Inhibition of soluble epoxide hydrolase attenuated atherosclerosis, abdominal aortic aneurysm formation, and dyslipidemia.

PubWeight™: 1.19‹?› | Rank: Top 10%

🔗 View Article (PMID 19667112)

Published in Arterioscler Thromb Vasc Biol on August 10, 2009

Authors

Le-Ning Zhang1, Jon Vincelette, Ying Cheng, Upasana Mehra, Dawn Chen, Sampath-Kumar Anandan, Richard Gless, Heather K Webb, Yi-Xin Jim Wang

Author Affiliations

1: Arête Therapeutics Inc, 3912 Trust Way, Hayward, CA 94545, USA. lzhang@aretetherapeutics.com

Articles citing this

Impact of soluble epoxide hydrolase and epoxyeicosanoids on human health. Annu Rev Pharmacol Toxicol (2012) 2.01

Epoxides and soluble epoxide hydrolase in cardiovascular physiology. Physiol Rev (2012) 1.82

Cytochrome P450 epoxygenases, soluble epoxide hydrolase, and the regulation of cardiovascular inflammation. J Mol Cell Cardiol (2009) 1.52

Inhibition of soluble epoxide hydrolase attenuates high-fat-diet-induced hepatic steatosis by reduced systemic inflammatory status in mice. PLoS One (2012) 1.11

Evaluation of cytochrome P450-derived eicosanoids in humans with stable atherosclerotic cardiovascular disease. Atherosclerosis (2012) 1.07

Crosstalk between EET and HO-1 downregulates Bach1 and adipogenic marker expression in mesenchymal stem cell derived adipocytes. Prostaglandins Other Lipid Mediat (2011) 1.04

Pharmacokinetics and in vivo potency of soluble epoxide hydrolase inhibitors in cynomolgus monkeys. Br J Pharmacol (2012) 1.02

Anti-inflammatory effects of epoxyeicosatrienoic acids. Int J Vasc Med (2012) 1.01

1-(1-acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea (AR9281) as a potent, selective, and orally available soluble epoxide hydrolase inhibitor with efficacy in rodent models of hypertension and dysglycemia. Bioorg Med Chem Lett (2010) 0.98

Cytochrome P450-derived eicosanoids and vascular dysfunction in coronary artery disease patients. Atherosclerosis (2013) 0.94

Soluble epoxide hydrolase inhibitors and heart failure. Cardiovasc Ther (2011) 0.93

Soluble epoxide hydrolase in atherosclerosis. Curr Atheroscler Rep (2010) 0.93

Soluble epoxide hydrolase regulates hematopoietic progenitor cell function via generation of fatty acid diols. Proc Natl Acad Sci U S A (2012) 0.92

A potent soluble epoxide hydrolase inhibitor, t-AUCB, acts through PPARγ to modulate the function of endothelial progenitor cells from patients with acute myocardial infarction. Int J Cardiol (2012) 0.92

Enalapril reverses high-fat diet-induced alterations in cytochrome P450-mediated eicosanoid metabolism. Am J Physiol Endocrinol Metab (2011) 0.90

Basal and inducible anti-inflammatory epoxygenase activity in endothelial cells. Biochem Biophys Res Commun (2014) 0.86

CYP2J2 overexpression increases EETs and protects against angiotensin II-induced abdominal aortic aneurysm in mice. J Lipid Res (2013) 0.83

Aging, estrogen loss and epoxyeicosatrienoic acids (EETs). PLoS One (2013) 0.79

Inside epoxyeicosatrienoic acids and cardiovascular disease. Front Pharmacol (2014) 0.79

8,9-Epoxyeicosatrienoic acid inhibits antibody production of B lymphocytes in mice. PLoS One (2012) 0.79

11,12-Epoxyecosatrienoic acids mitigate endothelial dysfunction associated with estrogen loss and aging: Role of membrane depolarization. J Mol Cell Cardiol (2016) 0.78

