The 6-min walk test (6MW) as an efficacy endpoint in pulmonary arterial hypertension clinical trials: demonstration of a ceiling effect.

PubWeight™: 1.09‹?› | Rank: Top 10%

🔗 View Article (PMID 15890561)

Published in Vascul Pharmacol on June 01, 2005

Authors

Adaani E Frost1, D Langleben, R Oudiz, N Hill, E Horn, V McLaughlin, I M Robbins, S Shapiro, V F Tapson, D Zwicke, T DeMarco, R Schilz, M Rubenfire, R J Barst

Author Affiliations

1: Baylor College of Medicine, Houston, TX, United States. frost@bcm.tmc.edu

Articles citing this

Idiopathic pulmonary fibrosis: prognostic value of changes in physiology and six-minute-walk test. Am J Respir Crit Care Med (2006) 2.37

Inhibition of endothelin receptors in the treatment of pulmonary arterial hypertension: does selectivity matter? Eur Heart J (2008) 1.10

Bosentan in the treatment of pulmonary arterial hypertension with the focus on the mildly symptomatic patient. Vasc Health Risk Manag (2009) 0.94

Surrogate end points in pulmonary arterial hypertension: assessing the response to therapy. Clin Chest Med (2007) 0.93

Physical activity limitation as measured by accelerometry in pulmonary arterial hypertension. Chest (2012) 0.92

A dosing/cross-development study of the multikinase inhibitor sorafenib in patients with pulmonary arterial hypertension. Clin Pharmacol Ther (2009) 0.87

Lack of relationship between functional and perceived quality of life outcomes following pulmonary rehabilitation. Cardiopulm Phys Ther J (2008) 0.82

Heart rate recovery is an important predictor of outcomes in patients with connective tissue disease-associated pulmonary hypertension. Pulm Circ (2015) 0.79

Maximal cardiac output determines 6 minutes walking distance in pulmonary hypertension. PLoS One (2014) 0.79

Cardiopulmonary exercise testing in lung transplantation: a review. Pulm Med (2012) 0.78

Step climbing capacity in patients with pulmonary hypertension. Clin Res Cardiol (2012) 0.76

A review of sitaxsentan sodium in patients with pulmonary arterial hypertension. Vasc Health Risk Manag (2007) 0.76

Noninvasive assessment of right heart function and hemodynamics during exercise in patients with pulmonary arterial hypertension. South Med J (2013) 0.76

Exercise Capacity, Heart Failure Risk, and Mortality in Older Adults: The Health ABC Study. Am J Prev Med (2016) 0.75

Macitentan in pulmonary arterial hypertension: The SERAPHIN trial. Glob Cardiol Sci Pract (2014) 0.75

Use of Six-Minute Walk Test to Measure Functional Capacity After Liver Transplantation. Phys Ther (2016) 0.75

Combination therapy in pulmonary arterial hypertension: recent accomplishments and future challenges. Pulm Circ (2017) 0.75

Articles by these authors

Ten- to fourteen-year effect of screening on breast cancer mortality. J Natl Cancer Inst (1982) 13.25

Survival in patients with primary pulmonary hypertension. Results from a national prospective registry. Ann Intern Med (1991) 13.21

Promotion of Breastfeeding Intervention Trial (PROBIT): a randomized trial in the Republic of Belarus. JAMA (2001) 11.31

A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension. N Engl J Med (1996) 8.02

Evidence on screening for breast cancer from a randomized trial. Cancer (1977) 7.91

Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: a randomised placebo-controlled study. Lancet (2001) 6.88

Report of the International Workshop on Screening for Breast Cancer. J Natl Cancer Inst (1993) 6.02

Periodic breast cancer screening in reducing mortality from breast cancer. JAMA (1971) 5.91

Expression of endothelin-1 in the lungs of patients with pulmonary hypertension. N Engl J Med (1993) 4.91

Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene. Am J Hum Genet (2000) 4.42

Risk of aspirin-associated major upper-gastrointestinal bleeding with enteric-coated or buffered product. Lancet (1996) 4.21

Continuous intravenous epoprostenol for pulmonary hypertension due to the scleroderma spectrum of disease. A randomized, controlled trial. Ann Intern Med (2000) 4.07

Periconceptional folic acid exposure and risk of occurrent neural tube defects. JAMA (1993) 3.71

The reluctant participant in a breast cancer screening program. Public Health Rep (1968) 3.60

Utilization of health and mental health services. Three Epidemiologic Catchment Area sites. Arch Gen Psychiatry (1984) 3.55

A comparison of the requirements for primary care physicians in HMOs with projections made by the GMENAC. N Engl J Med (1986) 3.54

Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formation. Nat Genet (1997) 3.40

