Published in Circulation on July 19, 2004
Ischemia/reperfusion injury and cardioprotective mechanisms: Role of mitochondria and reactive oxygen species. World J Cardiol (2011) 1.51
Different mechanisms of mitochondrial proton leak in ischaemia/reperfusion injury and preconditioning: implications for pathology and cardioprotection. Biochem J (2006) 1.47
Muscle mitochondrial uncoupling dismantles neuromuscular junction and triggers distal degeneration of motor neurons. PLoS One (2009) 1.45
Neuronal PPARgamma deficiency increases susceptibility to brain damage after cerebral ischemia. J Neurosci (2009) 1.41
Biochemical dysfunction in heart mitochondria exposed to ischaemia and reperfusion. Biochem J (2005) 1.40
Improvements in skeletal muscle strength and cardiac function induced by resveratrol during exercise training contribute to enhanced exercise performance in rats. J Physiol (2012) 1.37
Mitochondrial reactive oxygen species: a double edged sword in ischemia/reperfusion vs preconditioning. Redox Biol (2014) 1.37
Ru360, a specific mitochondrial calcium uptake inhibitor, improves cardiac post-ischaemic functional recovery in rats in vivo. Br J Pharmacol (2006) 1.36
Enhancing repair of the mammalian heart. Circ Res (2007) 1.21
Uncoupling protein downregulation in doxorubicin-induced heart failure improves mitochondrial coupling but increases reactive oxygen species generation. Cancer Chemother Pharmacol (2010) 1.10
Local IGF-1 isoform protects cardiomyocytes from hypertrophic and oxidative stresses via SirT1 activity. Aging (Albany NY) (2009) 1.09
Tissue-specific short chain fatty acid metabolism and slow metabolic recovery after ischemia from hyperpolarized NMR in vivo. J Biol Chem (2009) 1.06
Mitochondrial matrix K+ flux independent of large-conductance Ca2+-activated K+ channel opening. Am J Physiol Cell Physiol (2010) 1.01
Expression of UCP3 in CHO cells does not cause uncoupling, but controls mitochondrial activity in the presence of glucose. Biochem J (2006) 0.98
Role of uncoupling protein 3 in ischemia-reperfusion injury, arrhythmias, and preconditioning. Am J Physiol Heart Circ Physiol (2013) 0.98
AMP-activated protein kinase alpha2 deficiency affects cardiac cardiolipin homeostasis and mitochondrial function. Diabetes (2007) 0.97
Autophagy: an affair of the heart. Heart Fail Rev (2013) 0.97
Avian uncoupling protein expressed in yeast mitochondria prevents endogenous free radical damage. Proc Biol Sci (2005) 0.93
Mitochondrial ATP-sensitive K+ channels prevent oxidative stress, permeability transition and cell death. J Bioenerg Biomembr (2005) 0.89
Mitochondrial therapeutics for cardioprotection. Curr Pharm Des (2011) 0.89
Changing the energy of an immune response. Am J Clin Exp Immunol (2013) 0.88
Uncoupling proteins in heart failure. Curr Heart Fail Rep (2008) 0.87
Physiological aspects of the mitochondrial cyclosporin A-insensitive palmitate/Ca2+-induced pore: tissue specificity, age profile and dependence on the animal's adaptation to hypoxia. J Bioenerg Biomembr (2009) 0.82
Mitochondrial Dysfunction in Alzheimer's Disease and the Rationale for Bioenergetics Based Therapies. Aging Dis (2016) 0.81
The Role of Mitochondrial Functional Proteins in ROS Production in Ischemic Heart Diseases. Oxid Med Cell Longev (2016) 0.79
UCP2 and ANT differently modulate proton-leak in brain mitochondria of long-term hyperglycemic and recurrent hypoglycemic rats. J Bioenerg Biomembr (2013) 0.78
Ischemic preconditioning enhances fatty acid-dependent mitochondrial uncoupling. J Bioenerg Biomembr (2007) 0.78
