Published in Toxicol Sci on May 11, 2005
Activation of inflammation/NF-kappaB signaling in infants born to arsenic-exposed mothers. PLoS Genet (2007) 2.19
Lung tumors in mice induced by "whole-life" inorganic arsenic exposure at human-relevant doses. Arch Toxicol (2014) 2.17
Chronic exposure to arsenic in the drinking water alters the expression of immune response genes in mouse lung. Environ Health Perspect (2009) 1.48
The vascular system as a target of metal toxicity. Toxicol Sci (2007) 1.47
SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylation. EMBO J (2009) 1.41
Arsenic-stimulated liver sinusoidal capillarization in mice requires NADPH oxidase-generated superoxide. J Clin Invest (2008) 1.33
Arsenic-specific stem cell selection during malignant transformation. J Natl Cancer Inst (2010) 1.24
Arsenic stimulates sinusoidal endothelial cell capillarization and vessel remodeling in mouse liver. Hepatology (2007) 1.23
Angiogenic potential of 3-nitro-4-hydroxy benzene arsonic acid (roxarsone). Environ Health Perspect (2008) 1.18
Low level arsenic promotes progressive inflammatory angiogenesis and liver blood vessel remodeling in mice. Toxicol Appl Pharmacol (2006) 1.02
Arsenic requires sphingosine-1-phosphate type 1 receptors to induce angiogenic genes and endothelial cell remodeling. Am J Pathol (2009) 1.01
Targeting hypoxia-inducible factor-1alpha with Tf-PEI-shRNA complex via transferrin receptor-mediated endocytosis inhibits melanoma growth. Mol Ther (2008) 0.96
Role and mechanism of arsenic in regulating angiogenesis. PLoS One (2011) 0.94
Arsenic-induced decreases in the vascular matrix. Toxicol Pathol (2008) 0.92
Ethanol enhances tumor angiogenesis in vitro induced by low-dose arsenic in colon cancer cells through hypoxia-inducible factor 1 alpha pathway. Toxicol Sci (2012) 0.88
Arsenite stabilizes HIF-1α protein through p85α-mediated up-regulation of inducible Hsp70 protein expression. Cell Mol Life Sci (2010) 0.87
Functional role of inorganic trace elements in angiogenesis part III: (Ti, Li, Ce, As, Hg, Va, Nb and Pb). Crit Rev Oncol Hematol (2015) 0.83
Metal ions-stimulated iron oxidation in hydroxylases facilitates stabilization of HIF-1 alpha protein. Toxicol Sci (2008) 0.79
A MALAT1/HIF-2α feedback loop contributes to arsenite carcinogenesis. Oncotarget (2016) 0.77
Arsenite Acutely Decreases Nitric Oxide Production via the ROS-Protein Phosphatase 1-Endothelial Nitric Oxide Synthase-Thr(497) Signaling Cascade. Biomol Ther (Seoul) (2014) 0.77
Differential transcriptional regulation of hypoxia-inducible factor-1α by arsenite under normoxia and hypoxia: involvement of Nrf2. J Mol Med (Berl) (2016) 0.76
The N-terminal region of p27 inhibits HIF-1α protein translation in ribosomal protein S6-dependent manner by regulating PHLPP-Ras-ERK-p90RSK axis. Cell Death Dis (2014) 0.76
Oscillating glucose is more deleterious to endothelial function and oxidative stress than mean glucose in normal and type 2 diabetic patients. Diabetes (2008) 4.05
Low-dose arsenic compromises the immune response to influenza A infection in vivo. Environ Health Perspect (2009) 2.47
Genomic and proteomic profiling of responses to toxic metals in human lung cells. Environ Health Perspect (2003) 2.21
Clinical review 2: The "metabolic memory": is more than just tight glucose control necessary to prevent diabetic complications? J Clin Endocrinol Metab (2008) 2.21
Enabling a community to dissect an organism: overview of the Neurospora functional genomics project. Adv Genet (2007) 2.19
Novel STAT3 phosphorylation inhibitors exhibit potent growth-suppressive activity in pancreatic and breast cancer cells. Cancer Res (2010) 1.91
Nucleotide excision repair- and polymerase eta-mediated error-prone removal of mitomycin C interstrand cross-links. Mol Cell Biol (2003) 1.76
