Published in Structure on July 03, 2008
Biology of interleukin-22. Semin Immunopathol (2010) 2.92
Structural linkage between ligand discrimination and receptor activation by type I interferons. Cell (2011) 2.39
IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine. Nature (2012) 2.36
Interferon-lambda is functionally an interferon but structurally related to the interleukin-10 family. J Biol Chem (2009) 1.73
Structure and mechanism of receptor sharing by the IL-10R2 common chain. Structure (2010) 1.63
Interleukin-22: immunobiology and pathology. Annu Rev Immunol (2015) 1.60
Structural and dynamic determinants of type I interferon receptor assembly and their functional interpretation. Immunol Rev (2012) 1.38
Crystal structure of human interferon-λ1 in complex with its high-affinity receptor interferon-λR1. J Mol Biol (2010) 1.09
Interleukin 22 signaling promotes cell growth in mantle cell lymphoma. Transl Oncol (2011) 1.03
Interleukin-26: an IL-10-related cytokine produced by Th17 cells. Cytokine Growth Factor Rev (2010) 1.03
Structural basis for receptor sharing and activation by interleukin-20 receptor-2 (IL-20R2) binding cytokines. Proc Natl Acad Sci U S A (2012) 1.03
IL-22 is related to development of human colon cancer by activation of STAT3. BMC Cancer (2013) 1.01
Structural analysis of cytokines comprising the IL-10 family. Cytokine Growth Factor Rev (2010) 0.99
Cytokine-receptor interactions as drug targets. Curr Opin Chem Biol (2010) 0.98
A novel role for IL-22R1 as a driver of inflammation. Blood (2010) 0.98
Structure-based design of a protein immunogen that displays an HIV-1 gp41 neutralizing epitope. J Mol Biol (2011) 0.87
Insights into cytokine-receptor interactions from cytokine engineering. Annu Rev Immunol (2014) 0.87
Multifarious determinants of cytokine receptor signaling specificity. Adv Immunol (2014) 0.83
Interleukin-22 Signaling in the Regulation of Intestinal Health and Disease. Front Cell Dev Biol (2016) 0.80
Biological and pathological activities of interleukin-22. J Mol Med (Berl) (2016) 0.80
The molecular basis of IL-10 function: from receptor structure to the onset of signaling. Curr Top Microbiol Immunol (2014) 0.80
STAT3-Activating Cytokines: A Therapeutic Opportunity for Inflammatory Bowel Disease? J Interferon Cytokine Res (2015) 0.80
Interleukin-22 as a molecular adjuvant facilitates IL-17-producing CD8+ T cell responses against a HBV DNA vaccine in mice. Hum Vaccin Immunother (2013) 0.80
The multiple sclerosis risk gene IL22RA2 contributes to a more severe murine autoimmune neuroinflammation. Genes Immun (2014) 0.79
The crystal structure of zebrafish IL-22 reveals an evolutionary, conserved structure highly similar to that of human IL-22. Genes Immun (2014) 0.76
Mechanisms of immunomodulation by mammalian and viral decoy receptors: insights from structures. Nat Rev Immunol (2016) 0.76
IL-22 dampens the T cell response in experimental malaria. Sci Rep (2016) 0.75
Purification, crystallization and preliminary X-ray diffraction analysis of the IL-20-IL-20R1-IL-20R2 complex. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.75
How Does Interleukin-22 Mediate Liver Regeneration and Prevent Injury and Fibrosis? J Immunol Res (2016) 0.75
Crystallization and preliminary X-ray diffraction analysis of human IL-22 bound to its soluble decoy receptor IL-22BP. Acta Crystallogr Sect F Struct Biol Cryst Commun (2009) 0.75
The IFN-λ-IFN-λR1-IL-10Rβ Complex Reveals Structural Features Underlying Type III IFN Functional Plasticity. Immunity (2017) 0.75
The CCP4 suite: programs for protein crystallography. Acta Crystallogr D Biol Crystallogr (1994) 187.88
Crystallography & NMR system: A new software suite for macromolecular structure determination. Acta Crystallogr D Biol Crystallogr (1998) 169.28
Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr A (1991) 119.63
VMD: visual molecular dynamics. J Mol Graph (1996) 117.02
Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol (2001) 25.63
Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J Exp Med (2006) 13.74
Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens. Nat Med (2008) 12.68
IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia. Nat Med (2008) 9.05
IL-22 increases the innate immunity of tissues. Immunity (2004) 8.30
Ribbons. Methods Enzymol (1997) 5.83
Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation. Immunity (2007) 5.73
Interleukin-10 and related cytokines and receptors. Annu Rev Immunol (2004) 5.41
Multiple protein sequence alignment from tertiary structure comparison: assignment of global and residue confidence levels. Proteins (1992) 4.92
IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis. Eur J Immunol (2006) 4.88
