Published in Immunol Res on January 01, 2005
Epigenetic regulation of the alternatively activated macrophage phenotype. Blood (2009) 3.76
The innate immune system in SLE: type I interferons and dendritic cells. Lupus (2008) 2.52
Genomic views of STAT function in CD4+ T helper cell differentiation. Nat Rev Immunol (2011) 2.09
Signal transducer and activator of transcription 4 is required for the transcription factor T-bet to promote T helper 1 cell-fate determination. Immunity (2008) 2.04
A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5. Hum Mol Genet (2008) 1.98
Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome. Nat Genet (2013) 1.79
Genome-wide association studies: a new window into immune-mediated diseases. Nat Rev Immunol (2008) 1.59
STAT4 associates with systemic lupus erythematosus through two independent effects that correlate with gene expression and act additively with IRF5 to increase risk. Ann Rheum Dis (2008) 1.42
Stat4 limits DNA methyltransferase recruitment and DNA methylation of the IL-18Ralpha gene during Th1 differentiation. EMBO J (2007) 1.34
Gene expression profiling of ATL patients: compilation of disease-related genes and evidence for TCF4 involvement in BIRC5 gene expression and cell viability. Blood (2009) 1.21
STAT proteins - key regulators of anti-viral responses, inflammation, and tumorigenesis in the liver. J Hepatol (2012) 1.15
High-density genotyping of STAT4 reveals multiple haplotypic associations with systemic lupus erythematosus in different racial groups. Arthritis Rheum (2009) 1.11
Temporal induction pattern of STAT4 target genes defines potential for Th1 lineage-specific programming. J Immunol (2009) 1.10
Impaired development of human Th1 cells in patients with deficient expression of STAT4. Blood (2009) 1.07
Cytokines and STATs in Liver Fibrosis. Front Physiol (2012) 1.02
Stat4 isoforms differentially regulate inflammation and demyelination in experimental allergic encephalomyelitis. J Immunol (2008) 0.98
Evaluation of the rheumatoid arthritis susceptibility loci HLA-DRB1, PTPN22, OLIG3/TNFAIP3, STAT4 and TRAF1/C5 in an inception cohort. Arthritis Res Ther (2010) 0.98
Hlx homeobox transcription factor negatively regulates interferon-gamma production in monokine-activated natural killer cells. Blood (2006) 0.94
Cell-intrinsic IL-27 and gp130 cytokine receptor signaling regulates virus-specific CD4⁺ T cell responses and viral control during chronic infection. Immunity (2013) 0.93
STAT4 deficiency reduces obesity-induced insulin resistance and adipose tissue inflammation. Diabetes (2013) 0.93
STAT4 isoforms differentially regulate Th1 cytokine production and the severity of inflammatory bowel disease. J Immunol (2008) 0.91
Pathogenesis of Systemic Sclerosis. Front Immunol (2015) 0.89
Association of STAT4 polymorphism with severe renal insufficiency in lupus nephritis. PLoS One (2013) 0.88
Definition of IFN-γ-related pathways critical for chemically-induced systemic autoimmunity. J Autoimmun (2012) 0.87
Genetic associations in type I interferon related pathways with autoimmunity. Arthritis Res Ther (2010) 0.86
Opposing roles of STAT4 and Dnmt3a in Th1 gene regulation. J Immunol (2013) 0.85
Genetic variations in STAT4,C2,HLA-DRB1 and HLA-DQ associated with risk of hepatitis B virus-related liver cirrhosis. Sci Rep (2015) 0.84
Wheezing and itching: The requirement for STAT proteins in allergic inflammation. JAKSTAT (2012) 0.84
Abnormal genetic and epigenetic changes in signal transducer and activator of transcription 4 in the pathogenesis of inflammatory bowel diseases. Dig Dis Sci (2012) 0.83
Mangiferin attenuates TH1/TH2 cytokine imbalance in an ovalbumin-induced asthmatic mouse model. PLoS One (2014) 0.82
Interferons in Sjögren's Syndrome: Genes, Mechanisms, and Effects. Front Immunol (2013) 0.82
STAT4 gene polymorphisms are associated with susceptibility and ANA status in primary biliary cirrhosis. Dis Markers (2014) 0.82
Polymorphisms in JAK/STAT signaling pathway genes and risk of non-Hodgkin lymphoma. Leuk Res (2013) 0.82
Virus-specific CD4 and CD8 T cell responses in the absence of Th1-associated transcription factors. J Leukoc Biol (2013) 0.81
STAT4 knockout mice are more susceptible to concanavalin A-induced T-cell hepatitis. Am J Pathol (2014) 0.80
Contribution of STAT4 gene single-nucleotide polymorphism to systemic lupus erythematosus in the Polish population. Mol Biol Rep (2012) 0.80
Lactobacillus paracasei and Lactobacillus plantarum strains downregulate proinflammatory genes in an ex vivo system of cultured human colonic mucosa. Genes Nutr (2012) 0.79
Altered STAT4 Isoform Expression in Patients with Inflammatory Bowel Disease. Inflamm Bowel Dis (2015) 0.79
Decreased STAT4 indicates poor prognosis and enhanced cell proliferation in hepatocellular carcinoma. World J Gastroenterol (2015) 0.79
STAT4 gene polymorphism in patients after renal allograft transplantation. Cent Eur J Immunol (2016) 0.78
Association of STAT4 polymorphisms with susceptibility to type-1 autoimmune hepatitis in the Japanese population. PLoS One (2013) 0.77
STAT4 deficiency reduces the development of atherosclerosis in mice. Atherosclerosis (2015) 0.77
Association of STAT4 rs7574865 with susceptibility to systemic lupus erythematosus in Iranian population. Inflammation (2013) 0.77
STAT4 regulates antiviral gamma interferon responses and recurrent disease during herpes simplex virus 2 infection. J Virol (2012) 0.77
STAT4 is required for IL-23 responsiveness in Th17 memory cells and NKT cells. JAKSTAT (2014) 0.76
Chicken-Specific Kinome Array Reveals that Salmonella enterica Serovar Enteritidis Modulates Host Immune Signaling Pathways in the Cecum to Establish a Persistence Infection. Int J Mol Sci (2016) 0.76
STAT4 contributes to adipose tissue inflammation and atherosclerosis. J Endocrinol (2015) 0.76
STAT signaling in inflammation. JAKSTAT (2013) 0.76
From molecular interaction to acute promyelocytic leukemia: Calculating leukemogenesis and remission from endogenous molecular-cellular network. Sci Rep (2016) 0.75
Key Role of STAT4 Deficiency in the Hematopoietic Compartment in Insulin Resistance and Adipose Tissue Inflammation. Mediators Inflamm (2017) 0.75
Complement Activation and STAT4 Expression Are Associated with Early Inflammation in Diabetic Wounds. PLoS One (2017) 0.75
Negative Regulators of JAK/STAT Signaling in Rheumatoid Arthritis and Osteoarthritis. Int J Mol Sci (2017) 0.75
Suppression of Autoimmune Arthritis by Small Molecule Inhibitors of the JAK/STAT Pathway. Pharmaceuticals (Basel) (2010) 0.75
Association of STAT4 and PTPN22 polymorphisms and their interactions with type-1 autoimmune hepatitis susceptibility in Chinese Han children. Oncotarget (2017) 0.75
The prognostic values of signal transducers activators of transcription family in ovarian cancer. Biosci Rep (2017) 0.75
STAT4 Regulates the CD8(+) Regulatory T Cell/T Follicular Helper Cell Axis and Promotes Atherogenesis in Insulin-Resistant Ldlr(-/-) Mice. J Immunol (2017) 0.75