Published in Oncogene on April 18, 2005
pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4alpha tumor suppressor gene. Genes Dev (2007) 3.31
APC/C(Cdc20) controls the ubiquitin-mediated degradation of p21 in prometaphase. Mol Cell (2007) 2.35
Only Akt1 is required for proliferation, while Akt2 promotes cell cycle exit through p21 binding. Mol Cell Biol (2006) 2.01
DDB1 is essential for genomic stability in developing epidermis. Proc Natl Acad Sci U S A (2007) 1.20
The p16INK4a tumor suppressor controls p21WAF1 induction in response to ultraviolet light. Nucleic Acids Res (2006) 1.15
Anaplastic thyroid carcinoma: A comprehensive review of current and future therapeutic options. World J Clin Oncol (2011) 1.10
Review of therapeutic strategies for osteosarcoma, chondrosarcoma, and Ewing's sarcoma. Med Sci Monit (2011) 1.07
Regulation of CDK4. Cell Div (2006) 1.06
Protein phosphatase 2A subunit PR70 interacts with pRb and mediates its dephosphorylation. Mol Cell Biol (2007) 1.04
p16( INK4a) positively regulates cyclin D1 and E2F1 through negative control of AUF1. PLoS One (2011) 1.02
p19Ink4d is a tumor suppressor and controls pituitary anterior lobe cell proliferation. Mol Cell Biol (2014) 0.97
CDK4 T172 phosphorylation is central in a CDK7-dependent bidirectional CDK4/CDK2 interplay mediated by p21 phosphorylation at the restriction point. PLoS Genet (2013) 0.96
Expression of anion exchanger 1 sequestrates p16 in the cytoplasm in gastric and colonic adenocarcinoma. Neoplasia (2007) 0.96
p107 in the public eye: an Rb understudy and more. Cell Div (2010) 0.94
FGF-16 is released from neonatal cardiac myocytes and alters growth-related signaling: a possible role in postnatal development. Am J Physiol Cell Physiol (2008) 0.92
Role of DMP1 and its future in lung cancer diagnostics. Expert Rev Mol Diagn (2008) 0.91
Logic of a mammalian metabolic cycle: an oscillated NAD+/NADH redox signaling regulates coordinated histone expression and S-phase progression. Cell Cycle (2009) 0.89
E2F1-mediated upregulation of p19INK4d determines its periodic expression during cell cycle and regulates cellular proliferation. PLoS One (2011) 0.87
Stability and function of JC virus large T antigen and T' proteins are altered by mutation of their phosphorylated threonine 125 residues. J Virol (2006) 0.86
Nitric oxide-donating aspirin inhibits the growth of pancreatic cancer cells through redox-dependent signaling. Cancer Lett (2008) 0.86
p16(INK4A) positively regulates p21(WAF1) expression by suppressing AUF1-dependent mRNA decay. PLoS One (2013) 0.84
Evidence for a CDK4-dependent checkpoint in a conditional model of cellular senescence. Cell Cycle (2015) 0.83
CDK2 and PKA mediated-sequential phosphorylation is critical for p19INK4d function in the DNA damage response. PLoS One (2012) 0.83
Anaplastic thyroid carcinoma. Front Endocrinol (Lausanne) (2012) 0.82
Tissue microarray analysis of cyclin-dependent kinase inhibitors p21 and p16 in Fuchs dystrophy. Cornea (2013) 0.81
Stromal p16 expression is significantly increased in malignant ovarian neoplasms. Oncotarget (2016) 0.79
The differential cell signaling effects of two positional isomers of the anticancer NO-donating aspirin. Int J Oncol (2009) 0.79
p16INK4a suppresses BRCA1-deficient mammary tumorigenesis. Oncotarget (2016) 0.77
P16(INK4A) is required for cisplatin resistance in cervical carcinoma SiHa cells. Oncol Lett (2014) 0.77
Rescue from early-onset hearing loss in a mouse model lacking the cyclin-dependent kinase inhibitor p19(Ink4d). Cell Death Dis (2016) 0.75
Stromal p16 expression is significantly increased in endometrial carcinoma. Oncotarget (2016) 0.75
Gata3 restrains B cell proliferation and cooperates with p18INK4c to repress B cell lymphomagenesis. Oncotarget (2016) 0.75
Unexpected role of CDK4 in a G2/M checkpoint. Cell Cycle (2015) 0.75
p16 loss rescues functional decline of Brca1-deficient mammary stem cells. Cell Cycle (2017) 0.75
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell (2011) 11.44
Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha. Science (2009) 10.78
Regulation of cellular metabolism by protein lysine acetylation. Science (2010) 10.55
Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux. Science (2010) 6.04
Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters. Nat Genet (2011) 5.62
Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases. Nat Cell Biol (2003) 5.18
TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway. Mol Cell Biol (2008) 5.02
Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway. Mol Cell Biol (2003) 4.61
BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase. Mol Cell Biol (2005) 4.53
Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth. Mol Cell (2011) 3.78
Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage. Nat Cell Biol (2004) 3.72
Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage. Mol Cell (2006) 3.39
pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4alpha tumor suppressor gene. Genes Dev (2007) 3.31
TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. J Biol Chem (2009) 3.20
Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases. Cell (2004) 3.07
NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases. Mol Cell (2002) 3.03
Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase. Mol Cell (2011) 2.84
DDB1 functions as a linker to recruit receptor WD40 proteins to CUL4-ROC1 ubiquitin ligases. Genes Dev (2006) 2.75
Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors. Genes Dev (2012) 2.70
Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c. Proc Natl Acad Sci U S A (2005) 2.59
CRL4s: the CUL4-RING E3 ubiquitin ligases. Trends Biochem Sci (2009) 2.59
Regulation of intermediary metabolism by protein acetylation. Trends Biochem Sci (2010) 2.36
The hippo tumor pathway promotes TAZ degradation by phosphorylating a phosphodegron and recruiting the SCF{beta}-TrCP E3 ligase. J Biol Chem (2010) 2.27
Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS. EMBO Rep (2011) 2.20
CDK inhibitor p18(INK4c) is a downstream target of GATA3 and restrains mammary luminal progenitor cell proliferation and tumorigenesis. Cancer Cell (2009) 2.17
A role for NF-kappaB essential modifier/IkappaB kinase-gamma (NEMO/IKKgamma) ubiquitination in the activation of the IkappaB kinase complex by tumor necrosis factor-alpha. J Biol Chem (2003) 2.12
An evolutionarily conserved function of proliferating cell nuclear antigen for Cdt1 degradation by the Cul4-Ddb1 ubiquitin ligase in response to DNA damage. J Biol Chem (2006) 1.90
Characterization of Arabidopsis and rice DWD proteins and their roles as substrate receptors for CUL4-RING E3 ubiquitin ligases. Plant Cell (2008) 1.77
Nutrient sensing, metabolism, and cell growth control. Mol Cell (2013) 1.67
Mitogenic and oncogenic stimulation of K433 acetylation promotes PKM2 protein kinase activity and nuclear localization. Mol Cell (2013) 1.65
WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase. Genes Dev (2008) 1.61
Arabidopsis CAND1, an unmodified CUL1-interacting protein, is involved in multiple developmental pathways controlled by ubiquitin/proteasome-mediated protein Degradation. Plant Cell (2004) 1.60
Haploinsufficiency of p18(INK4c) sensitizes mice to carcinogen-induced tumorigenesis. Mol Cell Biol (2003) 1.58
IDH1 and IDH2 mutations in tumorigenesis: mechanistic insights and clinical perspectives. Clin Cancer Res (2012) 1.36
Human immunodeficiency virus type 1 Vpr-binding protein VprBP, a WD40 protein associated with the DDB1-CUL4 E3 ubiquitin ligase, is essential for DNA replication and embryonic development. Mol Cell Biol (2008) 1.36
DDB1-CUL4 and MLL1 mediate oncogene-induced p16INK4a activation. Cancer Res (2009) 1.34
Expression of p16Ink4a compensates for p18Ink4c loss in cyclin-dependent kinase 4/6-dependent tumors and tissues. Cancer Res (2007) 1.32
Activation of UBC5 ubiquitin-conjugating enzyme by the RING finger of ROC1 and assembly of active ubiquitin ligases by all cullins. J Biol Chem (2002) 1.29
Lysine-5 acetylation negatively regulates lactate dehydrogenase A and is decreased in pancreatic cancer. Cancer Cell (2013) 1.29
X-linked mental retardation gene CUL4B targets ubiquitylation of H3K4 methyltransferase component WDR5 and regulates neuronal gene expression. Mol Cell (2011) 1.29
Arabidopsis DDB1-CUL4 ASSOCIATED FACTOR1 forms a nuclear E3 ubiquitin ligase with DDB1 and CUL4 that is involved in multiple plant developmental processes. Plant Cell (2008) 1.23
Alterations of metabolic genes and metabolites in cancer. Semin Cell Dev Biol (2012) 1.18
CDK inhibitor p18(INK4c) is required for the generation of functional plasma cells. Immunity (2002) 1.18
A role for Saccharomyces cerevisiae Cul8 ubiquitin ligase in proper anaphase progression. J Biol Chem (2003) 1.18
The N-terminal phosphodegron targets TAZ/WWTR1 protein for SCFβ-TrCP-dependent degradation in response to phosphatidylinositol 3-kinase inhibition. J Biol Chem (2012) 1.17
Negative regulation of TSC1-TSC2 by mammalian D-type cyclins. Cancer Res (2005) 1.16