IL-22 is required for Th17 cell-mediated pathology in a mouse model of psoriasis-like skin inflammation. J Clin Invest (2008) 4.12
Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation. Hepatology (2004) 3.84
Tools for comparative protein structure modeling and analysis. Nucleic Acids Res (2003) 3.68
The effects of IL-20 subfamily cytokines on reconstituted human epidermis suggest potential roles in cutaneous innate defense and pathogenic adaptive immunity in psoriasis. J Immunol (2007) 3.06
Erythropoietin receptor activation by a ligand-induced conformation change. Science (1999) 2.98
Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R. J Biol Chem (2000) 2.73
Interleukin-22 (IL-22) activates the JAK/STAT, ERK, JNK, and p38 MAP kinase pathways in a rat hepatoma cell line. Pathways that are shared with and distinct from IL-10. J Biol Chem (2002) 2.73
Cloning and characterization of IL-10-related T cell-derived inducible factor (IL-TIF), a novel cytokine structurally related to IL-10 and inducible by IL-9. J Immunol (2000) 2.71
Interleukin 20: discovery, receptor identification, and role in epidermal function. Cell (2001) 2.45
A role for T cell-derived interleukin 22 in psoriatic skin inflammation. Clin Exp Immunol (2007) 2.16
CLAMP: a biosensor kinetic data analysis program. Trends Biochem Sci (1998) 2.12
Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types. J Immunol (2001) 2.07
Identification and functional characterization of a second chain of the interleukin-10 receptor complex. EMBO J (1997) 2.03
Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor. Proc Natl Acad Sci U S A (2000) 2.01
Model for growth hormone receptor activation based on subunit rotation within a receptor dimer. Nat Struct Mol Biol (2005) 1.83
IL-22 induces lipopolysaccharide-binding protein in hepatocytes: a potential systemic role of IL-22 in Crohn's disease. J Immunol (2007) 1.80
Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site. Immunity (2001) 1.64
Crystal structure of interleukin-10 reveals the functional dimer with an unexpected topological similarity to interferon gamma. Structure (1995) 1.54
Cloning and characterization of IL-22 binding protein, a natural antagonist of IL-10-related T cell-derived inducible factor/IL-22. J Immunol (2001) 1.49
A soluble class II cytokine receptor, IL-22RA2, is a naturally occurring IL-22 antagonist. Proc Natl Acad Sci U S A (2001) 1.43
Interleukin (IL)-19, IL-20 and IL-24 are produced by and act on keratinocytes and are distinct from classical ILs. Exp Dermatol (2006) 1.41
Expression patterns of IL-10 ligand and receptor gene families provide leads for biological characterization. Int Immunopharmacol (2004) 1.38
Identification, cloning, and characterization of a novel soluble receptor that binds IL-22 and neutralizes its activity. J Immunol (2001) 1.35
Crystal structure of interleukin 10 reveals an interferon gamma-like fold. Biochemistry (1995) 1.32
Conformational changes mediate interleukin-10 receptor 2 (IL-10R2) binding to IL-10 and assembly of the signaling complex. J Biol Chem (2006) 1.31
Same structure, different function crystal structure of the Epstein-Barr virus IL-10 bound to the soluble IL-10R1 chain. Structure (2005) 1.26
Differential IL-10R1 expression plays a critical role in IL-10-mediated immune regulation. J Immunol (2001) 1.18
Crystal structure of recombinant human interleukin-22. Structure (2002) 1.08
The IL-10R2 binding hot spot on IL-22 is located on the N-terminal helix and is dependent on N-linked glycosylation. J Mol Biol (2004) 1.07
Comparison of interleukin-22 and interleukin-10 soluble receptor complexes. J Interferon Cytokine Res (2002) 0.98
Structure of insect-cell-derived IL-22. Acta Crystallogr D Biol Crystallogr (2005) 0.94
Cloning and characterization of mouse IL-22 binding protein. Genes Immun (2003) 0.92
Interactions among the components of the interleukin-10 receptor complex. Biochem Biophys Res Commun (2005) 0.91
A model of the ternary complex of interleukin-10 with its soluble receptors. BMC Struct Biol (2005) 0.86
Interleukin-22 forms dimers that are recognized by two interleukin-22R1 receptor chains. Biophys J (2007) 0.85
Crystallization and preliminary X-ray diffraction analysis of human IL-22 bound to the extracellular IL-22R1 chain. Acta Crystallogr Sect F Struct Biol Cryst Commun (2008) 0.77
Interferons, interferon-like cytokines, and their receptors. Immunol Rev (2004) 6.21
Interleukin-10 and related cytokines and receptors. Annu Rev Immunol (2004) 5.41
Reversal of persistent fibrosis in aging by targeting Nox4-Nrf2 redox imbalance. Sci Transl Med (2014) 3.23
Structure and mechanism of receptor sharing by the IL-10R2 common chain. Structure (2010) 1.63
