Published in Cancer Res on April 12, 2011
Dysfunction of the TP53 tumor suppressor gene in lymphoid malignancies. Blood (2012) 1.25
The emerging role of speckle-type POZ protein (SPOP) in cancer development. Drug Discov Today (2014) 1.16
RBR E3 ubiquitin ligases: new structures, new insights, new questions. Biochem J (2014) 1.13
Emerging role of DYRK family protein kinases as regulators of protein stability in cell cycle control. Cell Cycle (2012) 1.05
p19Ink4d is a tumor suppressor and controls pituitary anterior lobe cell proliferation. Mol Cell Biol (2014) 0.97
Calpain-mediated processing of p53-associated parkin-like cytoplasmic protein (PARC) affects chemosensitivity of human ovarian cancer cells by promoting p53 subcellular trafficking. J Biol Chem (2011) 0.89
A CULLINary ride across the secretory pathway: more than just secretion. Trends Cell Biol (2014) 0.86
The E3 ligase PARC mediates the degradation of cytosolic cytochrome c to promote survival in neurons and cancer cells. Sci Signal (2014) 0.86
CUL9 mediates the functions of the 3M complex and ubiquitylates survivin to maintain genome integrity. Mol Cell (2014) 0.85
MSEA: detection and quantification of mutation hotspots through mutation set enrichment analysis. Genome Biol (2014) 0.85
Age-dependent transcriptome and proteome following transection of neonatal spinal cord of Monodelphis domestica (South American grey short-tailed opossum). PLoS One (2014) 0.78
Induction of nuclear translocation of mutant cytoplasmic p53 by geranylgeranoic acid in a human hepatoma cell line. Sci Rep (2014) 0.77
p53 regulation upon genotoxic stress: intricacies and complexities. Mol Cell Oncol (2014) 0.76
microRNA-143/145 loss induces Ras signaling to promote aggressive Pten-deficient basal-like breast cancer. JCI Insight (2017) 0.75
Cytoplasmic E3 ubiquitin ligase CUL9 controls cell proliferation, senescence, apoptosis and genome integrity through p53. Oncogene (2017) 0.75
Decreased expression of speckle-type POZ protein for the prediction of poor prognosis in patients with non-small cell lung cancer. Oncol Lett (2017) 0.75
The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature (1986) 14.56
Cytoplasmic functions of the tumour suppressor p53. Nature (2009) 5.23
The c-myc oncogene perturbs B lymphocyte development in E-mu-myc transgenic mice. Cell (1986) 3.72
Mass spectrometric analysis of the anaphase-promoting complex from yeast: identification of a subunit related to cullins. Science (1998) 3.38
Parc: a cytoplasmic anchor for p53. Cell (2003) 3.06
Identification of a cullin homology region in a subunit of the anaphase-promoting complex. Science (1998) 2.61
CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex. Proc Natl Acad Sci U S A (2002) 1.89
Haploinsufficiency of p18(INK4c) sensitizes mice to carcinogen-induced tumorigenesis. Mol Cell Biol (2003) 1.58
Cytoplasmic localized ubiquitin ligase cullin 7 binds to p53 and promotes cell growth by antagonizing p53 function. Oncogene (2006) 1.36
The conserved CPH domains of Cul7 and PARC are protein-protein interaction modules that bind the tetramerization domain of p53. J Biol Chem (2007) 1.26
Regulation of p53: TRIM24 enters the RING. Cell Cycle (2009) 1.11
Genetic evidence for functional dependency of p18Ink4c on Cdk4. Mol Cell Biol (2004) 1.06
Dimerization of CUL7 and PARC is not required for all CUL7 functions and mouse development. Mol Cell Biol (2005) 1.00
A novel p53-binding domain in CUL7. Biochem Biophys Res Commun (2006) 0.96
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell (2011) 11.44
Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha. Science (2009) 10.78
Regulation of cellular metabolism by protein lysine acetylation. Science (2010) 10.55
Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux. Science (2010) 6.04
Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters. Nat Genet (2011) 5.62
Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases. Nat Cell Biol (2003) 5.18
TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway. Mol Cell Biol (2008) 5.02
Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway. Mol Cell Biol (2003) 4.61
BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase. Mol Cell Biol (2005) 4.53
Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth. Mol Cell (2011) 3.78
Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage. Nat Cell Biol (2004) 3.72
Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage. Mol Cell (2006) 3.39
pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4alpha tumor suppressor gene. Genes Dev (2007) 3.31
TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. J Biol Chem (2009) 3.20
Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases. Cell (2004) 3.07
NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases. Mol Cell (2002) 3.03
Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase. Mol Cell (2011) 2.84
DDB1 functions as a linker to recruit receptor WD40 proteins to CUL4-ROC1 ubiquitin ligases. Genes Dev (2006) 2.75
Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors. Genes Dev (2012) 2.70
Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c. Proc Natl Acad Sci U S A (2005) 2.59
CRL4s: the CUL4-RING E3 ubiquitin ligases. Trends Biochem Sci (2009) 2.59
Supportive versus palliative care: what's in a name?: a survey of medical oncologists and midlevel providers at a comprehensive cancer center. Cancer (2009) 2.58
Regulation of intermediary metabolism by protein acetylation. Trends Biochem Sci (2010) 2.36
The hippo tumor pathway promotes TAZ degradation by phosphorylating a phosphodegron and recruiting the SCF{beta}-TrCP E3 ligase. J Biol Chem (2010) 2.27
HIV and syphilis prevalence among men who have sex with men: a cross-sectional survey of 61 cities in China. Clin Infect Dis (2013) 2.24
Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS. EMBO Rep (2011) 2.20
CDK inhibitor p18(INK4c) is a downstream target of GATA3 and restrains mammary luminal progenitor cell proliferation and tumorigenesis. Cancer Cell (2009) 2.17
A role for NF-kappaB essential modifier/IkappaB kinase-gamma (NEMO/IKKgamma) ubiquitination in the activation of the IkappaB kinase complex by tumor necrosis factor-alpha. J Biol Chem (2003) 2.12
The effect of combined antihypertensive treatment (felodipine with either irbesartan or metoprolol) on erectile function: a randomized controlled trial. Cardiology (2013) 2.02
An evolutionarily conserved function of proliferating cell nuclear antigen for Cdt1 degradation by the Cul4-Ddb1 ubiquitin ligase in response to DNA damage. J Biol Chem (2006) 1.90
Characterization of Arabidopsis and rice DWD proteins and their roles as substrate receptors for CUL4-RING E3 ubiquitin ligases. Plant Cell (2008) 1.77
Nutrient sensing, metabolism, and cell growth control. Mol Cell (2013) 1.67
Mitogenic and oncogenic stimulation of K433 acetylation promotes PKM2 protein kinase activity and nuclear localization. Mol Cell (2013) 1.65
Biochemical and cellular mechanisms of mammalian CDK inhibitors: a few unresolved issues. Oncogene (2005) 1.61
Association between a name change from palliative to supportive care and the timing of patient referrals at a comprehensive cancer center. Oncologist (2011) 1.61
WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase. Genes Dev (2008) 1.61
Arabidopsis CAND1, an unmodified CUL1-interacting protein, is involved in multiple developmental pathways controlled by ubiquitin/proteasome-mediated protein Degradation. Plant Cell (2004) 1.60
