Published in Proc Biol Sci on April 22, 2005
Identification of a protein mediating respiratory supercomplex stability. Cell Metab (2012) 1.95
Mitochondria contribute to LPS-induced MAPK activation via uncoupling protein UCP2 in macrophages. Biochem J (2007) 1.47
Avian UCP: the killjoy in the evolution of the mitochondrial uncoupling proteins. J Mol Evol (2007) 0.92
Increased thermoregulation in cold-exposed transgenic mice overexpressing lipoprotein lipase in skeletal muscle: an avian phenotype? J Lipid Res (2008) 0.90
Up-regulation of avian uncoupling protein in cold-acclimated and hyperthyroid ducklings prevents reactive oxygen species production by skeletal muscle mitochondria. BMC Physiol (2010) 0.87
Novel reptilian uncoupling proteins: molecular evolution and gene expression during cold acclimation. Proc Biol Sci (2008) 0.85
Exercise ameliorates the detrimental effect of chloroquine on skeletal muscles in mice via restoring autophagy flux. Acta Pharmacol Sin (2013) 0.85
High anoxia tolerance in the subterranean salamander Proteus anguinus without oxidative stress nor activation of antioxidant defenses during reoxygenation. J Comp Physiol B (2009) 0.85
Energetics and longevity in birds. Age (Dordr) (2008) 0.83
Chronic mitochondrial uncoupling treatment prevents acute cold-induced oxidative stress in birds. J Comp Physiol B (2014) 0.80
Protopanaxtriol protects against 3-nitropropionic acid-induced oxidative stress in a rat model of Huntington's disease. Acta Pharmacol Sin (2015) 0.79
The extract of Ginkgo biloba EGb 761 reactivates a juvenile profile in the skeletal muscle of sarcopenic rats by transcriptional reprogramming. PLoS One (2009) 0.77
Hydroxynonenal, a lipid peroxidation end product, stimulates uncoupling protein activity in Acanthamoeba castellanii mitochondria; the sensitivity of the inducible activity to purine nucleotides depends on the membranous ubiquinone redox state. J Bioenerg Biomembr (2012) 0.76
Oxygen recovery up-regulates avian UCP and ANT in newly hatched ducklings. J Comp Physiol B (2009) 0.76
The free radical theory of aging matures. Physiol Rev (1998) 9.83
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The p66shc adaptor protein controls oxidative stress response and life span in mammals. Nature (1999) 7.85
An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria. Neuron (1995) 6.03
Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. Nat Genet (1997) 5.54
Superoxide activates mitochondrial uncoupling proteins. Nature (2002) 5.43
Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. Nat Genet (2000) 5.42
Thermogenic mechanisms in brown fat. Physiol Rev (1984) 5.34
Topology of superoxide production from different sites in the mitochondrial electron transport chain. J Biol Chem (2002) 5.31
Good genes, oxidative stress and condition-dependent sexual signals. Proc Biol Sci (1999) 5.07
Carotenoid modulation of immune function and sexual attractiveness in zebra finches. Science (2003) 3.56
Extension of life-span with superoxide dismutase/catalase mimetics. Science (2000) 3.41
The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP. Biochem J (2000) 3.26
Mitochondria, oxygen free radicals, disease and ageing. Trends Biochem Sci (2000) 3.04
Costly sexual signals: are carotenoids rare, risky or required? Trends Ecol Evol (1998) 2.96
A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling. EMBO J (2003) 2.43
Uncoupling protein 2, in vivo distribution, induction upon oxidative stress, and evidence for translational regulation. J Biol Chem (2000) 2.36
Reactive oxygen species, mitochondria, apoptosis and aging. Mol Cell Biochem (1997) 1.92
Evolutionary and mechanistic theories of aging. Annu Rev Entomol (2005) 1.77
Mitochondrial matrix reactive oxygen species production is very sensitive to mild uncoupling. Biochem Soc Trans (2003) 1.57
Neonatal nutrition, adult antioxidant defences and sexual attractiveness in the zebra finch. Proc Biol Sci (2003) 1.54
Retinoids activate proton transport by the uncoupling proteins UCP1 and UCP2. EMBO J (1999) 1.47
No evidence for a basal, retinoic, or superoxide-induced uncoupling activity of the uncoupling protein 2 present in spleen or lung mitochondria. J Biol Chem (2002) 1.40
Mitochondrial uncoupling protein 1 expressed in the heart of transgenic mice protects against ischemic-reperfusion damage. Circulation (2004) 1.21
Artifactual uncoupling by uncoupling protein 3 in yeast mitochondria at the concentrations found in mouse and rat skeletal-muscle mitochondria. Biochem J (2002) 1.19