BiP/GRP78 is an intracellular target for MDA-7/IL-24 induction of cancer-specific apoptosis. Cancer Res (2006) 1.58
Unique aspects of mda-7/IL-24 antitumor bystander activity: establishing a role for secretion of MDA-7/IL-24 protein by normal cells. Oncogene (2005) 1.49
Isolation of flagellated bacteria implicated in Crohn's disease. Inflamm Bowel Dis (2007) 1.40
Crystal structure of human cytomegalovirus IL-10 bound to soluble human IL-10R1. Proc Natl Acad Sci U S A (2002) 1.32
Conformational changes mediate interleukin-10 receptor 2 (IL-10R2) binding to IL-10 and assembly of the signaling complex. J Biol Chem (2006) 1.31
Same structure, different function crystal structure of the Epstein-Barr virus IL-10 bound to the soluble IL-10R1 chain. Structure (2005) 1.26
The IL-10R2 binding hot spot on IL-22 is located on the N-terminal helix and is dependent on N-linked glycosylation. J Mol Biol (2004) 1.07
Structural basis for receptor sharing and activation by interleukin-20 receptor-2 (IL-20R2) binding cytokines. Proc Natl Acad Sci U S A (2012) 1.03
Interleukin-26: an IL-10-related cytokine produced by Th17 cells. Cytokine Growth Factor Rev (2010) 1.03
Substitution of adenovirus serotype 3 hexon onto a serotype 5 oncolytic adenovirus reduces factor X binding, decreases liver tropism, and improves antitumor efficacy. Mol Cancer Ther (2010) 1.02
Comparison of interleukin-22 and interleukin-10 soluble receptor complexes. J Interferon Cytokine Res (2002) 0.98
Very early onset inflammatory bowel disease associated with aberrant trafficking of IL-10R1 and cure by T cell replete haploidentical bone marrow transplantation. J Clin Immunol (2014) 0.98
Cytokine-receptor interactions as drug targets. Curr Opin Chem Biol (2010) 0.98
Induction of regulatory dendritic cells by dexamethasone and 1alpha,25-Dihydroxyvitamin D(3). Immunol Lett (2004) 0.98
A docking model based on mass spectrometric and biochemical data describes phage packaging motor incorporation. Mol Cell Proteomics (2010) 0.95
Structure of insect-cell-derived IL-22. Acta Crystallogr D Biol Crystallogr (2005) 0.94
An early stage of Mason-Pfizer monkey virus budding is regulated by the hydrophobicity of the Gag matrix domain core. J Virol (2004) 0.92
Structure and mechanism of IFN-gamma antagonism by an orthopoxvirus IFN-gamma-binding protein. Proc Natl Acad Sci U S A (2008) 0.90
Noncompetitive antibody neutralization of IL-10 revealed by protein engineering and x-ray crystallography. Structure (2002) 0.88
Inhibition of nuclear factor kappa-B signaling reduces growth in medulloblastoma in vivo. BMC Cancer (2011) 0.84
Host immune responses to a viral immune modulating protein: immunogenicity of viral interleukin-10 in rhesus cytomegalovirus-infected rhesus macaques. PLoS One (2012) 0.84
Protein crystallization. Methods Mol Biol (2007) 0.84
Biophysical properties of human medulloblastoma cells. J Membr Biol (2010) 0.84
Design and analysis of rhesus cytomegalovirus IL-10 mutants as a model for novel vaccines against human cytomegalovirus. PLoS One (2011) 0.83
Epstein-Barr virus IL-10 engages IL-10R1 by a two-step mechanism leading to altered signaling properties. J Biol Chem (2012) 0.83
The unique C termini of orthopoxvirus gamma interferon binding proteins are essential for ligand binding. J Virol (2006) 0.83
Vaccination against a virus-encoded cytokine significantly restricts viral challenge. J Virol (2013) 0.81
Identification and characterization of a +1 frameshift observed during the expression of Epstein-Barr virus IL-10 in Escherichia coli. Protein Expr Purif (2006) 0.80
The old but new IgM Fc receptor (FcμR). Curr Top Microbiol Immunol (2014) 0.77
Crystallization and preliminary X-ray diffraction analysis of human IL-22 bound to the extracellular IL-22R1 chain. Acta Crystallogr Sect F Struct Biol Cryst Commun (2008) 0.77
Kinetic analysis of cytokine-mediated receptor assembly using engineered FC heterodimers. Protein Sci (2013) 0.77
Crystallization and X-ray diffraction analysis of insect-cell-derived IL-22. Acta Crystallogr D Biol Crystallogr (2004) 0.76
Missense splice variant (g.20746A>G, p.Ile183Val) of interferon gamma receptor 1 (IFNGR1) coincidental with mycobacterial osteomyelitis - a screen of osteoarticular lesions. Bosn J Basic Med Sci (2016) 0.75
Purification, crystallization and preliminary X-ray diffraction analysis of the IL-20-IL-20R1-IL-20R2 complex. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.75
Crystallization of cytokine-receptor complexes. Methods Mol Biol (2004) 0.75
Missense splice variant (g.20746A>G, p.Ile183Val) of interferon gamma receptor 1 (IFNGR1) coincidental with mycobacterial osteomyelitis - a screen of osteoarticular lesions. Bosn J Basic Med Sci (2016) 0.75