Human T-cell leukemia virus type I (HTLV-I) infection and the onset of adult T-cell leukemia (ATL).

HTLV-I basic leucine zipper factor gene mRNA supports proliferation of adult T cell leukemia cells. Proc Natl Acad Sci U S A (2006) 3.11

Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy. Nat Rev Cancer (2016) 2.19

Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-kappaB activation. EMBO J (2008) 1.87

Retracted Inhibition of constitutively active Jak-Stat pathway suppresses cell growth of human T-cell leukemia virus type 1-infected T-cell lines and primary adult T-cell leukemia cells. Retrovirology (2006) 1.60

In vivo expression of the HBZ gene of HTLV-1 correlates with proviral load, inflammatory markers and disease severity in HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). Retrovirology (2009) 1.58

Characteristic expression of HTLV-1 basic zipper factor (HBZ) transcripts in HTLV-1 provirus-positive cells. Retrovirology (2008) 1.37

HTLV-1 HBZ cooperates with JunD to enhance transcription of the human telomerase reverse transcriptase gene (hTERT). Retrovirology (2007) 1.29

Abnormal centrosome amplification in cells through the targeting of Ran-binding protein-1 by the human T cell leukemia virus type-1 Tax oncoprotein. Proc Natl Acad Sci U S A (2005) 1.24

Cooperation of NF-kappaB2/p100 activation and the PDZ domain binding motif signal in human T-cell leukemia virus type 1 (HTLV-1) Tax1 but not HTLV-2 Tax2 is crucial for interleukin-2-independent growth transformation of a T-cell line. J Virol (2007) 1.17

Abnormally high levels of virus-infected IFN-gamma+ CCR4+ CD4+ CD25+ T cells in a retrovirus-associated neuroinflammatory disorder. PLoS One (2009) 1.15

Preferential selection of human T-cell leukemia virus type 1 provirus lacking the 5' long terminal repeat during oncogenesis. J Virol (2007) 1.10

The HTLV-1 Tax protein binding domain of cyclin-dependent kinase 4 (CDK4) includes the regulatory PSTAIRE helix. Retrovirology (2005) 1.02

Early neurologic abnormalities associated with human T-cell lymphotropic virus type 1 infection in a cohort of Peruvian children. J Pediatr (2009) 1.01

Human T-lymphotropic virus type 1 (HTLV-1) and regulatory T cells in HTLV-1-associated neuroinflammatory disease. Viruses (2011) 0.98

Retracted Adult T-cell leukemia/lymphoma development in HTLV-1-infected humanized SCID mice. Blood (2010) 0.97

Ubiquitination of HTLV-I Tax in response to DNA damage regulates nuclear complex formation and nuclear export. Retrovirology (2007) 0.97

CADM1 interacts with Tiam1 and promotes invasive phenotype of human T-cell leukemia virus type I-transformed cells and adult T-cell leukemia cells. J Biol Chem (2010) 0.94

Molecular characterization of HTLV-1 Tax interaction with the KIX domain of CBP/p300. J Mol Biol (2007) 0.94

Inactivation of tumor suppressor Dlg1 augments transformation of a T-cell line induced by human T-cell leukemia virus type 1 Tax protein. Retrovirology (2006) 0.93

Human T-cell leukemia virus type 2 Tax protein induces interleukin 2-independent growth in a T-cell line. Retrovirology (2006) 0.90

Is human T cell lymphotropic type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) syndrome a neglected disease? PLoS Negl Trop Dis (2009) 0.88

Quantitative differences in HTLV-I antibody responses: classification and relative risk assessment for asymptomatic carriers and ATL and HAM/TSP patients from Jamaica. Blood (2012) 0.87

Mutual regulation between deubiquitinase CYLD and retroviral oncoprotein Tax. Cell Biosci (2011) 0.85

Multi-stage Friend murine erythroleukemia: molecular insights into oncogenic cooperation. Retrovirology (2008) 0.84

Human T-lymphotropic virus type 1 Tax protein complexes with P-TEFb and competes for Brd4 and 7SK snRNP/HEXIM1 binding. J Virol (2010) 0.84

HTLV-1 bZIP factor supports proliferation of adult T cell leukemia cells through suppression of C/EBPα signaling. Retrovirology (2013) 0.83