Haploinsufficiency of p18(INK4c) sensitizes mice to carcinogen-induced tumorigenesis. Mol Cell Biol (2003) 1.58
Retracted Postconditioning promotes the cardiac repair through balancing collagen degradation and synthesis after myocardial infarction in rats. Basic Res Cardiol (2012) 1.57
Review of HIV and other sexually transmitted infections among female sex workers in China. AIDS Care (2011) 1.57
Members of the Toc159 import receptor family represent distinct pathways for protein targeting to plastids. Mol Biol Cell (2004) 1.54
Discharge outcomes and survival of patients with advanced cancer admitted to an acute palliative care unit at a comprehensive cancer center. J Palliat Med (2010) 1.48
Effect of felodipine with irbesartan or metoprolol on sexual function and oxidative stress in women with essential hypertension. J Hypertens (2012) 1.47
Ischemia-modified albumin in patients with hyperthyroidism and hypothyroidism. Eur J Intern Med (2012) 1.45
Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil. J Mol Biol (2005) 1.40
Human immunodeficiency virus type 1 Vpr-binding protein VprBP, a WD40 protein associated with the DDB1-CUL4 E3 ubiquitin ligase, is essential for DNA replication and embryonic development. Mol Cell Biol (2008) 1.36
IDH1 and IDH2 mutations in tumorigenesis: mechanistic insights and clinical perspectives. Clin Cancer Res (2012) 1.36
Import pathways of chloroplast interior proteins and the outer-membrane protein OEP14 converge at Toc75. Plant Cell (2004) 1.35
Plasma and cerebrospinal fluid pharmacokinetics of erlotinib and its active metabolite OSI-420. Clin Cancer Res (2007) 1.35
DDB1-CUL4 and MLL1 mediate oncogene-induced p16INK4a activation. Cancer Res (2009) 1.34
Expression of p16Ink4a compensates for p18Ink4c loss in cyclin-dependent kinase 4/6-dependent tumors and tissues. Cancer Res (2007) 1.32
The lack of standard definitions in the supportive and palliative oncology literature. J Pain Symptom Manage (2011) 1.30
Abnormal neural activity in the patients with remitted geriatric depression: a resting-state functional magnetic resonance imaging study. J Affect Disord (2008) 1.29
Activation of UBC5 ubiquitin-conjugating enzyme by the RING finger of ROC1 and assembly of active ubiquitin ligases by all cullins. J Biol Chem (2002) 1.29
Lysine-5 acetylation negatively regulates lactate dehydrogenase A and is decreased in pancreatic cancer. Cancer Cell (2013) 1.29
X-linked mental retardation gene CUL4B targets ubiquitylation of H3K4 methyltransferase component WDR5 and regulates neuronal gene expression. Mol Cell (2011) 1.29
Spatial approximation between the amino terminus of a peptide agonist and the top of the sixth transmembrane segment of the secretin receptor. J Biol Chem (2003) 1.26
Arabidopsis DDB1-CUL4 ASSOCIATED FACTOR1 forms a nuclear E3 ubiquitin ligase with DDB1 and CUL4 that is involved in multiple plant developmental processes. Plant Cell (2008) 1.23
Gefitinib modulates the function of multiple ATP-binding cassette transporters in vivo. Cancer Res (2006) 1.23
Impact of delirium and recall on the level of distress in patients with advanced cancer and their family caregivers. Cancer (2009) 1.20
A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjögren's syndrome at 7q11.23. Nat Genet (2013) 1.19
Antineoplastic therapy use in patients with advanced cancer admitted to an acute palliative care unit at a comprehensive cancer center: a simultaneous care model. Cancer (2010) 1.19
Alterations of metabolic genes and metabolites in cancer. Semin Cell Dev Biol (2012) 1.18
A role for Saccharomyces cerevisiae Cul8 ubiquitin ligase in proper anaphase progression. J Biol Chem (2003) 1.18
CDK inhibitor p18(INK4c) is required for the generation of functional plasma cells. Immunity (2002) 1.18