Dependence of excitotoxic neurodegeneration on mitochondrial aconitase inactivation. J Neurochem (2001) 1.19
Uncoupling protein and ATP/ADP carrier increase mitochondrial proton conductance after cold adaptation of king penguins. J Physiol (2004) 1.14
Fatty acids as acute regulators of the proton conductance of hamster brown-fat mitochondria. Eur J Biochem (1982) 1.13
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Cysteine residues are not essential for uncoupling protein function. Biochem J (1993) 1.07
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An uncoupling protein homologue putatively involved in facultative muscle thermogenesis in birds. Biochem J (2001) 1.00
Cold-induced enhancement of avian uncoupling protein expression, heat production, and triiodothyronine concentrations in broiler chicks. Gen Comp Endocrinol (2003) 0.89
Cloning and functional characterization of an uncoupling protein homolog in hummingbirds. Physiol Genomics (2001) 0.88
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Superoxide activates a GDP-sensitive proton conductance in skeletal muscle mitochondria from king penguin (Aptenodytes patagonicus). Biochem Biophys Res Commun (2003) 0.88
Thyroid status, but not insulin status, affects expression of avian uncoupling protein mRNA in chicken. Am J Physiol Endocrinol Metab (2002) 0.87
Effects of dietary macronutrient content on energy metabolism and uncoupling protein mRNA expression in broiler chickens. Br J Nutr (2003) 0.81
Expression of an uncoupling protein gene homolog in chickens. Comp Biochem Physiol A Mol Integr Physiol (2002) 0.80
Possible basic and specific functions of plant uncoupling proteins (pUCP). Biosci Rep (2001) 0.79
Acquirement of brown fat cell features by human white adipocytes. J Biol Chem (2003) 3.05
The biology of mitochondrial uncoupling proteins. Diabetes (2004) 2.66
King penguin population threatened by Southern Ocean warming. Proc Natl Acad Sci U S A (2008) 2.55
Reliability of flipper-banded penguins as indicators of climate change. Nature (2011) 2.52
A central thermogenic-like mechanism in feeding regulation: an interplay between arcuate nucleus T3 and UCP2. Cell Metab (2007) 2.48
Marine animal behaviour: neglecting ocean currents can lead us up the wrong track. Proc Biol Sci (2006) 2.39
Endangered species: where leatherback turtles meet fisheries. Nature (2004) 2.31
Huddling behavior in emperor penguins: Dynamics of huddling. Physiol Behav (2006) 2.18
Uncoupling protein-2 controls proliferation by promoting fatty acid oxidation and limiting glycolysis-derived pyruvate utilization. FASEB J (2007) 1.77
Mitochondria contribute to LPS-induced MAPK activation via uncoupling protein UCP2 in macrophages. Biochem J (2007) 1.47
One for all and all for one: the energetic benefits of huddling in endotherms. Biol Rev Camb Philos Soc (2009) 1.45
No evidence for a basal, retinoic, or superoxide-induced uncoupling activity of the uncoupling protein 2 present in spleen or lung mitochondria. J Biol Chem (2002) 1.40
Listeria monocytogenes transiently alters mitochondrial dynamics during infection. Proc Natl Acad Sci U S A (2011) 1.38
UCP2 transports C4 metabolites out of mitochondria, regulating glucose and glutamine oxidation. Proc Natl Acad Sci U S A (2014) 1.38
White-to-brown transdifferentiation of omental adipocytes in patients affected by pheochromocytoma. Biochim Biophys Acta (2013) 1.33
Mitochondrial uncoupling protein 1 expressed in the heart of transgenic mice protects against ischemic-reperfusion damage. Circulation (2004) 1.21
Plasticity in foraging strategies of inshore birds: how Little Penguins maintain body reserves while feeding offspring. Ecology (2011) 1.20
Intestinal gluconeogenesis and glucose transport according to body fuel availability in rats. J Physiol (2005) 1.19
The uncoupling protein 2 modulates the cytokine balance in innate immunity. Cytokine (2006) 1.19
Year-round recordings of behavioural and physiological parameters reveal the survival strategy of a poorly insulated diving endotherm during the Arctic winter. J Exp Biol (2005) 1.17
Effects of individual pre-fledging traits and environmental conditions on return patterns in juvenile king penguins. PLoS One (2011) 1.16
Population dynamics in a long-lived seabird: I. Impact of breeding activity on survival and breeding probability in unbanded king penguins. J Anim Ecol (2007) 1.15