The human T-cell leukemia virus type 1 oncoprotein tax controls forkhead box O4 activity through degradation by the proteasome. J Virol (2011) 0.83

High human T cell leukemia virus type-1(HTLV-1) provirus load in patients with HTLV-1 carriers complicated with HTLV-1-unrelated disorders. Virol J (2010) 0.83

SUN2 Overexpression Deforms Nuclear Shape and Inhibits HIV. J Virol (2016) 0.82

The proto-oncogene Bcl3, induced by Tax, represses Tax-mediated transcription via p300 displacement from the human T-cell leukemia virus type 1 promoter. J Virol (2008) 0.81

Cell surface markers in HTLV-1 pathogenesis. Viruses (2011) 0.80

The 2011 Retrovirology Prize winner Masao Matsuoka: forward looking and antisense. Interview by Kuan-Teh Jeang. Retrovirology (2011) 0.80

Evidence for cooperative transforming activity of the human pituitary tumor transforming gene and human T-cell leukemia virus type 1 Tax. J Virol (2007) 0.78

HTLV-1, Immune Response and Autoimmunity. Viruses (2015) 0.77

Seroprevalence of human T-cell lymphoma/leukemia virus type-1 (HTLV-1) antibodies among blood donors at Enugu, Nigeria. J Blood Med (2015) 0.77

The Impact of Opportunistic Infections on Clinical Outcome and Healthcare Resource Uses for Adult T Cell Leukaemia. PLoS One (2015) 0.76

A rare case of adult T cell leukemia/lymphoma: clinicopathological correlation with autopsy confirmation. Indian J Hematol Blood Transfus (2012) 0.75

Retargeting Oncolytic Vesicular Stomatitis Virus to Human T-Cell Lymphotropic Virus Type 1-Associated Adult T-Cell Leukemia. J Virol (2015) 0.75

Opportunistic Infections in Patients with HTLV-1 Infection. Case Rep Hematol (2015) 0.75

Adult T-cell leukemia/lymphoma: a case report of primary cutaneous tumoral type. Dermatol Pract Concept (2012) 0.75

The evolution of sex-specific virulence in infectious diseases. Nat Commun (2016) 0.75

Seroprevalence and correlates of human T-cell lymphoma/leukemia virus type 1 antibodies among pregnant women at the University of Nigeria Teaching Hospital, Enugu, Nigeria. Int J Womens Health (2014) 0.75

Viral Causes of Lymphoma: The History of Epstein-Barr Virus and Human T-Lymphotropic Virus 1. Virology (Auckl) (2017) 0.75

Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc Natl Acad Sci U S A (1980) 30.08

Human adult T-cell leukemia virus: complete nucleotide sequence of the provirus genome integrated in leukemia cell DNA. Proc Natl Acad Sci U S A (1983) 14.09

Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera. Proc Natl Acad Sci U S A (1981) 11.92

Origin of HIV-1 in the chimpanzee Pan troglodytes troglodytes. Nature (1999) 10.97

Adult T-cell leukemia: clinical and hematologic features of 16 cases. Blood (1977) 10.69

HTLV-I associated myelopathy, a new clinical entity. Lancet (1986) 10.49

Spread of HTLV-I between lymphocytes by virus-induced polarization of the cytoskeleton. Science (2003) 5.19

Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1. Cell (1998) 4.21

Transcriptional (p40x) and post-transcriptional (p27x-III) regulators are required for the expression and replication of human T-cell leukemia virus type I genes. Proc Natl Acad Sci U S A (1987) 4.10

Fas ligand-induced apoptosis. Annu Rev Genet (1999) 3.59

Commitment and differentiation of osteoclast precursor cells by the sequential expression of c-Fms and receptor activator of nuclear factor kappaB (RANK) receptors. J Exp Med (1999) 3.07

Infective dermatitis of Jamaican children: a marker for HTLV-I infection. Lancet (1990) 2.96

A retrospective study on transmission of adult T cell leukemia virus by blood transfusion: seroconversion in recipients. Vox Sang (1984) 2.91

The discovery of the first human retrovirus: HTLV-1 and HTLV-2. Retrovirology (2005) 2.62

Multiple viral strategies of HTLV-1 for dysregulation of cell growth control. Annu Rev Immunol (2001) 2.54

