Published in Drug Discov Today on May 01, 2005
Myeloperoxidase-derived oxidation: mechanisms of biological damage and its prevention. J Clin Biochem Nutr (2010) 1.15
Cytotoxic effects of the dietary flavones chrysin and apigenin in a normal trout liver cell line. Chem Biol Interact (2007) 0.82
An overview on the proposed mechanisms of antithyroid drugs-induced liver injury. Adv Pharm Bull (2015) 0.81
Protective Effects of N-acetylcysteine Against the Statins Cytotoxicity in Freshly Isolated Rat Hepatocytes. Adv Pharm Bull (2014) 0.81
Flutamide-induced cytotoxicity and oxidative stress in an in vitro rat hepatocyte system. Oxid Med Cell Longev (2014) 0.79
Green tea (Camellia sinesis) ameliorates female Schistosoma mansoni-induced changes in the liver of Balb/C mice. Saudi J Biol Sci (2011) 0.79
Metabolite profile resulting from the activation/inactivation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 2-methyltetrahydro-β-carboline by oxidative enzymes. Biomed Res Int (2013) 0.78
Concurrent Inflammation Augments Antimalarial Drugs-Induced Liver Injury in Rats. Adv Pharm Bull (2016) 0.75
Liver Effects of Clinical Drugs Differentiated in Human Liver Slices. Int J Mol Sci (2017) 0.75
Modulatory effect of luteolin on redox homeostasis and inflammatory cytokines in a mouse model of liver cancer. Oncol Lett (2016) 0.75
δ-Aminolevulinate Dehydratase Activity is Stimulated in a MPTP Mouse Model of Parkinson's Disease: Correlation with Myeloperoxidase Activity. Cell Mol Neurobiol (2016) 0.75
Fit-for-purpose method development and validation for successful biomarker measurement. Pharm Res (2006) 2.96
Cellular and in vivo hepatotoxicity caused by green tea phenolic acids and catechins. Free Radic Biol Med (2005) 2.40
100 most cited articles in orthopaedic surgery. Clin Orthop Relat Res (2010) 2.21
Potential toxicity of flavonoids and other dietary phenolics: significance for their chemopreventive and anticancer properties. Free Radic Biol Med (2004) 2.07
Toward 'omic scale metabolite profiling: a dual separation-mass spectrometry approach for coverage of lipid and central carbon metabolism. Anal Chem (2013) 1.76
Prooxidant activity and cellular effects of the phenoxyl radicals of dietary flavonoids and other polyphenolics. Toxicology (2002) 1.54
Method validation and measurement of biomarkers in nonclinical and clinical samples in drug development: a conference report. Pharm Res (2005) 1.44
Current thinking about acute compartment syndrome of the lower extremity. Can J Surg (2010) 1.43
H2S cytotoxicity mechanism involves reactive oxygen species formation and mitochondrial depolarisation. Toxicology (2004) 1.34
Surgical treatment of a displaced lateral malleolus fracture: the antiglide technique versus lateral plate fixation. J Orthop Trauma (2002) 1.30
Molecular cytotoxic mechanisms of anticancer hydroxychalcones. Chem Biol Interact (2004) 1.27
Principles of treatment for periprosthetic femoral shaft fractures around well-fixed total hip arthroplasty. J Am Acad Orthop Surg (2009) 1.25
Molecular mechanisms of hydrogen sulfide toxicity. Drug Metab Rev (2006) 1.22
Herbal monoterpene alcohols inhibit propofol metabolism and prolong anesthesia time. Life Sci (2006) 1.19
Bonding-induced thermal conductance enhancement at inorganic heterointerfaces using nanomolecular monolayers. Nat Mater (2012) 1.18
Mitochondrial function and toxicity: role of B vitamins on the one-carbon transfer pathways. Chem Biol Interact (2006) 1.17
Diagnostic techniques in acute compartment syndrome of the leg. J Orthop Trauma (2008) 1.17
Prevention of hydrogen sulfide (H2S)-induced mouse lethality and cytotoxicity by hydroxocobalamin (vitamin B(12a)). Toxicology (2007) 1.13
Carcinogenic metal induced sites of reactive oxygen species formation in hepatocytes. Toxicol In Vitro (2003) 1.11
