Published in Eur J Pharmacol on April 11, 2005
Decreased perivascular fibrosis but not cardiac hypertrophy in ROCK1+/- haploinsufficient mice. Circulation (2005) 2.09
Air pollution and cardiac remodeling: a role for RhoA/Rho-kinase. Am J Physiol Heart Circ Physiol (2009) 1.44
Rho-associated coiled-coil containing kinases (ROCK): structure, regulation, and functions. Small GTPases (2014) 1.38
Involvement of RhoA/ROCK in myocardial fibrosis in a rat model of type 2 diabetes. Acta Pharmacol Sin (2011) 1.08
ROCKing Regeneration: Rho Kinase Inhibition as Molecular Target for Neurorestoration. Front Mol Neurosci (2011) 1.02
FHL2 prevents cardiac hypertrophy in mice with cardiac-specific deletion of ROCK2. FASEB J (2012) 0.95
Obesity, metabolic dysfunction, and cardiac fibrosis: pathophysiological pathways, molecular mechanisms, and therapeutic opportunities. Transl Res (2014) 0.94
Fasudil, a Rho-kinase inhibitor, protects against excessive endurance exercise training-induced cardiac hypertrophy, apoptosis and fibrosis in rats. Eur J Appl Physiol (2011) 0.91
Cyclophilin A promotes cardiac hypertrophy in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol (2011) 0.88
Rho-associated kinase activity is a predictor of cardiovascular outcomes. Hypertension (2013) 0.86
Wound contraction is attenuated by fasudil inhibition of Rho-associated kinase. Plast Reconstr Surg (2011) 0.82
Simvastatin activates the PPARγ-dependent pathway to prevent left ventricular hypertrophy associated with inhibition of RhoA signaling. Tex Heart Inst J (2013) 0.82
Differential roles of endothelin-1 in angiotensin II-induced atherosclerosis and aortic aneurysms in apolipoprotein E-null mice. Am J Pathol (2011) 0.82
Increased Rho kinase activity in congestive heart failure. Eur J Heart Fail (2012) 0.81
Blunted activation of Rho-kinase in yak pulmonary circulation. Biomed Res Int (2015) 0.77
Rho-kinase inhibition is involved in the activation of PI3-kinase/Akt during ischemic-preconditioning-induced cardiomyocyte apoptosis. Int J Clin Exp Med (2014) 0.77
The Role of the Rho/ROCK Pathway in Ang II and TGF-β1-Induced Atrial Remodeling. PLoS One (2016) 0.75
T-helper type 2-driven inflammation defines major subphenotypes of asthma. Am J Respir Crit Care Med (2009) 7.11
Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects. Nat Chem Biol (2008) 5.32
Ranibizumab for macular edema due to retinal vein occlusions: implication of VEGF as a critical stimulator. Mol Ther (2008) 2.59
The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors. Nat Neurosci (2010) 2.37
Blockade of Nogo-66, myelin-associated glycoprotein, and oligodendrocyte myelin glycoprotein by soluble Nogo-66 receptor promotes axonal sprouting and recovery after spinal injury. J Neurosci (2004) 2.29
Exploring the effects of omalizumab in allergic asthma: an analysis of biomarkers in the EXTRA study. Am J Respir Crit Care Med (2013) 2.25
Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients. J Allergy Clin Immunol (2012) 2.24
Pharmacokinetics and pharmacodynamics of LCZ696, a novel dual-acting angiotensin receptor-neprilysin inhibitor (ARNi). J Clin Pharmacol (2009) 2.21
Heterogenic loss of the wild-type BRCA allele in human breast tumorigenesis. Ann Surg Oncol (2007) 2.19
Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening. Proc Natl Acad Sci U S A (2010) 2.16
Hypertension in mice lacking the proatrial natriuretic peptide convertase corin. Proc Natl Acad Sci U S A (2005) 1.84
Urokinase-type plasminogen activator plays a critical role in angiotensin II-induced abdominal aortic aneurysm. Circ Res (2003) 1.81
Pharmacokinetics of the oral direct renin inhibitor aliskiren alone and in combination with irbesartan in renal impairment. Clin Pharmacokinet (2007) 1.57
PET of glial metabolism using 2-18F-fluoroacetate. J Nucl Med (2009) 1.56
Analysis of the complications induced by polyacrylamide hydrogel injection. Plast Reconstr Surg (2004) 1.47
Renal and hormonal responses to direct renin inhibition with aliskiren in healthy humans. Circulation (2008) 1.45
Angiotensin II promotes thoracic aortic dissections and ruptures in Col3a1 haploinsufficient mice. Hypertension (2013) 1.43
Response to "Different measures of 'genome-wide' DNA methylation exhibit unique properties in placental and somatic tissues". Epigenetics (2012) 1.40
Increased expression of immunoreactive thymic stromal lymphopoietin in patients with severe asthma. J Allergy Clin Immunol (2011) 1.38
Angiotensin II is associated with activation of NF-kappaB-mediated genes and downregulation of PPARs. Physiol Genomics (2002) 1.32