Arsenic as an endocrine disruptor: effects of arsenic on estrogen receptor-mediated gene expression in vivo and in cell culture. Toxicol Sci (2007) 1.61
Chronic exposure to arsenic in the drinking water alters the expression of immune response genes in mouse lung. Environ Health Perspect (2009) 1.48
Chemoenzymatic synthesis with distinct Pasteurella heparosan synthases: monodisperse polymers and unnatural structures. J Biol Chem (2007) 1.43
Intraretinal leakage and oxidation of LDL in diabetic retinopathy. Invest Ophthalmol Vis Sci (2008) 1.42
Arsenic exposure is associated with decreased DNA repair in vitro and in individuals exposed to drinking water arsenic. Environ Health Perspect (2006) 1.41
Arsenic at very low concentrations alters glucocorticoid receptor (GR)-mediated gene activation but not GR-mediated gene repression: complex dose-response effects are closely correlated with levels of activated GR and require a functional GR DNA binding domain. Chem Res Toxicol (2004) 1.38
Arsenic stimulates angiogenesis and tumorigenesis in vivo. Toxicol Sci (2003) 1.35
Laboratory diet profoundly alters gene expression and confounds genomic analysis in mouse liver and lung. Chem Biol Interact (2008) 1.34
Synthesis and biological activity of N(4)-phenylsubstituted-6-(2,4-dichloro phenylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic and antitumor agents. Bioorg Med Chem (2010) 1.30
Decreased DNA repair gene expression among individuals exposed to arsenic in United States drinking water. Int J Cancer (2003) 1.29
Mercury bioavailability and bioaccumulation in estuarine food webs in the Gulf of Maine. Environ Sci Technol (2009) 1.26
Gene response profiles for Daphnia pulex exposed to the environmental stressor cadmium reveals novel crustacean metallothioneins. BMC Genomics (2007) 1.23
Arsenic as an endocrine disruptor: arsenic disrupts retinoic acid receptor-and thyroid hormone receptor-mediated gene regulation and thyroid hormone-mediated amphibian tail metamorphosis. Environ Health Perspect (2008) 1.15
Activation of Hedgehog signaling by the environmental toxicant arsenic may contribute to the etiology of arsenic-induced tumors. Cancer Res (2010) 1.15
Exposure to arsenic at levels found inU.S. drinking water modifies expression in the mouse lung. Toxicol Sci (2007) 1.13
Environmental exposure and fingernail analysis of arsenic and mercury in children and adults in a Nicaraguan gold mining community. Arch Environ Health (2004) 1.12
Arsenic disruption of steroid receptor gene activation: Complex dose-response effects are shared by several steroid receptors. Chem Res Toxicol (2006) 1.10
Antiangiogenic and antitumor agents. Design, synthesis, and evaluation of novel 2-amino-4-(3-bromoanilino)-6-benzylsubstituted pyrrolo[2,3-d]pyrimidines as inhibitors of receptor tyrosine kinases. Bioorg Med Chem (2003) 1.09
Toenail mercury and dietary fish consumption. J Expo Sci Environ Epidemiol (2006) 1.05
Effects of low-dose drinking water arsenic on mouse fetal and postnatal growth and development. PLoS One (2012) 1.03
Serum selenium and risk of prostate cancer-a nested case-control study. Am J Clin Nutr (2007) 1.02
Workgroup report: Biomonitoring study design, interpretation, and communication--lessons learned and path forward. Environ Health Perspect (2005) 1.02
Is glutathione the major cellular target of cisplatin? A study of the interactions of cisplatin with cancer cell extracts. J Med Chem (2009) 1.01
Comparative toxicity of cadmium, zinc, and mixtures of cadmium and zinc to daphnids. Environ Toxicol Chem (2006) 1.01
Role of glucocorticoid receptor in acclimation of killifish (Fundulus heteroclitus) to seawater and effects of arsenic. Am J Physiol Regul Integr Comp Physiol (2006) 1.00
High serum selenium and reduced risk of advanced colorectal adenoma in a colorectal cancer early detection program. Cancer Epidemiol Biomarkers Prev (2006) 0.98
