Published in J Biol Chem on May 13, 2005
Crystal structures of human alpha-defensins HNP4, HD5, and HD6. Protein Sci (2006) 1.68
The roles of antimicrobial peptides in innate host defense. Curr Pharm Des (2009) 1.58
Through the looking glass, mechanistic insights from enantiomeric human defensins. J Biol Chem (2009) 1.25
Antiviral mechanisms of human defensins. J Mol Biol (2013) 1.22
The conserved salt bridge in human alpha-defensin 5 is required for its precursor processing and proteolytic stability. J Biol Chem (2008) 1.16
Trp-26 imparts functional versatility to human alpha-defensin HNP1. J Biol Chem (2010) 1.12
Strain-specific polymorphisms in Paneth cell α-defensins of C57BL/6 mice and evidence of vestigial myeloid α-defensin pseudogenes. Infect Immun (2010) 1.06
Human defensins 5 and 6 enhance HIV-1 infectivity through promoting HIV attachment. Retrovirology (2011) 1.04
Functional determinants of human enteric α-defensin HD5: crucial role for hydrophobicity at dimer interface. J Biol Chem (2012) 1.03
Identifying the hotspots on the top faces of WD40-repeat proteins from their primary sequences by β-bulges and DHSW tetrads. PLoS One (2012) 1.03
The membrane-bound structure and topology of a human α-defensin indicate a dimer pore mechanism for membrane disruption. Biochemistry (2010) 1.01
The antimicrobial activity of CCL28 is dependent on C-terminal positively-charged amino acids. Eur J Immunol (2010) 0.94
Impact of pro segments on the folding and function of human neutrophil alpha-defensins. J Mol Biol (2007) 0.92
The α-defensin salt-bridge induces backbone stability to facilitate folding and confer proteolytic resistance. Amino Acids (2012) 0.89
Invariant gly residue is important for α-defensin folding, dimerization, and function: a case study of the human neutrophil α-defensin HNP1. J Biol Chem (2012) 0.87
Antimicrobial peptides and proteins of the horse--insights into a well-armed organism. Vet Res (2011) 0.86
Delineation of interfaces on human alpha-defensins critical for human adenovirus and human papillomavirus inhibition. PLoS Pathog (2014) 0.86
3D (13)C-(13)C-(13)C correlation NMR for de novo distance determination of solid proteins and application to a human alpha-defensin. J Magn Reson (2009) 0.86
R-thanatin inhibits growth and biofilm formation of methicillin-resistant Staphylococcus epidermidis in vivo and in vitro. Antimicrob Agents Chemother (2013) 0.84
Hydrophobic determinants of α-defensin bactericidal activity. Infect Immun (2014) 0.81
The repertoire of equine intestinal alpha-defensins. BMC Genomics (2009) 0.81
A novel horse alpha-defensin: gene transcription, recombinant expression and characterization of the structure and function. Biochem J (2007) 0.81
Arginine-specific mono ADP-ribosylation in vitro of antimicrobial peptides by ADP-ribosylating toxins. PLoS One (2012) 0.80
Is glycine a surrogate for a D-amino acid in the collagen triple helix? Protein Sci (2006) 0.80
Enhancement of antiviral activity of human alpha-defensin 5 against herpes simplex virus 2 by arginine mutagenesis at adaptive evolution sites. J Virol (2012) 0.79
Modelling study of dimerization in mammalian defensins. BMC Bioinformatics (2006) 0.79
Structure-antimicrobial activity relationship between pleurocidin and its enantiomer. Exp Mol Med (2008) 0.78
Initial insights into structure-activity relationships of avian defensins. J Biol Chem (2011) 0.78
Effect of selectively introducing arginine and D-amino acids on the antimicrobial activity and salt sensitivity in analogs of human beta-defensins. PLoS One (2013) 0.78
Molecular Evolutionary Analysis of β-Defensin Peptides in Vertebrates. Evol Bioinform Online (2015) 0.77
An ancestral host defence peptide within human β-defensin 3 recapitulates the antibacterial and antiviral activity of the full-length molecule. Sci Rep (2015) 0.77