Uncoupling proteins: current status and therapeutic prospects. EMBO Rep (2005) 1.14
Mutations in UCP2 in congenital hyperinsulinism reveal a role for regulation of insulin secretion. PLoS One (2008) 1.13
Three new PAX6 mutations including one causing an unusual ophthalmic phenotype associated with neurodevelopmental abnormalities. Mol Vis (2007) 1.12
Resistance to diet-induced obesity in mu-opioid receptor-deficient mice: evidence for a "thrifty gene". Diabetes (2005) 1.12
Emperor penguin mates: keeping together in the crowd. Proc Biol Sci (2009) 1.11
UCP2 is a mitochondrial transporter with an unusual very short half-life. FEBS Lett (2007) 1.11
UCP2, a metabolic sensor coupling glucose oxidation to mitochondrial metabolism? IUBMB Life (2009) 1.08
Resistance to cerebral ischemic injury in UCP2 knockout mice: evidence for a role of UCP2 as a regulator of mitochondrial glutathione levels. J Neurochem (2004) 1.07
Role of uncoupling protein UCP2 in cell-mediated immunity: how macrophage-mediated insulitis is accelerated in a model of autoimmune diabetes. Proc Natl Acad Sci U S A (2007) 1.07
Dive and beak movement patterns in leatherback turtles Dermochelys coriacea during internesting intervals in French Guiana. J Anim Ecol (2008) 1.06
Increased mitochondrial fatty acid oxidation is sufficient to protect skeletal muscle cells from palmitate-induced apoptosis. J Biol Chem (2010) 1.03
Modified glutamine catabolism in macrophages of Ucp2 knock-out mice. Biochim Biophys Acta (2007) 1.00
Mercury concentrations in king penguin (Aptenodytes patagonicus) feathers at Crozet Islands (sub-Antarctic): temporal trend between 1966--1974 and 2000--2001. Environ Toxicol Chem (2005) 1.00
Uncoupling protein-2 controls adiponectin gene expression in adipose tissue through the modulation of reactive oxygen species production. Diabetes (2007) 0.99
King penguins adjust their diving behaviour with age. J Exp Biol (2012) 0.97
High level of uncoupling protein 1 expression in muscle of transgenic mice selectively affects muscles at rest and decreases their IIb fiber content. J Biol Chem (2002) 0.97
Uncoupling protein 2 has protective function during experimental autoimmune encephalomyelitis. Am J Pathol (2006) 0.97
CL316,243 and cold stress induce heterogeneous expression of UCP1 mRNA and protein in rodent brown adipocytes. J Histochem Cytochem (2002) 0.96
Avian UCP: the killjoy in the evolution of the mitochondrial uncoupling proteins. J Mol Evol (2007) 0.92
Bone marrow transplantation reveals the in vivo expression of the mitochondrial uncoupling protein 2 in immune and nonimmune cells during inflammation. J Biol Chem (2003) 0.92
Should I stay or should I go? Hormonal control of nest abandonment in a long-lived bird, the Adélie penguin. Horm Behav (2010) 0.91
Mitochondrial uncoupling proteins: new perspectives for evolutionary ecologists. Am Nat (2005) 0.91
A large genomic deletion in the PDHX gene caused by the retrotranspositional insertion of a full-length LINE-1 element. Hum Mutat (2007) 0.91
Phytohemagglutinin response and immunoglobulin index decrease during incubation fasting in female common eiders. Physiol Biochem Zool (2006) 0.91
Energy saving processes in huddling emperor penguins: from experiments to theory. J Exp Biol (2008) 0.91
Dietary palmitate and linoleate oxidations, oxidative stress, and DNA damage differ according to season in mouse lemurs exposed to a chronic food deprivation. Am J Physiol Regul Integr Comp Physiol (2009) 0.89
Effect of physical inactivity on the oxidation of saturated and monounsaturated dietary Fatty acids: results of a randomized trial. PLoS Clin Trials (2006) 0.89
Mitochondrial thermogenesis and obesity. Curr Opin Clin Nutr Metab Care (2007) 0.89
Uncoupling protein 2, but not uncoupling protein 1, is expressed in the female mouse reproductive tract. J Biol Chem (2003) 0.89
Mitochondrial uncoupling prevents cold-induced oxidative stress: a case study using UCP1 knockout mice. J Exp Biol (2013) 0.88
Thermoregulation: what role for UCPs in mammals and birds? Biosci Rep (2005) 0.88
The grey mouse lemur uses season-dependent fat or protein sparing strategies to face chronic food restriction. PLoS One (2010) 0.88
Free radicals run in lizard families: a mitochondrial uncoupling phenomenon or not? Biol Lett (2009) 0.88
Uncoupling protein 2: a novel player in neuroprotection. Trends Mol Med (2003) 0.86
Clinical and biochemical heterogeneity associated with fumarase deficiency. Hum Mutat (2011) 0.86
