Critical protective role for annexin 1 gene expression in the endotoxemic murine microcirculation.

PubWeight™: 1.27‹?› | Rank: Top 10%

🔗 View Article (PMC 1602430)

Published in Am J Pathol on June 01, 2005

Authors

Amilcar S Damazo1, Simon Yona, Fulvio D'Acquisto, Roderick J Flower, Sonia M Oliani, Mauro Perretti

Author Affiliations

1: The William Harvey Research Institute, Centre of Biochemical Pharmacology, Queen Mary School of Medicine and Dentistry, Charterhouse Square, London, EC1M 6BQ, UK.

Articles citing this

Annexin A1 and glucocorticoids as effectors of the resolution of inflammation. Nat Rev Immunol (2009) 3.32

Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair. J Clin Invest (2012) 1.57

Spatial and temporal profiles for anti-inflammatory gene expression in leukocytes during a resolving model of peritonitis. J Immunol (2006) 1.52

Annexin-A1: a pivotal regulator of the innate and adaptive immune systems. Br J Pharmacol (2008) 1.43

Exploiting the Annexin A1 pathway for the development of novel anti-inflammatory therapeutics. Br J Pharmacol (2009) 1.39

Annexin A1 regulates intestinal mucosal injury, inflammation, and repair. J Immunol (2008) 1.18

Functional and ultrastructural analysis of annexin A1 and its receptor in extravasating neutrophils during acute inflammation. Am J Pathol (2008) 0.99

The impact of endogenous annexin A1 on glucocorticoid control of inflammatory arthritis. Ann Rheum Dis (2012) 0.96

Annexin-A1 peptide down-regulates the leukocyte recruitment and up-regulates interleukin-10 release into lung after intestinal ischemia-reperfusion in mice. J Inflamm (Lond) (2013) 0.91

Nonredundant protective properties of FPR2/ALX in polymicrobial murine sepsis. Proc Natl Acad Sci U S A (2014) 0.91

The return of the Scarlet Pimpernel: cobalamin in inflammation II - cobalamins can both selectively promote all three nitric oxide synthases (NOS), particularly iNOS and eNOS, and, as needed, selectively inhibit iNOS and nNOS. J Nutr Environ Med (2007) 0.90

Cromoglycate drugs suppress eicosanoid generation in U937 cells by promoting the release of Anx-A1. Biochem Pharmacol (2009) 0.89

Modulation of experimental autoimmune encephalomyelitis by endogenous annexin A1. J Neuroinflammation (2009) 0.88

Annexin A1 regulates neutrophil clearance by macrophages in the mouse bone marrow. FASEB J (2011) 0.87

Gene deletion reveals roles for annexin A1 in the regulation of lipolysis and IL-6 release in epididymal adipose tissue. Am J Physiol Endocrinol Metab (2006) 0.87

Annexin A1: potential for glucocorticoid sparing in RA. Nat Rev Rheumatol (2013) 0.84

Annexin A1 and the Resolution of Inflammation: Modulation of Neutrophil Recruitment, Apoptosis, and Clearance. J Immunol Res (2016) 0.83

Mast cells modulate the inflammatory process in endotoxin-induced uveitis. Mol Vis (2011) 0.82

Dysregulation of anti-inflammatory annexin A1 expression in progressive Crohns Disease. PLoS One (2013) 0.82

Downstream gene activation of the receptor ALX by the agonist annexin A1. PLoS One (2010) 0.82

Endogenous annexin A1 counter-regulates bleomycin-induced lung fibrosis. BMC Immunol (2011) 0.81

Effect of exogenous galectin-1 on leukocyte migration: modulation of cytokine levels and adhesion molecules. Int J Clin Exp Pathol (2010) 0.81

Dexamethasone modulates Salmonella enterica serovar Typhimurium infection in vivo independently of the glucocorticoid-inducible protein annexin-A1. FEMS Immunol Med Microbiol (2008) 0.80

The landscape of protein biomarkers proposed for periodontal disease: markers with functional meaning. Biomed Res Int (2014) 0.78

Myenteric denervation in gastric carcinogenesis: differential modulation of nitric oxide and annexin-A1. Int J Clin Exp Pathol (2012) 0.78

Role and interactions of annexin A1 and oestrogens in the manifestation of sexual dimorphisms in cerebral and systemic inflammation. Br J Pharmacol (2013) 0.78

Annexin A1 protein attenuates cyclosporine-induced renal hemodynamics changes and macrophage infiltration in rats. Inflamm Res (2011) 0.78

Enhanced Muscular Dystrophy from Loss of Dysferlin Is Accompanied by Impaired Annexin A6 Translocation after Sarcolemmal Disruption. Am J Pathol (2016) 0.77