Effects of soluble epoxide hydrolase inhibitor on the expression of fatty acid synthase in peripheral blood mononuclear cell in patients with acute coronary syndrome. Lipids Health Dis (2013) 0.77

The role of 14,15-dihydroxyeicosatrienoic acid levels in inflammation and its relationship to lipoproteins. Lipids Health Dis (2013) 0.77

CYP450-derived oxylipins mediate inflammatory resolution. Proc Natl Acad Sci U S A (2016) 0.76

Inhibition of soluble epoxide hydrolase in mice promotes reverse cholesterol transport and regression of atherosclerosis. Atherosclerosis (2015) 0.76

The Role of Cytochrome P450 Epoxygenases, Soluble Epoxide Hydrolase, and Epoxyeicosatrienoic Acids in Metabolic Diseases. Adv Nutr (2016) 0.75

Aberrant soluble epoxide hydrolase and oxylipin levels in a porcine arteriovenous graft stenosis model. J Vasc Res (2014) 0.75

Pro-atherogenic role of smooth muscle Nox4-based NADPH oxidase. J Mol Cell Cardiol (2016) 0.75

Endothelial Nox4-based NADPH oxidase regulates atherosclerosis via soluble epoxide hydrolase. Biochim Biophys Acta (2017) 0.75

Serglycin protects against high fat diet-induced increase in serum LDL in mice. Glycoconj J (2015) 0.75

Articles by these authors

The European Nucleotide Archive. Nucleic Acids Res (2010) 6.48

Improvements to services at the European Nucleotide Archive. Nucleic Acids Res (2009) 5.00

Gefitinib versus placebo as maintenance therapy in patients with locally advanced or metastatic non-small-cell lung cancer (INFORM; C-TONG 0804): a multicentre, double-blind randomised phase 3 trial. Lancet Oncol (2012) 2.98

Icotinib versus gefitinib in previously treated advanced non-small-cell lung cancer (ICOGEN): a randomised, double-blind phase 3 non-inferiority trial. Lancet Oncol (2013) 2.94

Apatinib for chemotherapy-refractory advanced metastatic gastric cancer: results from a randomized, placebo-controlled, parallel-arm, phase II trial. J Clin Oncol (2013) 2.69

Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital. Mol Pharmacol (2002) 2.49

The GUDMAP database--an online resource for genitourinary research. Development (2011) 2.20

Final overall survival results from a phase III, randomized, placebo-controlled, parallel-group study of gefitinib versus placebo as maintenance therapy in patients with locally advanced or metastatic non-small-cell lung cancer (INFORM; C-TONG 0804). J Thorac Oncol (2015) 2.14

Major submissions tool developments at the European Nucleotide Archive. Nucleic Acids Res (2011) 1.94

Global disruption of the cerebellar transcriptome in a Down syndrome mouse model. Hum Mol Genet (2003) 1.80

Cediranib plus FOLFOX/CAPOX versus placebo plus FOLFOX/CAPOX in patients with previously untreated metastatic colorectal cancer: a randomized, double-blind, phase III study (HORIZON II). J Clin Oncol (2012) 1.73

The crystal structures of human steroidogenic factor-1 and liver receptor homologue-1. Proc Natl Acad Sci U S A (2005) 1.67

Identification of Sox17 as a transcription factor that regulates oligodendrocyte development. J Neurosci (2006) 1.59

DNA-PK phosphorylation sites in XRCC4 are not required for survival after radiation or for V(D)J recombination. DNA Repair (Amst) (2003) 1.55

Leucine deprivation increases hepatic insulin sensitivity via GCN2/mTOR/S6K1 and AMPK pathways. Diabetes (2011) 1.55

Expanding the subproteome of the inner mitochondria using protein separation technologies: one- and two-dimensional liquid chromatography and two-dimensional gel electrophoresis. Mol Cell Proteomics (2006) 1.48

