization of a +1 frameshift observed during the expression of Epstein-Barr virus IL-10 in Escherichia coli. Protein Expr Purif (2006) 0.80
The molecular basis of IL-10 function: from receptor structure to the onset of signaling. Curr Top Microbiol Immunol (2014) 0.80
Dithiocarbamates and viral IL-10 collaborate in the immortalization and evasion of immune response in EBV-infected human B lymphocytes. Chem Biol Interact (2007) 0.77
Mechanisms of immunomodulation by mammalian and viral decoy receptors: insights from structures. Nat Rev Immunol (2016) 0.76
Secretory expression of biologically active human Herpes virus interleukin-10 analogues in Escherichia coli via a modified Sec-dependent transporter construct. BMC Biotechnol (2013) 0.76
Binding of interferon reduces the force of unfolding for interferon receptor 1. PLoS One (2017) 0.75
Purification, crystallization and preliminary X-ray diffraction analysis of the IL-20-IL-20R1-IL-20R2 complex. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.75
IL-10: A Multifunctional Cytokine in Viral Infections. J Immunol Res (2017) 0.75
A workflow for in silico design of hIL-10 and ebvIL-10 inhibitors using well-known miniprotein scaffolds. J Mol Model (2017) 0.75
Interferons, interferon-like cytokines, and their receptors. Immunol Rev (2004) 6.21
Interleukin-10 and related cytokines and receptors. Annu Rev Immunol (2004) 5.41
Reversal of persistent fibrosis in aging by targeting Nox4-Nrf2 redox imbalance. Sci Transl Med (2014) 3.23
Structure and mechanism of receptor sharing by the IL-10R2 common chain. Structure (2010) 1.63
BiP/GRP78 is an intracellular target for MDA-7/IL-24 induction of cancer-specific apoptosis. Cancer Res (2006) 1.58
Unique aspects of mda-7/IL-24 antitumor bystander activity: establishing a role for secretion of MDA-7/IL-24 protein by normal cells. Oncogene (2005) 1.49
Isolation of flagellated bacteria implicated in Crohn's disease. Inflamm Bowel Dis (2007) 1.40
Crystal structure of human cytomegalovirus IL-10 bound to soluble human IL-10R1. Proc Natl Acad Sci U S A (2002) 1.32
Conformational changes mediate interleukin-10 receptor 2 (IL-10R2) binding to IL-10 and assembly of the signaling complex. J Biol Chem (2006) 1.31
Structure of IL-22 bound to its high-affinity IL-22R1 chain. Structure (2008) 1.23
The IL-10R2 binding hot spot on IL-22 is located on the N-terminal helix and is dependent on N-linked glycosylation. J Mol Biol (2004) 1.07
Structural basis for receptor sharing and activation by interleukin-20 receptor-2 (IL-20R2) binding cytokines. Proc Natl Acad Sci U S A (2012) 1.03
Interleukin-26: an IL-10-related cytokine produced by Th17 cells. Cytokine Growth Factor Rev (2010) 1.03
Substitution of adenovirus serotype 3 hexon onto a serotype 5 oncolytic adenovirus reduces factor X binding, decreases liver tropism, and improves antitumor efficacy. Mol Cancer Ther (2010) 1.02
Comparison of interleukin-22 and interleukin-10 soluble receptor complexes. J Interferon Cytokine Res (2002) 0.98
Very early onset inflammatory bowel disease associated with aberrant trafficking of IL-10R1 and cure by T cell replete haploidentical bone marrow transplantation. J Clin Immunol (2014) 0.98
Cytokine-receptor interactions as drug targets. Curr Opin Chem Biol (2010) 0.98
Induction of regulatory dendritic cells by dexamethasone and 1alpha,25-Dihydroxyvitamin D(3). Immunol Lett (2004) 0.98
A docking model based on mass spectrometric and biochemical data describes phage packaging motor incorporation. Mol Cell Proteomics (2010) 0.95
Structure of insect-cell-derived IL-22. Acta Crystallogr D Biol Crystallogr (2005) 0.94
An early stage of Mason-Pfizer monkey virus budding is regulated by the hydrophobicity of the Gag matrix domain core. J Virol (2004) 0.92
Structure and mechanism of IFN-gamma antagonism by an orthopoxvirus IFN-gamma-binding protein. Proc Natl Acad Sci U S A (2008) 0.90
Noncompetitive antibody neutralization of IL-10 revealed by protein engineering and x-ray crystallography. Structure (2002) 0.88
Inhibition of nuclear factor kappa-B signaling reduces growth in medulloblastoma in vivo. BMC Cancer (2011) 0.84
Host immune responses to a viral immune modulating protein: immunogenicity of viral interleukin-10 in rhesus cytomegalovirus-infected rhesus macaques. PLoS One (2012) 0.84
Protein crystallization. Methods Mol Biol (2007) 0.84
Biophysical properties of human medulloblastoma cells. J Membr Biol (2010) 0.84
Design and analysis of rhesus cytomegalovirus IL-10 mutants as a model for novel vaccines against human cytomegalovirus. PLoS One (2011) 0.83
Epstein-Barr virus IL-10 engages IL-10R1 by a two-step mechanism leading to altered signaling properties. J Biol Chem (2012) 0.83
The unique C termini of orthopoxvirus gamma interferon binding proteins are essential for ligand binding. J Virol (2006) 0.83
Vaccination against a virus-encoded cytokine significantly restricts viral challenge. J Virol (2013) 0.81
Identification and characterization of a +1 frameshift observed during the expression of Epstein-Barr virus IL-10 in Escherichia coli. Protein Expr Purif (2006) 0.80
The old but new IgM Fc receptor (FcμR). Curr Top Microbiol Immunol (2014) 0.77
Crystallization and preliminary X-ray diffraction analysis of human IL-22 bound to the extracellular IL-22R1 chain. Acta Crystallogr Sect F Struct Biol Cryst Commun (2008) 0.77
Kinetic analysis of cytokine-mediated receptor assembly using engineered FC heterodimers. Protein Sci (2013) 0.77
Crystallization and X-ray diffraction analysis of insect-cell-derived IL-22. Acta Crystallogr D Biol Crystallogr (2004) 0.76
Missense splice variant (g.20746A>G, p.Ile183Val) of interferon gamma receptor 1 (IFNGR1) coincidental with mycobacterial osteomyelitis - a screen of osteoarticular lesions. Bosn J Basic Med Sci (2016) 0.75
Purification, crystallization and preliminary X-ray diffraction analysis of the IL-20-IL-20R1-IL-20R2 complex. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.75
Missense splice variant (g.20746A>G, p.Ile183Val) of interferon gamma receptor 1 (IFNGR1) coincidental with mycobacterial osteomyelitis - a screen of osteoarticular lesions. Bosn J Basic Med Sci (2016) 0.75
Crystallization of cytokine-receptor complexes. Methods Mol Biol (2004) 0.75