Published in Blood on February 15, 2001
HTLV-I basic leucine zipper factor gene mRNA supports proliferation of adult T cell leukemia cells. Proc Natl Acad Sci U S A (2006) 3.11
Human T-cell leukemia virus type I (HTLV-I) infection and the onset of adult T-cell leukemia (ATL). Retrovirology (2005) 1.86
5'-long terminal repeat-selective CpG methylation of latent human T-cell leukemia virus type 1 provirus in vitro and in vivo. J Virol (2002) 1.77
Human T-cell leukemia virus type-1 antisense-encoded gene, Hbz, promotes T-lymphocyte proliferation. Blood (2008) 1.63
A novel alternative splicing isoform of human T-cell leukemia virus type 1 bZIP factor (HBZ-SI) targets distinct subnuclear localization. J Virol (2006) 1.58
Silencing of human T-cell leukemia virus type I gene transcription by epigenetic mechanisms. Retrovirology (2005) 1.55
Major histocompatibility complex heterozygote superiority during coinfection. Infect Immun (2003) 1.52
Viruses associated with human cancer. Biochim Biophys Acta (2007) 1.47
Expression profiles of adult T-cell leukemia-lymphoma and associations with clinical responses to zidovudine and interferon alpha. Leuk Lymphoma (2010) 1.46
The HBZ gene, a key player in HTLV-1 pathogenesis. Retrovirology (2009) 1.43
HTLV-1 bZIP Factor Enhances T-cell Proliferation by Impeding the Suppressive Signaling of Co-inhibitory Receptors. PLoS Pathog (2017) 1.38
Distinct functions of HTLV-1 Tax1 from HTLV-2 Tax2 contribute key roles to viral pathogenesis. Retrovirology (2009) 1.21
Human T Lymphotropic Virus Type 1 (HTLV-1): Molecular Biology and Oncogenesis. Viruses (2010) 1.13
APOBEC3G generates nonsense mutations in human T-cell leukemia virus type 1 proviral genomes in vivo. J Virol (2010) 1.12
Preferential selection of human T-cell leukemia virus type 1 provirus lacking the 5' long terminal repeat during oncogenesis. J Virol (2007) 1.10
HTLV-1 propels untransformed CD4 lymphocytes into the cell cycle while protecting CD8 cells from death. J Clin Invest (2006) 1.03
Experimental viral evolution to specific host MHC genotypes reveals fitness and virulence trade-offs in alternative MHC types. Proc Natl Acad Sci U S A (2012) 1.01
Human T cell leukemia virus reactivation with progression of adult T-cell leukemia-lymphoma. PLoS One (2009) 0.99
Tax-independent constitutive IkappaB kinase activation in adult T-cell leukemia cells. Neoplasia (2004) 0.99
Human T-cell lymphotropic virus: a model of NF-κB-associated tumorigenesis. Viruses (2011) 0.97
Mouse model for the equilibration interaction between the host immune system and human T-cell leukemia virus type 1 gene expression. J Virol (2002) 0.92
Tax gene expression and cell cycling but not cell death are selected during HTLV-1 infection in vivo. Retrovirology (2010) 0.90
New insight into the oncogenic mechanism of the retroviral oncoprotein Tax. Protein Cell (2012) 0.87
Multifaceted functions and roles of HBZ in HTLV-1 pathogenesis. Retrovirology (2016) 0.87
Dendritic cells in viral pathogenesis: protective or defective? Int J Exp Pathol (2005) 0.86
Retracted Apoptosis induced by the histone deacetylase inhibitor FR901228 in human T-cell leukemia virus type 1-infected T-cell lines and primary adult T-cell leukemia cells. J Virol (2004) 0.86
Roles of HTLV-1 basic Zip Factor (HBZ) in Viral Chronicity and Leukemic Transformation. Potential New Therapeutic Approaches to Prevent and Treat HTLV-1-Related Diseases. Viruses (2015) 0.86
TCF1 and LEF1 act as T-cell intrinsic HTLV-1 antagonists by targeting Tax. Proc Natl Acad Sci U S A (2015) 0.85
Controversies in targeted therapy of adult T cell leukemia/lymphoma: ON target or OFF target effects? Viruses (2011) 0.84
Interplay between the HTLV-2 Tax and APH-2 proteins in the regulation of the AP-1 pathway. Retrovirology (2012) 0.84
Is There a Role for HTLV-1-Specific CTL in Adult T-Cell Leukemia/Lymphoma? Leuk Res Treatment (2011) 0.82