Docosahexaenoic acid inhibits superoxide dismutase 1 gene transcription in human cancer cells: the involvement of peroxisome proliferator-activated receptor alpha and hypoxia-inducible factor-2alpha signaling. Mol Pharmacol (2009) 0.95
Chemotoxicity of doxorubicin and surface expression of P-glycoprotein (MDR1) is regulated by the Pseudomonas aeruginosa toxin Cif. Am J Physiol Cell Physiol (2008) 0.94
A novel multidrug resistance phenotype of bladder tumor cells grown on Matrigel or SIS gel. Cancer Lett (2005) 0.94
Chemoenzymatic synthesis of uridine diphosphate-GlcNAc and uridine diphosphate-GalNAc analogs for the preparation of unnatural glycosaminoglycans. J Org Chem (2012) 0.93
Regulatory network of inflammation downstream of proteinase-activated receptors. BMC Physiol (2007) 0.93
Arsenic-induced decreases in the vascular matrix. Toxicol Pathol (2008) 0.92
The influence of exposure history on arsenic accumulation and toxicity in the killifish, Fundulus heteroclitus. Environ Toxicol Chem (2007) 0.92
Mandatory role of proteinase-activated receptor 1 in experimental bladder inflammation. BMC Physiol (2007) 0.91
Arsenic inhibits CFTR-mediated chloride secretion by killifish (Fundulus heteroclitus) opercular membrane. Cell Physiol Biochem (2006) 0.91
Effects of putative hydroxylated thalidomide metabolites on blood vessel density in the chorioallantoic membrane (CAM) assay and on tumor and endothelial cell proliferation. Biol Pharm Bull (2002) 0.91
Mutant p53 facilitates pro-angiogenic, hyperproliferative phenotype in response to chronic relative hypoxia. Cancer Lett (2006) 0.91
Enhanced angiogenesis of modified porcine small intestinal submucosa with hyaluronic acid-poly(lactide-co-glycolide) nanoparticles: from fabrication to preclinical validation. J Biomed Mater Res A (2010) 0.90
Disruption of histone modification and CARM1 recruitment by arsenic represses transcription at glucocorticoid receptor-regulated promoters. PLoS One (2009) 0.89
A refined model for the TSG-6 link module in complex with hyaluronan: use of defined oligosaccharides to probe structure and function. J Biol Chem (2014) 0.89
MRP2 and acquired tolerance to inorganic arsenic in the kidney of killifish (Fundulus heteroclitus). Toxicol Sci (2007) 0.87
Structure/function analysis of Pasteurella multocida heparosan synthases: toward defining enzyme specificity and engineering novel catalysts. J Biol Chem (2012) 0.87
Gene expression profile of peripheral blood lymphocytes from renal cell carcinoma patients treated with IL-2, interferon-α and dendritic cell vaccine. PLoS One (2012) 0.86
High-throughput production of gene replacement mutants in Neurospora crassa. Methods Mol Biol (2011) 0.85
Transcription factor network downstream of protease activated receptors (PARs) modulating mouse bladder inflammation. BMC Immunol (2007) 0.85
Assessing element-specific patterns of bioaccumulation across New England lakes. Sci Total Environ (2012) 0.83
Design, synthesis and biological evaluation of substituted pyrrolo[2,3-d]pyrimidines as multiple receptor tyrosine kinase inhibitors and antiangiogenic agents. Bioorg Med Chem (2008) 0.83
N-sulfotestosteronan, a novel substrate for heparan sulfate 6-o-sulfotransferases and its analysis by oxidative degradation. Biopolymers (2013) 0.82
Suppression and activation of the malignant phenotype by extracellular matrix in xenograft models of bladder cancer: a model for tumor cell "dormancy". PLoS One (2013) 0.82
Arsenite regulates Cystic Fibrosis Transmembrane Conductance Regulator and P-glycoprotein: evidence of pathway independence. Cell Physiol Biochem (2005) 0.82
Monomethylated trivalent arsenic species disrupt steroid receptor interactions with their DNA response elements at non-cytotoxic cellular concentrations. J Appl Toxicol (2013) 0.82