Mitochondrial function and toxicity: role of the B vitamin family on mitochondrial energy metabolism. Chem Biol Interact (2006) 1.10
Drug-induced mitochondrial toxicity. Expert Opin Drug Metab Toxicol (2005) 1.06
Single- versus multiple-dose antibiotic prophylaxis in the surgical treatment of closed fractures: a meta-analysis. J Orthop Trauma (2008) 1.03
Applications of cytotoxicity assays and pre-lethal mechanistic assays for assessment of human hepatotoxicity potential. Chem Biol Interact (2004) 1.03
Mechanism of sulfite cytotoxicity in isolated rat hepatocytes. Chem Biol Interact (2008) 1.02
The reliability and validity of the Disabilities of Arm, Shoulder, and Hand, EuroQol-5D, Health Utilities Index, and Short Form-6D outcome instruments in patients with proximal humeral fractures. J Shoulder Elbow Surg (2010) 1.02
The cytotoxic mechanism of glyoxal involves oxidative stress. Biochem Pharmacol (2004) 0.99
Prooxidant and antioxidant activity of vitamin E analogues and troglitazone. Chem Res Toxicol (2005) 0.98
Role of hydrazine in isoniazid-induced hepatotoxicity in a hepatocyte inflammation model. Toxicol Appl Pharmacol (2008) 0.98
Leading 20 at 20: top cited articles and authors in the Journal of Orthopaedic Trauma, 1987-2007. J Orthop Trauma (2010) 0.97
Dietary flavonoid iron complexes as cytoprotective superoxide radical scavengers. Free Radic Biol Med (2003) 0.96
Endogenous and endobiotic induced reactive oxygen species formation by isolated hepatocytes. Free Radic Biol Med (2002) 0.95
Coenzyme Q cytoprotective mechanisms for mitochondrial complex I cytopathies involves NAD(P)H: quinone oxidoreductase 1(NQO1). Free Radic Res (2002) 0.95
Effects of phosphodiesterase 3,4,5 inhibitors on hepatocyte cAMP levels, glycogenolysis, gluconeogenesis and susceptibility to a mitochondrial toxin. Mol Cell Biochem (2003) 0.94
Metabolism, not autoxidation, plays a role in alpha-oxoaldehyde- and reducing sugar-induced erythrocyte GSH depletion: relevance for diabetes mellitus. Mol Cell Biochem (2003) 0.94
Muscle function and functional outcome following standard antegrade reamed intramedullary nailing of isolated femoral shaft fractures. J Orthop Trauma (2008) 0.93
Risk factors for acute compartment syndrome of the leg associated with tibial diaphyseal fractures in adults. J Orthop Traumatol (2014) 0.92
The development of a fully-integrated immune response model (FIRM) simulator of the immune response through integration of multiple subset models. BMC Syst Biol (2013) 0.92
Idiosyncratic NSAID drug induced oxidative stress. Chem Biol Interact (2002) 0.92
Metabolic products and pathways of fluorotelomer alcohols in isolated rat hepatocytes. Chem Biol Interact (2005) 0.91
Mechanism of mitochondrial uncouplers, inhibitors, and toxins: focus on electron transfer, free radicals, and structure-activity relationships. Curr Med Chem (2005) 0.91
Optimization of analytical and pre-analytical variables associated with an ex vivo cytokine secretion assay. J Pharm Biomed Anal (2006) 0.90
What outcomes are important for patients after pelvic trauma? Subjective responses and psychometric analysis of three published pelvic-specific outcome instruments. J Orthop Trauma (2014) 0.89
Oxidative stress mediated idiosyncratic drug toxicity. Drug Metab Rev (2005) 0.89
The results of early primary open reduction and internal fixation for treatment of OTA 43.C-type tibial pilon fractures: a cohort study. J Orthop Trauma (2010) 0.89
Radiographic displacement in pelvic ring disruption: reliability of 3 previously described measurement techniques. J Orthop Trauma (2014) 0.88
Structure-activity relationships for thiol reactivity and rat or human hepatocyte toxicity induced by substituted p-benzoquinone compounds. J Appl Toxicol (2008) 0.88
