Usage of primary cells to delineate IFN-gamma-responsive DNA elements in the HLA-DRA promoter and to identify a novel IFN-gamma-enhanced nuclear factor.

PubWeight™: 0.95‹?› | Rank: Top 15%

🔗 View Article (PMID 1588050)

Published in J Immunol on June 01, 1992

Authors

H Moses1, R B Panek, E N Benveniste, J P Ting

Author Affiliations

1: Curriculum in Neurobiology, University of North Carolina, Chapel Hill 27599-7295.

Articles citing this

The genomic structure of the murine ICSBP gene reveals the presence of the gamma interferon-responsive element, to which an ISGF3 alpha subunit (or similar) molecule binds. Mol Cell Biol (1993) 2.06

Transcriptional scaffold: CIITA interacts with NF-Y, RFX, and CREB to cause stereospecific regulation of the class II major histocompatibility complex promoter. Mol Cell Biol (2000) 1.62

CCAAT box binding protein NF-Y facilitates in vivo recruitment of upstream DNA binding transcription factors. EMBO J (1994) 1.53

Coordinate regulation of the human TAP1 and LMP2 genes from a shared bidirectional promoter. J Exp Med (1995) 1.46

In vivo footprint analysis of the HLA-DRA gene promoter: cell-specific interaction at the octamer site and up-regulation of X box binding by interferon gamma. Proc Natl Acad Sci U S A (1992) 1.15

YB-1 DNA-binding protein represses interferon gamma activation of class II major histocompatibility complex genes. J Exp Med (1994) 1.03

Characterization of a cis-acting regulatory element which silences expression of the class II-A beta gene in epithelium. J Exp Med (1994) 0.87

Activation of the HLA-DRA gene in primary human T lymphocytes: novel usage of TATA and the X and Y promoter elements. Mol Cell Biol (1992) 0.84

Affinity enrichment and functional characterization of TRAX1, a novel transcription activator and X1-sequence-binding protein of HLA-DRA. Mol Cell Biol (1995) 0.80

Identification of a transcription factor that binds to the S box of the I-A beta gene of the major histocompatibility complex. Biochem J (1996) 0.77

Tumor necrosis factor alpha response elements in the HLA-DRA promoter: identification of a tumor necrosis factor alpha-induced DNA-protein complex in astrocytes. Proc Natl Acad Sci U S A (1992) 0.76

Articles by these authors

(truncated to the top 100)

Immune function of astrocytes. Glia (2001) 4.05

TNF alpha promotes proliferation of oligodendrocyte progenitors and remyelination. Nat Neurosci (2001) 3.50

A new member of the leucine zipper class of proteins that binds to the HLA DR alpha promoter. Science (1990) 2.83

How Stat1 mediates constitutive gene expression: a complex of unphosphorylated Stat1 and IRF1 supports transcription of the LMP2 gene. EMBO J (2000) 2.33

Cytokines in inflammatory brain lesions: helpful and harmful. Trends Neurosci (1996) 2.20

Upstream DNA sequences required for tissue-specific expression of the HLA-DR alpha gene. Proc Natl Acad Sci U S A (1987) 2.00

GTP binding by class II transactivator: role in nuclear import. Science (1999) 1.94

Tumor necrosis factor-alpha production by astrocytes. Induction by lipopolysaccharide, IFN-gamma, and IL-1 beta. J Immunol (1990) 1.89

BLIMP-I mediates extinction of major histocompatibility class II transactivator expression in plasma cells. Nat Immunol (2000) 1.76

The transcription factors Sp1, Sp3, and AP-2 are required for constitutive matrix metalloproteinase-2 gene expression in astroglioma cells. J Biol Chem (1999) 1.68

Interleukin-6 expression and regulation in astrocytes. J Neuroimmunol (1999) 1.67

Class II transactivator: mastering the art of major histocompatibility complex expression. Mol Cell Biol (2000) 1.66

Microglial/macrophage accumulation during cuprizone-induced demyelination in C57BL/6 mice. J Neuroimmunol (1998) 1.63

Transcriptional scaffold: CIITA interacts with NF-Y, RFX, and CREB to cause stereospecific regulation of the class II major histocompatibility complex promoter. Mol Cell Biol (2000) 1.62

CCAAT box binding protein NF-Y facilitates in vivo recruitment of upstream DNA binding transcription factors. EMBO J (1994) 1.53

Induction of MHC class I expression by the MHC class II transactivator CIITA. Immunity (1997) 1.51