HLA alleles determine human T-lymphotropic virus-I (HTLV-I) proviral load and the risk of HTLV-I-associated myelopathy. Proc Natl Acad Sci U S A (1999) 2.45

The ubiquitous glucose transporter GLUT-1 is a receptor for HTLV. Cell (2003) 2.28

Predominant recognition of human T cell leukemia virus type I (HTLV-I) pX gene products by human CD8+ cytotoxic T cells directed against HTLV-I-infected cells. Int Immunol (1991) 2.27

Selection, the mutation rate and cancer: ensuring that the tail does not wag the dog. Nat Med (1999) 2.14

Discovery of adult T-cell leukemia. Retrovirology (2005) 2.13

Life, death, and tax: role of HTLV-I oncoprotein in genetic instability and cellular transformation. J Biol Chem (2004) 2.04

Genetic and epigenetic inactivation of tax gene in adult T-cell leukemia cells. Int J Cancer (2004) 2.04

The HBZ factor of human T-cell leukemia virus type I dimerizes with transcription factors JunB and c-Jun and modulates their transcriptional activity. J Biol Chem (2003) 2.02

Radioimmunotherapy of interleukin-2R alpha-expressing adult T-cell leukemia with Yttrium-90-labeled anti-Tac. Blood (1995) 1.99

HTLV-1-encoded p30II is a post-transcriptional negative regulator of viral replication. Nat Med (2004) 1.97

Bay 11-7082 inhibits transcription factor NF-kappaB and induces apoptosis of HTLV-I-infected T-cell lines and primary adult T-cell leukemia cells. Blood (2002) 1.97

Constitutive activation of NF-kappa B is essential for transformation of rat fibroblasts by the human T-cell leukemia virus type I Tax protein. EMBO J (1996) 1.85

Existence of escape mutant in HTLV-I tax during the development of adult T-cell leukemia. Blood (2001) 1.80

5'-long terminal repeat-selective CpG methylation of latent human T-cell leukemia virus type 1 provirus in vitro and in vivo. J Virol (2002) 1.77

Constitutive activation of NF-kappaB in primary adult T-cell leukemia cells. Blood (1999) 1.73

HTLV-1 Tax protein interacts with cyclin-dependent kinase inhibitor p16INK4A and counteracts its inhibitory activity towards CDK4. EMBO J (1996) 1.69

Provirus load in breast milk and risk of mother-to-child transmission of human T lymphotropic virus type I. J Infect Dis (2004) 1.69

HTLV-1 HBZ suppresses AP-1 activity by impairing both the DNA-binding ability and the stability of c-Jun protein. Oncogene (2005) 1.66

Human T-cell leukemia virus type I and adult T-cell leukemia. Oncogene (2003) 1.66

Two types of defective human T-lymphotropic virus type I provirus in adult T-cell leukemia. Blood (1996) 1.59

The human OX40/gp34 system directly mediates adhesion of activated T cells to vascular endothelial cells. J Exp Med (1996) 1.59

A new G-CSF-supported combination chemotherapy, LSG15, for adult T-cell leukaemia-lymphoma: Japan Clinical Oncology Group Study 9303. Br J Haematol (2001) 1.57

Persistent clonal proliferation of human T-lymphotropic virus type I-infected cells in vivo. Cancer Res (1997) 1.56

Identification of aberrantly methylated genes in association with adult T-cell leukemia. Cancer Res (2004) 1.48

Induction of Bcl-x(L) expression by human T-cell leukemia virus type 1 Tax through NF-kappaB in apoptosis-resistant T-cell transfectants with Tax. J Virol (1999) 1.48

Transcriptional activation of survivin through the NF-kappaB pathway by human T-cell leukemia virus type I tax. Int J Cancer (2005) 1.46

In vivo infection of human T-cell leukemia virus type I in non-T cells. Virology (1993) 1.43

Alterations of the p27KIP1 gene in non-Hodgkin's lymphomas and adult T-cell leukemia/lymphoma. Blood (1995) 1.42

Frequent expression of CCR4 in adult T-cell leukemia and human T-cell leukemia virus type 1-transformed T cells. Blood (2002) 1.42

The role of CD95 in the regulation of peripheral T-cell apoptosis. Immunol Rev (2003) 1.41

