Published in J Biol Chem on May 02, 2005
Protein tyrosine phosphatase function: the substrate perspective. Biochem J (2007) 2.17
Actin machinery and mechanosensitivity in invadopodia, podosomes and focal adhesions. J Cell Sci (2009) 2.13
Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion. J Cell Biol (2008) 1.79
Concerted regulation of focal adhesion dynamics by galectin-3 and tyrosine-phosphorylated caveolin-1. J Cell Biol (2008) 1.52
Targeting PTPs with small molecule inhibitors in cancer treatment. Cancer Metastasis Rev (2008) 1.32
The Eyes Absent phosphatase-transactivator proteins promote proliferation, transformation, migration, and invasion of tumor cells. Oncogene (2010) 1.28
Increased hypothalamic protein tyrosine phosphatase 1B contributes to leptin resistance with age. Endocrinology (2006) 1.26
Turnover of focal adhesions and cancer cell migration. Int J Cell Biol (2012) 1.22
Stimulation of the alveolar macrophage respiratory burst by ADP causes selective glutathionylation of protein tyrosine phosphatase 1B. Free Radic Biol Med (2006) 1.21
Acquisition of a potent and selective TC-PTP inhibitor via a stepwise fluorophore-tagged combinatorial synthesis and screening strategy. J Am Chem Soc (2009) 1.17
Activation of Src by protein tyrosine phosphatase 1B Is required for ErbB2 transformation of human breast epithelial cells. Cancer Res (2009) 1.16
Substrate specificity of protein tyrosine phosphatases 1B, RPTPα, SHP-1, and SHP-2. Biochemistry (2011) 1.13
Thiol-based redox switches. Biochim Biophys Acta (2014) 1.03
RACK1 regulates Src activity and modulates paxillin dynamics during cell migration. Exp Cell Res (2007) 1.03
β3 integrin-EGF receptor cross-talk activates p190RhoGAP in mouse mammary gland epithelial cells. Mol Biol Cell (2011) 0.90
Protein tyrosine phosphatase, PTP1B, expression and activity in rat corneal endothelial cells. Mol Vis (2007) 0.88
JNK pathway-associated phosphatase dephosphorylates focal adhesion kinase and suppresses cell migration. J Biol Chem (2009) 0.88
Targeting inactive enzyme conformation: aryl diketoacid derivatives as a new class of PTP1B inhibitors. J Am Chem Soc (2008) 0.85
ER-bound protein tyrosine phosphatase PTP1B interacts with Src at the plasma membrane/substrate interface. PLoS One (2012) 0.85
Protein-tyrosine phosphatase 1B substrates and metabolic regulation. Semin Cell Dev Biol (2014) 0.82
A novel role for protein tyrosine phosphatase 1B as a positive regulator of neuroinflammation. J Neuroinflammation (2016) 0.82
Interaction of constitutive photomorphogenesis 1 protein with protein-tyrosine phosphatase 1B suppresses protein-tyrosine phosphatase 1B activity and enhances insulin signaling. J Biol Chem (2013) 0.80
Protein phosphatase 1b in the solitary tract nucleus is necessary for normal baroreflex function. J Cardiovasc Pharmacol (2012) 0.80
CB₁ cannabinoid receptors promote maximal FAK catalytic activity by stimulating cooperative signaling between receptor tyrosine kinases and integrins in neuronal cells. Cell Signal (2013) 0.80
The nucleus- and endoplasmic reticulum-targeted forms of protein tyrosine phosphatase 61F regulate Drosophila growth, life span, and fecundity. Mol Cell Biol (2013) 0.80
Regulation of Endothelial Adherens Junctions by Tyrosine Phosphorylation. Mediators Inflamm (2015) 0.78
Protein tyrosine phosphatase PTP1B in cell adhesion and migration. Cell Adh Migr (2013) 0.78
Phosphatase inhibitors with anti-angiogenic effect in vitro. APMIS (2010) 0.78
Proteinase-activated receptor 1- and 4-promoted migration of Hep3B hepatocellular carcinoma cells depends on ROS formation and RTK transactivation. J Cancer Res Clin Oncol (2014) 0.76
Inhibition of PTP1B disrupts cell-cell adhesion and induces anoikis in breast epithelial cells. Cell Death Dis (2017) 0.75
PTP1B inhibitor promotes endothelial cell motility by activating the DOCK180/Rac1 pathway. Sci Rep (2016) 0.75
Cofilin promotes actin polymerization and defines the direction of cell motility. Science (2004) 5.12
Illuminating the chemistry of life: design, synthesis, and applications of "caged" and related photoresponsive compounds. ACS Chem Biol (2009) 2.67
Cutting edge: the PTPN22 allelic variant associated with autoimmunity impairs B cell signaling. J Immunol (2009) 2.21
Epidermal growth factor receptor overexpression results in increased tumor cell motility in vivo coordinately with enhanced intravasation and metastasis. Cancer Res (2006) 2.17
Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases. Proc Natl Acad Sci U S A (2007) 2.12
PTP1B as a drug target: recent developments in PTP1B inhibitor discovery. Drug Discov Today (2007) 2.09