Human T Lymphotropic Virus Type I (HTLV-I) Oncogenesis: Molecular Aspects of Virus and Host Interactions in Pathogenesis of Adult T cell Leukemia/Lymphoma (ATL). Iran J Basic Med Sci (2013) 0.81
Molecular Studies of HTLV-1 Replication: An Update. Viruses (2016) 0.80
Elevated expression of CD30 in adult T-cell leukemia cell lines: possible role in constitutive NF-kappaB activation. Retrovirology (2005) 0.79
Application of targeted enrichment to next-generation sequencing of retroviruses integrated into the host human genome. Sci Rep (2016) 0.77
Modes of Human T Cell Leukemia Virus Type 1 Transmission, Replication and Persistence. Viruses (2015) 0.77
HTLV-1 proviral integration sites differ between asymptomatic carriers and patients with HAM/TSP. Virol J (2014) 0.77
Transcriptional and Epigenetic Regulatory Mechanisms Affecting HTLV-1 Provirus. Viruses (2016) 0.76
When magic bullets miss their mark. Blood (2001) 0.76
Enhanced Stabilization of MCL1 by the Human T-Cell Leukemia Virus Type 1 bZIP Factor Is Modulated by Blocking the Recruitment of Cullin 1 to the SCF Complex. Mol Cell Biol (2016) 0.75
The Role of HBZ in HTLV-1-Induced Oncogenesis. Viruses (2016) 0.75
HTLV-1 bZIP factor suppresses TDP1 expression through inhibition of NRF-1 in adult T-cell leukemia. Sci Rep (2017) 0.75
Genetic alterations in adult T-cell leukemia/lymphoma. Cancer Sci (2017) 0.75
STLV-1 infection of Papio Anubis: tax Sequence Heterogeneity and T Cell Recognition. J Virol (2017) 0.75
HTLV-I associated myelopathy, a new clinical entity. Lancet (1986) 10.49
Hemodynamic shear stress and its role in atherosclerosis. JAMA (1999) 9.27
Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro. Cell (1993) 4.15
Molecular characterization of angiotensin II--induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype. Circ Res (1993) 3.87
The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development. Development (1999) 3.74
The cellular and molecular response of cardiac myocytes to mechanical stress. Annu Rev Physiol (1997) 3.70
The conserved phosphoinositide 3-kinase pathway determines heart size in mice. EMBO J (2000) 3.64
Analysis of HTLV-I proviral load in 202 HAM/TSP patients and 243 asymptomatic HTLV-I carriers: high proviral load strongly predisposes to HAM/TSP. J Neurovirol (1998) 3.32
Csx: a murine homeobox-containing gene specifically expressed in the developing heart. Proc Natl Acad Sci U S A (1993) 3.11
Chronic progressive myelopathy associated with elevated antibodies to human T-lymphotropic virus type I and adult T-cell leukemialike cells. Ann Neurol (1987) 2.99
FOG-2, a cofactor for GATA transcription factors, is essential for heart morphogenesis and development of coronary vessels from epicardium. Cell (2000) 2.86
The risk of development of HTLV-I-associated myelopathy/tropical spastic paraparesis among persons infected with HTLV-I. J Acquir Immune Defic Syndr (1990) 2.65
All members of the MHC multigene family respond to thyroid hormone in a highly tissue-specific manner. Science (1986) 2.57
Molecular characterization of the stretch-induced adaptation of cultured cardiac cells. An in vitro model of load-induced cardiac hypertrophy. J Biol Chem (1992) 2.55
Transgenic expression of green fluorescence protein can cause dilated cardiomyopathy. Nat Med (2000) 2.52
Apoptosis and heart failure: A critical review of the literature. Circ Res (2000) 2.48
HLA alleles determine human T-lymphotropic virus-I (HTLV-I) proviral load and the risk of HTLV-I-associated myelopathy. Proc Natl Acad Sci U S A (1999) 2.45
Mechanical stretch rapidly activates multiple signal transduction pathways in cardiac myocytes: potential involvement of an autocrine/paracrine mechanism. EMBO J (1993) 2.44
Myosin heavy chain messenger RNA and protein isoform transitions during cardiac hypertrophy. Interaction between hemodynamic and thyroid hormone-induced signals. J Clin Invest (1987) 2.37