Noninvasive measurement of abdominal aortic aneurysms in intact mice by a high-frequency ultrasound imaging system. Ultrasound Med Biol (2005) 1.27

Measuring T2 in vivo with J-difference editing: application to GABA at 3 Tesla. J Magn Reson Imaging (2011) 1.24

Fasudil, a Rho-kinase inhibitor, attenuates angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-deficient mice by inhibiting apoptosis and proteolysis. Circulation (2005) 1.24

Multidimensional liquid chromatography separation of intact proteins by chromatographic focusing and reversed phase of the human serum proteome: optimization and protein database. Mol Cell Proteomics (2005) 1.23

Gait analysis in a murine model of collagen-induced arthritis. Arthritis Res Ther (2007) 1.19

Factors associated with work satisfaction of registered nurses. J Nurs Scholarsh (2006) 1.16

Enalapril attenuates angiotensin II-induced atherosclerosis and vascular inflammation. Atherosclerosis (2005) 1.12

ATF4 regulates lipid metabolism and thermogenesis. Cell Res (2010) 1.12

Inhibiting TGF-beta signaling restores immune surveillance in the SMA-560 glioma model. Neuro Oncol (2007) 1.10

Inhibition of Rho-kinase by fasudil attenuated angiotensin II-induced cardiac hypertrophy in apolipoprotein E deficient mice. Eur J Pharmacol (2005) 1.10

SRY-box containing gene 17 regulates the Wnt/β-catenin signaling pathway in oligodendrocyte progenitor cells. J Neurosci (2011) 1.10

Pharmacokinetics and pharmacodynamics of AR9281, an inhibitor of soluble epoxide hydrolase, in single- and multiple-dose studies in healthy human subjects. J Clin Pharmacol (2011) 1.09

17beta-estradiol activates estrogen receptor beta-signalling and inhibits transient receptor potential vanilloid receptor 1 activation by capsaicin in adult rat nociceptor neurons. Endocrinology (2008) 1.08

Inhibition of soluble epoxide hydrolase attenuates endothelial dysfunction in animal models of diabetes, obesity and hypertension. Eur J Pharmacol (2010) 1.05

Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent. Proc Natl Acad Sci U S A (2008) 1.03

Double-balloon enteroscopy in small bowel tumors: a Chinese single-center study. World J Gastroenterol (2013) 1.03

Mechanisms of regulation of oligodendrocyte development by p38 mitogen-activated protein kinase. J Neurosci (2010) 1.03

Toxoplasma gondii protease TgSUB1 is required for cell surface processing of micronemal adhesive complexes and efficient adhesion of tachyzoites. Cell Microbiol (2010) 1.01

Antiviral and myocyte protective effects of murine interferon-beta and -{alpha}2 in coxsackievirus B3-induced myocarditis and epicarditis in Balb/c mice. Am J Physiol Heart Circ Physiol (2007) 1.01

MiR-139 targets CXCR4 and inhibits the proliferation and metastasis of laryngeal squamous carcinoma cells. Med Oncol (2013) 1.01

Identification and characterization of Dicer-like, Argonaute and RNA-dependent RNA polymerase gene families in maize. Plant Cell Rep (2011) 1.00

Chinese guidelines on the diagnosis and treatment of primary lung cancer (2011). J Thorac Dis (2012) 0.99

Development of protein biomarkers in cerebrospinal fluid for secondary progressive multiple sclerosis using selected reaction monitoring mass spectrometry (SRM-MS). Clin Proteomics (2012) 0.98

1-(1-acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea (AR9281) as a potent, selective, and orally available soluble epoxide hydrolase inhibitor with efficacy in rodent models of hypertension and dysglycemia. Bioorg Med Chem Lett (2010) 0.98

Predictors of RNs' intent to work and work decisions 1 year later in a U.S. national sample. Int J Nurs Stud (2008) 0.96

MiR-21 plays an important role in radiation induced carcinogenesis in BALB/c mice by directly targeting the tumor suppressor gene Big-h3. Int J Biol Sci (2011) 0.94