Effect of questionnaire design on recall of drug exposure in pregnancy. Am J Epidemiol (1986) 3.34

Five-year blood pressure control and mortality following health education for hypertensive patients. Am J Public Health (1983) 3.33

Comparison of the lay Diagnostic Interview Schedule and a standardized psychiatric diagnosis. Experience in eastern Baltimore. Arch Gen Psychiatry (1985) 3.18

Oral-contraceptive use in relation to myocardial infarction. Lancet (1979) 3.04

Trial of pyrethroid impregnated bednets in an area of Tanzania holoendemic for malaria. Part 2. Effects on the malaria vector population. Acta Trop (1991) 3.04

Efficacy and toxicity of heparin in relation to age and sex. N Engl J Med (1968) 2.99

A hypothesis: nonsteroidal anti-inflammatory drugs reduce the incidence of large-bowel cancer. J Natl Cancer Inst (1991) 2.96

Efficacy of laparoscopic subtotal hysterectomy in the management of menorrhagia: 400 consecutive cases. BJOG (2008) 2.96

Comprehensive drug surveillance. JAMA (1970) 2.92

Increased plasma endothelin-1 in pulmonary hypertension: marker or mediator of disease? Ann Intern Med (1991) 2.88

Survival with first-line bosentan in patients with primary pulmonary hypertension. Eur Respir J (2005) 2.83

Mammography and clinical examination in mass screening for cancer of the breast. Cancer (1967) 2.80

Functional recovery and medical costs of trauma: an analysis by type and severity of injury. J Trauma (1988) 2.74

Antenatal exposure to doxylamine succinate and dicyclomine hydrochloride (Benedectin) in relation to congenital malformations, perinatal mortality rate, birth weight, and intelligence quotient score. Am J Obstet Gynecol (1977) 2.65

Epoprostenol for treatment of pulmonary hypertension in patients with systemic lupus erythematosus. Chest (2000) 2.64

The risk of myocardial infarction after quitting smoking in men under 55 years of age. N Engl J Med (1985) 2.64

Induction of an active transport system for glucose 6-phosphate in Escherichia coli. Arch Biochem Biophys (1966) 2.53

Mental health and social characteristics of the homeless: a survey of mission users. Am J Public Health (1986) 2.50

Drug rash with ampicillin and other penicillins. Lancet (1969) 2.50

SCH-C (SCH 351125), an orally bioavailable, small molecule antagonist of the chemokine receptor CCR5, is a potent inhibitor of HIV-1 infection in vitro and in vivo. Proc Natl Acad Sci U S A (2001) 2.49

A case-control study of baldness in relation to myocardial infarction in men. JAMA (1993) 2.49

Venous thromboembolic disease and ABO blood type. A cooperative study. Lancet (1969) 2.38

The methodology and operation of a pilot randomized control trial of the effectiveness of the Bug Busting method against a single application insecticide product for head louse treatment. Public Health (2000) 2.38

Impact of efforts to increase participation in repetitive screenings for early breast cancer detection. Am J Public Health (1972) 2.35

Breast cancer and cigarette smoking: a hypothesis. Am J Epidemiol (1991) 2.35

Race, family income, and low birth weight. Am J Epidemiol (1991) 2.30

Electron-beam computed tomography in the diagnosis of coronary artery disease: a meta-analysis. Arch Intern Med (2001) 2.28

Current practice of artificial insemination by donor in the United States. N Engl J Med (1979) 2.24

Medical economics survey-methods study: cost-effectiveness of alternative survey strategies. Med Care (1978) 2.22

Nifedipine therapy for coronary-artery spasm. Experience in 127 patients. N Engl J Med (1980) 2.20

Limited Pap screening associated with reduced risk of cervical cancer in South Africa. Int J Epidemiol (2003) 2.17

A multicenter, randomized, double-blinded trial of pyridostigmine in postpolio syndrome. Neurology (1999) 2.16

The search for risk factors in breast cancer. Am J Public Health Nations Health (1968) 2.16

The economic impact of traumatic injuries. One-year treatment-related expenditures. JAMA (1988) 2.15

Association of coronary atherosclerosis with hyperapobetalipoproteinemia [increased protein but normal cholesterol levels in human plasma low density (beta) lipoproteins]. Proc Natl Acad Sci U S A (1980) 2.13

The Abbreviated Injury Scale and Injury Severity Score. Levels of inter- and intrarater reliability. Med Care (1985) 2.11

Methyl-coenzyme M, an intermediate in methanogenic dissimilation of C1 compounds by Methanosarcina barkeri. J Bacteriol (1980) 2.11

Proceedings: A more uniform measurement of factor VIII inhibitors. Thromb Diath Haemorrh (1975) 2.10