Inhibition of SHP2 ameliorates the pathogenesis of systemic lupus erythematosus. J Clin Invest (2016) 2.06
Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4(+)CD25(+) regulatory T-cells of type 1 diabetic subjects. Diabetes (2009) 1.88
Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion. J Cell Biol (2008) 1.79
The specificity of extracellular signal-regulated kinase 2 dephosphorylation by protein phosphatases. J Biol Chem (2002) 1.70
Structural and functional analysis of the costimulatory receptor programmed death-1. Immunity (2004) 1.70
PRL3 promotes cell invasion and proliferation by down-regulation of Csk leading to Src activation. J Biol Chem (2006) 1.63
Visual snapshots of intracellular kinase activity at the onset of mitosis. Chem Biol (2007) 1.63
Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT. Blood (2012) 1.63
Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2). J Med Chem (2010) 1.63
Overexpression of the autoimmunity-associated phosphatase PTPN22 promotes survival of antigen-stimulated CLL cells by selectively activating AKT. Blood (2012) 1.61
Integrin-mediated type II TGF-β receptor tyrosine dephosphorylation controls SMAD-dependent profibrotic signaling. J Clin Invest (2014) 1.59
Acquisition of Fyn-selective SH3 domain ligands via a combinatorial library strategy. Chem Biol (2005) 1.58
Targeting mycobacterium protein tyrosine phosphatase B for antituberculosis agents. Proc Natl Acad Sci U S A (2010) 1.57
Structural basis of docking interactions between ERK2 and MAP kinase phosphatase 3. Proc Natl Acad Sci U S A (2006) 1.55
A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus. Hum Mol Genet (2008) 1.43
Structural genomics of protein phosphatases. J Struct Funct Genomics (2007) 1.40
Design and characterization of an improved protein tyrosine phosphatase substrate-trapping mutant. Biochemistry (2002) 1.35
Elevated expression of mitogen-activated protein kinase phosphatase 3 in breast tumors: a mechanism of tamoxifen resistance. Cancer Res (2006) 1.35
A modified cysteinyl-labeling assay reveals reversible oxidation of protein tyrosine phosphatases in angiomyolipoma cells. Proc Natl Acad Sci U S A (2008) 1.33
Self-reporting fluorescent substrates of protein tyrosine kinases. J Am Chem Soc (2006) 1.33
Targeting PTPs with small molecule inhibitors in cancer treatment. Cancer Metastasis Rev (2008) 1.32
Novel trisubstituted benzimidazoles, targeting Mtb FtsZ, as a new class of antitubercular agents. J Med Chem (2010) 1.29
Crystal structure of PTP1B complexed with a potent and selective bidentate inhibitor. J Biol Chem (2003) 1.29
Increased hypothalamic protein tyrosine phosphatase 1B contributes to leptin resistance with age. Endocrinology (2006) 1.26
Light-regulated sampling of protein tyrosine kinase activity. J Am Chem Soc (2006) 1.25
A light-activated probe of intracellular protein kinase activity. J Am Chem Soc (2003) 1.24
Structure and biochemical properties of PRL-1, a phosphatase implicated in cell growth, differentiation, and tumor invasion. Biochemistry (2005) 1.23
PRL1 promotes cell migration and invasion by increasing MMP2 and MMP9 expression through Src and ERK1/2 pathways. Biochemistry (2009) 1.22
Activity-based probes for protein tyrosine phosphatases. Proc Natl Acad Sci U S A (2004) 1.22
Elevated hypothalamic TCPTP in obesity contributes to cellular leptin resistance. Cell Metab (2011) 1.21
Src phosphorylates Cas on tyrosine 253 to promote migration of transformed cells. J Biol Chem (2003) 1.20
Spatially discrete, light-driven protein expression. Chem Biol (2002) 1.18
TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway. Genes Dev (2011) 1.18
Small molecule tools for functional interrogation of protein tyrosine phosphatases. FEBS J (2012) 1.17
Acquisition of a potent and selective TC-PTP inhibitor via a stepwise fluorophore-tagged combinatorial synthesis and screening strategy. J Am Chem Soc (2009) 1.17
Activation of Src by protein tyrosine phosphatase 1B Is required for ErbB2 transformation of human breast epithelial cells. Cancer Res (2009) 1.16
ErbB3-dependent motility and intravasation in breast cancer metastasis. Cancer Res (2006) 1.15
Environmental effects on phosphoryl group bonding probed by vibrational spectroscopy: implications for understanding phosphoryl transfer and enzymatic catalysis. J Am Chem Soc (2002) 1.15
Inactivation of p21WAF1/cip1 enhances intestinal tumor formation in Muc2-/- mice. Am J Pathol (2005) 1.14
Aurintricarboxylic acid blocks in vitro and in vivo activity of YopH, an essential virulent factor of Yersinia pestis, the agent of plague. J Biol Chem (2003) 1.13
Mapping ERK2-MKP3 binding interfaces by hydrogen/deuterium exchange mass spectrometry. J Biol Chem (2006) 1.12