Beneficial role of the GPR30 agonist G-1 in an animal model of multiple sclerosis. J Neuroimmunol (2009) 1.32
Noninvasive measurement of abdominal aortic aneurysms in intact mice by a high-frequency ultrasound imaging system. Ultrasound Med Biol (2005) 1.27
Fasudil, a Rho-kinase inhibitor, attenuates angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-deficient mice by inhibiting apoptosis and proteolysis. Circulation (2005) 1.24
Alzheimer precursor protein interaction with the Nogo-66 receptor reduces amyloid-beta plaque deposition. J Neurosci (2006) 1.24
From task parameters to motor synergies: A hierarchical framework for approximately-optimal control of redundant manipulators. J Robot Syst (2005) 1.22
17 Beta-estradiol attenuates development of angiotensin II-induced aortic abdominal aneurysm in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol (2003) 1.20
Inhibition of soluble epoxide hydrolase attenuated atherosclerosis, abdominal aortic aneurysm formation, and dyslipidemia. Arterioscler Thromb Vasc Biol (2009) 1.19
Effect of estrogen on endothelial function and angiogenesis. Vascul Pharmacol (2002) 1.18
Tissue-specific, development-dependent phenolic compounds accumulation profile and gene expression pattern in tea plant [Camellia sinensis]. PLoS One (2013) 1.15
Synovial phenotypes in rheumatoid arthritis correlate with response to biologic therapeutics. Arthritis Res Ther (2014) 1.15
Thrombin-activatable fibrinolysis inhibitor (TAFI) deficiency is compatible with murine life. J Clin Invest (2002) 1.13
Validation of genetic association in apelin-AGTRL1 system with hypertension in a larger Han Chinese population. J Hypertens (2010) 1.13
Enalapril attenuates angiotensin II-induced atherosclerosis and vascular inflammation. Atherosclerosis (2005) 1.12
Monitoring ocular drug therapy by analysis of aqueous samples. Ophthalmology (2009) 1.12
Death receptors DR6 and TROY regulate brain vascular development. Dev Cell (2012) 1.10
Calmodulin kinase II is required for angiotensin II-mediated vascular smooth muscle hypertrophy. Am J Physiol Heart Circ Physiol (2009) 1.07
Anti-EphA2 antibodies decrease EphA2 protein levels in murine CT26 colorectal and human MDA-231 breast tumors but do not inhibit tumor growth. Neoplasia (2006) 1.06
Interference of Frizzled 1 (FZD1) reverses multidrug resistance in breast cancer cells through the Wnt/β-catenin pathway. Cancer Lett (2012) 1.05
Inhibition of soluble epoxide hydrolase attenuates endothelial dysfunction in animal models of diabetes, obesity and hypertension. Eur J Pharmacol (2010) 1.05
Citron-kinase, a protein essential to cytokinesis in neuronal progenitors, is deleted in the flathead mutant rat. J Neurosci (2002) 1.04
Identification of a novel prostate tumor target, mindin/RG-1, for antibody-based radiotherapy of prostate cancer. Cancer Res (2005) 1.04
Fetal sex chromosome testing by maternal plasma DNA sequencing: clinical laboratory experience and biology. Obstet Gynecol (2015) 1.04
Noninvasive biomarkers that predict treatment benefit from biologic therapies in asthma. Ann Am Thorac Soc (2013) 1.03
Clinical pharmacokinetics and pharmacodynamics of aliskiren. Clin Pharmacokinet (2008) 1.02
In vivo biodistribution, PET imaging, and tumor accumulation of 86Y- and 111In-antimindin/RG-1, engineered antibody fragments in LNCaP tumor-bearing nude mice. J Nucl Med (2009) 1.02
SKLB1002, a novel potent inhibitor of VEGF receptor 2 signaling, inhibits angiogenesis and tumor growth in vivo. Clin Cancer Res (2011) 1.02
Antiviral and myocyte protective effects of murine interferon-beta and -{alpha}2 in coxsackievirus B3-induced myocarditis and epicarditis in Balb/c mice. Am J Physiol Heart Circ Physiol (2007) 1.01
Estrogen inhibits the initiation of fatty streaks throughout the vasculature but does not inhibit intra-plaque hemorrhage and the progression of established lesions in apolipoprotein E deficient mice. Atherosclerosis (2002) 1.00
Angiotensin II injures the arterial wall causing increased aortic stiffening in apolipoprotein E-deficient mice. Am J Physiol Regul Integr Comp Physiol (2002) 1.00
Characterization of tunable piperidine and piperazine carbamates as inhibitors of endocannabinoid hydrolases. J Med Chem (2010) 1.00
Complete genome sequence of Alcanivorax dieselolei type strain B5. J Bacteriol (2012) 1.00
The effect of age, gender, and body mass index on the pharmacokinetics and pharmacodynamics of vildagliptin in healthy volunteers. Br J Clin Pharmacol (2007) 0.99