Human β-defensin 4 with non-native disulfide bridges exhibit antimicrobial activity. PLoS One (2015) 0.75
Guardians of the Gut: Enteric Defensins. Front Microbiol (2017) 0.75
Targeting and inactivation of bacterial toxins by human defensins. Biol Chem (2017) 0.75
DNAWorks: an automated method for designing oligonucleotides for PCR-based gene synthesis. Nucleic Acids Res (2002) 5.75
Multiple roles of antimicrobial defensins, cathelicidins, and eosinophil-derived neurotoxin in host defense. Annu Rev Immunol (2004) 2.72
Many chemokines including CCL20/MIP-3alpha display antimicrobial activity. J Leukoc Biol (2003) 2.62
Human α-defensin 6 promotes mucosal innate immunity through self-assembled peptide nanonets. Science (2012) 2.44
Engineering disulfide bridges to dissect antimicrobial and chemotactic activities of human beta-defensin 3. Proc Natl Acad Sci U S A (2003) 2.32
Antibacterial activity and specificity of the six human {alpha}-defensins. Antimicrob Agents Chemother (2005) 2.11
α-Defensins in human innate immunity. Immunol Rev (2012) 2.10
Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX. Proc Natl Acad Sci U S A (2009) 1.94
Human beta-defensins suppress human immunodeficiency virus infection: potential role in mucosal protection. J Virol (2005) 1.75
Crystal structures of human alpha-defensins HNP4, HD5, and HD6. Protein Sci (2006) 1.68
Human alpha- and beta-defensins block multiple steps in herpes simplex virus infection. J Immunol (2006) 1.64
Antimicrobial characterization of human beta-defensin 3 derivatives. Antimicrob Agents Chemother (2003) 1.63
The structure of human macrophage inflammatory protein-3alpha /CCL20. Linking antimicrobial and CC chemokine receptor-6-binding activities with human beta-defensins. J Biol Chem (2002) 1.53
Human alpha-defensins block papillomavirus infection. Proc Natl Acad Sci U S A (2006) 1.48
Induction of group A Streptococcus virulence by a human antimicrobial peptide. Proc Natl Acad Sci U S A (2008) 1.45
Interactions between human glutamate carboxypeptidase II and urea-based inhibitors: structural characterization. J Med Chem (2008) 1.39
Insight into the mechanisms of adenovirus capsid disassembly from studies of defensin neutralization. PLoS Pathog (2010) 1.34
D-peptide inhibitors of the p53-MDM2 interaction for targeted molecular therapy of malignant neoplasms. Proc Natl Acad Sci U S A (2010) 1.29
Cervicovaginal secretions contribute to innate resistance to herpes simplex virus infection. J Infect Dis (2005) 1.29
A remote arene-binding site on prostate specific membrane antigen revealed by antibody-recruiting small molecules. J Am Chem Soc (2010) 1.29
Toward understanding the cationicity of defensins. Arg and Lys versus their noncoded analogs. J Biol Chem (2007) 1.28
Functional interaction of human neutrophil peptide-1 with the cell wall precursor lipid II. FEBS Lett (2010) 1.26
Structural basis of interaction between urokinase-type plasminogen activator and its receptor. J Mol Biol (2006) 1.25
Through the looking glass, mechanistic insights from enantiomeric human defensins. J Biol Chem (2009) 1.25
Retrocyclins kill bacilli and germinating spores of Bacillus anthracis and inactivate anthrax lethal toxin. J Biol Chem (2006) 1.25
A novel role for defensins in intestinal homeostasis: regulation of IL-1beta secretion. J Immunol (2007) 1.23
Dying and necrotic neutrophils are anti-inflammatory secondary to the release of alpha-defensins. J Immunol (2009) 1.21
Multivalent binding of carbohydrates by the human alpha-defensin, HD5. J Immunol (2009) 1.20
TREM-like transcript-1 protects against inflammation-associated hemorrhage by facilitating platelet aggregation in mice and humans. J Clin Invest (2009) 1.20
Productive folding of human neutrophil alpha-defensins in vitro without the pro-peptide. J Am Chem Soc (2003) 1.18
Multifaceted mechanisms of HIV-1 entry inhibition by human α-defensin. J Biol Chem (2012) 1.18
