Published in Bioorg Med Chem Lett on June 15, 2005
Evaluating the 3C-like protease activity of SARS-Coronavirus: recommendations for standardized assays for drug discovery. Virus Res (2007) 0.96
Progress in Anti-SARS Coronavirus Chemistry, Biology and Chemotherapy. Annu Rep Med Chem (2007) 0.96
[18F]- and [11C]-labeled N-benzyl-isatin sulfonamide analogues as PET tracers for apoptosis: synthesis, radiolabeling mechanism, and in vivo imaging study of apoptosis in Fas-treated mice using [11C]WC-98. Org Biomol Chem (2009) 0.96
Biological targets for isatin and its analogues: Implications for therapy. Biologics (2007) 0.82
Identification of novel drug scaffolds for inhibition of SARS-CoV 3-Chymotrypsin-like protease using virtual and high-throughput screenings. Bioorg Med Chem (2013) 0.78
New developments for the design, synthesis and biological evaluation of potent SARS-CoV 3CL(pro) inhibitors. Bioorg Med Chem Lett (2009) 0.78
Nano-ZnO catalyzed multicomponent one-pot synthesis of novel spiro(indoline-pyranodioxine) derivatives. ScientificWorldJournal (2014) 0.75
Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases. Proc Natl Acad Sci U S A (2007) 2.00
Stable benzotriazole esters as mechanism-based inactivators of the severe acute respiratory syndrome 3CL protease. Chem Biol (2006) 1.63
Crystal structures of undecaprenyl pyrophosphate synthase in complex with magnesium, isopentenyl pyrophosphate, and farnesyl thiopyrophosphate: roles of the metal ion and conserved residues in catalysis. J Biol Chem (2005) 1.62
The ARID domain of the H3K4 demethylase RBP2 binds to a DNA CCGCCC motif. Nat Struct Mol Biol (2008) 1.28
Mechanism of the maturation process of SARS-CoV 3CL protease. J Biol Chem (2005) 1.27
Small molecules targeting severe acute respiratory syndrome human coronavirus. Proc Natl Acad Sci U S A (2004) 1.25
High-throughput identification of compounds targeting influenza RNA-dependent RNA polymerase activity. Proc Natl Acad Sci U S A (2010) 1.24
Structural basis of inhibition specificities of 3C and 3C-like proteases by zinc-coordinating and peptidomimetic compounds. J Biol Chem (2009) 1.23
Polymorphisms inside microRNAs and microRNA target sites predict clinical outcomes in prostate cancer patients receiving androgen-deprivation therapy. Clin Cancer Res (2010) 1.13
Life-threatening cardiotoxicity due to chronic oral phenytoin overdose. Neurol India (2009) 1.12
Crystal structure of octaprenyl pyrophosphate synthase from hyperthermophilic Thermotoga maritima and mechanism of product chain length determination. J Biol Chem (2003) 1.08
E339...R416 salt bridge of nucleoprotein as a feasible target for influenza virus inhibitors. Proc Natl Acad Sci U S A (2011) 1.04
Inhibition of the severe acute respiratory syndrome 3CL protease by peptidomimetic alpha,beta-unsaturated esters. Bioorg Med Chem (2005) 1.00
Genetic variants in microRNAs and microRNA target sites predict biochemical recurrence after radical prostatectomy in localized prostate cancer. Int J Cancer (2014) 0.99
Grid-enabled high-throughput in silico screening against influenza A neuraminidase. IEEE Trans Nanobioscience (2006) 0.98
Novel five-membered iminocyclitol derivatives as selective and potent glycosidase inhibitors: new structures for antivirals and osteoarthritis. Chembiochem (2006) 0.93
HotLig: a molecular surface-directed approach to scoring protein-ligand interactions. J Chem Inf Model (2013) 0.93
Generation of carcinoembryonic antigen (CEA)-specific T-cell responses in HLA-A*0201 and HLA-A*2402 late-stage colorectal cancer patients after vaccination with dendritic cells loaded with CEA peptides. Clin Cancer Res (2004) 0.92
Novel mutation of topoisomerase I in rendering cells resistant to camptothecin. Cancer Res (2002) 0.92