Hydrogen-rich saline protects immunocytes from radiation-induced apoptosis. Med Sci Monit (2012) 0.93

Non-urea functionality as the primary pharmacophore in soluble epoxide hydrolase inhibitors. Bioorg Med Chem Lett (2009) 0.93

Attenuation of cisplatin-induced renal injury by inhibition of soluble epoxide hydrolase involves nuclear factor κB signaling. J Pharmacol Exp Ther (2012) 0.92

Visible light-induced intramolecular cyclization reactions of diamines: a new strategy to construct tetrahydroimidazoles. Chem Commun (Camb) (2011) 0.92

High-throughput screen for inhibitors of transglycosylase and/or transpeptidase activities of Escherichia coli penicillin binding protein 1b. Antimicrob Agents Chemother (2004) 0.91

S6K1 in the central nervous system regulates energy expenditure via MC4R/CRH pathways in response to deprivation of an essential amino acid. Diabetes (2012) 0.91

Aprepitant triple therapy for the prevention of chemotherapy-induced nausea and vomiting following high-dose cisplatin in Chinese patients: a randomized, double-blind, placebo-controlled phase III trial. Support Care Cancer (2013) 0.89

Up-regulated expression of miR-23a/b targeted the pro-apoptotic Fas in radiation-induced thymic lymphoma. Cell Physiol Biochem (2013) 0.89

Comparision of piceid and resveratrol in antioxidation and antiproliferation activities in vitro. PLoS One (2013) 0.89

Unsymmetrical non-adamantyl N,N'-diaryl urea and amide inhibitors of soluble expoxide hydrolase. Bioorg Med Chem Lett (2009) 0.89

Epoxyeicosatrienoic acids prevent cisplatin-induced renal apoptosis through a p38 mitogen-activated protein kinase-regulated mitochondrial pathway. Mol Pharmacol (2013) 0.89

Metallothionein I and II mitigate age-dependent secondary brain injury. J Neurosci Res (2004) 0.88

Interferon-beta attenuates angiotensin II-accelerated atherosclerosis and vascular remodeling in apolipoprotein E deficient mice. Atherosclerosis (2007) 0.88

14-3-3 regulates the LNK/JAK2 pathway in mouse hematopoietic stem and progenitor cells. J Clin Invest (2012) 0.87

[Chinese guidelines on the diagnosis and treatment of primary lung cancer 
(2011 version)]. Zhongguo Fei Ai Za Zhi (2012) 0.86

Disruption of the phospholipase D gene attenuates the virulence of Aspergillus fumigatus. Infect Immun (2011) 0.86

siRNA targeting mCD14 inhibits TNF-α, MIP-2, and IL-6 secretion and NO production from LPS-induced RAW264.7 cells. Appl Microbiol Biotechnol (2011) 0.86

Evaluation of the relationship between extremity soft tissue sarcomas and adjacent major vessels using contrast-enhanced multidetector CT and three-dimensional volume-rendered CT angiography: a preliminary study. Acta Radiol (2013) 0.85

Epidemiology of a Salmonella enterica subsp. enterica serovar Typhimurium strain associated with a songbird outbreak. Appl Environ Microbiol (2012) 0.85

A novel P2Y(12) adenosine diphosphate receptor antagonist that inhibits platelet aggregation and thrombus formation in rat and dog models. Thromb Haemost (2007) 0.85

Two-dimensional gel-based approaches for the assessment of N-Linked and O-GlcNAc glycosylation in human and simian immunodeficiency viruses. Proteomics (2008) 0.85

Organocatalytic asymmetric sulfa-michael/michael addition reactions: a strategy for the synthesis of highly substituted chromans with a quaternary stereocenter. Angew Chem Int Ed Engl (2010) 0.84

[Diagnostic values of double-balloon enteroscopy and abdominal computed tomography in small bowel disease]. Zhonghua Yi Xue Za Zhi (2008) 0.84