The cardioprotective compound cloxyquin uncouples mitochondria and induces autophagy. Am J Physiol Heart Circ Physiol (2015) 0.77
The circadian gene Rev-erbα improves cellular bioenergetics and provides preconditioning for protection against oxidative stress. Free Radic Biol Med (2016) 0.76
C1q/TNF-Related Protein 9 Protects Diabetic Rat Heart against Ischemia Reperfusion Injury: Role of Endoplasmic Reticulum Stress. Oxid Med Cell Longev (2016) 0.76
Cardiac Ryanodine Receptor (Ryr2)-mediated Calcium Signals Specifically Promote Glucose Oxidation via Pyruvate Dehydrogenase. J Biol Chem (2016) 0.75
Blood flow in glaucoma. Br J Ophthalmol (2007) 0.75
Protective Effect of Peroxisome Proliferator-Activated Receptor α Activation against Cardiac Ischemia-Reperfusion Injury Is Related to Upregulation of Uncoupling Protein-3. Oxid Med Cell Longev (2015) 0.75
The biology of mitochondrial uncoupling proteins. Diabetes (2004) 2.66
S6 kinase deletion suppresses muscle growth adaptations to nutrient availability by activating AMP kinase. Cell Metab (2007) 1.92
Down-regulation of OPA1 alters mouse mitochondrial morphology, PTP function, and cardiac adaptation to pressure overload. Cardiovasc Res (2012) 1.79
Effects of exercise programs to prevent decline in health-related quality of life in highly deconditioned institutionalized elderly persons: a randomized controlled trial. Arch Intern Med (2010) 1.78
Uncoupling protein-2 controls proliferation by promoting fatty acid oxidation and limiting glycolysis-derived pyruvate utilization. FASEB J (2007) 1.77
Toxic lipids stored by Kupffer cells correlates with their pro-inflammatory phenotype at an early stage of steatohepatitis. J Hepatol (2012) 1.68
Intestinal microbiota determines development of non-alcoholic fatty liver disease in mice. Gut (2012) 1.64
Mitochondria contribute to LPS-induced MAPK activation via uncoupling protein UCP2 in macrophages. Biochem J (2007) 1.47
Nonalcoholic fatty liver disease: from pathogenesis to patient care. Nat Clin Pract Endocrinol Metab (2007) 1.31
Activation of AMP kinase alpha1 subunit induces aortic vasorelaxation in mice. J Physiol (2007) 1.19
The uncoupling protein 2 modulates the cytokine balance in innate immunity. Cytokine (2006) 1.19
Adaptative metabolic response of human colonic epithelial cells to the adverse effects of the luminal compound sulfide. Biochim Biophys Acta (2005) 1.18
31P NMR detection of subcellular creatine kinase fluxes in the perfused rat heart: contractility modifies energy transfer pathways. J Biol Chem (2002) 1.15
ATP generation in the Trypanosoma brucei procyclic form: cytosolic substrate level is essential, but not oxidative phosphorylation. J Biol Chem (2003) 1.15
Resveratrol improves survival, hemodynamics and energetics in a rat model of hypertension leading to heart failure. PLoS One (2011) 1.13
UCP2 is a mitochondrial transporter with an unusual very short half-life. FEBS Lett (2007) 1.11
Real-time assessment of myocardial contractility using shear wave imaging. J Am Coll Cardiol (2011) 1.10
Phosphodiesterase 4B in the cardiac L-type Ca²⁺ channel complex regulates Ca²⁺ current and protects against ventricular arrhythmias in mice. J Clin Invest (2011) 1.09
UCP2, a metabolic sensor coupling glucose oxidation to mitochondrial metabolism? IUBMB Life (2009) 1.08
Mitochondrial energetics is impaired in vivo in aged skeletal muscle. Aging Cell (2013) 1.06
Role of the alpha2-isoform of AMP-activated protein kinase in the metabolic response of the heart to no-flow ischemia. Am J Physiol Heart Circ Physiol (2006) 1.04