High-throughput identification of antibacterials against methicillin-resistant Staphylococcus aureus (MRSA) and the transglycosylase. Bioorg Med Chem (2010) 0.91
Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus. J Med Chem (2007) 0.89
Homodimeric hexaprenyl pyrophosphate synthase from the thermoacidophilic crenarchaeon Sulfolobus solfataricus displays asymmetric subunit structures. J Bacteriol (2005) 0.89
Discovery of potent anilide inhibitors against the severe acute respiratory syndrome 3CL protease. J Med Chem (2005) 0.87
Manganese binds to Clostridium difficile Fbp68 and is essential for fibronectin binding. J Biol Chem (2010) 0.85
Synthesis and antiproliferative evaluation of 3,5-disubstituted 1,2,4-triazoles containing flurophenyl and trifluoromethanephenyl moieties. Bioorg Med Chem Lett (2011) 0.85
HA-pseudotyped retroviral vectors for influenza antagonist screening. J Biomol Screen (2009) 0.85
Evaluation of metal-conjugated compounds as inhibitors of 3CL protease of SARS-CoV. FEBS Lett (2004) 0.84
Structure-based drug design and structural biology study of novel nonpeptide inhibitors of severe acute respiratory syndrome coronavirus main protease. J Med Chem (2006) 0.84
Metabolism and pharmacokinetics of san-huang-xie-xin-tang, a polyphenol-rich chinese medicine formula, in rats and ex-vivo antioxidant activity. Evid Based Complement Alternat Med (2011) 0.84
A molecular ruler for chain elongation catalyzed by octaprenyl pyrophosphate synthase and its structure-based engineering to produce unprecedented long chain trans-prenyl products. Biochemistry (2004) 0.82
Potential risk of mulberry-drug interaction: modulation on P-glycoprotein and cytochrome P450 3A. J Agric Food Chem (2013) 0.82
Structural basis of mercury- and zinc-conjugated complexes as SARS-CoV 3C-like protease inhibitors. FEBS Lett (2007) 0.82
Xiao-Qing-Long-Tang shows preventive effect of asthma in an allergic asthma mouse model through neurotrophin regulation. BMC Complement Altern Med (2013) 0.82
The immunologically active oligosaccharides isolated from wheatgrass modulate monocytes via Toll-like receptor-2 signaling. J Biol Chem (2013) 0.81
An ecdysone and tetracycline dual regulatory expression system for studies on Rac1 small GTPase-mediated signaling. Am J Physiol Cell Physiol (2003) 0.81
Roles of amino acids in the Escherichia coli octaprenyl diphosphate synthase active site probed by structure-guided site-directed mutagenesis. Biochemistry (2012) 0.81
Vitamin D receptor gene variants and clinical outcomes after androgen-deprivation therapy for prostate cancer. World J Urol (2011) 0.81
Suppression on metastasis by rhubarb through modulation on MMP-2 and uPA in human A549 lung adenocarcinoma: an ex vivo approach. J Ethnopharmacol (2010) 0.81
Genetic variants in nuclear factor-kappa B binding sites are associated with clinical outcomes in prostate cancer patients. Eur J Cancer (2013) 0.81
Engineering transaldolase in Pichia stipitis to improve bioethanol production. ACS Chem Biol (2011) 0.81
Fluorescent substrate analog for monitoring chain elongation by undecaprenyl pyrophosphate synthase in real time. Anal Biochem (2011) 0.81
Mitochondria-mediated and p53-associated apoptosis induced in human cancer cells by a novel selenophene derivative, D-501036. Biochem Pharmacol (2006) 0.80
Concurrent delivery of tumor antigens and activation signals to dendritic cells by irradiated CD40 ligand-transfected tumor cells resulted in efficient activation of specific CD8+ T cells. Cancer Gene Ther (2004) 0.80
D-501036, a novel selenophene-based triheterocycle derivative, exhibits potent in vitro and in vivo antitumoral activity which involves DNA damage and ataxia telangiectasia-mutated nuclear protein kinase activation. Mol Cancer Ther (2007) 0.80