The involvement of anti-inflammatory protein, annexin A1, in ocular toxoplasmosis. Mol Vis (2012) 0.77

Effects of exogenous annexin-1 on lipopolysaccharide-induced proliferation and reactive oxygen species production partially through modulation of CRAC channels but independent of NF-kappaB pathway. Inflamm Res (2009) 0.76

Influenza A virus enhances its propagation through the modulation of Annexin-A1 dependent endosomal trafficking and apoptosis. Cell Death Differ (2016) 0.75

Mast Cells Mediate Early Neutrophil Recruitment and Exhibit Anti-Inflammatory Properties via FPR2/ALX. Br J Pharmacol (2017) 0.75

A most important annexation. Am J Pathol (2005) 0.75

Articles cited by this

Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science (1998) 37.15

The pathophysiology and treatment of sepsis. N Engl J Med (2003) 21.67

Tissue destruction by neutrophils. N Engl J Med (1989) 13.81

Cachectin and tumour necrosis factor as two sides of the same biological coin. Nature (1986) 11.09

Annexins: from structure to function. Physiol Rev (2002) 6.78

Treatment of septic shock with the tumor necrosis factor receptor:Fc fusion protein. The Soluble TNF Receptor Sepsis Study Group. N Engl J Med (1996) 5.25

Novel strategies for the treatment of sepsis. Nat Med (2003) 5.14

Inflammatory resolution: new opportunities for drug discovery. Nat Rev Drug Discov (2004) 5.08

Cutting edge: endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface toll-like receptor 4 expression. J Immunol (2000) 4.10

Risk and the efficacy of antiinflammatory agents: retrospective and confirmatory studies of sepsis. Am J Respir Crit Care Med (2002) 2.95

Normal responses to injury prevent systemic inflammation and can be immunosuppressive. Am J Respir Crit Care Med (2001) 2.82

Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor. Nat Med (2002) 2.75

An intracellular signaling hierarchy determines direction of migration in opposing chemotactic gradients. J Cell Biol (2002) 2.48

Eleventh Gaddum memorial lecture. Lipocortin and the mechanism of action of the glucocorticoids. Br J Pharmacol (1988) 2.38

Aberrant inflammation and resistance to glucocorticoids in annexin 1-/- mouse. FASEB J (2002) 2.13

Leukokinetic studies. 13. A non-steady-state kinetic evaluation of the mechanism of cortisone-induced granulocytosis. J Clin Invest (1968) 1.97

Mobilizing lipocortin 1 in adherent human leukocytes downregulates their transmigration. Nat Med (1996) 1.96

Anti-inflammatory lipocortin 1 production by peripheral blood leucocytes in response to hydrocortisone. Lancet (1990) 1.88

Glucocorticoid receptor regulates expression of L-selectin and CD11/CD18 on human neutrophils. Circulation (1997) 1.86

Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1. Proc Natl Acad Sci U S A (1998) 1.60

Leukocyte antiadhesive actions of annexin 1: ALXR- and FPR-related anti-inflammatory mechanisms. Blood (2003) 1.60

Inhibition of O2- generation by dexamethasone is mimicked by lipocortin I in alveolar macrophages. J Clin Invest (1989) 1.42

Neutrophil migration during endotoxemia. J Leukoc Biol (1999) 1.42

Modulation of inflammation and response to dexamethasone by Annexin 1 in antigen-induced arthritis. Arthritis Rheum (2004) 1.39

Lipocortin 1 mediates dexamethasone-induced growth arrest of the A549 lung adenocarcinoma cell line. Proc Natl Acad Sci U S A (1992) 1.34

Lipocortin 1 mediates the inhibition by dexamethasone of the induction by endotoxin of nitric oxide synthase in the rat. Proc Natl Acad Sci U S A (1995) 1.24

Attenuation of glucocorticoid functions in an Anx-A1-/- cell line. Biochem J (2003) 1.11

Measurement of lipocortin 1 levels in murine peripheral blood leukocytes by flow cytometry: modulation by glucocorticoids and inflammation. Br J Pharmacol (1996) 1.11

Clinical review: corticotherapy in sepsis. Crit Care (2003) 1.11

The anti-inflammatory peptides, antiflammins, regulate the expression of adhesion molecules on human leukocytes and prevent neutrophil adhesion to endothelial cells. FASEB J (2000) 1.10

Detection of intracellular lipocortin 1 in human leukocyte subsets. Clin Immunol Immunopathol (1995) 1.08

Profound differences in leukocyte-endothelial cell responses to lipopolysaccharide versus lipoteichoic acid. J Immunol (2002) 1.03

Corticosteroids inhibit lymphocyte binding to endothelium and intercellular adhesion: an additional mechanism for their anti-inflammatory and immunosuppressive effect. J Immunol (1997) 1.00