PP1 cooperates with ASPP2 to dephosphorylate and activate TAZ. J Biol Chem (2010) 1.15
14-3-3beta binds to and negatively regulates the tuberous sclerosis complex 2 (TSC2) tumor suppressor gene product, tuberin. J Biol Chem (2002) 1.14
Lysine 88 acetylation negatively regulates ornithine carbamoyltransferase activity in response to nutrient signals. J Biol Chem (2009) 1.13
Generation of acetyllysine antibodies and affinity enrichment of acetylated peptides. Nat Protoc (2010) 1.13
p18 Ink4c and Pten constrain a positive regulatory loop between cell growth and cell cycle control. Mol Cell Biol (2006) 1.11
p18Ink4c collaborates with Men1 to constrain lung stem cell expansion and suppress non-small-cell lung cancers. Cancer Res (2007) 1.10
Genetic evidence for functional dependency of p18Ink4c on Cdk4. Mol Cell Biol (2004) 1.06
Signaling pathways that control cell proliferation. Cold Spring Harb Perspect Biol (2013) 1.05
p53 binds to and is required for the repression of Arf tumor suppressor by HDAC and polycomb. Cancer Res (2011) 1.04
Human tumor suppressor ARF impedes S-phase progression independent of p53. Cancer Res (2002) 1.03
Acetylation negatively regulates glycogen phosphorylase by recruiting protein phosphatase 1. Cell Metab (2012) 1.02
Ectromelia virus encodes a novel family of F-box proteins that interact with the SCF complex. J Virol (2008) 1.01
Cytoplasmic CUL9/PARC ubiquitin ligase is a tumor suppressor and promotes p53-dependent apoptosis. Cancer Res (2011) 1.00
p18Ink4c, but not p27Kip1, collaborates with Men1 to suppress neuroendocrine organ tumors. Mol Cell Biol (2006) 0.99
NOTCH-induced aldehyde dehydrogenase 1A1 deacetylation promotes breast cancer stem cells. J Clin Invest (2014) 0.97
Assays for RING family ubiquitin ligases. Methods Mol Biol (2005) 0.96
Vpr-binding protein antagonizes p53-mediated transcription via direct interaction with H3 tail. Mol Cell Biol (2011) 0.94
Ectromelia virus BTB/kelch proteins, EVM150 and EVM167, interact with cullin-3-based ubiquitin ligases. Virology (2008) 0.92
Estrogen regulates Hippo signaling via GPER in breast cancer. J Clin Invest (2015) 0.91
CRL4A-FBXW5-mediated degradation of DLC1 Rho GTPase-activating protein tumor suppressor promotes non-small cell lung cancer cell growth. Proc Natl Acad Sci U S A (2013) 0.88
CUL9 mediates the functions of the 3M complex and ubiquitylates survivin to maintain genome integrity. Mol Cell (2014) 0.85
R-2-hydroxyglutarate as the key effector of IDH mutations promoting oncogenesis. Cancer Cell (2013) 0.85
VprBP binds full-length RAG1 and is required for B-cell development and V(D)J recombination fidelity. EMBO J (2011) 0.84
Glyceraldehyde-3-phosphate dehydrogenase is activated by lysine 254 acetylation in response to glucose signal. J Biol Chem (2013) 0.84
Recruiting substrates to cullin 4-dependent ubiquitin ligases by DDB1. Cell Cycle (2005) 0.83
Targeted polyubiquitylation of RASSF1C by the Mule and SCFβ-TrCP ligases in response to DNA damage. Biochem J (2012) 0.83
The mechanisms of IDH mutations in tumorigenesis. Cell Res (2012) 0.82
Variants in CUL4B are associated with cerebral malformations. Hum Mutat (2015) 0.82
p18(INK4c) collaborates with other CDK-inhibitory proteins in the regenerating liver. Hepatology (2003) 0.81
Cell type-dependent requirement for PIP box-regulated Cdt1 destruction during S phase. Mol Biol Cell (2010) 0.81
Targeting protein ubiquitylation: DDB1 takes its RING off. Nat Cell Biol (2009) 0.80
Twice primed: cyclin E is phosphorylated and isomerized before being ubiquitinated. Mol Cell (2006) 0.80
Metabolic alteration in tumorigenesis. Sci China Life Sci (2013) 0.79
LDH-A acetylation: implication in cancer. Oncotarget (2013) 0.78
Targeted ubiquitylation: the prey becomes predator. Mol Cell (2010) 0.78
Acetylation control of cancer cell metabolism. Curr Pharm Des (2014) 0.77
Correction: Insulin and mTOR Pathway Regulate HDAC3-Mediated Deacetylation and Activation of PGK1. PLoS Biol (2015) 0.77
Corrigendum: inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors. Genes Dev (2015) 0.75
Chromatin regulation by CRL4 E3 ubiquitin ligases: CUL4B targets WDR5 ubiquitylation in the nucleus. Cell Cycle (2011) 0.75
Imaging and detection of morphological changes of single cells before and after secretion using scanning electrochemical microscopy. Analyst (2007) 0.75
Investigation of Protein-Protein Interactions and Conformational Changes in Hedgehog Signaling Pathway by FRET. Methods Mol Biol (2015) 0.75