PTP1B inhibitors as potential therapeutics in the treatment of type 2 diabetes and obesity. Expert Opin Investig Drugs (2003) 1.12
Cellular effects of small molecule PTP1B inhibitors on insulin signaling. Biochemistry (2003) 1.11
A biosensor of S100A4 metastasis factor activation: inhibitor screening and cellular activation dynamics. Biochemistry (2007) 1.10
Aryl vinyl sulfonates and sulfones as active site-directed and mechanism-based probes for protein tyrosine phosphatases. J Am Chem Soc (2008) 1.09
Deep quench: an expanded dynamic range for protein kinase sensors. J Am Chem Soc (2007) 1.08
Phosphatase activity, trimerization, and the C-terminal polybasic region are all required for PRL1-mediated cell growth and migration. J Biol Chem (2007) 1.07
Peptide-based fluorescent sensors of protein kinase activity: design and applications. Biochim Biophys Acta (2007) 1.07
Phosphorylation-driven protein-protein interactions: a protein kinase sensing system. J Am Chem Soc (2005) 1.07
Parkinson disease-associated mutation R1441H in LRRK2 prolongs the "active state" of its GTPase domain. Proc Natl Acad Sci U S A (2014) 1.05
p27kip1 in intestinal tumorigenesis and chemoprevention in the mouse. Cancer Res (2005) 1.05
Crystal structure of the Yersinia protein-tyrosine phosphatase YopH complexed with a specific small molecule inhibitor. J Biol Chem (2003) 1.04
Therapeutic potential of targeting the oncogenic SHP2 phosphatase. J Med Chem (2014) 1.04
Biosensors of protein kinase action: from in vitro assays to living cells. Biochim Biophys Acta (2004) 1.03
Direct observation of frequency modulated transcription in single cells using light activation. Elife (2013) 1.03
Design and synthesis of a fluorescent reporter of protein kinase activity. J Am Chem Soc (2002) 1.02
The activity of the extracellular signal-regulated kinase 2 is regulated by differential phosphorylation in the activation loop. J Biol Chem (2002) 1.01
Catalytic and regulatory domains of doublecortin kinase-1. Biochemistry (2003) 1.01
Metabolism of peptide reporters in cell lysates and single cells. Analyst (2012) 1.00
Acquisition of a "Group A"-selective Src kinase inhibitor via a global targeting strategy. J Am Chem Soc (2006) 1.00
Discovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cells. J Med Chem (2011) 1.00
Discovery and evaluation of novel inhibitors of mycobacterium protein tyrosine phosphatase B from the 6-Hydroxy-benzofuran-5-carboxylic acid scaffold. J Med Chem (2013) 1.00
Probing the molecular basis for potent and selective protein-tyrosine phosphatase 1B inhibition. J Biol Chem (2002) 0.99
Loop dynamics and ligand binding kinetics in the reaction catalyzed by the Yersinia protein tyrosine phosphatase. Biochemistry (2007) 0.99
Suramin derivatives as inhibitors and activators of protein-tyrosine phosphatases. J Biol Chem (2004) 0.98
Suborganelle sensing of mitochondrial cAMP-dependent protein kinase activity. J Am Chem Soc (2010) 0.98
SHP2 is a target of the immunosuppressant tautomycetin. Chem Biol (2011) 0.98
Rhodium-catalyzed silylcarbocyclization (SiCaC) and carbonylative silylcarbocyclization (CO-SiCaC) reactions of enynes. J Am Chem Soc (2002) 0.97
Dual wavelength photoactivation of cAMP- and cGMP-dependent protein kinase signaling pathways. ACS Chem Biol (2011) 0.97
Structural and mechanistic insights into LEOPARD syndrome-associated SHP2 mutations. J Biol Chem (2013) 0.97
Negative regulation of Stat3 by activating PTPN11 mutants contributes to the pathogenesis of Noonan syndrome and juvenile myelomonocytic leukemia. J Biol Chem (2009) 0.96
Multicolor monitoring of dysregulated protein kinases in chronic myelogenous leukemia. ACS Chem Biol (2010) 0.96
Real time visualization of protein kinase activity in living cells. J Biol Chem (2002) 0.95
Identification of phosphocaveolin-1 as a novel protein tyrosine phosphatase 1B substrate. Biochemistry (2006) 0.95
An overview of the protein tyrosine phosphatase superfamily. Curr Top Med Chem (2003) 0.94
A highly potent and selective PKCalpha inhibitor generated via combinatorial modification of a peptide scaffold. J Am Chem Soc (2004) 0.93
Comparative mechanistic and substrate specificity study of inositol polyphosphate 5-phosphatase Schizosaccharomyces pombe Synaptojanin and SHIP2. J Biol Chem (2004) 0.92
Simultaneous fluorescent monitoring of proteasomal subunit catalysis. J Am Chem Soc (2010) 0.92
Light-mediated liberation of enzymatic activity: "small molecule" caged protein equivalents. J Am Chem Soc (2008) 0.91
Tunable visible and near-IR photoactivation of light-responsive compounds by using fluorophores as light-capturing antennas. Angew Chem Int Ed Engl (2013) 0.91