Chronic inflammatory arthropathy associated with HTLV-I. Lancet (1989) 2.28
Mechanism of endothelial cell shape change and cytoskeletal remodeling in response to fluid shear stress. J Cell Sci (1996) 2.18
Greatly raised vascular endothelial growth factor (VEGF) in POEMS syndrome. Lancet (1996) 2.17
Cardiac involvement in mitochondrial diseases. A study on 17 patients with documented mitochondrial DNA defects. Circulation (1995) 2.15
Morphological and molecular characterization of adult cardiomyocyte apoptosis during hypoxia and reoxygenation. Circ Res (2000) 2.14
CD4+CD8+ thymocytes are susceptible to DNA fragmentation induced by phorbol ester, calcium ionophore and anti-CD3 antibody. Eur J Immunol (1990) 2.08
Overproduction of vascular endothelial growth factor/vascular permeability factor is causative in Crow-Fukase (POEMS) syndrome. Muscle Nerve (1998) 2.06
The cardiac tissue-restricted homeobox protein Csx/Nkx2.5 physically associates with the zinc finger protein GATA4 and cooperatively activates atrial natriuretic factor gene expression. Mol Cell Biol (1998) 2.05
High accumulation of fluorine-18-fluorodeoxyglucose in turpentine-induced inflammatory tissue. J Nucl Med (1995) 2.05
Apoptosis: basic mechanisms and implications for cardiovascular disease. Circ Res (1998) 2.01
Direct visualization of antigen-specific T cells: HTLV-1 Tax11-19- specific CD8(+) T cells are activated in peripheral blood and accumulate in cerebrospinal fluid from HAM/TSP patients. Proc Natl Acad Sci U S A (1998) 1.95
Detection of human T-lymphotropic virus type I (HTLV-I) tax RNA in the central nervous system of HTLV-I-associated myelopathy/tropical spastic paraparesis patients by in situ hybridization. Ann Neurol (1995) 1.91
Abundant tax protein expression in CD4+ T cells infected with human T-cell lymphotropic virus type I (HTLV-I) is prevented by cytotoxic T lymphocytes. Blood (2000) 1.87
Angiotensin II induces c-fos mRNA in aortic smooth muscle. Role of Ca2+ mobilization and protein kinase C activation. J Biol Chem (1989) 1.83
Phylogenetic subgroups of human T cell lymphotropic virus (HTLV) type I in the tax gene and their association with different risks for HTLV-I-associated myelopathy/tropical spastic paraparesis. J Infect Dis (2000) 1.80
Cardiac and extracardiac expression of Csx/Nkx2.5 homeodomain protein. Circ Res (1998) 1.78
The influence of HLA class I alleles and heterozygosity on the outcome of human T cell lymphotropic virus type I infection. J Immunol (2000) 1.73
Blood transfusion and HTLV-I associated myelopathy. Lancet (1986) 1.67
Ocular manifestations in patients infected with human T-lymphotropic virus type I. Jpn J Ophthalmol (1989) 1.63
Increased replication of HTLV-I in HTLV-I-associated myelopathy. Ann Neurol (1989) 1.60
Signal transduction pathways of angiotensin II--induced c-fos gene expression in cardiac myocytes in vitro. Roles of phospholipid-derived second messengers. Circ Res (1993) 1.59
A new G-CSF-supported combination chemotherapy, LSG15, for adult T-cell leukaemia-lymphoma: Japan Clinical Oncology Group Study 9303. Br J Haematol (2001) 1.57
Angiotensin II type1a receptor gene expression in the heart: AP-1 and GATA-4 participate in the response to pressure overload. Proc Natl Acad Sci U S A (1997) 1.56
Marked increase in plasma interleukin-6 in burn patients. J Lab Clin Med (1992) 1.55
Myosin light chain kinase mediates sarcomere organization during cardiac hypertrophy in vitro. Nat Med (2000) 1.55
Two cases of necrotizing myelopathy associated with malignancy caused by herpes simplex virus type 2. Acta Neuropathol (1989) 1.53
Cardiac-specific overexpression of cyclin-dependent kinase 2 increases smaller mononuclear cardiomyocytes. Circ Res (2001) 1.50
Human BAC library: construction and rapid screening. Gene (1997) 1.50