Why is the Arg5-Glu13 salt bridge conserved in mammalian alpha-defensins? J Biol Chem (2005) 1.17
The conserved salt bridge in human alpha-defensin 5 is required for its precursor processing and proteolytic stability. J Biol Chem (2008) 1.16
Systematic mutational analysis of peptide inhibition of the p53-MDM2/MDMX interactions. J Mol Biol (2010) 1.16
Neisseria gonorrhoeae-induced human defensins 5 and 6 increase HIV infectivity: role in enhanced transmission. J Immunol (2008) 1.15
Inhibition of pathologic retinal neovascularization by alpha-defensins. Blood (2005) 1.13
Trp-26 imparts functional versatility to human alpha-defensin HNP1. J Biol Chem (2010) 1.12
Turning a scorpion toxin into an antitumor miniprotein. J Am Chem Soc (2008) 1.10
Critical determinants of human α-defensin 5 activity against non-enveloped viruses. J Biol Chem (2012) 1.10
Structural insight into the pharmacophore pocket of human glutamate carboxypeptidase II. J Med Chem (2007) 1.08
Structure-dependent functional properties of human defensin 5. FEBS Lett (2007) 1.07
The structure of the extracellular domain of triggering receptor expressed on myeloid cells like transcript-1 and evidence for a naturally occurring soluble fragment. J Biol Chem (2006) 1.05
Human defensins 5 and 6 enhance HIV-1 infectivity through promoting HIV attachment. Retrovirology (2011) 1.04
Functional determinants of human enteric α-defensin HD5: crucial role for hydrophobicity at dimer interface. J Biol Chem (2012) 1.03
Selective arginines are important for the antibacterial activity and host cell interaction of human alpha-defensin 5. FEBS Lett (2009) 1.03
Sometimes it takes two to tango: contributions of dimerization to functions of human α-defensin HNP1 peptide. J Biol Chem (2012) 1.03
N-terminal proteolytic processing by cathepsin G converts RANTES/CCL5 and related analogs into a truncated 4-68 variant. J Leukoc Biol (2006) 1.02
Studies of the biological properties of human beta-defensin 1. J Biol Chem (2006) 1.02
Structural basis of interactions between human glutamate carboxypeptidase II and its substrate analogs. J Mol Biol (2008) 1.01
Total chemical synthesis of N-myristoylated HIV-1 matrix protein p17: structural and mechanistic implications of p17 myristoylation. Proc Natl Acad Sci U S A (2004) 1.01
Human alpha-defensins inhibit hemolysis mediated by cholesterol-dependent cytolysins. Infect Immun (2009) 1.01
The membrane-bound structure and topology of a human α-defensin indicate a dimer pore mechanism for membrane disruption. Biochemistry (2010) 1.01
Human neutrophil alpha-defensin 4 inhibits HIV-1 infection in vitro. FEBS Lett (2005) 1.01
Bioisosterism of urea-based GCPII inhibitors: Synthesis and structure-activity relationship studies. Bioorg Med Chem Lett (2009) 1.00
Defensins in innate immunity. Curr Opin Hematol (2014) 0.99
Population pharmacokinetic modelling for enterohepatic circulation of mycophenolic acid in healthy Chinese and the influence of polymorphisms in UGT1A9. Br J Clin Pharmacol (2008) 0.99
In vitro and in vivo studies on mucoadhesive microspheres of amoxicillin. J Control Release (2005) 0.99
A high-resolution structure of ligand-free human glutamate carboxypeptidase II. Acta Crystallogr Sect F Struct Biol Cryst Commun (2007) 0.98
Crystal structure of XMRV protease differs from the structures of other retropepsins. Nat Struct Mol Biol (2011) 0.97
The association between post-traumatic stress disorder symptoms and the quality of life among Wenchuan earthquake survivors: the role of social support as a moderator. Qual Life Res (2012) 0.97
Turning defense into offense: defensin mimetics as novel antibiotics targeting lipid II. PLoS Pathog (2013) 0.97
MR imaging of tumor angiogenesis using sterically stabilized Gd-DTPA liposomes targeted to CD105. Eur J Radiol (2008) 0.96
Human defensins: synthesis and structural properties. Curr Pharm Des (2007) 0.96