Regulation of immune recognition molecules by flavivirus, West Nile. Viral Immunol (2002) 0.83

The role of L. monocytogenes serotype 4b gtcA in gastrointestinal listeriosis in A/J mice. Foodborne Pathog Dis (2009) 0.83

Deleterious effects of minocycline after in vivo target deprivation of thalamocortical neurons in the immature, metallothionein-deficient mouse brain. J Neurosci Res (2009) 0.83

Efficient removal of Cr(VI) from aqueous solution with Fe@Fe2O3 core-shell nanowires. Environ Sci Technol (2008) 0.83

Basic science; metallothionein I and II attenuate the thalamic microglial response following traumatic axotomy in the immature brain. J Neurotrauma (2007) 0.83

Information matrices and standard errors for MLEs of item parameters in IRT. Psychometrika (2013) 0.82

Protective effects of L-arginine on reperfusion injury after pancreaticoduodenal transplantation in rats. Hepatobiliary Pancreat Dis Int (2004) 0.82

Activation of STAT3 signaling in human stomach adenocarcinoma drug-resistant cell line and its relationship with expression of vascular endothelial growth factor. World J Gastroenterol (2005) 0.82

Double-balloon enteroscopy for obscure gastrointestinal bleeding: a single center experience in China. World J Gastroenterol (2010) 0.82

Pichia fabianii blood infection in a premature infant in China: case report. BMC Res Notes (2013) 0.82

Analysis of the clonality of Candida tropicalis strains from a general hospital in Beijing using multilocus sequence typing. PLoS One (2012) 0.81

Ginkgolide B protects against cisplatin-induced ototoxicity: enhancement of Akt-Nrf2-HO-1 signaling and reduction of NADPH oxidase. Cancer Chemother Pharmacol (2015) 0.81

Down regulation of miR200c promotes radiation-induced thymic lymphoma by targeting BMI1. J Cell Biochem (2014) 0.81

Effect of 40 mg versus 10 mg of atorvastatin on oxidized low-density lipoprotein, high-sensitivity C-reactive protein, circulating endothelial-derived microparticles, and endothelial progenitor cells in patients with ischemic cardiomyopathy. Clin Cardiol (2012) 0.81

A novel inhibitor of activated thrombin activatable fibrinolysis inhibitor (TAFIa) - part II: enhancement of both exogenous and endogenous fibrinolysis in animal models of thrombosis. Thromb Haemost (2007) 0.81

The multicenter, phase II prospective study of paclitaxel plus capecitabine as first-line chemotherapy in advanced gastric carcinoma. Oncologist (2014) 0.81

Partially hydrolyzed cow's milk formula has a therapeutic effect on the infants with mild to moderate atopic dermatitis: a randomized, double-blind study. Pediatr Allergy Immunol (2011) 0.81

RNAi screening identifies KAT8 as a key molecule important for cancer cell survival. Int J Clin Exp Pathol (2013) 0.81

Hypertriglyceridemic waist is associated with increased carotid atherosclerosis in chronic kidney disease patients. Nephron Clin Pract (2013) 0.80

[Consensus on dignosis for ALK positive non-small cell lung cancer in China, the 2013 version]. Zhonghua Bing Li Xue Za Zhi (2013) 0.80

Inhibition of tumor angiogenesis by interferon-γ by suppression of tumor-associated macrophage differentiation. Oncol Res (2014) 0.80

Angiotensin II induces histomorphologic features of unstable plaque in a murine model of accelerated atherosclerosis. J Vasc Surg (2006) 0.80

Experimental and theoretical study of three new benzothiazole-fused carbazole derivatives. Spectrochim Acta A Mol Biomol Spectrosc (2011) 0.80

A CDK4/6 inhibitor enhances cytotoxicity of paclitaxel in lung adenocarcinoma cells harboring mutant KRAS as well as wild-type KRAS. Cancer Biol Ther (2013) 0.80