Effects of long-term infusion of prostacyclin (epoprostenol) on echocardiographic measures of right ventricular structure and function in primary pulmonary hypertension. Primary Pulmonary Hypertension Study Group. Circulation (1997) 2.03

Graduated compression stockings to treat acute leg pain associated with proximal DVT. A randomised controlled trial. Thromb Haemost (2014) 2.02

Prepregnant weight in relation to risk of neural tube defects. JAMA (1996) 2.02

Physiological changes during low- and high-intensity noninvasive ventilation. Eur Respir J (2011) 2.01

Intra-aortic balloon counterpulsation in cardiogenic shock. Report of a co-operative clinical trial. N Engl J Med (1973) 2.00

Evaluation of periodic breast cancer screening with mammography. Methodology and early observations. JAMA (1966) 2.00

Pseudobacteremia attributed to contamination of povidone-iodine with Pseudomonas cepacia. Ann Intern Med (1981) 1.96

Decline in the risk of myocardial infarction among women who stop smoking. N Engl J Med (1990) 1.95

Reproductive factors and risk of myocardial infarction. Am J Epidemiol (1992) 1.94

Type 2 diabetes: evidence for linkage on chromosome 20 in 716 Finnish affected sib pairs. Proc Natl Acad Sci U S A (1999) 1.91

Multivitamin supplementation and risk of birth defects. Am J Epidemiol (1999) 1.91

Noncontraceptive estrogens and myocardial infarction in young women. JAMA (1980) 1.88

Selection, follow-up, and analysis in the Health Insurance Plan Study: a randomized trial with breast cancer screening. Natl Cancer Inst Monogr (1985) 1.87

End result measurements of quality of medical care. Milbank Mem Fund Q (1967) 1.87

Relevance of correlates of infant deaths for significant morbidity at 1 year of age. Am J Obstet Gynecol (1980) 1.85

Prognosis of men after first myocardial infarction: mortality and first recurrence in relation to selected parameters. Am J Public Health Nations Health (1968) 1.85

Vasectomy and the risk of prostate cancer. Am J Epidemiol (1990) 1.84

Like mother, like child: intergenerational patterns of age at first birth and associations with childhood and adolescent characteristics and adult outcomes in the second generation. Dev Psychol (1998) 1.81

Anxiety and depression in a primary care clinic. Comparison of Diagnostic Interview Schedule, General Health Questionnaire, and practitioner assessments. Arch Gen Psychiatry (1987) 1.81

Nicotine and carbon monoxide content of cigarette smoke and the risk of myocardial infarction in young men. N Engl J Med (1983) 1.80

Pulmonary veno-occlusive disease: a case series and new observations. Chest (2000) 1.80

Patterns of medical use by the indigent aged under two systems of medical care. Am J Public Health Nations Health (1967) 1.80

The diagnostic approach to acute venous thromboembolism. Clinical practice guideline. American Thoracic Society. Am J Respir Crit Care Med (1999) 1.80

Ventricular premature beats and mortality after myocardial infarction. N Engl J Med (1977) 1.79

POSTOPERATIVE THROMBO-EMBOLIZATION: THE PLATELET COUNT AND THE PROTHROMBIN TIME AFTER SURGICAL OPERATIONS: A SIMPLE METHOD FOR DETECTING REDUCTIONS AND ELEVATIONS OF THE PROTHROMBIN CONCENTRATION (OR ACTIVITY) OF THE BLOOD PLASMA. Ann Surg (1942) 1.79

Calcium channel blockers and the risk of cancer. JAMA (1998) 1.78

Molecular and functional analysis identifies ALK-1 as the predominant cause of pulmonary hypertension related to hereditary haemorrhagic telangiectasia. J Med Genet (2003) 1.76

Breast cancer before age 45 and oral contraceptive use: new findings. Am J Epidemiol (1989) 1.76

Survival in patients with class III idiopathic pulmonary arterial hypertension treated with first line oral bosentan compared with an historical cohort of patients started on intravenous epoprostenol. Thorax (2005) 1.76

Stature and the risk of myocardial infarction in women. Am J Epidemiol (1990) 1.73

Combination of bosentan with epoprostenol in pulmonary arterial hypertension: BREATHE-2. Eur Respir J (2004) 1.73

The risk of acute major upper gastrointestinal bleeding among users of aspirin and ibuprofen at various levels of alcohol consumption. Am J Gastroenterol (1999) 1.73

Validation of an in vitro biofilm model of supragingival plaque. J Dent Res (2001) 1.73

Ventricular contraction abnormalities in dilated cardiomyopathy: effect of biventricular pacing to correct interventricular dyssynchrony. J Am Coll Cardiol (2000) 1.73