Two distinct gamma interferon-inducible promoters of the major histocompatibility complex class II transactivator gene are differentially regulated by STAT1, interferon regulatory factor 1, and transforming growth factor beta. Mol Cell Biol (1999) 1.50

Coordinate regulation of the human TAP1 and LMP2 genes from a shared bidirectional promoter. J Exp Med (1995) 1.46

Detailed delineation of an interferon-gamma-responsive element important in human HLA-DRA gene expression in a glioblastoma multiform line. Proc Natl Acad Sci U S A (1988) 1.46

Adhesion molecule expression and regulation on cells of the central nervous system. J Neuroimmunol (1999) 1.46

Identification of an interferon-gamma response region 5' of the human histocompatibility leukocyte antigen DR alpha chain gene which is active in human glioblastoma multiforme lines. J Immunol (1987) 1.45

Involvement of STAT-1 and ets family members in interferon-gamma induction of CD40 transcription in microglia/macrophages. J Biol Chem (2000) 1.45

MEK inhibition enhances paclitaxel-induced tumor apoptosis. J Biol Chem (2000) 1.40

Molecular analysis of G1B and G3A IFN gamma mutants reveals that defects in CIITA or RFX result in defective class II MHC and Ii gene induction. Immunity (1994) 1.39

Regulation of LMP2 and TAP1 genes by IRF-1 explains the paucity of CD8+ T cells in IRF-1-/- mice. Immunity (1996) 1.35

Interleukin-6 (IL-6) production by astrocytes: autocrine regulation by IL-6 and the soluble IL-6 receptor. J Neurosci (1999) 1.34

Major histocompatibility complex class II-transfected tumor cells present endogenous antigen and are potent inducers of tumor-specific immunity. Proc Natl Acad Sci U S A (1997) 1.34

Induction of the chemokines interleukin-8 and IP-10 by human immunodeficiency virus type 1 tat in astrocytes. J Virol (2000) 1.32

A defect in the nuclear translocation of CIITA causes a form of type II bare lymphocyte syndrome. Immunity (1999) 1.31

Cyclin-dependent kinase activation and S-phase induction of the cyclin B1 gene are linked through the CCAAT elements. Cell Growth Differ (1997) 1.28

TGF-beta suppresses IFN-gamma induction of class II MHC gene expression by inhibiting class II transactivator messenger RNA expression. J Immunol (1997) 1.27

IL-8 reduced tumorigenicity of human ovarian cancer in vivo due to neutrophil infiltration. J Immunol (2000) 1.26

Inhibition of IFN-gamma signaling by an Epstein-Barr virus immediate-early protein. Immunity (2001) 1.26

Class II box consensus sequences in the HLA-DR alpha gene: transcriptional function and interaction with nuclear proteins. Mol Cell Biol (1989) 1.24

ICAM-1-induced expression of proinflammatory cytokines in astrocytes: involvement of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways. J Immunol (2000) 1.21

Functional analysis of c-Myb protein in T-lymphocytic cell lines shows that it trans-activates the c-myc promoter. Mol Cell Biol (1990) 1.20

Identification of distinct regions of 5' flanking DNA that mediate constitutive, IFN-gamma, STAT1, and TGF-beta-regulated expression of the class II transactivator gene. J Immunol (1998) 1.20

CCAAT-binding factor NF-Y and RFX are required for in vivo assembly of a nucleoprotein complex that spans 250 base pairs: the invariant chain promoter as a model. Mol Cell Biol (1997) 1.20

The transcriptional regulatory protein, YB-1, promotes single-stranded regions in the DRA promoter. J Biol Chem (1995) 1.17

Cytokine regulation of CC and CXC chemokine expression by human astrocytes. J Neurovirol (1999) 1.17

Two distinct domains within CIITA mediate self-association: involvement of the GTP-binding and leucine-rich repeat domains. Mol Cell Biol (2001) 1.16

The central nervous system as an immunocompetent organ: role of glial cells in antigen presentation. J Immunol (1996) 1.16

In vivo footprint analysis of the HLA-DRA gene promoter: cell-specific interaction at the octamer site and up-regulation of X box binding by interferon gamma. Proc Natl Acad Sci U S A (1992) 1.15

Envelope glycoprotein gp120 of human immunodeficiency virus type 1 alters ion transport in astrocytes: implications for AIDS dementia complex. Proc Natl Acad Sci U S A (1994) 1.14