Constitutive expression of parathyroid hormone-related protein gene in human T cell leukemia virus type 1 (HTLV-1) carriers and adult T cell leukemia patients that can be trans-activated by HTLV-1 tax gene. J Exp Med (1990) 1.39

Expression of FoxP3, a key molecule in CD4CD25 regulatory T cells, in adult T-cell leukaemia/lymphoma cells. Br J Haematol (2004) 1.38

Evaluation of adult T-cell leukemia/lymphoma incidence and its impact on non-Hodgkin lymphoma incidence in southwestern Japan. Int J Cancer (2000) 1.37

Cyclosporin A-sensitive transcription factor Egr-3 regulates Fas ligand expression. Mol Cell Biol (1998) 1.36

Fratricide among CD8(+) T lymphocytes naturally infected with human T cell lymphotropic virus type I. Immunity (2000) 1.34

Global epidemic of human T-cell lymphotropic virus type-I (HTLV-I). J Emerg Med (2000) 1.32

Role of Tax protein in human T-cell leukemia virus type-I leukemogenicity. Retrovirology (2004) 1.32

Overexpression of a cell adhesion molecule, TSLC1, as a possible molecular marker for acute-type adult T-cell leukemia. Blood (2004) 1.31

Proteasome inhibitor, bortezomib, potently inhibits the growth of adult T-cell leukemia cells both in vivo and in vitro. Leukemia (2004) 1.30

PDZ domain-binding motif of human T-cell leukemia virus type 1 Tax oncoprotein augments the transforming activity in a rat fibroblast cell line. Virology (2004) 1.29

Protein profile of tax-associated complexes. J Biol Chem (2003) 1.28

Persistent oligoclonal expansion of human T-cell leukemia virus type 1-infected circulating cells in patients with Tropical spastic paraparesis/HTLV-1 associated myelopathy. Oncogene (1998) 1.28

A human T-cell leukemia virus Tax variant incapable of activating NF-kappaB retains its immortalizing potential for primary T-lymphocytes. J Biol Chem (1998) 1.28

Human T-cell leukemia virus type 2 (HTLV-2) Tax protein transforms a rat fibroblast cell line but less efficiently than HTLV-1 Tax. J Virol (2002) 1.26

Inactivation of p53 by human T-cell lymphotropic virus type 1 Tax requires activation of the NF-kappaB pathway and is dependent on p53 phosphorylation. Mol Cell Biol (2000) 1.26

Proteasome inhibitor PS-341, a potential therapeutic agent for adult T-cell leukemia. Cancer Res (2002) 1.25

Noninfectious anterior uveitis in patients infected with human T-lymphotropic virus type I. Jpn J Ophthalmol (1989) 1.25

HTLV-I Tax directly binds the Cdc20-associated anaphase-promoting complex and activates it ahead of schedule. Proc Natl Acad Sci U S A (2004) 1.23

Genome-wide expression changes induced by HTLV-1 Tax: evidence for MLK-3 mixed lineage kinase involvement in Tax-mediated NF-kappaB activation. Oncogene (2001) 1.23

The interleukin-2 receptor: a target for monoclonal antibody treatment of human T-cell lymphotrophic virus I-induced adult T-cell leukemia. Blood (1993) 1.22

HTLV-1 tax oncoprotein represses the p53-mediated trans-activation function through coactivator CBP sequestration. Oncogene (2000) 1.22

Cytotoxic T-cell abundance and virus load in human immunodeficiency virus type 1 and human T-cell leukaemia virus type 1. Proc Biol Sci (2001) 1.19

Role of HTLV-1 proviral DNA load and clonality in the development of adult T-cell leukemia/lymphoma in asymptomatic carriers. Int J Cancer (2004) 1.19

T-cell control by human T-cell leukemia/lymphoma virus type 1. Int J Hematol (2003) 1.18

Improved outcome of adult T cell leukemia/lymphoma with allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant (2001) 1.17

Impaired production of naive T lymphocytes in human T-cell leukemia virus type I-infected individuals: its implications in the immunodeficient state. Blood (2001) 1.16

Mutations of the p53 gene in adult T-cell leukemia. Blood (1992) 1.14

Aberrant expression of the MEL1S gene identified in association with hypomethylation in adult T-cell leukemia cells. Blood (2003) 1.13

The CC chemokine receptor 4 as a novel specific molecular target for immunotherapy in adult T-Cell leukemia/lymphoma. Clin Cancer Res (2004) 1.13