Increased mitochondrial fatty acid oxidation is sufficient to protect skeletal muscle cells from palmitate-induced apoptosis. J Biol Chem (2010) 1.03
Decreased expression and activity of cAMP phosphodiesterases in cardiac hypertrophy and its impact on beta-adrenergic cAMP signals. Circ Res (2009) 1.03
Mitochondrial ATP synthase disorders: molecular mechanisms and the quest for curative therapeutic approaches. Biochim Biophys Acta (2008) 1.02
Modulation of energy transfer pathways between mitochondria and myofibrils by changes in performance of perfused heart. J Biol Chem (2010) 1.01
Impaired voluntary running capacity of creatine kinase-deficient mice. J Physiol (2005) 1.00
Dual cardiac contractile effects of the alpha2-AMPK deletion in low-flow ischemia and reperfusion. Am J Physiol Heart Circ Physiol (2007) 0.99
AMP-activated protein kinase alpha2 deficiency affects cardiac cardiolipin homeostasis and mitochondrial function. Diabetes (2007) 0.97
High level of uncoupling protein 1 expression in muscle of transgenic mice selectively affects muscles at rest and decreases their IIb fiber content. J Biol Chem (2002) 0.97
Housekeeping gene variability in the liver of alcoholic patients. Alcohol Clin Exp Res (2011) 0.97
Alteration of mitochondrial oxidative phosphorylation in aged skeletal muscle involves modification of adenine nucleotide translocator. Biochim Biophys Acta (2009) 0.94
Insulin-induced up-regulated uncoupling protein-1 expression is mediated by insulin receptor substrate 1 through the phosphatidylinositol 3-kinase/Akt signaling pathway in fetal brown adipocytes. J Biol Chem (2003) 0.94
Cyclic AMP compartmentation due to increased cAMP-phosphodiesterase activity in transgenic mice with a cardiac-directed expression of the human adenylyl cyclase type 8 (AC8). FASEB J (2003) 0.93
Avian uncoupling protein expressed in yeast mitochondria prevents endogenous free radical damage. Proc Biol Sci (2005) 0.93
Consequences of the pathogenic T9176C mutation of human mitochondrial DNA on yeast mitochondrial ATP synthase. Biochim Biophys Acta (2010) 0.92
Avian UCP: the killjoy in the evolution of the mitochondrial uncoupling proteins. J Mol Evol (2007) 0.92
Bone marrow transplantation reveals the in vivo expression of the mitochondrial uncoupling protein 2 in immune and nonimmune cells during inflammation. J Biol Chem (2003) 0.92
Mitochondrial uncoupling proteins: new perspectives for evolutionary ecologists. Am Nat (2005) 0.91
Accurate determination of the oxidative phosphorylation affinity for ADP in isolated mitochondria. PLoS One (2011) 0.91
Harmful effect of adipose tissue on liver lesions in patients with alcoholic liver disease. J Hepatol (2010) 0.89
Uncoupling protein 2, but not uncoupling protein 1, is expressed in the female mouse reproductive tract. J Biol Chem (2003) 0.89
Mitochondrial uncoupling prevents cold-induced oxidative stress: a case study using UCP1 knockout mice. J Exp Biol (2013) 0.88
Ablation of succinate production from glucose metabolism in the procyclic trypanosomes induces metabolic switches to the glycerol 3-phosphate/dihydroxyacetone phosphate shuttle and to proline metabolism. J Biol Chem (2010) 0.88
Thermoregulation: what role for UCPs in mammals and birds? Biosci Rep (2005) 0.88
Free radicals run in lizard families: a mitochondrial uncoupling phenomenon or not? Biol Lett (2009) 0.88
LIM-only protein FHL2 activates NF-κB signaling in the control of liver regeneration and hepatocarcinogenesis. Mol Cell Biol (2013) 0.87
Microglia in close vicinity of glioma cells: correlation between phenotype and metabolic alterations. Front Neuroenergetics (2010) 0.86