Role of huddling on the energetic of growth in a newborn altricial mammal. Am J Physiol Regul Integr Comp Physiol (2007) 0.85
Exogenous corticosterone and nest abandonment: a study in a long-lived bird, the Adélie penguin. Horm Behav (2011) 0.84
A proteomic approach to identify differentially expressed plasma proteins between the fed and prolonged fasted states. Proteomics (2009) 0.84
Spheniscins, avian beta-defensins in preserved stomach contents of the king penguin, Aptenodytes patagonicus. J Biol Chem (2003) 0.83
Increased ROS production: a component of the longevity equation in the male mygalomorph, Brachypelma albopilosa. PLoS One (2010) 0.83
Kainic acid upregulates uncoupling protein-2 mRNA expression in the mouse brain. Neuroreport (2003) 0.82
Physical limitations of the TOBEC method: accuracy and long-term stability. Physiol Behav (2002) 0.82
Foraging in an oxidative environment: relationship between delta13C values and oxidative status in Adelie penguins. Proc Biol Sci (2009) 0.82
Reliability in estimates of body composition of birds: oxygen-18 versus deuterium dilution. Physiol Biochem Zool (2005) 0.82
High sensitivity identification of membrane proteins by MALDI TOF-MASS spectrometry using polystyrene beads. J Proteome Res (2007) 0.82
Functional changes with feeding in the gastro-intestinal epithelia of the Burmese python (Python molurus). Zoolog Sci (2009) 0.82
Proteasomes associated with the Blm10 activator protein antagonize mitochondrial fission through degradation of the fission protein Dnm1. J Biol Chem (2014) 0.82
Identification of four new PITX2 gene mutations in patients with Axenfeld-Rieger syndrome. Mol Vis (2006) 0.82
Fasting-induced changes of immunological and stress indicators in breeding female eiders. Gen Comp Endocrinol (2006) 0.81
Fasting increases gene expressions of uncoupling proteins and peroxisome proliferator-activated receptor-gamma in brown adipose tissue of ventromedial hypothalamus-lesioned rats. Life Sci (2003) 0.81
Alteration of plant mitochondrial proton conductance by free fatty acids. Uncoupling protein involvement. J Biol Chem (2002) 0.81
Multiple sources of metabolic disturbance in ETHE1-related ethylmalonic encephalopathy. J Inherit Metab Dis (2010) 0.81
Differences in the expression of lipolytic-related genes in rat white adipose tissues. Biochem Biophys Res Commun (2003) 0.80
Induction of Ucp2 expression in brain phagocytes and neurons following murine toxoplasmosis: an essential role of IFN-gamma and an association with negative energy balance. J Neuroimmunol (2007) 0.80
Gut hormones in relation to body mass and torpor pattern changes during food restriction and re-feeding in the gray mouse lemur. J Comp Physiol B (2008) 0.80
Growth prior to thermogenesis for a quick fledging of Adélie penguin chicks (Pygoscelis adeliae). PLoS One (2013) 0.80
Population pharmacokinetics and pharmacodynamics of cysteamine in nephropathic cystinosis patients. Orphanet J Rare Dis (2011) 0.79
Intestinal apoptotic changes linked to metabolic status in fasted and refed rats. Pflugers Arch (2005) 0.79
Innate immunity, assessed by plasma NO measurements, is not suppressed during the incubation fast in eiders. Dev Comp Immunol (2006) 0.78
Exogenous corticosterone mimics a late fasting stage in captive Adelie penguins (Pygoscelis adeliae). Am J Physiol Regul Integr Comp Physiol (2011) 0.78
Alterations in anxiety-like behavior following knockout of the uncoupling protein 2 (ucp2) gene in mice. Life Sci (2011) 0.78
Observations of the intestinal mucosa using environmental scanning electron microscopy (ESEM); comparison with conventional scanning electron microscopy (CSEM). Micron (2003) 0.78
Clay ingestion enhances intestinal triacylglycerol hydrolysis and non-esterified fatty acid absorption. Br J Nutr (2009) 0.78
Analysis of uncoupling protein 2-deficient mice upon anaesthesia and sedation revealed a role for UCP2 in locomotion. PLoS One (2012) 0.77
A new renal mitochondrial carrier, KMCP1, is up-regulated during tubular cell regeneration and induction of antioxidant enzymes. J Biol Chem (2005) 0.77
Thymus uncoupling protein 1 is exclusive to typical brown adipocytes and is not found in thymocytes. J Histochem Cytochem (2006) 0.77
Proximate and ultimate mechanisms underlying immunosuppression during the incubation fast in female eiders: roles of triiodothyronine and corticosterone. Gen Comp Endocrinol (2008) 0.77