Trans labilization of am(m)ine ligands from platinum(II) complexes by cancer cell extracts. J Biol Inorg Chem (2008) 0.82
Fibroblast growth factor-based signaling through synthetic heparan sulfate blocks copolymers studied using high cell density three-dimensional cell printing. J Biol Chem (2014) 0.81
N⁴-(3-Bromophenyl)-7-(substituted benzyl) pyrrolo[2,3-d]pyrimidines as potent multiple receptor tyrosine kinase inhibitors: design, synthesis, and in vivo evaluation. Bioorg Med Chem (2012) 0.81
Novel tricyclic indeno[2,1-d]pyrimidines with dual antiangiogenic and cytotoxic activities as potent antitumor agents. Bioorg Med Chem (2012) 0.81
Blending chitosan with polycaprolactone: porous scaffolds and toxicity. Macromol Biosci (2007) 0.81
Synthesis and evaluation of novel Tc-99m labeled probestin conjugates for imaging APN/CD13 expression in vivo. Bioconjug Chem (2011) 0.81
Synthesis of uridine 5'-diphosphoiduronic acid: a potential substrate for the chemoenzymatic synthesis of heparin. J Org Chem (2008) 0.81
Structure-activity relationships studies of the anti-angiogenic activities of linomide. Bioorg Med Chem Lett (2003) 0.81
Assessment of angiogenic properties of biomaterials using the chicken embryo chorioallantoic membrane assay. Biomed Mater (2007) 0.80
Repeated BCG treatment of mouse bladder selectively stimulates small GTPases and HLA antigens and inhibits single-spanning uroplakins. BMC Cancer (2007) 0.80
Preferential binding of human XPA to the mitomycin C-DNA interstrand crosslink and modulation by arsenic and cadmium. Chem Biol Interact (2007) 0.80
Altered biogenesis of deltaF508-CFTR following treatment with doxorubicin. Cell Physiol Biochem (2007) 0.80
Design, synthesis and evaluation of 2-amino-4-m-bromoanilino-6-arylmethyl-7H-pyrrolo[2,3-d]pyrimidines as tyrosine kinase inhibitors and antiangiogenic agents. Bioorg Med Chem (2010) 0.79
The contribution of a 2-amino group on receptor tyrosine kinase inhibition and antiangiogenic activity in 4-anilinosubstituted pyrrolo[2,3-d]pyrimidines. Bioorg Med Chem Lett (2010) 0.79
A long-term "memory" of HIF induction in response to chronic mild decreased oxygen after oxygen normalization. BMC Cardiovasc Disord (2007) 0.79
Evaluation of 99mTc-probestin for imaging APN expressing tumors by SPECT. Bioorg Med Chem Lett (2013) 0.78
SOCS3 modulates interleukin-6R signaling preference in dermal fibroblasts. J Interferon Cytokine Res (2012) 0.78
Low level methylmercury enhances CNTF-evoked STAT3 signaling and glial differentiation in cultured cortical progenitor cells. Neurotoxicology (2013) 0.77
Synthesis and biological activity of 5-chloro-N⁴-substituted phenyl-9H-pyrimido[4,5-b]indole-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic agents. Bioorg Med Chem (2013) 0.76
Analytical approaches for assaying metallodrugs in biological samples: recent methodological developments and future trends. Curr Drug Metab (2012) 0.76
N⁴-Aryl-6-substitutedphenylmethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as receptor tyrosine kinase inhibitors. Bioorg Med Chem (2011) 0.76
Synthesis and biodistribution studies of technetium-99m-labeled aminopeptidase N inhibitor conjugates. Bioorg Med Chem Lett (2012) 0.76
Chronic exposure to low-dose arsenic modulates lipogenic gene expression in mice. J Biochem Mol Toxicol (2014) 0.75
Synthesis of 4-azido-N-acetylhexosamine uridine diphosphate donors: Clickable glycosaminoglycans. J Org Chem (2017) 0.75
Solid phase synthesis and biological evaluation of probestin as an angiogenesis inhibitor. Bioorg Med Chem Lett (2013) 0.75
Hyphenation of ultra performance liquid chromatography (UPLC) with inductively coupled plasma mass spectrometry (ICP-MS) for fast analysis of bromine containing preservatives. J Pharm Biomed Anal (2006) 0.75