1-(1-acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea (AR9281) as a potent, selective, and orally available soluble epoxide hydrolase inhibitor with efficacy in rodent models of hypertension and dysglycemia. Bioorg Med Chem Lett (2010) 0.98
Increased progesterone receptor expression in benign epithelium of BRCA1-related breast cancers. Cancer Res (2004) 0.97
Alpha 7 nicotinic acetylcholine receptors mediate beta-amyloid peptide-induced tau protein phosphorylation. J Biol Chem (2003) 0.97
Anti-atherosclerotic effect of simvastatin depends on the presence of apolipoprotein E. Atherosclerosis (2002) 0.96
Glucocorticoid receptor β and histone deacetylase 1 and 2 expression in the airways of severe asthma. Thorax (2011) 0.95
Crystal structures of two potent nonamidine inhibitors bound to factor Xa. Biochemistry (2002) 0.95
The multifunctional Ca2+/calmodulin-dependent kinase II regulates vascular smooth muscle migration through matrix metalloproteinase 9. Am J Physiol Heart Circ Physiol (2012) 0.94
Flavobacterium beibuense sp. nov., isolated from marine sediment. Int J Syst Evol Microbiol (2010) 0.92
Identification of tissue of origin in body fluid specimens using a gene expression microarray assay. Cancer Cytopathol (2011) 0.91
A model of the acid sphingomyelinase phosphoesterase domain based on its remote structural homolog purple acid phosphatase. Protein Sci (2004) 0.91
TRPS1 expression promotes angiogenesis and affects VEGFA expression in breast cancer. Exp Biol Med (Maywood) (2014) 0.91
Characterization of a small molecule PAI-1 inhibitor, ZK4044. Thromb Res (2004) 0.90
Enhanced therapeutic effects of mesenchymal stem cells on myocardial infarction by ischemic postconditioning through paracrine mechanisms in rats. J Mol Cell Cardiol (2011) 0.90
Expression and prognostic relevance of STAT3 and cyclin D1 in non-small cell lung cancer. Int J Biol Markers (2012) 0.89
Endothelial NO synthase deficiency promotes smooth muscle progenitor cells in association with upregulation of stromal cell-derived factor-1alpha in a mouse model of carotid artery ligation. Arterioscler Thromb Vasc Biol (2006) 0.89
Pharmacokinetics of the oral direct renin inhibitor aliskiren in combination with digoxin, atorvastatin, and ketoconazole in healthy subjects: the role of P-glycoprotein in the disposition of aliskiren. J Clin Pharmacol (2008) 0.89
Interferon-beta attenuates angiotensin II-accelerated atherosclerosis and vascular remodeling in apolipoprotein E deficient mice. Atherosclerosis (2007) 0.88
Vildagliptin, a novel dipeptidyl peptidase IV inhibitor, has no pharmacokinetic interactions with the antihypertensive agents amlodipine, valsartan, and ramipril in healthy subjects. J Clin Pharmacol (2007) 0.87
Gluten-sensitive enteropathy coincides with decreased capability of intestinal T cells to secrete IL-17 and IL-22 in a macaque model for celiac disease. Clin Immunol (2013) 0.87
Molecular cloning and gene expression analysis of the leptin receptor in the Chinese mitten crab Eriocheir sinensis. PLoS One (2010) 0.86
Interlayer catalytic exfoliation realizing scalable production of large-size pristine few-layer graphene. Sci Rep (2013) 0.85
A multicenter study directly comparing the diagnostic accuracy of gene expression profiling and immunohistochemistry for primary site identification in metastatic tumors. Am J Surg Pathol (2013) 0.85
Atrial natriuretic peptide regulates lipid mobilization and oxygen consumption in human adipocytes by activating AMPK. Biochem Biophys Res Commun (2011) 0.85
A novel P2Y(12) adenosine diphosphate receptor antagonist that inhibits platelet aggregation and thrombus formation in rat and dog models. Thromb Haemost (2007) 0.85
The multifunctional Ca²⁺/calmodulin-dependent kinase IIδ (CaMKIIδ) regulates arteriogenesis in a mouse model of flow-mediated remodeling. PLoS One (2013) 0.84
Disconnect between sputum neutrophils and other measures of airway inflammation in asthma. Eur Respir J (2013) 0.84
Modulation of phenotypic and functional maturation of murine dendritic cells (DCs) by purified Achyranthes bidentata polysaccharide (ABP). Int Immunopharmacol (2011) 0.84
Treatment of divided eyelid nevus with island skin flap: report of ten cases and review of the literature. Ophthal Plast Reconstr Surg (2009) 0.84
Urokinase plasminogen activator receptor promotes macrophage infiltration into the vascular wall of ApoE deficient mice. J Cell Physiol (2005) 0.84
Roles of miRNA in the initiation and development of colorectal carcinoma. Curr Pharm Des (2013) 0.84