Published in Biochemistry on May 10, 2005
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Double-stranded RNA is produced by positive-strand RNA viruses and DNA viruses but not in detectable amounts by negative-strand RNA viruses. J Virol (2006) 5.48
Transcriptional profiling of interferon regulatory factor 3 target genes: direct involvement in the regulation of interferon-stimulated genes. J Virol (2002) 4.31
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Efficient replication of the novel human betacoronavirus EMC on primary human epithelium highlights its zoonotic potential. MBio (2013) 2.17
Crystal structure of the 2'-specific and double-stranded RNA-activated interferon-induced antiviral protein 2'-5'-oligoadenylate synthetase. Mol Cell (2003) 2.16
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Curaxins: anticancer compounds that simultaneously suppress NF-κB and activate p53 by targeting FACT. Sci Transl Med (2011) 2.03
Interferons and viral infections. Biofactors (2009) 1.99
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Interferon-induced Ifit2/ISG54 protects mice from lethal VSV neuropathogenesis. PLoS Pathog (2012) 1.84
Viral stress-inducible protein p56 inhibits translation by blocking the interaction of eIF3 with the ternary complex eIF2.GTP.Met-tRNAi. J Biol Chem (2003) 1.74
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Pandemic H1N1 2009 influenza A virus induces weak cytokine responses in human macrophages and dendritic cells and is highly sensitive to the antiviral actions of interferons. J Virol (2009) 1.72
p53 cooperates with DNA methylation and a suicidal interferon response to maintain epigenetic silencing of repeats and noncoding RNAs. Proc Natl Acad Sci U S A (2012) 1.71
Endoplasmic reticulum stress induces hyaluronan deposition and leukocyte adhesion. J Biol Chem (2003) 1.68
Interferon-inducible protein, P56, inhibits HPV DNA replication by binding to the viral protein E1. EMBO J (2008) 1.66
Mouse p56 blocks a distinct function of eukaryotic initiation factor 3 in translation initiation. J Biol Chem (2004) 1.63
2'-O methylation of the viral mRNA cap by West Nile virus evades ifit1-dependent and -independent mechanisms of host restriction in vivo. PLoS Pathog (2012) 1.62
The oligoadenylate synthetase family: an ancient protein family with multiple antiviral activities. J Interferon Cytokine Res (2010) 1.59
Novel characteristics of the function and induction of murine p56 family proteins. J Virol (2008) 1.52
Inhibition of PACT-mediated activation of PKR by the herpes simplex virus type 1 Us11 protein. J Virol (2002) 1.52
Select paramyxoviral V proteins inhibit IRF3 activation by acting as alternative substrates for inhibitor of kappaB kinase epsilon (IKKe)/TBK1. J Biol Chem (2008) 1.45
Inflammation-induced endothelial-to-mesenchymal transition: a novel mechanism of intestinal fibrosis. Am J Pathol (2011) 1.45
Interferon lambda 4 signals via the IFNλ receptor to regulate antiviral activity against HCV and coronaviruses. EMBO J (2013) 1.40
Induction and mode of action of the viral stress-inducible murine proteins, P56 and P54. Virology (2005) 1.40
Characterization of the periplasmic heme-binding protein shut from the heme uptake system of Shigella dysenteriae. Biochemistry (2005) 1.31
Hck is a key regulator of gene expression in alternatively activated human monocytes. J Biol Chem (2011) 1.31
Double-stranded RNA signaling by Toll-like receptor 3 requires specific tyrosine residues in its cytoplasmic domain. J Biol Chem (2002) 1.29
Molecular basis for PKR activation by PACT or dsRNA. Proc Natl Acad Sci U S A (2006) 1.28
Tissue-specific and inducer-specific differential induction of ISG56 and ISG54 in mice. J Virol (2007) 1.28
A role of the double-stranded RNA-binding protein PACT in mouse ear development and hearing. Proc Natl Acad Sci U S A (2006) 1.26
HSV infection induces production of ROS, which potentiate signaling from pattern recognition receptors: role for S-glutathionylation of TRAF3 and 6. PLoS Pathog (2011) 1.26
Lipopolysaccharide is a direct agonist for platelet RNA splicing. J Immunol (2008) 1.24
Differential regulation of the OASL and OAS1 genes in response to viral infections. J Interferon Cytokine Res (2009) 1.13
The IRF-3/Bax-mediated apoptotic pathway, activated by viral cytoplasmic RNA and DNA, inhibits virus replication. J Virol (2011) 1.13
Full-length, membrane-anchored TWEAK can function as a juxtacrine signaling molecule and activate the NF-kappaB pathway. J Biol Chem (2010) 1.13
Epidermal growth factor receptor is essential for Toll-like receptor 3 signaling. Sci Signal (2012) 1.12
Chamomile, a novel and selective COX-2 inhibitor with anti-inflammatory activity. Life Sci (2009) 1.11
The interferon (IFN)-induced GTPase, mGBP-2. Role in IFN-gamma-induced murine fibroblast proliferation. J Biol Chem (2001) 1.09