Cytokine modulation of liver annexin 1 expression during experimental endotoxemia. Am J Pathol (2001) 0.99

Glucocorticoid receptor activation reduces CD11b and CD49d levels on murine eosinophils: characterization and functional relevance. Am J Respir Cell Mol Biol (2000) 0.90

Stimulus-specific defect in the phagocytic pathways of annexin 1 null macrophages. Br J Pharmacol (2004) 0.89

Intra-abdominal sepsis attenuates local inflammation-mediated increases in microvascular permeability at remote sites in mice in vivo. Surgery (2004) 0.79

Articles by these authors

Resolution of inflammation: state of the art, definitions and terms. FASEB J (2007) 5.12

Inflammatory resolution: new opportunities for drug discovery. Nat Rev Drug Discov (2004) 5.08

Role of the immune system in chronic pain. Nat Rev Neurosci (2005) 4.10

PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation. Science (2005) 3.74

Annexin A1 and glucocorticoids as effectors of the resolution of inflammation. Nat Rev Immunol (2009) 3.32

Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Nature (2009) 3.27

Selective inhibition of NF-kappa B blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo. Nat Med (2004) 2.94

The MAGUK family protein CARD11 is essential for lymphocyte activation. Immunity (2003) 2.67

Aberrant inflammation and resistance to glucocorticoids in annexin 1-/- mouse. FASEB J (2002) 2.13

A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation. Nat Neurosci (2013) 2.03

Pericytes support neutrophil subendothelial cell crawling and breaching of venular walls in vivo. J Exp Med (2012) 2.02

Resolution of inflammation: an integrated view. EMBO Mol Med (2013) 2.01

Mononuclear phagocyte miRNome analysis identifies miR-142 as critical regulator of murine dendritic cell homeostasis. Blood (2012) 1.82

Modulation of phagocytosis of apoptotic neutrophils by supernatant from dexamethasone-treated macrophages and annexin-derived peptide Ac(2-26). J Immunol (2005) 1.68

Resolvin D1 limits polymorphonuclear leukocyte recruitment to inflammatory loci: receptor-dependent actions. Arterioscler Thromb Vasc Biol (2012) 1.67

Annexin 1 and its bioactive peptide inhibit neutrophil-endothelium interactions under flow: indication of distinct receptor involvement. Blood (2005) 1.62

Annexin 1 mediates the rapid anti-inflammatory effects of neutrophil-derived microparticles. Blood (2008) 1.61

Leukocyte antiadhesive actions of annexin 1: ALXR- and FPR-related anti-inflammatory mechanisms. Blood (2003) 1.60

Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair. J Clin Invest (2012) 1.57

Annexin I regulates SKCO-15 cell invasion by signaling through formyl peptide receptors. J Biol Chem (2006) 1.55

Cutting edge: Humanized nano-proresolving medicines mimic inflammation-resolution and enhance wound healing. J Immunol (2011) 1.52

Spatial and temporal profiles for anti-inflammatory gene expression in leukocytes during a resolving model of peritonitis. J Immunol (2006) 1.52

Origins and tissue-context-dependent fates of blood monocytes. Immunol Cell Biol (2008) 1.50

Ligand-specific conformational change of the G-protein-coupled receptor ALX/FPR2 determines proresolving functional responses. Proc Natl Acad Sci U S A (2013) 1.49

Annexin 1-deficient neutrophils exhibit enhanced transmigration in vivo and increased responsiveness in vitro. J Leukoc Biol (2005) 1.43

Functionally relevant neutrophilia in CD11c diphtheria toxin receptor transgenic mice. Nat Methods (2012) 1.40

The link module from human TSG-6 inhibits neutrophil migration in a hyaluronan- and inter-alpha -inhibitor-independent manner. J Biol Chem (2002) 1.39

Modulation of inflammation and response to dexamethasone by Annexin 1 in antigen-induced arthritis. Arthritis Rheum (2004) 1.39

NCX-1015, a nitric-oxide derivative of prednisolone, enhances regulatory T cells in the lamina propria and protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis in mice. Proc Natl Acad Sci U S A (2002) 1.36

Neutrophil elastase (NE)-deficient mice demonstrate a nonredundant role for NE in neutrophil migration, generation of proinflammatory mediators, and phagocytosis in response to zymosan particles in vivo. J Immunol (2004) 1.31

A novel calcium-dependent proapoptotic effect of annexin 1 on human neutrophils. FASEB J (2003) 1.30

Glucocorticoids induce protein S-dependent phagocytosis of apoptotic neutrophils by human macrophages. J Immunol (2009) 1.30

Microglia, seen from the CX3CR1 angle. Front Cell Neurosci (2013) 1.30

Therapeutic anti-inflammatory potential of formyl-peptide receptor agonists. Pharmacol Ther (2010) 1.29