The N-terminal phosphodegron targets TAZ/WWTR1 protein for SCFβ-TrCP-dependent degradation in response to phosphatidylinositol 3-kinase inhibition. J Biol Chem (2012) 1.17
Negative regulation of TSC1-TSC2 by mammalian D-type cyclins. Cancer Res (2005) 1.16
In vivo analysis of the role of atTic20 in protein import into chloroplasts. Plant Cell (2002) 1.15
PP1 cooperates with ASPP2 to dephosphorylate and activate TAZ. J Biol Chem (2010) 1.15
14-3-3beta binds to and negatively regulates the tuberous sclerosis complex 2 (TSC2) tumor suppressor gene product, tuberin. J Biol Chem (2002) 1.14
Symptom distress, interventions, and outcomes of intensive care unit cancer patients referred to a palliative care consult team. Cancer (2009) 1.13
Lysine 88 acetylation negatively regulates ornithine carbamoyltransferase activity in response to nutrient signals. J Biol Chem (2009) 1.13
Generation of acetyllysine antibodies and affinity enrichment of acetylated peptides. Nat Protoc (2010) 1.13
Association study of the decreased serum BDNF concentrations in amnestic mild cognitive impairment and the Val66Met polymorphism in Chinese Han. J Clin Psychiatry (2008) 1.12
p18 Ink4c and Pten constrain a positive regulatory loop between cell growth and cell cycle control. Mol Cell Biol (2006) 1.11
Essential role of the G-domain in targeting of the protein import receptor atToc159 to the chloroplast outer membrane. J Cell Biol (2002) 1.11
Impairments in cognition and resting-state connectivity of the hippocampus in elderly subjects with type 2 diabetes. Neurosci Lett (2010) 1.10
p18Ink4c collaborates with Men1 to constrain lung stem cell expansion and suppress non-small-cell lung cancers. Cancer Res (2007) 1.10
The roles of toc34 and toc75 in targeting the toc159 preprotein receptor to chloroplasts. J Biol Chem (2003) 1.08
Abnormal insula functional network is associated with episodic memory decline in amnestic mild cognitive impairment. Neuroimage (2012) 1.07
Genetic evidence for functional dependency of p18Ink4c on Cdk4. Mol Cell Biol (2004) 1.06
Symptom distress in advanced cancer patients with anxiety and depression in the palliative care setting. Support Care Cancer (2008) 1.06
Role of ATP-binding cassette and solute carrier transporters in erlotinib CNS penetration and intracellular accumulation. Clin Cancer Res (2010) 1.06
Enzymatic properties and nucleotide and amino acid sequences of a thermostable beta-agarase from the novel marine isolate, JAMB-A94. Biosci Biotechnol Biochem (2004) 1.05
Signaling pathways that control cell proliferation. Cold Spring Harb Perspect Biol (2013) 1.05
Betulinic acid derivatives that target gp120 and inhibit multiple genetic subtypes of human immunodeficiency virus type 1. Antimicrob Agents Chemother (2007) 1.05
PEPFAR's evolving HIV prevention approaches for key populations--people who inject drugs, men who have sex with men, and sex workers: progress, challenges, and opportunities. J Acquir Immune Defic Syndr (2012) 1.04
p53 binds to and is required for the repression of Arf tumor suppressor by HDAC and polycomb. Cancer Res (2011) 1.04
Altered baseline brain activity in type 2 diabetes: a resting-state fMRI study. Psychoneuroendocrinology (2013) 1.04
Cloning, expression, and characterization of a glycoside hydrolase family 86 beta-agarase from a deep-sea Microbulbifer-like isolate. Appl Microbiol Biotechnol (2004) 1.04
Human tumor suppressor ARF impedes S-phase progression independent of p53. Cancer Res (2002) 1.03
Acetylation negatively regulates glycogen phosphorylase by recruiting protein phosphatase 1. Cell Metab (2012) 1.02
Human immunodeficiency virus knowledge and attitudes among hospital-based healthcare professionals in Guangxi Zhuang Autonomous Region, People's Republic of China. Infect Control Hosp Epidemiol (2003) 1.02