Purification of acetylcholine receptors, reconstitution into lipid vesicles, and study of agonist-induced cation channel regulation. J Biol Chem (1980) 1.48
Muscle is the major source of plasma gelsolin. J Biol Chem (1988) 1.47
Angiotensin II activates RhoA in cardiac myocytes: a critical role of RhoA in angiotensin II-induced premyofibril formation. Circ Res (1998) 1.46
Usefulness of transcutaneous Doppler jugular venous echo to predict pulmonary hypertension in COPD patients. Eur Respir J (2001) 1.46
HTLV-I proviral load correlates with progression of motor disability in HAM/TSP: analysis of 239 HAM/TSP patients including 64 patients followed up for 10 years. J Neurovirol (2001) 1.43
HLA haplotype-linked high immune responsiveness against HTLV-I in HTLV-I-associated myelopathy: comparison with adult T-cell leukemia/lymphoma. Ann Neurol (1988) 1.43
Pulmonary manifestations in cerebrotendinous xanthomatosis. Intern Med (1998) 1.42
Treatment of cerebrotendinous xanthomatosis with low-density lipoprotein (LDL)-apheresis. J Neurol Sci (1993) 1.42
Nationwide survey of neurologic manifestations of acquired immunodeficiency syndrome in Japan. Intern Med (1997) 1.40
A hemophiliac with human immunodeficiency virus (HIV)-1-associated dementia complex. Intern Med (1995) 1.40
Quantitative densitometric analysis using a commercially available handheld CCD digital camera. Biotechniques (1997) 1.40
Characterization of homo- and heterodimerization of cardiac Csx/Nkx2.5 homeoprotein. J Biol Chem (2000) 1.39
HTLV-I-associated myelopathy: analysis of 213 patients based on clinical features and laboratory findings. J Neurovirol (1995) 1.39
The effects of shounousui on the three responses of the blink reflex in man. Muscle Nerve (1997) 1.39
HTLV-1-associated myelopathy/tropical spastic paraparesis with pseudohypoparathyroidism. Neurology (2001) 1.39
Identification of the in vivo casein kinase II phosphorylation site within the homeodomain of the cardiac tisue-specifying homeobox gene product Csx/Nkx2.5. Mol Cell Biol (1999) 1.38
Familial skeletal myopathy with atrioventricular block. Intern Med (1999) 1.38
Roles of mechano-sensitive ion channels, cytoskeleton, and contractile activity in stretch-induced immediate-early gene expression and hypertrophy of cardiac myocytes. Proc Natl Acad Sci U S A (1992) 1.38
Relation of sarcomere length and muscle length in resting myocardium. Am J Physiol (1970) 1.37
Fluid shear stress differentially modulates expression of genes encoding basic fibroblast growth factor and platelet-derived growth factor B chain in vascular endothelium. J Clin Invest (1993) 1.33
Physiological fluid shear stress causes downregulation of endothelin-1 mRNA in bovine aortic endothelium. Am J Physiol (1992) 1.33
Progressive atrioventricular conduction defects and heart failure in mice expressing a mutant Csx/Nkx2.5 homeoprotein. J Clin Invest (2001) 1.33
Interferon-alpha is effective in HTLV-I-associated myelopathy: a multicenter, randomized, double-blind, controlled trial. Neurology (1996) 1.32
Specific role of the extracellular signal-regulated kinase pathway in angiotensin II-induced cardiac hypertrophy in vitro. Biochem J (2000) 1.31
Therapeutic trials in 200 patients with HTLV-I-associated myelopathy/ tropical spastic paraparesis. J Neurovirol (1996) 1.29
Expansion of unstable DNA region in Japanese myotonic dystrophy patients. Lancet (1992) 1.29
Cardiac expression of the ventricle-specific homeobox gene Irx4 is modulated by Nkx2-5 and dHand. Dev Biol (2000) 1.29
Immunocytochemical analysis of the cellular infiltrate in the spinal cord lesions in HTLV-I-associated myelopathy. J Neuropathol Exp Neurol (1993) 1.29
Loss of function and inhibitory effects of human CSX/NKX2.5 homeoprotein mutations associated with congenital heart disease. J Clin Invest (2000) 1.28
Slow myosin in developing rat skeletal muscle. J Cell Biol (1987) 1.28