Amodiaquine-induced oxidative stress in a hepatocyte inflammation model. Toxicology (2008) 0.88
Application of quantitative structure-toxicity relationships for the comparison of the cytotoxicity of 14 p-benzoquinone congeners in primary cultured rat hepatocytes versus PC12 cells. Toxicol Sci (2004) 0.87
Molecular cytotoxic mechanisms of catecholic polychlorinated biphenyl metabolites in isolated rat hepatocytes. Chem Biol Interact (2007) 0.86
Simultaneous detection of the antioxidant and pro-oxidant activity of dietary polyphenolics in a peroxidase system. Free Radic Res (2003) 0.86
High content analysis of cytotoxic effects of pDMAEMA on human intestinal epithelial and monocyte cultures. J Control Release (2010) 0.86
Bacterial cholangiohepatitis in a dog. Can Vet J (2012) 0.85
Glyoxal and methylglyoxal: autoxidation from dihydroxyacetone and polyphenol cytoprotective antioxidant mechanisms. Chem Biol Interact (2012) 0.85
Hepatocyte or serum albumin protein carbonylation by oxidized fructose metabolites: Glyceraldehyde or glycolaldehyde as endogenous toxins? Chem Biol Interact (2010) 0.85
Cytoprotective mechanisms of carbonyl scavenging drugs in isolated rat hepatocytes. Chem Biol Interact (2008) 0.84
Quantitative structure toxicity relationships for phenols in isolated rat hepatocytes. Chem Biol Interact (2003) 0.84
A-CD estrogens. I. Substituent effects, hormone potency, and receptor subtype selectivity in a new family of flexible estrogenic compounds. J Med Chem (2010) 0.84
Differences in glyoxal and methylglyoxal metabolism determine cellular susceptibility to protein carbonylation and cytotoxicity. Chem Biol Interact (2011) 0.84
The effects of partial thiamin deficiency and oxidative stress (i.e., glyoxal and methylglyoxal) on the levels of alpha-oxoaldehyde plasma protein adducts in Fischer 344 rats. FEBS Lett (2005) 0.84
A thermolyzed diet increases oxidative stress, plasma alpha-aldehydes and colonic inflammation in the rat. Chem Biol Interact (2007) 0.82
High content analysis to determine cytotoxicity of the antimicrobial peptide, melittin and selected structural analogs. Peptides (2011) 0.82
A systematic review of thromboprophylaxis for pelvic and acetabular fractures. J Orthop Trauma (2009) 0.82
Metastatic disease of the long bones: a review of the health care burden in a major trauma centre. Can J Surg (2012) 0.82
Mitochondrial involvement in genetically determined transition metal toxicity I. Iron toxicity. Chem Biol Interact (2006) 0.81
Hepatocyte cytotoxicity induced by hydroperoxide (oxidative stress model) or glyoxal (carbonylation model): prevention by bioactive nut extracts or catechins. Chem Biol Interact (2008) 0.81
Bioactivation of fluorotelomer alcohols in isolated rat hepatocytes. Chem Biol Interact (2008) 0.81
Prooxidant activity of free radicals derived from phenol-containing neurotransmitters. Toxicology (2002) 0.81
Single-dose versus multiple-dose antibiotic prophylaxis for the surgical treatment of closed fractures. Acta Orthop (2010) 0.81
Copper-catalyzed ascorbate oxidation results in glyoxal/AGE formation and cytotoxicity. Mol Nutr Food Res (2007) 0.81
Biomechanical evaluation of proximal humeral fracture fixation supplemented with calcium phosphate cement. J Bone Joint Surg Am (2002) 0.81
Metabolic activation of 3-hydroxyanisole by isolated rat hepatocytes. Chem Biol Interact (2003) 0.81
Hybrid quantum dot-fatty ester stealth nanoparticles: toward clinically relevant in vivo optical imaging of deep tissue. ACS Nano (2011) 0.81
Sulfation and glucuronidation of phenols: implications in coenyzme Q metabolism. Methods Enzymol (2005) 0.81