The two groups of zebrafish virus-induced interferons signal via distinct receptors with specific and shared chains. J Immunol (2009) 1.09
Phosphorylation of specific serine residues in the PKR activation domain of PACT is essential for its ability to mediate apoptosis. J Biol Chem (2006) 1.07
Conformational diversity in prion protein variants influences intermolecular beta-sheet formation. EMBO J (2009) 1.07
Inhibition of RNase L and RNA-dependent protein kinase (PKR) by sunitinib impairs antiviral innate immunity. J Biol Chem (2011) 1.05
Specific-sized hyaluronan fragments promote expression of human β-defensin 2 in intestinal epithelium. J Biol Chem (2012) 1.05
Two tyrosine residues of Toll-like receptor 3 trigger different steps of NF-kappa B activation. J Biol Chem (2006) 1.02
Long-term effect of interferon on keratinocytes that maintain human papillomavirus type 31. J Virol (2002) 1.02
The p59 oligoadenylate synthetase-like protein possesses antiviral activity that requires the C-terminal ubiquitin-like domain. J Gen Virol (2008) 1.02
High-throughput screening for TLR3-IFN regulatory factor 3 signaling pathway modulators identifies several antipsychotic drugs as TLR inhibitors. J Immunol (2010) 1.02
Characterization of the 2'-5'-oligoadenylate synthetase ubiquitin-like family. Nucleic Acids Res (2003) 1.01
Phosphatidylinositol 3-kinase signaling delays sendai virus-induced apoptosis by preventing XIAP degradation. J Virol (2011) 1.00
A role for Ifit2 in restricting West Nile virus infection in the brain. J Virol (2013) 1.00
Febrile-range temperature modifies cytokine gene expression in LPS-stimulated macrophages by differentially modifying NF-{kappa}B recruitment to cytokine gene promoters. Am J Physiol Cell Physiol (2009) 1.00
Viral degradasome hijacks mitochondria to suppress innate immunity. Cell Res (2013) 0.99
Vid22p, a novel plasma membrane protein, is required for the fructose-1,6-bisphosphatase degradation pathway. J Cell Sci (2002) 0.99
The HER2- and heregulin β1 (HRG)-inducible TNFR superfamily member Fn14 promotes HRG-driven breast cancer cell migration, invasion, and MMP9 expression. Mol Cancer Res (2013) 0.99
Human milk hyaluronan enhances innate defense of the intestinal epithelium. J Biol Chem (2013) 0.98
The inhibitory action of P56 on select functions of E1 mediates interferon's effect on human papillomavirus DNA replication. J Virol (2010) 0.98
Role of interferon regulatory factor 3-mediated apoptosis in the establishment and maintenance of persistent infection by Sendai virus. J Virol (2012) 0.98
IRF-3 and Bax: a deadly affair. Cell Cycle (2010) 0.95
Extracellular 2'-5' oligoadenylate synthetase stimulates RNase L-independent antiviral activity: a novel mechanism of virus-induced innate immunity. J Virol (2010) 0.95
Maintenance of normal blood pressure and renal functions are independent effects of angiotensin-converting enzyme. J Biol Chem (2003) 0.94
Crystal structure of interleukin-21 receptor (IL-21R) bound to IL-21 reveals that sugar chain interacting with WSXWS motif is integral part of IL-21R. J Biol Chem (2012) 0.94
Calmodulin binds to the cytoplasmic domain of angiotensin-converting enzyme and regulates its phosphorylation and cleavage secretion. J Biol Chem (2005) 0.91
Hitching RIG to action. Nat Immunol (2005) 0.91
dsRNA-activation of TLR3 and RLR signaling: gene induction-dependent and independent effects. J Interferon Cytokine Res (2014) 0.91
Hyaluronan-mediated leukocyte adhesion and dextran sulfate sodium-induced colitis are attenuated in the absence of signal transducer and activator of transcription 1. Am J Pathol (2008) 0.90
Viral evasion of the interferon system. J Interferon Cytokine Res (2009) 0.90
Histiocytic sarcoma arising from clonally related mantle cell lymphoma. J Clin Oncol (2011) 0.89
Caspase-8-mediated cleavage inhibits IRF-3 protein by facilitating its proteasome-mediated degradation. J Biol Chem (2011) 0.89
The double-stranded RNA-binding protein, PACT, is required for postnatal anterior pituitary proliferation. Proc Natl Acad Sci U S A (2009) 0.88
TAK-441, a novel investigational smoothened antagonist, delays castration-resistant progression in prostate cancer by disrupting paracrine hedgehog signaling. Int J Cancer (2013) 0.88
Crystal structure of Zebrafish interferons I and II reveals conservation of type I interferon structure in vertebrates. J Virol (2011) 0.88
Ifit2 deficiency results in uncontrolled neurotropic coronavirus replication and enhanced encephalitis via impaired alpha/beta interferon induction in macrophages. J Virol (2013) 0.88
Targeting FACT complex suppresses mammary tumorigenesis in Her2/neu transgenic mice. Cancer Prev Res (Phila) (2012) 0.88
Shaping the murine macrophage phenotype: IL-4 and cyclic AMP synergistically activate the arginase I promoter. J Immunol (2013) 0.87