Graft-versus-Tax response in adult T-cell leukemia patients after hematopoietic stem cell transplantation. Cancer Res (2004) 1.12

Efficacy and mechanism of action of the proteasome inhibitor PS-341 in T-cell lymphomas and HTLV-I associated adult T-cell leukemia/lymphoma. Oncogene (2005) 1.12

The role of CTLs in persistent viral infection: cytolytic gene expression in CD8+ lymphocytes distinguishes between individuals with a high or low proviral load of human T cell lymphotropic virus type 1. J Immunol (2004) 1.11

Dating the origin of the African human T-cell lymphotropic virus type-i (HTLV-I) subtypes. Mol Biol Evol (2001) 1.10

Allogeneic stem-cell transplantation with reduced conditioning intensity as a novel immunotherapy and antiviral therapy for adult T-cell leukemia/lymphoma. Blood (2005) 1.09

Increasing methylation of the CDKN2A gene is associated with the progression of adult T-cell leukemia. Cancer Res (2000) 1.09

Bcl-X(L) is up-regulated by HTLV-I and HTLV-II in vitro and in ex vivo ATLL samples. Blood (2000) 1.09

Effects of the proteasome inhibitor PS-341 on tumor growth in HTLV-1 Tax transgenic mice and Tax tumor transplants. Blood (2004) 1.09

Tax protein of HTLV-1 inhibits CBP/p300-mediated transcription by interfering with recruitment of CBP/p300 onto DNA element of E-box or p53 binding site. Oncogene (1999) 1.09

Human T-cell lymphotropic virus type 1 tax inhibits transforming growth factor-beta signaling by blocking the association of Smad proteins with Smad-binding element. J Biol Chem (2002) 1.09

Human T-cell leukemia virus type I oncoprotein Tax represses Smad-dependent transforming growth factor beta signaling through interaction with CREB-binding protein/p300. Blood (2001) 1.09

Polygenic control of human T lymphotropic virus type I (HTLV-I) provirus load and the risk of HTLV-I-associated myelopathy/tropical spastic paraparesis. J Infect Dis (2002) 1.08

Fas gene mutation in the progression of adult T cell leukemia. J Exp Med (1999) 1.07

The contribution of NF-kappa B activity to spontaneous proliferation and resistance to apoptosis in human T-cell leukemia virus type 1 Tax-induced tumors. Blood (2001) 1.07

The low evolutionary rate of human T-cell lymphotropic virus type-1 confirmed by analysis of vertical transmission chains. Mol Biol Evol (2004) 1.07

Risk factors for adult T-cell leukemia among carriers of human T-lymphotropic virus type I. Blood (1998) 1.04

Increased chemokine receptor CCR7/EBI1 expression enhances the infiltration of lymphoid organs by adult T-cell leukemia cells. Blood (2000) 1.04

Lymphoproliferative disorders in renal transplant patients in Japan. Int J Cancer (2001) 1.03

Homozygous deletions of the p15 (MTS2) and p16 (CDKN2/MTS1) genes in adult T-cell leukemia. Blood (1995) 1.03

Virus markers associated with vertical transmission of human T lymphotropic virus type 1 in Jamaica. Clin Infect Dis (2002) 1.03

Binding of the human T-cell leukemia virus Tax protein to the coactivator CBP interferes with CBP-mediated transcriptional control. Oncogene (1999) 1.03

Regression of human T-cell leukemia virus type I (HTLV-I)-associated lymphomas in a rat model: peptide-induced T-cell immunity. J Natl Cancer Inst (2001) 1.02

Human T-lymphotropic virus type 1 (HTLV-1): persistence and immune control. Int J Hematol (2003) 1.01

Mechanism of hypercalcemia in adult T-cell leukemia: overexpression of receptor activator of nuclear factor kappaB ligand on adult T-cell leukemia cells. Blood (2002) 1.01

An alternative transcript derived from the trio locus encodes a guanosine nucleotide exchange factor with mouse cell-transforming potential. J Biol Chem (2004) 1.01

Hypercalcemia and osteoclast proliferation in adult T-cell leukemia. Cancer (1987) 0.98

Human T-cell leukemia virus type I and adult T-cell leukemia. Oncogene (2003) 1.66