Cytokine-induced expression of vascular cell adhesion molecule-1 (VCAM-1) by astrocytes and astrocytoma cell lines. J Immunol (1995) 1.14

Major histocompatibility complex class II-associated invariant chain gene expression is up-regulated by cooperative interactions of Sp1 and NF-Y. J Biol Chem (1995) 1.13

Importance of acidic, proline/serine/threonine-rich, and GTP-binding regions in the major histocompatibility complex class II transactivator: generation of transdominant-negative mutants. Proc Natl Acad Sci U S A (1997) 1.13

Stereospecific alignment of the X and Y elements is required for major histocompatibility complex class II DRA promoter function. Mol Cell Biol (1991) 1.12

Expression and synthesis of murine immune response-associated (Ia) antigens by brain cells. Proc Natl Acad Sci U S A (1981) 1.11

Transcriptional suppression of matrix metalloproteinase-9 gene expression by IFN-gamma and IFN-beta: critical role of STAT-1alpha. J Immunol (2001) 1.11

Reduced IL-4-, lipopolysaccharide-, and IFN-gamma-induced MHC class II expression in mice lacking class II transactivator due to targeted deletion of the GTP-binding domain. J Immunol (1999) 1.10

Differential tumor necrosis factor alpha expression by astrocytes from experimental allergic encephalomyelitis-susceptible and -resistant rat strains. J Exp Med (1991) 1.10

Absence of MHC class II molecules reduces CNS demyelination, microglial/macrophage infiltration, and twitching in murine globoid cell leukodystrophy. Cell (1994) 1.10

Cytokine regulation of interleukin-6 gene expression in astrocytes involves activation of an NF-kappa B-like nuclear protein. J Neuroimmunol (1992) 1.08

Differential regulation and function of Fas expression on glial cells. J Immunol (2000) 1.08

Affinity-purified CCAAT-box-binding protein (YEBP) functionally regulates expression of a human class II major histocompatibility complex gene and the herpes simplex virus thymidine kinase gene. Proc Natl Acad Sci U S A (1991) 1.08

Isolation and characterization of a human pro alpha 2(I) collagen gene segment. J Invest Dermatol (1984) 1.08

Post-transcriptional inhibition of CD40 gene expression in microglia by transforming growth factor-beta. Eur J Immunol (1998) 1.07

CIITA stimulation of transcription factor binding to major histocompatibility complex class II and associated promoters in vivo. Proc Natl Acad Sci U S A (1998) 1.07

The prolyl isomerase Pin1 regulates the NF-kappaB signaling pathway and interleukin-8 expression in glioblastoma. Oncogene (2009) 1.07

Mechanisms of nuclear import and export that control the subcellular localization of class II transactivator. J Immunol (2001) 1.07

Stat1 alpha expression is involved in IFN-gamma induction of the class II transactivator and class II MHC genes. J Immunol (1996) 1.07

A 36-amino-acid region of CIITA is an effective inhibitor of CBP: novel mechanism of gamma interferon-mediated suppression of collagen alpha(2)(I) and other promoters. Mol Cell Biol (2001) 1.05

IFN-gamma regulation of the type IV class II transactivator promoter in astrocytes. J Immunol (1999) 1.05

X-box-binding proteins positively and negatively regulate transcription of the HLA-DRA gene through interaction with discrete upstream W and V elements. Proc Natl Acad Sci U S A (1990) 1.05

Signal transduction pathways mediating astrocyte IL-6 induction by IL-1 beta and tumor necrosis factor-alpha. J Immunol (1994) 1.05

Stimulation of oligodendroglial proliferation and maturation by interleukin-2. Nature (1986) 1.04

Structural constraints within a trimeric transcriptional regulatory region. Constitutive and interferon-gamma-inducible expression of the HLA-DRA gene. J Biol Chem (1992) 1.03

Mechanism of c-myc regulation by c-Myb in different cell lineages. Mol Cell Biol (1993) 1.03

Interferon-gamma-induced astrocyte class II major histocompatibility complex gene expression is associated with both protein kinase C activation and Na+ entry. J Biol Chem (1991) 1.03

Identification of tumor-specific paclitaxel (Taxol)-responsive regulatory elements in the interleukin-8 promoter. Mol Cell Biol (1997) 1.02

Paclitaxel (Taxol)-induced gene expression and cell death are both mediated by the activation of c-Jun NH2-terminal kinase (JNK/SAPK). J Biol Chem (1998) 1.02