Dexamethasone induces rapid serine-phosphorylation and membrane translocation of annexin 1 in a human folliculostellate cell line via a novel nongenomic mechanism involving the glucocorticoid receptor, protein kinase C, phosphatidylinositol 3-kinase, and mitogen-activated protein kinase. Endocrinology (2003) 1.28

Human beta-defensin 3 has immunosuppressive activity in vitro and in vivo. Eur J Immunol (2010) 1.26

Antiinflammatory activity of soluble guanylate cyclase: cGMP-dependent down-regulation of P-selectin expression and leukocyte recruitment. Proc Natl Acad Sci U S A (2004) 1.26

FPR2/ALX receptor expression and internalization are critical for lipoxin A4 and annexin-derived peptide-stimulated phagocytosis. FASEB J (2010) 1.23

Activation of the annexin 1 counter-regulatory circuit affords protection in the mouse brain microcirculation. FASEB J (2007) 1.22

Advances in the pathophysiology of constitutive and inducible cyclooxygenases: two enzymes in the spotlight. Biochem Pharmacol (2003) 1.21

A novel biological activity for galectin-1: inhibition of leukocyte-endothelial cell interactions in experimental inflammation. Am J Pathol (2003) 1.20

Annexin A1 regulates intestinal mucosal injury, inflammation, and repair. J Immunol (2008) 1.18

Melanocortin receptor signaling in RAW264.7 macrophage cell line. Peptides (2005) 1.16

Activation of melanocortin type 3 receptor as a molecular mechanism for adrenocorticotropic hormone efficacy in gouty arthritis. Arthritis Rheum (2002) 1.15

Novel insights into the inhibitory effects of Galectin-1 on neutrophil recruitment under flow. J Leukoc Biol (2008) 1.14

On-site education of VEGF-recruited monocytes improves their performance as angiogenic and arteriogenic accessory cells. J Exp Med (2013) 1.14

Redundancy of a functional melanocortin 1 receptor in the anti-inflammatory actions of melanocortin peptides: studies in the recessive yellow (e/e) mouse suggest an important role for melanocortin 3 receptor. J Immunol (2003) 1.13

Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair. J Clin Invest (2015) 1.13

Inhibitory control of endothelial galectin-1 on in vitro and in vivo lymphocyte trafficking. FASEB J (2007) 1.12

Ligand-specific glucocorticoid receptor activation in human platelets. Blood (2005) 1.12

Ligation of the adhesion-GPCR EMR2 regulates human neutrophil function. FASEB J (2007) 1.11

Annexin-1 modulates T-cell activation and differentiation. Blood (2006) 1.10

Annexin 1 cleavage in activated neutrophils: a pivotal role for proteinase 3. J Biol Chem (2007) 1.10

Melanocortin 3 receptors control crystal-induced inflammation. FASEB J (2006) 1.08

An overview of the effects of annexin 1 on cells involved in the inflammatory process. Mem Inst Oswaldo Cruz (2005) 1.08

The peritoneal tumour microenvironment of high-grade serous ovarian cancer. J Pathol (2012) 1.07

Interleukin 17 sustains rather than induces inflammation. Biochem Pharmacol (2008) 1.06

Anti-inflammatory and antiosteoclastogenesis properties of endogenous melanocortin receptor type 3 in experimental arthritis. FASEB J (2010) 1.06

Microparticle alpha-2-macroglobulin enhances pro-resolving responses and promotes survival in sepsis. EMBO Mol Med (2013) 1.05

Formyl-peptide receptor is not involved in the protection afforded by annexin 1 in murine acute myocardial infarct. FASEB J (2004) 1.05

Inhibitory effects of TSG-6 Link module on leukocyte-endothelial cell interactions in vitro and in vivo. Microcirculation (2004) 1.05

Aspirin and steroids: new mechanistic findings and avenues for drug discovery. Curr Opin Pharmacol (2005) 1.04

Increased adiposity, dysregulated glucose metabolism and systemic inflammation in Galectin-3 KO mice. PLoS One (2013) 1.04

The melanocortin agonist AP214 exerts anti-inflammatory and proresolving properties. Am J Pathol (2011) 1.03

Reduced inflammatory and neuropathic pain and decreased spinal microglial response in fractalkine receptor (CX3CR1) knockout mice. J Neurochem (2010) 1.03

Endogenous galectins and the control of the host inflammatory response. J Endocrinol (2009) 1.03

Annexin-1 modulates repair of gastric mucosal injury. Am J Physiol Gastrointest Liver Physiol (2008) 1.03

Interaction of human neutrophils with endothelial cells regulates the expression of endogenous proteins annexin 1, galectin-1 and galectin-3. Cell Biol Int (2006) 1.02