Comparative quantitative structure toxicity relationships for flavonoids evaluated in isolated rat hepatocytes and HeLa tumor cells. Chem Biol Interact (2002) 0.80
Evaluation of the cytotoxicity of organic dust components on THP1 monocytes-derived macrophages using high content analysis. Environ Toxicol (2012) 0.80
Tetramethylphenylenediamine-induced hepatocyte cytotoxicity caused by lysosomal labilisation and redox cycling with oxygen activation. Chem Biol Interact (2007) 0.80
Cytoprotection by almond skin extracts or catechins of hepatocyte cytotoxicity induced by hydroperoxide (oxidative stress model) versus glyoxal or methylglyoxal (carbonylation model). Chem Biol Interact (2010) 0.80
Catalase activity assays. Curr Protoc Toxicol (2006) 0.80
Plastic deformation of the forearm in an adult: treatment with multiple osteotomies. Clin Orthop Relat Res (2007) 0.80
Effect of diquat on the antioxidant system and cell growth in human neuroblastoma cells. Toxicol Appl Pharmacol (2002) 0.80
Structure-activity relationships for hepatocyte toxicity and electrophilic reactivity of alpha,beta-unsaturated esters, acrylates and methacrylates. J Appl Toxicol (2008) 0.80
Cytotoxic molecular mechanisms and cytoprotection by enzymic metabolism or autoxidation for glyceraldehyde, hydroxypyruvate and glycolaldehyde. Chem Biol Interact (2011) 0.80
The biosynthesis of ascorbate protects isolated rat hepatocytes from cumene hydroperoxide-mediated oxidative stress. Free Radic Biol Med (2005) 0.80
Modulating carbonyl cytotoxicity in intact rat hepatocytes by inhibiting carbonyl-metabolizing enzymes. I. Aliphatic alkenals. Chem Biol Interact (2003) 0.79
Peroxidase catalysed formation of cytotoxic prooxidant phenothiazine free radicals at physiological pH. Chem Biol Interact (2004) 0.79
Metabolism of caffeic acid by isolated rat hepatocytes and subcellular fractions. Toxicol Lett (2002) 0.79
Application of structure-activity relationships to investigate the molecular mechanisms of hepatocyte toxicity and electrophilic reactivity of alpha,beta-unsaturated aldehydes. J Appl Toxicol (2008) 0.79
Acrolein and chloroacetaldehyde: an examination of the cell and cell-free biomarkers of toxicity. Chem Biol Interact (2012) 0.79
Preventing cell death induced by carbonyl stress, oxidative stress or mitochondrial toxins with vitamin B anti-AGE agents. Mol Nutr Food Res (2008) 0.79
N-oxidation of aromatic amines by intracellular oxidases. Drug Metab Rev (2002) 0.79
Monitoring cellular accumulation of 3'-deoxy-3'-fluorothymidine (FLT) and its monophosphate metabolite (FLT-MP) by LC-MS/MS as a measure of cell proliferation in vitro. J Chromatogr B Analyt Technol Biomed Life Sci (2011) 0.79
Metabolic mechanisms of methanol/formaldehyde in isolated rat hepatocytes: carbonyl-metabolizing enzymes versus oxidative stress. Chem Biol Interact (2011) 0.79
Structure-activity relationships for halobenzene induced cytotoxicity in rat and human hepatocytes. Chem Biol Interact (2006) 0.79
Organochlorines inhibit acetaminophen glucuronidation by redirecting UDP-glucuronic acid towards the D-glucuronate pathway. Toxicol Appl Pharmacol (2008) 0.78
On the synergistic effect of doxorubicin and mitomycin C against breast cancer cells. Drug Metabol Drug Interact (2007) 0.78
Molecular cytotoxic mechanisms of chlorpromazine in isolated rat hepatocytes. Can J Physiol Pharmacol (2013) 0.78
Rescuing hepatocytes from iron-catalyzed oxidative stress using vitamins B1 and B6. Toxicol In Vitro (2011) 0.78
Cytotoxic effects of polychlorinated biphenyl hydroquinone metabolites in rat hepatocytes. J Appl Toxicol (2010) 0.78
Cytoprotective and anticancer properties of coenzyme Q versus capsaicin. Biofactors (2003) 0.77
Preventing hepatocyte oxidative stress cytotoxicity with Mangifera indica L. extract (Vimang). Drug Metabol Drug Interact (2005) 0.77