Augmentation of cardiac contractility with no change in L-type Ca2+ current in transgenic mice with a cardiac-directed expression of the human adenylyl cyclase type 8 (AC8). FASEB J (2002) 0.86
Independent and opposite associations of trunk fat and leg fat with liver enzyme levels. Liver Int (2008) 0.86
The histone acetyltransferase GCN5 modulates the retrograde response and genome stability determining yeast longevity. Biogerontology (2004) 0.86
4D retrospective black blood trueFISP imaging of mouse heart. Magn Reson Med (2009) 0.85
Improved energy supply regulation in chronic hypoxic mouse counteracts hypoxia-induced altered cardiac energetics. PLoS One (2010) 0.85
Glucocorticoid-induced leucine zipper: A key protein in the sensitization of monocytes to lipopolysaccharide in alcoholic hepatitis. Hepatology (2007) 0.85
Epac stimulation induces rapid increases in connexin43 phosphorylation and function without preconditioning effect. Pflugers Arch (2010) 0.84
Parameter estimation in modeling phosphocreatine recovery in human skeletal muscle. Eur J Appl Physiol (2003) 0.83
Increased ROS production: a component of the longevity equation in the male mygalomorph, Brachypelma albopilosa. PLoS One (2010) 0.83
Proteasomes associated with the Blm10 activator protein antagonize mitochondrial fission through degradation of the fission protein Dnm1. J Biol Chem (2014) 0.82
Control of cytoplasmic and nuclear protein kinase A by phosphodiesterases and phosphatases in cardiac myocytes. Cardiovasc Res (2014) 0.80
Inhibition of cardiac contractility by 5-hydroxydecanoate and tetraphenylphosphonium ion: a possible role of mitoKATP in response to inotropic stress. Am J Physiol Heart Circ Physiol (2006) 0.79
Physiological heart activation by adrenaline involves parallel activation of ATP usage and supply. Biochem J (2008) 0.79
Alcohol withdrawal alleviates adipose tissue inflammation in patients with alcoholic liver disease. Liver Int (2014) 0.79
Non-invasive integrative analysis of contraction energetics in intact beating heart. Int J Biochem Cell Biol (2012) 0.78
Modular regulation analysis of integrative effects of hypoxia on the energetics of contracting skeletal muscle in vivo. Biochem J (2009) 0.78
Modular control analysis of effects of chronic hypoxia on mouse heart. Am J Physiol Regul Integr Comp Physiol (2008) 0.77
A new renal mitochondrial carrier, KMCP1, is up-regulated during tubular cell regeneration and induction of antioxidant enzymes. J Biol Chem (2005) 0.77
Thymus uncoupling protein 1 is exclusive to typical brown adipocytes and is not found in thymocytes. J Histochem Cytochem (2006) 0.77
CXCR4 dysfunction in non-alcoholic steatohepatitis in mice and patients. Clin Sci (Lond) (2015) 0.76
Absence of mitochondrial activation during levosimendan inotropic action in perfused paced guinea pig hearts as demonstrated by modular control analysis. Am J Physiol Regul Integr Comp Physiol (2010) 0.76
System analysis of the effect of various drugs on cardiac contraction energetics. Biochem Soc Trans (2010) 0.75
Top down analysis ceramide-induced mitochondrial dysfunctions: role of mitochondrial swelling. Mol Biol Rep (2002) 0.75
Acute and chronic effects of bupivacaine on muscle energetics during contraction in vivo: a modular metabolic control analysis. Biochem J (2012) 0.75
A fast black-blood sequence for four-dimensional cardiac manganese-enhanced MRI in mouse. NMR Biomed (2010) 0.75
Effect of pyruvate, lactate and insulin on ATP supply and demand in unpaced perfused rat heart. Biochem J (2009) 0.75