Metabolism and pharmacokinetics of anthraquinones in Rheum palmatum in rats and ex vivo antioxidant activity. Planta Med (2009) 0.79
A novel hydroxyfuroic acid compound as an insulin receptor activator. Structure and activity relationship of a prenylindole moiety to insulin receptor activation. J Biomed Sci (2009) 0.78
Linker-modified triamine-linked acridine dimers: synthesis and cytotoxicity properties in vitro and in vivo. Bioorg Med Chem (2006) 0.77
Soluble toll-like receptor 4 reversed attenuating effect of Chinese herbal Xiao-Qing-Long-Tang on allergen induced nerve growth factor and thymic stromal lymphopoietin. Exp Ther Med (2013) 0.77
Lipoamide channel-binding sulfonamides selectively inhibit mycobacterial lipoamide dehydrogenase. Biochemistry (2013) 0.77
In vitro evaluation of novel inhibitors against the NS2B-NS3 protease of dengue fever virus type 4. Molecules (2013) 0.77
St. John's wort significantly increased the systemic exposure and toxicity of methotrexate in rats. Toxicol Appl Pharmacol (2012) 0.76
Expression of cytoplasmic-domain substituted epidermal growth factor receptor inhibits tumorigenicity of EGFR-overexpressed human glioblastoma multiforme. Int J Oncol (2004) 0.76
Ajugalide-B (ATMA) is an anoikis-inducing agent from Ajuga taiwanensis with antiproliferative activity against tumor cells in vitro. Phytochemistry (2012) 0.76
Acute and Chronic Administrations of Rheum palmatum Reduced the Bioavailability of Phenytoin in Rats: A New Herb-Drug Interaction. Evid Based Complement Alternat Med (2012) 0.75
Crystal structures of ligand-bound octaprenyl pyrophosphate synthase from Escherichia coli reveal the catalytic and chain-length determining mechanisms. Proteins (2014) 0.75
Interaction of rhubarb and methotrexate in rats: in vivo and ex vivo approaches. Am J Chin Med (2013) 0.75
Chemical constituents from Andrographis echioides and their anti-inflammatory activity. Int J Mol Sci (2012) 0.75
The effect of inorganic particles on slot die coating of poly(vinyl alcohol) solutions. J Colloid Interface Sci (2005) 0.75
Self-adaptive fall-detection apparatus embedded in glasses. Conf Proc IEEE Eng Med Biol Soc (2014) 0.75
Discovery of different types of inhibition between the human and thermotoga maritima alpha-fucosidases by fuconojirimycin-based derivatives. Biochemistry (2006) 0.75
Synthesis and antiproliferative activities of N-(naphthalen-2-yl)acetamide and N-(substituted phenyl)acetamide bearing quinolin-2(1H)-one and 3,4-dihydroquinolin-2(1H)-one derivatives. Eur J Med Chem (2012) 0.75
Constituents of the roots of Clausena lansium and their potential anti-inflammatory activity. J Nat Prod (2014) 0.75
Synthesis and antiproliferative evaluation of N,N-disubstituted-N'-[1-aryl-1H-pyrazol-5-yl]-methnimidamides. Bioorg Med Chem Lett (2010) 0.75
From natural product-inspired pyrrolidine scaffolds to the development of new human Golgi α-mannosidase II inhibitors. Chem Asian J (2013) 0.75
The immunologically active oligosaccharides isolated from wheatgrass modulate monocytes via Toll-like receptor-2 signaling. J Biol Chem (2015) 0.75
Synthesis and biological evaluation of substituted 6-alkynyl-4-anilinoquinazoline derivatives as potent EGFR inhibitors. Bioorg Med Chem Lett (2007) 0.75
Synthesis and antiproliferative evaluation of amide-containing anthraquinone, xanthone, and carbazole. Chem Pharm Bull (Tokyo) (2014) 0.75
Synthesis and antiproliferative evaluation of amide-containing flavone and isoflavone derivatives. Bioorg Med Chem (2008) 0.75
The mechanism investigation in substitution of 21-bromo-3alpha-hydroxyl-3beta-methoxymethyl-5alpha-pregnan-20-one with nucleophiles. Steroids (2006) 0.75
Drimane-type sesquiterpenes with a dioxabicyclooctane skeleton from the fruiting bodies of Nigrofomes melanoporus and their cytotoxicity. Planta Med (2012) 0.75