IFN-gamma regulation of class II transactivator promoter IV in macrophages and microglia: involvement of the suppressors of cytokine signaling-1 protein. J Immunol (2001) 1.02

Function of NF-kappa B/Rel binding sites in the major histocompatibility complex class II invariant chain promoter is dependent on cell-specific binding of different NF-kappa B/Rel subunits. Mol Cell Biol (1994) 1.01

Downregulation of CIITA function by protein kinase a (PKA)-mediated phosphorylation: mechanism of prostaglandin E, cyclic AMP, and PKA inhibition of class II major histocompatibility complex expression in monocytic lines. Mol Cell Biol (2001) 1.01

CXC chemokine receptor 4 expression and function in human astroglioma cells. J Immunol (2001) 1.01

IL-4-activated STAT-6 inhibits IFN-gamma-induced CD40 gene expression in macrophages/microglia. J Immunol (2000) 1.01

Remyelination by oligodendrocytes stimulated by antiserum to spinal cord. J Neuropathol Exp Neurol (1987) 1.01

The octamer motif is a B-lymphocyte-specific regulatory element of the HLA-DR alpha gene promoter. Proc Natl Acad Sci U S A (1989) 1.01

Transcriptional regulation of the HLA-DRA gene. Crit Rev Immunol (1991) 1.00

Fas-induced expression of chemokines in human glioma cells: involvement of extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase. Cancer Res (2001) 0.99

The Smad3 protein is involved in TGF-beta inhibition of class II transactivator and class II MHC expression. J Immunol (2001) 0.99

Transcriptional regulation of the human osteopontin promoter: functional analysis and DNA-protein interactions. Oncogene (2000) 0.97

Class II transactivator and class II MHC gene expression in microglia: modulation by the cytokines TGF-beta, IL-4, IL-13 and IL-10. Eur J Immunol (1999) 0.96

Role of IL-6 and the soluble IL-6 receptor in inhibition of VCAM-1 gene expression. J Immunol (1998) 0.96

Autoimmune Sjögren's-like lesions in salivary glands of TGF-beta1-deficient mice are inhibited by adhesion-blocking peptides. J Immunol (1996) 0.95

Interleukin-6 production by astrocytes: induction by the neurotransmitter norepinephrine. J Neuroimmunol (1993) 0.95

A novel element and a TEF-2-like element activate the major histocompatibility complex class II transactivator in B-lymphocytes. J Biol Chem (1999) 0.95

Effects of paclitaxel on cytokine synthesis by unprimed human monocytes, T lymphocytes, and breast cancer cells. Cancer Immunol Immunother (1998) 0.95

Activation and transdominant suppression of MHC class II and HLA-DMB promoters by a series of C-terminal class II transactivator deletion mutants. J Immunol (1997) 0.94

Biosynthesis and intracellular targeting of the lysosomal aspartic proteinase cathepsin D. Adv Exp Med Biol (1998) 0.94

Oncostatin M regulation of interleukin-6 expression in astrocytes: biphasic regulation involving the mitogen-activated protein kinases ERK1/2 and p38. J Neurochem (2000) 0.94

Expression of class I histocompatibility antigens on human T-B lymphoblast hybrids. Somat Cell Mol Genet (1984) 0.94

Cytokines and HIV envelope glycoprotein gp120 stimulate Na+/H+ exchange in astrocytes. J Biol Chem (1994) 0.94

Transcriptional suppression of matrix metalloproteinase-2 gene expression in human astroglioma cells by TNF-alpha and IFN-gamma. J Immunol (1998) 0.93

Regulation of inosine-5'-monophosphate dehydrogenase type II gene expression in human T cells. Role for a novel 5' palindromic octamer sequence. J Biol Chem (1997) 0.93

Production of MMPs in human cerebral endothelial cells and their role in shedding adhesion molecules. J Neuropathol Exp Neurol (2001) 0.92

Regulation of intercellular adhesion molecule-1 gene expression by tumor necrosis factor-alpha, interleukin-1 beta, and interferon-gamma in astrocytes. J Neuroimmunol (1994) 0.91

Intercellular adhesion molecule-1 gene expression by glial cells. Differential mechanisms of inhibition by IL-10 and IL-6. J Immunol (1995) 0.91

Differential selectivity of CIITA promoter activation by IFN-gamma and IRF-1 in astrocytes and macrophages: CIITA promoter activation is not affected by TNF-alpha. J Neuroimmunol (1999) 0.90